UCL INSTITUTE FOR WOMEN’S HEALTH
Previous Research Projects
MSc Prenatal Genetics and Fetal Medicine
2014-2015
Project subject/title
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The origin of chromosome aneuploidies in
embryos from couples undergoing preimplantation
genetic screening for repeated miscarriages and
repeated IVF failures
Exploring sex reversal in vitro through the
transdifferentiation of granulosa cells to Sertoli cells
Possible neuroprotective and neuroregenerative
effects of Exendin-4 on neonatal mice brain models of
hypoxia-ischemia and infection
Investigating the influence of culture conditions in the
reprogramming of amniotic fluid stem cells to
pluripotency
The role of the X Chromosome in growth regulation
Outcomes of oocyte donation in women with Turner
syndrome
Behavioural evaluation of motor function in murine
models of hypoxia-ischemia brain injury consequent to
treatment with Exendin-4
Comparson of P3 mouse strains at varying oxygen
exposure during hypoxia-ischemia: Finding a preterm
white matter injury model
Fertility outcomes for men with Klinefelter syndrome at
UCLH
Outcome of Laparoscopic ovarian drilling (LOD) for
women with Polycystic Ovary Syndrome (PCOS)
Analysis of expression of genes involved in fetal
growth after maternal VEGF Gene theraphy in the
Guinea Pig
UCL Institute for Women’s Health
86 – 96 Chenies Mews, London WC1E 6HX
Tel: +44 (0)20 6796050 Fax: +44 (0)20 7383 7429
www.instituteforwomenshealth.ucl.ac.uk
Supervisor
Joy Delhanty
Nitzan Gonen, NIMR
Eridan Rocha Ferreira
Pascale Guillot
James Turner, NIMR
Gerard Conway
Eridan Rocha Ferreira
Mariya Hristova
Gerard Conway
Mr Jamal Zaidi fertility
consultant at Conquest
Hospital (East Sussex
Healthcare)
Owen Vaughan
2013-2014
Project subject/title
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Does the origin of sperm affect ICSI outcome in infertile
men?
Development of the human microbiota and immune
system: from fetal to neonatal life
Investigation of the use of customised fetal growth charts
and their possible implementation at the UCLH practice
a comparison between the use of single step and
sequential media on the development of a preimplantation
embryo
The creation of an algorithm for the prediction of
pregnancy outcomes and blastocyst formation rate, using
morphokinetic parameters
Validation of karyomapping
Analysing stem cell lines by karyomapping to look at
recombination breakpoints
A qualitative study of the patient experience of PGD versus
NIPT
factors associated with delayed preterm birth in women
with elevated fetal fibronectin
gene therapy for thalassemia
Epigenetic characterisation of chemically induced
pluripotent stem cells (ciPS cells)
Molecular analysis for ARC syndrome in three patients and
Co-Immunoprecipitation of VBS33B-(L30P and wild type)
with Rab25
the impact of universal trained screening on diagnosis of
antenatal infections and the impact on preterm birth
Real-time PCR for aneuploidy protection in embryos
Analysis of nuclear genes involved in mitochondrial
functioning in early preimplantation embryo development
Development of a gene therapy treatment for FVII
deficiency
UCL Institute for Women’s Health
86 – 96 Chenies Mews, London WC1E 6HX
Tel: +44 (0)20 6796050 Fax: +44 (0)20 7383 7429
www.instituteforwomenshealth.ucl.ac.uk
Supervisor
Amr Abdel Raheem,
UCLH
Eric Jauniaux
Donald Peebles
Joyce Harper
Joyce Harper
Leoni Xanthopolou,
Genesis Genetics
Leoni Xanthopolou,
Genesis Genetics
Lyn Chitty
Natalie Greenwold, UCLH
Pancios Shangaris
Pascale Guillot
Paul Gissen
Penny James
Sioban SenGupta
Sioban SenGupta
Suzy Buckley
2012-2013
Project subject/title
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cff-DNA analysis for single gene disorders with DropletDigital PCR – Specific application to cystic fibrosis
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Analysis of visceral organs in a Gaucher's Type II mouse
model after prenatal gene therapy using AAV9-GBA-WT
single sperm analysis with array CGH
MET pathway in chemical reprogramming
Validation of Next Generation Sequencing of Whole
Genome Amplified Products from a Single Cell
Role of neuronal deletion of CAP23 in neonatal hupoxiaischemia
Investigation of the relationship between nuclear and
cytoplasmic volume in preimplantation mouse embryos
Evaluation of Affymetrix Cytoscan 750K cytogenetics
microarray for use with DNA from amniotic fluid and
chorionic villus samples
Rick factors for 3rd/4th degree perineal tears
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Supervisor
Fiona Macdonald &
Stephanie Allen, West
Midlands Regional
Genetics Laboratory
Ahad Rahim
Joyce Harper
Pascale Guillot
Sioban SenGupta
Mariya Hristova
Greg Fitzharris
Jonathan Waters, NE
Thames Regional
Genetics Service, GOSH
Arvind Vashisht, UCLh
Effect of Erythropoietin in brain damage due to hypoxia
ischemia
Pelvic Floor Dysfunction in Neurological Patients
Mariya Hristova
In PGD case, to what extent do abnormalities detected by
array CGH on day 3 persist to the blastocyst stage?
Validation of next generation sequencing [and SNP-arrays]
of whole genome amplified products from single cells
What is the cause and fate of micro nuclei in mouse
preimplantation development?
Validation of Neutral Red Staining for assessment of
viability of follicles in human ovarian cortex using CFDA-SE
assay
Joy Delhanty
UCL Institute for Women’s Health
86 – 96 Chenies Mews, London WC1E 6HX
Tel: +44 (0)20 6796050 Fax: +44 (0)20 7383 7429
www.instituteforwomenshealth.ucl.ac.uk
Suzy Elneil, UCLH
Sioban SenGupta
Greg Fitzharris
Paul Hardiman