Crossing Boundaries: Linking Metabolism to Epigenetics
May 1-2, 2014 | Cambridge, US | Norton Woods Conference Center
PROGRAM
Thursday May 1, 2014
8:30 – 9:00
Registration
Session I: Cancer, Metabolism and Epigenetics
Session Moderator: TBA
9:00 – 9:15
Welcome and Introductions
Raul Mostoslavsky
9:15 – 10:15
Keynote Speaker
“Metabolic Inputs into Cancer Epigenetics”
Craig Thompson, Sloan-Kettering Cancer Center, NY
10:15 – 10:45 “Decoding metabolic reprogramming by the AMPK Pathway”
Reuben Shaw, The Salk Institute, San Diego
10:45-11:00
11:00 – 11:30
11:30 – 12:00
Abcam
Coffee Break I
“Dynamics of histone methylation mediated by methionine availability
and one carbon cycle flux”
Jason Locasale, Cornell University, NY
12:00 – 12:30 “The Histone deacetylase SIRT6 regulates cancer metabolism”
Raul Mostoslavsky, The Massachusetts General Hospital Cancer
Center, Harvard Medical School
12:30 – 12:45 Short talk: “Akt-dependent metabolic reprogramming regulates tumor
cell histone acetylation”
Kathryn Wellen, Univ. of Pennsylvania
12:45 – 1:45
Lunch break
Session II: Epigenetics in Metabolic Diseases
Session moderator: TBA
1:45 – 2:15
“Acetyl-CoA at the center of cell growth and survival”
Benjamin Tu, Univ. Texas Southwestern, Dallas
2:15 – 2:45
2:45 – 3:00
3:00 – 3:30
3:30 – 4:00
4:15 – 4:30
4:30 – 4:45
4:45 – 5:00
5:00 – 6:30
“Natural metabolites as inhibitors of epigenetic enzymes”
Eric Verdin, The Gladstone Institutes, San Francisco, CA
Short Talk: “ADP-ribosylation of histones: An additional module of the
histone code?”
Michael Hottiger, University of Zurich Switzerland
Coffee break II
”IDH mutations and the methylome of cancer”
Ari Melnick, Weill Cornell Medical College, NY
Short Talk “Integration of S-adenosylmethionine Metabolism with
Epigenetics and Cell Cycle”
Stacey Borrego, University of California Irvine
Short Talk “RNA epigenetics and metabolism”
Blerta Xhemalce, Univ. of Texas Austin
Day I Summary and Closing
Poster Session in Foyer
Friday May 2nd 2014
Session III: Signalling in metabolism and epigenetics
Session moderator: TBA
09:30 – 10:00
“Histone acetylation modulates intracellular pH”
Siavash Kurdistani, UCLA
10:00 – 10:30
“The Epigenetic Language of the Circadian Clock”
Paolo Sassone-Corsi, UC Irvine, Irvine
10:30 – 11:00
“Metabolic regulation of reprogramming and pluripotency”
George Daley, Children’s Hospital Boston, Harvard Medical School
11:00 – 11:30
Morning Coffee
11:30-11:45
Short talk: “Acetyl-CoA concentration alters specificity and selectivity of
CBP and p300”
Andrew Andrews, Fox Chase Cancer Center
11:45 – 12:00
Short Talk “Metabolic analysis of pRB-deficient cells”
Brandon Nicolay, The MGH Cancer Center, Boston
12:00 – 12:30
“Histone demethylases in cancer”
Johnathan Whetstine, MGH Cancer Center, Boston
12:30 – 1:30
Lunch
Session IV: Metabolism and chromatin dynamics in organismal models
Session Moderator: XX
2:45 – 3:15
“SIRTUINS, NAD and AGING”
Lenny Guarente, MIT, Boston
3:15 – 3:45
“The Microbial Metabolite Butyrate has Potent Energetic and Epigenetic
Functions in Homeostasis and Colorectal Cancer Prevention”
Scott Bultman, Univ. North Carolina
3:45 – 4:00
Short Talk ”A naturally occurring product isolated from fungi of
Chaetomium species improves prognosis in chronic heart failure”
Ruri Kaneda, Keio University, Japan
4:00 - 4:15
Short Talk “Tau promotes neurodegeneration through widespread
heterochromatin loss”
Bess Frost, Brigham and Women’s Hospital, Boston
4:15
Closing Remarks