The UCL Tobacco and Alcohol Research Group (UTARG) Output Health Behaviour Research Centre Institute of Epidemiology and Health Care, University College London, 1-19 Torrington Place, London WC1E 6BT Updated 17th November 2015 by Robert West (robertwest100@gmail.com) The UTARG undertakes clinical trials of smoking cessation and alcohol reduction interventions, national and international surveys of smoking and alcohol use patterns, analysis of large clinical data sets, field studies of behavioural support for smoking cessation in practice, and experimental and interview studies aimed at identifying novel intervention components. The four largest components of the programme are: 1) development and evaluation of digital smoking cessation and alcohol reduction aids, 2) the ‘Smoking Toolkit Study’ consisting of monthly national surveys of smoking and smoking cessation patterns in England, 3) the ‘Alcohol Toolkit Study’ which does a similar thing for alcohol use, and 4) identifying and promoting best practice in the national network of Stop-Smoking Services. The alcohol research was added in late 2013. This document shows the output of the Tobacco Research Group led by Professor Robert West since the beginning of the Cancer Research UK programme in April 2007, renewed in April 2012. Entries are listed in reverse date order. The most significant publications since 2011 are in bold. Primary research and systematic reviews in refereed journals Citations Key findings * denotes articles arising from the Smoking Toolkit Study ^ denotes studies arising from synergy with the National Centre for Smoking Cessation and Training 1. Ebbert J, Hughes J, West R, Rennard S, Russ C, McRae T, Treadow J, Ching-Ray Y, Dutro M, Park P, (2015) Effect of Varenicline on Smoking Cessation Through Smoking Reduction: A Randomized Clinical Trial. Journal of the American Medical Association. 313(7):687-94. doi: 10.1001/jama.2015.280. 2. Kotz D, Simpson C, Viechtbauer W, van Schayck O, West R, Sheikh A, (2015) Cardiovascular and neuropsychiatric safety of varenicline and bupropion compared with nicotine replacement therapy for smoking cessation: study protocol of a retrospective cohort study using the QResearch® general practice database. BMJ Open, 4(8):e005281. doi: 10.1136/bmjopen-2014-005281. 3. Ussher M, Lewis S, Aveyard P, Manyonda I, West R, Lewis B, Marcus B, Riaz M, Taylor A, Daley A, Coleman T, (2015) A randomised controlled trial of physical activity for smoking cessation in pregnancy. British Medical Journal, 14, 350:h2145. doi: 10.1136/bmj.h2145. 4. Beard E, Brown J, McNeill A, Michie S, West R, (2015) Has growth in electronic cigarette use by smokers been responsible UTARG Output Varenicline substantially improves smoking cessation rates when used by smokers not willing to stop in the next month but willing to reduce consumption with a view to quitting within the next 3 months. Varenicline does not appear to be associated with an increased risk of recorded cases of cardiovascular events, self-harm or depression requiring treatment compared with nicotine replacement therapy. Adding a physical activity intervention to behavioural smoking cessation support for pregnant women did not increase cessation rates at end-of-pregnancy. During pregnancy, physical activity is not recommended for smoking cessation but remains indicated for general health benefits The shapes of the trajectories since 2011 suggest that electronic cigarettes are probably not responsible for the decline in use of licensed Page 1 5. 6. 7. 8. for the decline in use of licensed nicotine products? Findings from repeated cross sectional surveys. Thorax, 70(10):974-8. doi: 10.1136/thoraxjnl-2015-206801.* Shahab L, Gilchrist G, Hagger-Johnson G, Shankar A, West E, West R, (2015) Reciprocal associations between smoking cessation and depression in older smokers: findings from the English Longitudinal Study of Ageing (ELSA). British Journal of Psychiatry, 207(3):243-9. doi: 10.1192/bjp.bp.114.153494. West R, Raw M, McNeill A, Stead L, Aveyard P, Britton J, Stapleton J, McRobbie H, Pokhrel S, Lester-George A, Borland R, (2015) Healthcare interventions to promote and assist tobacco cessation: a review of efficacy, effectiveness and affordability for use in national guideline development. Addiction, 110(9):1388-403. doi: 10.1111/add.12998. Brown J, West R Angus C, Beard E, Brennan A, Drummond C, Hickman M, Holmes J, Kaner E, Michie S, (2015) Comparison of brief interventions in primary care on smoking and excessive alcohol consumption in England: a population survey. British Journal of General Practice.* Ussher M, Kakar G, Hajek P, West R (2015) Dependence and motivation to stop smoking as predictors of success of a quit attempt among smokers seeking help to quit. Addictive Behaviors, 53, 175-180. doi: 10.1016/j.addbeh.2015.10.020. 9. Brown J, Michie S, Walmsley M, West R, (2015). An online documentary film to motivate quit attempts among smokers in the general population (4Weeks2Freedom): A randomised controlled trial. Nicotine & Tobacco Research, pii: ntv161. [Epub ahead of print] 10. Simon R, West R, (2015) Models of addiction and types of interventions. International Journal of Alcohol and Drug Research, 4(1), 13-20. doi:http://dx.doi.org/10.7895/ijadr.v4i1.198 11. Gilbody S, Peckham E, Man M, Mitchell N, Li J, Becque T, Hewitt C, Knowles S, Bradshaw UTARG Output nicotine products. Electronic cigarettes appear to have increased the total market for use of nontobacco nicotine-containing products. In older smokers, depression appears to act as an important barrier to quitting while quitting has no long-term impact on depression. Brief advice from a healthcare worker, telephone helplines, automated text messaging, printed selfhelp materials, cytisine and nortriptyline are globally affordable healthcare interventions to promote and assist smoking cessation. Evidence on smokeless tobacco cessation suggests that face-toface behavioural support and varenicline can promote cessation. Whereas approximately half of smokers in England visiting their GP in the past year report having received advice on cessation, less than 10% of those who drink excessively report having received advice on their alcohol consumption. Cigarette dependence, measured by the FTCD, or by its HSI or non-HSI components, predicts both shortterm and medium-term outcomes of attempts to stop smoking in treatment-seeking smokers, whereas strength of motivation to stop predicts neither. Both the HSI and non-HSI components may be considered as briefer alternatives to the full FTCD. The online documentary film (4Weeks2Freedom) designed to boost motivation and self-efficacy and to promote ex-smoker identity does not appear to prompt quit attempts among smokers. While substance- and non-substance-related addictions differ in a number of respects, they share key elements: a repeated powerful motivation to engage in a particular behaviour, acquired through enacting the behaviour, despite the experience or risk of significant harm. Nine different types of intervention to combat addiction found in the literature involve attempts to change one or more of three factors that interact to underpin behaviour: capability, opportunity, and motivation (the “COM-B” model). The models of addiction reviewed may serve as a basis for such interventions It is feasible to recruit people with severe mental illness into an RCT to assess the benefits of a bespoke Page 2 12. 13. 14. 15. 16. 17. T, Planner C, Parrott S, Michie S, Shepherd C, (2015) Bespoke smoking cessation for people with severe mental ill health (SCIMITAR): a pilot randomised controlled trial. Lancet Psychiatry, 19(25):1-148, v-vi. doi: 10.3310/hta19250. Brose L, McEwen A, Michie S, West R, Chew X, Lorencatto F, (2015) Treatment manual use and training with successful provision of stop smoking support. Behaviour Research & Therapy, 71:34-9. doi: 10.1016/j.brat.2015.05.013. Nelson V, Goniewicz M, Beard E, Brown J, Sheals K, West R, Shahab L, (2015) Comparison of the characteristics of long-term users of electronic cigarettes versus nicotine replacement therapy: a cross-sectional survey of English ex-smokers and current smokers. Drug and Alcohol Dependence. doi:10.1016/j.drugalcdep.2015.05.005. Beadman M, Das R, Freeman T, Scragg P, West R, Kamboj S, (2015) A comparison of emotion regulation strategies in response to craving cognitions: effects on smoking behaviour, craving and affect in dependent smokers. Behaviour Research and Therapy, 69:29-39. doi: 10.1016/j.brat.2015.03.013. Brose LS, Hitchman SC, Brown J, West R, McNeill A, (2015) Is the use of electronic cigarettes while smoking associated with smoking cessation attempts, cessation and reduced cigarette consumption? A survey with a 1-year follow-up. Addiction, 110(7):1160-8. doi: 10.1111/add.12917 . Hitchman S, Brose L, Brown J, Robson D, McNeill A, (2015) Associations Between ECigarette Type, Frequency of Use, and Quitting Smoking: Findings From a Longitudinal Online Panel Survey in Great Britain. Nicotine & Tobacco Research, 17(10):1187-94. doi: 10.1093/ntr/ntv078. Garnett C, Crane D, West R, Brown J, Michie S, (2015) Identification of behaviour change techniques and engagement strategies to design a smartphone app to reduce alcohol consumption using a formal consensus method. Journal of Medical Internet Research,3(2):e73) doi:10.2196/mhealth.3895. 18. Thompson TP, Aveyard P, Ayres R, Taylor RS, Warren FC, Campbell JL, Byng R, Ussher M, Michie S, West R, Green C, Greaves CJ, & Taylor AH, (2015). Lessons learned from recruiting socioeconomically disadvantaged smokers into a pilot randomised controlled trial to explore the role of Exercise Assisted Reduction then Stop (EARS) smoking. Trials, UTARG Output smoking cessation programme. Such a programme may improve 12-month abstinence rates compared with referral to standard stop-smoking services. Access to, and use of, treatment manuals among practitioners in the English stop-smoking services is associated with higher success rates. Compared with people who use NRT for at least 6 months, those who use EC over that time period appear to have a stronger smoker identity and like their products more. Among long-term users who have stopped smoking, EC are perceived as more helpful than NRT, appear more effective in controlling withdrawal symptoms and continued use may be more likely. Reappraisal appears to be better at achieving reduction in cigarette cravings than attempted suppression. Daily use of e-cigarettes while smoking appears to be associated with subsequent increases in rates of attempting to stop smoking and reducing smoking, but not with smoking cessation. Non-daily use of ecigarettes while smoking does not appear to be associated with cessation attempts, cessation or reduced smoking. Whether e-cigarette use is associated with quitting depends on type and frequency of use. Compared with respondents not using e-cigarettes, daily tank users were more likely, and non-daily cigalike users were less likely, to have quit. Tanks were more likely to be used by older respondents and respondents with lower education. The behaviour change techniques with greatest potential to include in a smartphone app to reduce alcohol consumption were judged by experts to be self-monitoring, goal-setting, action planning, and feedback in relation to goals. The strategies most likely to engage users were ease of use, design, tailoring of design and information, and unique smartphone features. Mailed invitations, and follow-up, from health professionals was an effective method of recruiting disadvantaged smokers into a trial of an exercise intervention to aid smoking reduction. Recruitment via community outreach approaches was largely ineffective. Page 3 16(1):1. doi:10.1186/1745-6215-16-1. 19. Thompson TP, Greaves CJ, Ayres R, Aveyard P, Warren FC, Byng R, Campbell JL, Taylor RS, Ussher M, Michie S, West R, Green C, & Taylor AH, (2015). An exploratory analysis of the smoking and physical activity outcomes from a pilot randomised controlled trial of an exercise assisted reduction to stop (EARS) smoking intervention in disadvantaged groups with various imputation methods. Nicotine & Tobacco Research. pii: ntv099. [Epub ahead of print] 20. Crane D, Garnett C, Brown J, West R, Michie S, (2015) Behaviour change techniques in popular alcohol reduction apps. Journal of Medical Internet Research, 17(5):e118. doi: 10.2196/jmir.4060. 21. Tombor I, Shahab L, Brown J, Notley C, West R, (2015) Does non-smoker identity following quitting predict long-term abstinence? Evidence from a population survey in England. Addictive Behaviors, 45, 99-103. doi: 10.1016/j.addbeh.2015.01.026. 22. Ubhi HK, Michie S, Kotz D, Wong WC, West R, (2015). A mobile app to aid smoking cessation: Preliminary evaluation of SmokeFree28. Journal of Medical Internet Research, (17)1:e17. doi: 10.2196/jmir.3479. 23. Ferguson S, Brown J, Frandsen M, West R, (2015) Associations between use of pharmacological aids in a smoking cessation attempt and subsequent quitting activity: a population study. Addiction, 110(3):513-8. doi: 10.1111/add.12795.* 24. Beard, E., Bruguera, C, McNeill, A., Brown, J., & West, R, (2015). Association of amount and duration of NRT use in smokers with cigarette consumption and motivation to stop smoking: a national survey of smokers in England.. Addictive Behaviors, 40C, 33-38. doi: 10.1016/j.addbeh.2014.08.008.* 25. Brown J, West R, (2014) Smoking prevalence in England is below 20% for the first time in 80 years. British Medical Journal, 348, g1378 doi: 10.1136/bmj.g1378.* 26. Brown J, Michie S, Geraghty A, Yardley L, Gardner B, Shahab L, Stapleton J, West R, (2014) Internet-based intervention for smoking cessation (StopAdvisor) in people with low and high socioeconomic status: a randomised controlled trial. Lancet UTARG Output A smoking reduction intervention for economically disadvantaged smokers which was structured around a programme of physical activity appears to be more effective than usual care in achieving reduction and may promote cessation. The effect does not appear to be mediated by an increase in physical activity. Only a minority of alcohol-related apps promote health while the majority implicitly or explicitly promote the use of alcohol. Alcohol-related apps that promote health contain few behaviour change techniques (BCTs) and none refer to theory. The mention of evidence is more prevalence in more popular apps, but popularity and user ratings are only weakly associated with the BCT content The majority of people who quit smoking recently consider themselves as non-smokers. Younger people and those who have been abstinent for longer are more likely to take on a non-smoker identity. Ex-smokers who make this mental transition following a quit attempt appear more likely to remain abstinent in the medium term than those who still think of themselves as smokers. The recorded 28-day abstinence rates from the mobile app, SF28, suggest that it may help some smokers to stop smoking. Further evaluation by means of a randomized trial appears to be warranted. Smokers who have tried to quit in the past year are more likely to try to quit again in the next 6 months regardless of whether they used a pharmacological aid, and they are more likely to use the same method again as they used previously. Amount of nicotine replacement therapy used for smoking reduction and duration of use are positively associated with motivation to stop smoking and negatively associated with daily cigarette consumption. Smoking prevalence continues to decline in England and latest figures put it at significantly below 20% in 2013 for the first time in at least 80 years. The interactive internet-based smoking cessation intervention, StopAdvisor, is more effective than an information-only website in smokers with lower, but not higher, socioeconomic status. User testing of the website was done exclusively in smokers with lower socioeconomic status and seems to have been Page 4 Respiratory Medicine, 12, 997-1006. doi.org/10.1016/S2213-2600(14)70195-X. 27. Pujades-Rodriguez M, George J, Shah A, Rapsomaniki E, Denaxas S, West R, Smeeth L, Timmis A, Hemingway H, (2014) Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1 937 360 people: lifetime risks and implications for risk prediction. International Journal of Epidemiology. 44(1):129-41. doi: 10.1093/ije/dyu218. 28. Brose L, West R, Michie S, McEwen A, (2014) Changes in success rates of smoking cessation treatment associated with take up of a national evidence-based training programme. Preventive Medicine, 69C, 1-4. doi: 10.1016/j.ypmed.2014.08.021. ^ 29. Brown J, Beard E, Kotz D, Michie S, West R, (2014) Real-world effectiveness of ecigarettes when used to aid smoking cessation: a cross-sectional population study. Addiction, 109, 1531-40. doi: 10.1111/add.12623.* 30. Brown J, West R, Beard E, Michie S, Shahab L, McNeill A, (2014) Prevalence and characteristics of electronic cigarette users in Great Britain: findings from a general population survey. Addictive Behaviors, 39, 1120-1125. doi: 10.1016/j.addbeh.2014.03.009. 31. Kotz D, Brown D, West R, (2014) Effectiveness of varenicline versus nicotine replacement therapy for smoking cessation with minimal professional support: evidence from an English population study. Psychopharmacology, 231, 37-42. doi: 10.1007/s00213-013-3202-x.* 32. Hsueh K, Hsueh S, Chou M, Pan, L, Tu M, McEwen A, West R, (2014) Varenicline versus Transdermal Nicotine Patch: A 3year Follow-up in a Smoking Cessation Clinic in Taiwan. Psychopharmacology, 231, 2819-23. doi: 10.1007/s00213-014-3482-9. 33. Garnett C, Crane D, West R, Michie S, Brown J, Winstock, (2014) Normative misperceptions about alcohol use in the general population of drinkers: a cross-sectional survey. Addictive Behaviors, 47, 63-6. doi: 10.1093/alcalc/agr125. 34. Shahab L, Beard E, Brown J, West R, (2014) Prevalence of NRT use and associated nicotine intake in smokers, recent ex-smokers and UTARG Output successful in producing an effective website for that group. There is substantial heterogeneity in associations between smoking and different CVD presentations suggests different underlying mechanisms. English stop smoking services that have greater uptake of a national evidence-based training programme have shown greater improvements in success rates Among smokers who have attempted to stop without professional support, those who use ecigarettes are more likely to report continued abstinence than those who used a licensed NRT product bought over-the-counter or not aid to cessation. The difference persists after adjusting for a range of smoker characteristics such as nicotine dependence. There is a near universal awareness of e-cigarettes and their use appears to be common among smokers in Great Britain although a quarter of all smokers are unsure as to whether e-cigarettes are less harmful than cigarettes. E-lites – a brand that delivers a low dose of nicotine – is the most popular. E-cigarette users appear to have higher socio-economic status, to smoke more cigarettes per day and to have attempted to quit in the past year. Varenicline use with minimal professional support in the general population of smokers appears more effective than NRT Rx in achieving short-term abstinence. However, this effect may disappear in the long term. Varenicline appears to yield higher abstinence rate out to 3 years than nicotine transdermal patch in a smokers clinic where smokers can choose their medication option. Underestimating one’s own alcohol consumption relative to other drinkers is common in Australia, Canada, the UK and US, with a substantial minority of harmful drinkers believing their consumption to be at or below average. Use of nicotine replacement therapy while smoking does not appear to increase overall nicotine intake, and ex-smokers using NRT longer-term have a lower Page 5 longer-term ex-smokers. Plos One, 9, e113045. doi: 10.1371/journal.pone.0113045. eCollection 2014.* 35. Kotz D, Brown J, West R, (2014) Prospective cohort study of the effectiveness of smoking cessation treatments used in the "real world". Mayo Clinic Proceedings, 89, 1360-7. doi: 10.1016/j.mayocp.2014.07.004.* 36. Herbec A, Beard E, Brown J, Gardner B, Tombor I, West R, (2014) The needs and preferences of pregnant smokers regarding tailored Internet-based Smoking Cessation Interventions: a qualitative interview study. BMC Public Health, 14, 1070. doi: 10.1186/1471-2458-14-1070. 37. Smit E, Hoving C, Schellerman-Offermans K, West R, de Vries H, (2014) Predictors of successful and unsuccessful quit attempts among smokers motivated to quit. Addictive Behaviors, 39, 1318-1324. doi: 10.1016/j.addbeh.2014.04.017. 38. Taylor A, Thompson T, Greaves C, Taylor R, Green C, Warren F, Kandiyali R, Aveyard P, Ayres R, Byng R, Campbell J, Ussher M, Michie S, West R, (2014) A pilot randomised trial to assess the methods and procedures for evaluating the effectiveness and costeffectiveness of Exercise Assisted Reduction then Stop (EARS) among disadvantaged smokers. Health Technology Assessment, 18 (4). doi: 10.3310/hta18040. 39. Raupach T, Brown J, Herbec A, Brose L, West R, (2014) A systematic review of studies assessing the association between adherence to smoking cessation medication and treatment success. Addiction, 109, 35-43 doi: 10.1111/add.12319. 40. Herbec, A, Brown J, Tombor I, Michie S, West R, (2014) Pilot randomized controlled trial of an internet-based smoking cessation intervention for pregnant smokers (‘MumsQuit’). Drug and Alcohol Dependence, 140, 130-6. doi: 10.1016/j.drugalcdep.2014.04.010. 41. Raupach T, Falk J, Vangeli E, Schiekirka S, Rustler C, Grassi M, Pipe A, West R, (2014) Structured smoking cessation training for health professionals on cardiology wards: a prospective study. European Journal of Preventive Cardiology, 21, 915-922 doi: 10.1177/2047487312462803. 42. Tombor I, Shahab L, Ruiz M, West R, (2014) Healthcare providers’ views on digital smoking cessation interventions for pregnant women. Journal of Smoking Cessation, 1-8. doi: 10.1017/jsc.2014.6. UTARG Output nicotine intake than smokers. The most successful method of stopping cigarette smoking in England is a combination of specialist behavioral support and prescription medication. Pregnant smokers willing to try using a digital smoking cessation intervention may particularly value one offering a high degree of targeting of comprehensive information to them as a group and tailoring support and advice to their individual needs, as well as one providing post-relapse support, peer-topeer communication and personal support from experts. Strength of intention to quit is important in predicting quit attempts in Dutch smokers motivated to quit but not the success of those attempts. Self-efficacy appears to play an important role in success of quit attempts in this group. Offering support for smoking reduction and physical activity appears to have value in promoting reduction and cessation in disadvantaged smokers not currently motivated to quit There is modest evidence to support the assumption that lack of adherence to nicotine replacement therapy regimens undermines effectiveness in clinical studies. MumsQuit is an engaging and possibly helpful form of support for pregnant women who seek cessation support online, and merits further development and evaluation in a full-scale RCT. Introduction of a set of standard operating procedures for smoking cessation advice was effective with physicians but not nurses. Analysis of the barriers suggested that motivation rather than capability or opportunity was the major factor that needed to be addressed. From the perspective of healthcare providers (HCPs) who interact with pregnant smokers, digital interventions offer a range of potential benefits that could make them useful for those who do not want HCP support, or as an adjunct to that support, but there Page 6 43. Kouimtsidis D, Stahl D, West R, Drummond C, (2014) Can outcome expectancies be measured across substances? Development and validation of a questionnaire for populations in treatment. Drugs and Alcohol Today. 14 Iss: 4, pp.172 – 186. doi.org/10.1108/DAT-02-20140007. 44. Silla K, Beard E, Shahab L, (2014) Characterization of characteristics of long-term nicotine replacement therapy users: evidence for a national survey. Nicotine & Tobacco Research, 16, 1050-5. doi: 10.1093/ntr/ntu019.* 45. Brown,J, Vangeli E, Fidler J, Raupach T, West R, (2014) Quitting Without Reporting Having Tried: Findings From a National Survey. Journal of Smoking Cessation. Available on CJO 2014 doi:10.1017/jsc.2013.41.* 46. Beard E, Brose L, Brown J, West R, McEwen A, (2014). How are the English Stop-Smoking Services responding to growth in use of electronic cigarettes? Patient Education and Counselling, 94, 276-281. doi: 10.1016/j.pec.2013.10.022.^ 47. Kouimtsidis D, Stahl D, West R, Drummond C, (2014) How important are Positive and Negative Outcome Expectancies in the treatment of Addiction. A narrative review of the literature. Drugs and Alcohol Today, 14, 137-149. doi: 10.1108/DAT-11-2013-0051 48. Shahab L, Brown J, Gardner B, Smith SG. (2014) Seeking health-related information and support online – does it differ as a function of engagement in risky health behaviours? Evidence from the Health Information National Trends Survey. Journal of Medical Internet Research. doi: 10.2196/jmir.3368. 49. West R, May S, West M, Croghan E, McEwen A (2013) Performance of English stop smoking services in first 10 years: analysis of service monitoring data. British Medical Journal, 47:f4921. doi: http://dx.doi.org/10.1136/bmj.f4921. ^ 50. Shahab L, Andrews S, West R (2013) Changes in prevalence of depression and anxiety following smoking cessation: results from an international cohort study (ATTEMPT). Psychological Medicine, 44, 127-41. doi: 10.1017/S0033291713000391. 51. Brose L, West R, Stapleton J (2013) Comparison of the effectiveness of varenicline and combination nicotine replacement therapy for smoking cessation in clinical practice. Mayo Clinic UTARG Output are important limitations that need to be considered. A new questionnaire that has been developed can assess outcome expectancies relating to drug use in a way that allows useful comparisons across substances. Smokers who have also been using nicotine products long term, are more motivated to stop smoking than smokers not using such products. A substantial minority of people who report having stopped in the past year may fail to report a corresponding quit attempt. However, quitting smoking without considering that one has tried appears to be rare. Instead, the most common reason for the discrepancy is inconsistent reporting of the timing of quit attempt. Although use of electronic cigarettes by smokers attending the English Stop Smoking Services is common, few provisions are in place to record their use. Practitioners mostly advise that products are not licensed. Both positive and negative expectancies in relation to drug use appear to be predictive of outcomes in substance use disorder p nicotiatients attending treatment programmes. Internet access and use to obtain health-related information and support is widespread and mostly independent of engagement in various health-risk behaviors. However, those with low fruit/vegetable intake or inadequate sun-protective behaviors may be more difficult to reach with Internet-based interventions. The English Stop Smoking Services have had an increasing impact in helping smokers to stop in their first 10 years of operation and successfully reached disadvantaged groups. However, performance across local services has varied considerably. Smoking cessation does not appear to be associated with an increase in anxiety or depression and may lead to reduced incidence of depression. Averaged across current English clinical practice and populations, varenicline is marginally more effective than combination nicotine replacement therapy (NRT) but there is very wide variation across local services, with varenicline being more Page 7 Proceedings, 88, 226-33. doi: 10.1016/j.mayocp.2012.11.013. ^ 52. Kotz D, Brown D, West R, (2013) Real world effectiveness of smoking cessation treatments: a population study. Addiction, 109, 491-9. doi: 10.1111/add.12429.* 53. Brown J, Kotz D, Michie S, Stapleton J, Walmsley M, West R, (2013) How effective and cost-effective was the national mass media smoking cessation campaign ‘Stoptober’? Drug and Alcohol Dependence, 135, 52-8. doi: 10.1016/j.drugalcdep.2013.11.003.* 54. Tombor I, Shahab L, Brown J, West R (2013) Positive smokier identity as a barrier to quitting smoking: findings from a national survey of smokers in England. Drug and Alcohol Dependence, 133, 740745. doi: 10.1016/j.drugalcdep.2013.09.001.* 55. Stapleton J, West R, Hajek P, Wheeler J, Vangeli E, Abdi Z, O’Gara C, McRobbie H, Humphrey K, Ali R, Strang J, Sutherland G (2013) Randomized trial of NRT, bupropion and NRT plus bupropion for smoking cessation. Addiction, 108, 2193-201. doi: 10.1111/add.12304. effective in some services and combination NRT being more effective in others. After adjusting for major confounding variables such as tobacco dependence, smokers in England who use a combination of behavioural support and pharmacotherapy in their quit attempts have almost three times the odds of success than those who use neither pharmacotherapy or behavioural support. Smokers who buy nicotine replacement therapy over the counter with no behavioural support have similar odds of success as stopping as those who stop without any aid. Designing a national public health campaign with a clear behavioural target (making a serious quit attempt) using key psychological principles can yield substantial behaviour change and public health impact. Only a minority of smokers in England have a positive smoker identity. However, where it is present it may be an important barrier to quitting smoking and merits further study. There appears to be no clinically meaningful difference overall between bupropion, nicotine replacement therapy and bupropion plus nicotine replacement therapy in effectiveness at helping smokers to stop in the context of an intensive behavioural support programme although bupropion may be more effective than NRT for smokers with a history of depression. Group support in the English Stop Smoking Services with NRT or bupropion can be expected to deliver 6 month sustained abstinence rates of approximately 25% when undertaken according to established principles. 56. Brose L, McEwen A, West R (2013) RCTs have failed to find a benefit for single form Association between nicotine replacement nicotine replacement therapy to aid smoking therapy use in pregnancy and smoking cessation in pregnancy. This may be because of cessation. Drug and Alcohol Dependence, inadequate dosing. Data from the English Stop 132, 660-4. doi: Smoking Services suggests that use of a 10.1016/j.drugalcdep.2013.04.017. ^ combination of nicotine patch and a faster acting form appears to confer a significant benefit where single form NRT does not. 57. Kralikova E, Kmetova A, Stepankova L, Smokers in the same behavioural support Zvolska K, Davis R, West R (2013) Fifty-two programme who use varenicline have a greater week continuous abstinence rates of smokers probability of achieving long-term abstinence than being treated with varenicline versus those using their choice of nicotine replacement nicotine replacement therapy, Addiction, therapy options, even after adjusting for potentially 108, 1497-502. doi: 10.1111/add.12219. confounding smoker characteristics taking after selection bias has been ruled out. 58. Brown J, Hajek P, McRobbie H, Locker J, Smokers who temporarily abstain in naturalistic Gillison F, McEwen A, Beard E, West R settings experience craving and withdrawal (2013) Cigarette craving and withdrawal symptoms that emerge linearly over the first 6 symptoms during temporary abstinence and hours of abstinence. Changes in craving and UTARG Output Page 8 the effect of nicotine gum. Psychopharmacology, 229, 209-18. doi: 10.1007/s00213-013-3100-2. 59. Lorencatto F, West R, Seymour N, Michie S (2013) Developing a method for specifying the components of behaviour change interventions in practice: the example of smoking cessation. Journal of Consulting and Clinical Psychology, 81, 528-44. doi: 10.1037/a0032106.^ 60. Lorencatto F, West R, Bruguera C, Michie S, (2013) A method for assessing fidelity of delivery of telephone-based smoking ccessation behavioural support in practice. Journal of Consulting & Clinical Psychology, 8, 40. doi:10.1186/1748-5908-8-40.^ 61. Lorencatto F, West R, Christopherson C, Michie S, (2013) Assessing fidelity of delivery of smoking cessation behavioural support in practice. Implementation Science, 8: 40. doi: 10.1186/1748-5908-8-40. 62. Shahab L, Brose L, West R (2013) Novel delivery systems for nicotine replacement therapy as an aid to smoking cessation: rationale and evidence for advantages over existing systems. CNS Drugs, 27, 1007-19. doi: 10.1007/s40263-013-0116-4. 63. Kouimstsidis C, Stahl D, West R, Drummond C (2013) Path analysis of cognitive behavioural models in substance misuse. What is the causal relationship between concepts involved? Journal of Substance Abuse. doi: 10.3109/14659891.2013.837974. 64. Ussher M, Brown J, Rajamanoharan A, West R (2013) How do prompts for attempts to quit smoking relate to method of quitting and quit success? Annals of Behavioral Medicine, 47, 358-68. doi: 10.1007/s12160-013-9545-z.* 65. Lindson-Hawley N, Begh R, McDermott M, McEwen A, Lycett D (2013) The importance of practitioner smoking status: a survey of NHS Stop Smoking Service practitioners. Patient Education and Counselling. doi: 10.1016/j.pec.2013.04.021.^ 66. Hiscock R, Murray S, Brose L, McEwen A, Leonardi-Bee J, Bauld L (2013) Behavioural therapy for smoking cessation: the effectiveness of different interventions for disadvantaged and affluent smokers. Addictive UTARG Output several mood withdrawal symptoms can be detected within the first three hours. Nicotine gum may not have an acute effect on the development of these symptoms. It is possible to apply a taxonomy to reliably identify and classify BCTs in smoking cessation behavioural support delivered in practice, and train inexperienced coders to do so reliably. This method can be used to investigate variability in provision of behavioural support across services, monitor fidelity of delivery, and identify training needs. The content of telephone-delivered behavioural support can be reliably coded in terms of behaviour change techniques. This can be used assess fidelity to treatment manuals and in turn identify training needs. Observed low fidelity underlines the need to establish routine procedures for monitoring delivery of behavioural support. The extent to which smoking cessation behavioural support is delivered as specified in treatment manuals can be reliably assessed using transcripts of audiotaped sessions. This allows the investigation of the implementation of evidence-based practice in relation to smoking cessation, a first step in designing interventions to improve it. There are grounds for believing that fidelity in the English Stop-Smoking Services may be low and that routine monitoring is warranted In theory, novel nicotine delivery systems that provide nicotine more rapidly in adjustable doses and in a form that is easy to use and with minimal local adverse reactions would be expected to improve on success rates of existing products. However, to date evidence is lacking that such products are more effective. Across a range of psychoactive substances (alcohol, stimulant and opioids), urges to use were strongly associated, and negative expectancies weakly positively related to positive outcomes of addiction treatment. Quit attempts prompted by health professional advice appear to be more likely to involve gradual reduction and use of treatments, while those prompted by health concerns and cost appear more likely to be successful. Smokers attending stop smoking services believe that stop smoking advisors are more effective if they are former smokers. Stop smoking services may enhance success rates with disadvantaged smokers if they promote use of open groups. Page 9 Behaviours, 38, 2787-96. doi: 10.1016/j.addbeh.2013.07.010. 67. Hughes, L., McIlvar, M, & McEwen, A. (2013) How to advise and refer inpatients who smoke. Nursing Times, 109(1/2):14-18. 68. Docherty G, Lewis S, Bauld L, McEwen A, Coleman T (2013) Does use of ‘non-trial’ cessation support help explain the lack of effect from offering NRT to quitline callers in a RCT? Nicotine & Tobacco Research. doi: 10.1136/tobaccocontrol-2013-051107. 69. Crutzen R, Viechtbauer W, Kotz D (2013) No differential attrition in randomized controlled trials published in general medical journals: a meta-analysis. Journal of Clinical Epidemiology, 66, 948-54. doi: 10.1016/j.jclinepi.2013.03.019. 70. Beard E, Brown J, West R. (2013) Does smoking reduction make smokers happier? Evidence from a cross-sectional survey. Journal of Smoking Cessation, 9, 1-5. doi: http://dx.doi.org/10.1017/jsc.2013.14.* 71. Langley T, Lewis S, McNeill A, Gilmore A, Szatkowski L, West R, Sims M (2013) Characterising tobacco control mass media campaigns in England. Addiction, 108, 2001-8. doi: 10.1111/add.12293. 72. Beard E, Shahab L, Curry S, West R (2013) Association between smoking cessation and short-term health-care utilisation: results from an international prospective cohort study (ATTEMPT) Addiction, 108, 1979-88. doi: 10.1111/add.12281. 73. Ussher M, Beard E, Abikoye G, Hajek P, West R (2013) Urge to smoke over 52 weeks of abstinence. Psychopharmacology, 226, 83-89. doi: 10.1007/s00213-013-3202-x. 74. Kotz, D, Willemsen M, Brown J, West R (2013) Light smokers are less likely to receive advice to quit from their GP than moderate to heavy smokers: a comparison of national survey data from the Netherlands and England. European Journal of General Practice, 19, 99105. doi: 10.3109/13814788.2013.766792.* 75. Krampe H, Strobel L, Beard E, Anders S, West R, Raupach T (2013) German medical students’ beliefs about how best to treat alcohol use disorder. European Addiction Research, 19, 245-251. doi: 10.1159/000346672. 76. Brown J, Michie S, Raupach T, West R (2013) Prevalence and characteristics of smokers interested in internet-based smoking cessation interventions: cross-sectional findings from a UTARG Output A whole-hospital approach involving online training in very brief advice on smoking for front line staff and electronic referral significantly increases identification of smoking patients and referral to stop smoking services. The failure of the PORTSS trial to show an effect of offering free NRT to callers to a telephone helpline cannot be explained by high levels of use of NRT by participants in the control condition. In general there appears to be no difference in attrition rates in active and control groups in major randomised trials. While smoking cessation is associated with increased life satisfaction and happiness, attempts at smoking reduction do not appear to be. Between 2004 and 2010 only a small proportion of tobacco control advertisements in England used the most effective strategies – negative health effect messages and testimonials from real-life smokers. The intensity of campaigns was below international recommendations. Smoking cessation does not appear to be associated with a substantial short-term increase or decrease in health-care utilisation after adjusting for pre-cessation morbidities Strength of urges to smoke decline exponentially over time following smoking cessation, though some smokers report strong urges after 6 months of abstinence, and urges are still reported by a third of smokers after 12 months. Smokers in the Netherlands are less than half as likely to receive advice to quit from their GP than smokers in England. In both countries, light smokers are less likely to receive advice to quit from their GP than moderate-to-heavy smokers In Germany, with an advanced undergraduate medical curriculum, more than a quarter of fifth year students believe that willpower alone is more effective than comprehensive treatment programmes to overcome alcohol use disorder. Almost half of all smokers in England are interested in using online smoking cessation interventions yet fewer than 1% have used them to support a quit attempt in the past year. Interest is not associated with social Page 10 national household survey. Journal of Medical Internet Research, 15(3):e50. doi: 10.2196/jmir.2342.* 77. Sarkar B, Arora M, Gupta V, Reddy K (2013) Determinants of Tobacco Cessation Behaviour among Smokers and Smokeless Tobacco Users in the States of Gujarat and Andhra Pradesh, India. Asian Pacific Journal of Cancer Control, 14, 1993-1999. 78. Fidler J, Ferguson S, Brown J, Stapleton J, West R (2013) How does rate of smoking cessation vary by age, gender and social grade? Findings from a population survey in England. Addiction, 108, 1680-5. doi: 10.1111/add.12241.* 79. Brose L, Tombor I, Shahab L, West R (2013) The effect of reducing the threshold for carbon monoxide validation of smoking abstinence – evidence from the English Stop Smoking Services. Addictive Behaviors, 38, 2529-31. doi: 10.1016/j.addbeh.2013.04.006. ^ 80. Beard E, Bruguera, C, Brown J, McNeill A, West R (2013) Was the expansion of the marketing licence for nicotine replacement therapy in the UK to include smoking reduction associated with changes in use and incidence of quit attempts? Nicotine & Tobacco Research, 15, 1777-81. doi: 10.1093/ntr/ntt044. 81. Kotz D, Brown J, West R (2013) Predictive validity of the Motivation To Stop Scale. Drug and Alcohol Dependence, 128, 15-19. doi: 10.1016/j.drugalcdep.2012.07.012.* 82. Gould G, Munn J, Watters T, McEwen A, Clough A (2013) Knowledge and views about maternal tobacco smoking and barriers for cessation in Aboriginal and Torres Strait Islanders: a systematic review and metaethnography. Nicotine & Tobacco Research, 15, 863-874. doi: 10.1093/ntr/nts211. 83. Shahab L, Sarkar B, West R (2013) The acute effects of yogic breathing exercises on craving and withdrawal symptoms in abstaining smokers. Psychopharmacology, 225, 875-882. doi: 10.1007/s00213-012-2876-9. 84. Lorencatto F, West R, Stavri Z, Michie S (2013) How well is intervention content described in published reports of smoking cessation interventions? Nicotine & Tobacco Research, 1273-1282. doi: 10.1093/ntr/nts266. 85. Wee LH, Bulgiba A, Shahab L, Vangeli E, West R (2013) Understanding smokers’ beliefs UTARG Output grade but is associated with being younger, more highly motivated, more cigarette dependent, having attempted to quit recently, having regular internet and handheld computer access and having recently searched for online smoking cessation information and support. Smokeless tobacco users in India and tobacco users with lower educational level are less likely to try to quit compared with smokers and tobacco users with higher educational level. The incidence of smoking cessation in England appears to be greater in young and old adults compared to those in middle age. Women and higher social grade smokers show a greater incidence of quitting than men and those from lower social grades specifically in young adulthood Reducing the threshold for expired-air CO concentration to validate abstinence would have a minimal effect on success rates unless the threshold were reduced substantially which would likely increase error of measurement. Expansion of the UK marketing licence for NRT to include smoking reduction without the intention of quitting was not associated with an increase in use of NRT for this purpose. It was followed by a reduction in the incidence of quit attempts (although not their success) though this may have been a continuation of a pre-existing decline. The Motivation to Stop Scale provides strong and accurate prediction of quit attempts and is a candidate for a standard measure for use in population surveys. Aboriginal and Torres Strait Islanders have limited knowledge of the harms of maternal smoking and there are significant barriers to their achieving cessation. Yogic breathing exercises can acutely reduce cigarette cravings in a controlled environment but it is not clear whether this effect generalises beyond the laboratory. Published reports of evaluations of smoking cessation behavioural support interventions typically mention fewer than half the behaviour change techniques specified in the intervention manuals; this deficit in reporting could be remedied by journals insisting on full manuals being provided as supplementary electronic files. A new model of behaviour changed (SNAP based on the PRIME Theory of motivation can be used as a Page 11 and feelings about smoking and quitting during basis for assessing potentially important aspects of a quit attempt: a preliminary evaluation of the smokers’ beliefs and feelings about stopping based on SNAP model. Journal of Smoking Cessation, 8, interview data. 17-23. doi: http://dx.doi.org/10.1017/jsc.2013.3. 86. Brose L, West R, Michie S, McEwen A (2013) Validation of content of an online knowledge training program. Nicotine & Tobacco Research, 15, 997-998. doi: 10.1093/ntr/nts258. ^ 87. Ferguson J, Docherty G, Bauld L, Lewis S, Lorgelly P, Boyd KA, McEwen A, Coleman T (2012) Effect of offering different levels of support and free nicotine replacement therapy via an English national telephone quitline: randomised controlled trial. BMJ, 344, e1696. doi: 10.1136/bmj.e1696. 88. Aveyard P, Begh R, Parsons A, West R (2012) Brief opportunistic smoking cessation interventions: a systematic review and metaanalysis to compare advice to quit and offer of assistance. Addiction, 107, 1066-1073. DOI: 10.1111/j.1360-0443.2011.03770.x. 89. Gould G, McEwen A, Watters T, Clough A, van der Zwan R (2012) Should anti-tobacco messages be culturally targeted for indigenous populations? A systematic review and narrative synthesis. Nicotine & Tobacco Research, 22(4):e7. doi: 10.1136/tobaccocontrol-2012050436. 90. McDermott M, Beard E, Brose L, West R, McEwen A (2012) Factors associated with differences in quit rates between specialist and community stop-smoking practitioners in the English stop-smoking services. Nicotine & Tobacco Research, 15, 1239-47. doi: 10.1093/ntr/nts262. ^ 91. McNeill A, Amos A, McEwen A, Ferguson J, Croghan E (2012) Developing the evidence base for addressing inequalities and smoking in the United Kingdom. Addiction, 107 Suppl 2, 1-7. doi: 10.1111/j.1360-0443.2012.04080.x.^ 92. McEwen A, Hackshaw L, Jones L, Laverty L, Amos A, Robinson J (2012) Evaluation of a programme to increase referrals to stopsmoking services using Children’s Centres and smoke-free family schemes. Addiction, 107 Suppl 2, 8-17. doi: 10.1111/j.13600443.2012.04081.x.^ 93. Beard E, Michie S, Fidler J, West R. (2012). Use of nicotine replacement therapy in situations involving temporary abstinence from smoking: a national survey of English smokers. UTARG Output Formative multiple choice questions following elements of an online training programme for stop smoking practitioners shows very high levels of understanding and short-term memory of what is being taught. An attempt to improve the effectiveness of the English NHS telephone support programme by adding more sessions and offering free nicotine replacement therapy did not yield a detectable improvement in quit rates. An offer of help with stopping by a GP appears to be more effective than advice to stop in promoting smoking cessation Although Indigenous people have good recall of generic anti-tobacco messages, culturally targeted messages are preferred. New Zealand Maori may be less responsive to holistic targeted campaigns, despite their additional benefits, compared to generic fear campaigns. Culturally targeted internet or mobile phone messages appear to be as effective in American Indians and Maori as generic messages in the general population. There is little research comparing the effect of culturally targeted versus generic messages with similar message content in Indigenous people "Specialist" practitioners in the English stopsmoking services report higher success rates than "community" practitioners and this is at least in part attributable to more extensive training and supervision and greater adherence to evidence-based practice including advising on medication usage and promoting abrupt rather than gradual quitting A set of pilot projects funded by the English Department of Health has identified ways in which stop-smoking services to disadvantages groups can be improved but without significant additional resources it is unlikely that progress will be made. Routine recording of smoking status and appropriate follow-up by trained staff in Children's Centres can lead to significant numbers of clients attending stopsmoking services, although relatively few stop smoking. The most common occasions of temporary abstinence when NRT is used are when at home and while travelling. Use of NRT in situations when one is unable to smoke may increase propensity to quit Page 12 Addictive Behaviors, 38, 1876-1879. doi: 10.1016/j.addbeh.2012.09.013.* 94. McDermott M, Thompson H, West R, Kenyon J, McEwen A (2012) Translating evidencebased guidelines into practice: A survey of practices of commissioners and managers of the English Stop Smoking Services. BMC Health Services Research, 12, 121. ^ 95. Brose L, McEwen A, West R (2012) Does it matter who you see to help you stop smoking? Short-term quit rates across specialist Stop Smoking Practitioners in England. Addiction, 107, 2029-2036. doi: 10.1111/j.13600443.2012.03935.x. ^ 96. Beard E, Aveyard P, McNeill A, Michie S, Fidler J, Brown J, West R (2012) Mediation analysis of the association between use of NRT for smoking reduction and attempts to stop smoking. Psychology and Health, 27, 11181133. doi: 10.1080/08870446.2012.685739. * 97. Strobel L, Schneider N, Krampe K, Beißbarth N, Pukrop T, Anders S, West R, Aveyard P, Raupach T (2012) German medical students lack knowledge of how to treat smoking and problem drinking. Addiction, 107, 1878-1882. doi: 10.1111/j.1360-0443.2012.03907.x. 98. Raupach T, West R, Brown T (2012) The most ‘successful’ method for failing to quit smoking is unassisted cessation. Nicotine & Tobacco Research, 15, 748-9. doi: 10.1093/ntr/nts164.* 99. Beard E, Brown J, Aveyard P, West R (2012) Assessing the association between the use of NRT for smoking reduction and attempts to quit smoking using propensity score matching. Drug and Alcohol Dependence, 126, 354-361. doi: 10.1016/j.drugalcdep.2012.05.039. * 100. Jarvis M, Cohen J, Delnevo C, Giovino G (2012) Dispelling myths about gender differences in smoking cessation: population data from the USA, Canada and Britain. Tobacco Control, 22, 356-60. doi: 10.1136/tobaccocontrol-2011-050279. 101. Giovino G, Mirza S, Samet J, Gupta P, Jarvis M, Bhala N, Peto R, Zatonski W, Hsia J, Morton J, Palipudi K (2012) Tobacco use in 3 billion individuals from 16 countries: an analysis of nationally representative cross sectional household surveys. Lancet, 380, 668679. doi: 10.1016/S0140-6736(12)61085-X. 102. Beard E, McDermott M, McEwen A, West R (2012) Beliefs of stop smoking practitioners in United Kingdom on the use of nicotine replacement therapy for smoking reduction. Nicotine & Tobacco Research, 14, 639-647. doi: 10.1093/ntr/ntr260.^ 103. Brown J, Michie S, Geraghty A, Miller S, UTARG Output smoking regardless of the specific type of situation and whether NRT is rated by the smoker as helpful in that situation. A substantial part of commissioning of Stop Smoking Services in England appears to take place without adequate consultation of evidence-based guidelines or specification of the service to be provided. This may account for at least some of the variation in success rates There are substantial differences in short-term success between individual specialist stop-smoking practitioners that are not explained by client demographics, intervention type or medication. If use of nicotine products to help reduce smoking or cope with periods of temporary abstinence promotes subsequent quit attempts, it probably does not do so by increasing confidence in ability to quit or reducing enjoyment of smoking; it may do so by increasing motivation to quit. Curriculum coverage in German medical schools of alcohol use disorders and smoking is half that of diabetes and hypertension, and in the final year of their undergraduate training most students reported inadequate knowledge of how to intervene to address them. The fact that most smokers who quit did so unaided tells us nothing about whether this is the best way to do it, as is evidenced by the fact that most smokers whose quit attempts failed also tried unaided. The increased likelihood of subsequently trying to stop smoking among smokers who use NRT to aid SR versus those who try to reduce without NRT remains after the two groups have been matched on motivational and other potentially relevant variables. Contrary to popular mythology, men are not more likely to stop smoking than women in the US, Canada and Britain. In the countries participating in the Global Adult Tobacco Survey (GATS - Bangladesh, Brazil, China, Egypt, India, Mexico, Philippines, Poland, Russia, Thailand, Turkey, Ukraine, Uruguay, and Vietnam) male smoking prevalence is 40.7% and female prevalence 5.0%. The proportion of ever smokers who have quit is less than 20%. A significant minority of stop smoking practitioners and stop smoking managers believe that NRT use for SR can be harmful to health and undermine smoking cessation. These beliefs should be addressed, especially if the use of NRT in these ways is provided as a route to quitting in SSSs Systematic application of theory, evidence, web- Page 13 Yardley L, Gardner B, Shahab L, Stapleton J, West R (2012) A pilot study of StopAdvisor: a theory-based interactive internet-based smoking cessation intervention aimed across the social spectrum. Addictive Behaviors, 37, 1365-1370. doi: 10.1016/j.addbeh.2012.05.016. 104. Michie S, Brown J, Geraghty A, Miller S, Yardley L, Gardner B, Shahab L, McEwen A, Stapleton J, West R (2012) Development of StopAdvisor: a theory-based interactive internet-based smoking cessation intervention. Translational Behavioral Medicine, 2, 263-275. doi: 10.1007/s13142-012-0135-6. 105. Black A, Beard E, Brown J, Fidler J, West R (2012) Beliefs about the harms of long-term use of nicotine replacement therapy: perceptions of smokers in England. Addiction, 107, 2037-2042. doi: 10.1111/j.13600443.2012.03955.x. * 106. Lorencatto F, West R, Michie S (2012) Specifying evidence-based behavior change techniques to aid smoking cessation in pregnancy. Nicotine & Tobacco Research, 14, 1019-1026. doi: 10.1093/ntr/ntr324. ^ 107. Beard E, Mcneill A, Aveyard P, Fidler F, Michie S, West R (2012) Association between the use of nicotine replacement therapy for harm reduction and smoking cessation: a prospective study of English smokers. Tobacco Control, doi:10.1136/tobaccocontrol-2011050007.* 108. Ferri CP, West R, Moriyama TS, et al. (2012) Tobacco use and dementia: evidence from the 1066 dementia population-based surveys in Latin America, China and India. International Journal of Geriatric Psychiatry, 26, 1177-88. doi: 10.1002/gps.2661. 109. Michie S, Free C, West R (2012) Characterising the ‘Txt2Stop’ smoking cessation text messaging intervention in terms of behaviour change techniques. Journal of Smoking Cessation, 7, 55-60. doi: http://dx.doi.org/10.1017/jsc.2012.12. 110. Beard E, West R (2012) Pilot study of the use of personal carbon monoxide monitoring to achieve radical smoking reduction. Journal of Smoking Cessation, 7, 12-17. doi: http://dx.doi.org/10.1017/jsc.2012.6. 111. Sims M, Mindell J, Jarvis M, Feyerabend UTARG Output design expertise, and user-testing has resulted in a website that shows sufficiently promising efficacy and usability to warrant evaluation in a RCT. The website appears to be similarly effective and acceptable to users across the social spectrum The systematic and transparent application of theory, evidence, web-design expertise and user-testing within an open-source development platform can provide a basis for multi-phase optimisation contributing to an ‘incremental technology’ of behaviour change A significant minority of smokers in England believe that the use of NRT for a year or more is harmful. However, belief that long-term NRT use can cause health harm does not appear to act as a deterrent to using it in a quit attempt or for smoking reduction. Whilst behaviour change techniques associated with effective smoking cessation support in pregnancy can be identified from high quality RCTs, English StopSmoking Services appear to use only a proportion of these. The use of nicotine replacement therapy for smoking reduction or temporary abstinence appears to be positively associated with subsequent attempts to quit smoking and abstinence among smokers in England, despite very little apparent effect on daily cigarette consumption. With replication, these findings support the potential benefit of using NRT for harm reduction but primarily as a means of promoting cessation. Dementia in developing countries appears to be positively associated with history of tobacco smoking but not smokeless tobacco use. Selective quitting in later life may bias estimation of associations An analysis of the content of Txt2Stop, the first automated text messaging intervention found to help smokers to stop, shows that its primary focus is on helping smokers with avoiding and managing urges to smoke and maintaining engagement with the intervention, and to a lesser degree on maintaining motivation to stop. Little attention is given to promoting effective use of adjuvant behaviours such as use of nicotine replacement therapy. As new interventions of this kind are developed it will be possible to compare their effectiveness and relate this to standardised descriptions of their content using this system. Personal monitoring of expired-air carbon monoxide concentrations of smoke exposure may be useful in helping smokers to reduce the amount they smoke. The impact of England's smokefree legislation on Page 14 C, Wardle H, Gilmore A (2012) Did smokefree legislation in England reduce exposure to secondhand smoke among non-smoking adults? Cotinine analysis from the Health Survey for England. Environmental Health Perspectives, 120, 425-430. doi: 10.1136/tobaccocontrol-2012-050582. 112. Bauld L, Ferguson J, McEwen A, Hiscock R (2012) Evaluation of a drop-in rolling-group model of support to stop smoking. Addiction, 107, 1687-1695. DOI: 10.1111/j.13600443.2012.03861.x. 113. Beard E, Vangeli E, Michie S, West R (2012) The use of Nicotine Replacement Therapy for smoking reduction and temporary abstinence: An interview study. Nicotine & Tobacco Research, 14, 849-856. doi: 10.1093/ntr/ntr297.* 114. Hackshaw, L., Bauld, L. & McEwen, A. (2012) Stop smoking service clients’ views following the introduction of smoke-free legislation in England. Journal of Smoking Cessation, 7, 1-8. doi: http://dx.doi.org/10.1017/jsc.2012.4. 115. Brose LS, West R, Michie S & McEwen (2012). Evaluation of face-to-face courses in behavioural support for Stop Smoking Practitioners. Journal of Smoking Cessation, 7, 25-30. doi: dx.doi.org/10.1017/jsc.2012.6. 116. Beard E, West R (2012) Use of nicotine replacement therapy for smoking reduction and temporary abstinence: an update of Beard et al 2011. Addiction, 107, 1186-1187. doi: 10.1111/j.1360-0443.2012.03839.x. 117. Stapleton J, West R (2012) A direct method and ICER tables for the estimation of the cost-effectiveness of smoking cessation interventions in general populations: application to a new cytisine trial and other examples. Nicotine & Tobacco Research, 14, 463-471. doi: 10.1093/ntr/ntr236. 118. Zhang C, Xiao D, West R, Michie S, Troughton R, Hajek P, Chen W (2012) Evaluation of 3-day smoking cessation training course for doctors from 38 cities in China. Chinese Medical Journal, 125, 1338-1340. 119. Brose L, West R, Michie S, Kenyon J, McEwen A (2012) Effectiveness of an online knowledge training and assessment program for Stop-Smoking Practitioners. Nicotine and Tobacco Research, 14, 849-856. UTARG Output secondhand smoke exposure was above and beyond the underlying long-term decline in secondhand smoke exposure and demonstrates the positive effect of the legislation. However, some population subgroups appear not to have benefitted significantly from the legislation. A wholly state-reimbursed clinical stop- service providing behavioural support and medication in a region of high economic and social disadvantage has reached a significant proportion of the smoking population. Long-term success rates are lower than are found typically in clinical trials, but higher than would be expected if the smokers were to try and quit unaided. Smokers use a variety of methods to reduce cigarette consumption including increasing the interval between cigarettes and attempting non-daily smoking. They also modify how they smoke the cigarette, trying to inhale less or stub out the cigarette early. Nicotine patches are attractive for smoking reduction because they are discreet, easy to use and have a prolonged effect. Smokers have little knowledge of restrictions on use described in the product labelling. Smokers clinic clients support smoke-free legislation and report reductions in smoking and an increase in quit attempts after introduction of the ban. The NCSCT skills training course appears to result in a substantial improvement in confidence in ability to deliver smoking cessation support and trainees evaluate it highly. If smokers use nicotine replacement therapy (NRT) for both temporary abstinence and smoking reduction they are more likely to go on to try to stop smoking than if they use NRT for either alone. This paper provides for the first time a set of look-up tables for policy makers to estimate the costeffectiveness of smoking cessation interventions based on the effect size and age profile of the population. A 3-day training course for doctors in China on helping smokers to stop is effective at increasing knowledge and confidence in delivering stop-smoking advice and support. Knowledge required to deliver effective stop smoking intervention is improved by using the National Centre for Smoking Cessation and Training online training program for English smoking cessation practitioners. Practitioners with all levels of prior knowledge Page 15 doi:10.1093/ntr/ntr286.^ 120. McDermott M, West R, Brose L, McEwen A (2012) Self-reported practices, attitudes and levels of training of practitioners in the English NHS Stop Smoking Services. Addictive Behaviors, 37, 498-506. doi: 10.1016/j.addbeh.2012.01.003.^ 121. Michie S, Whittington C, Hamoudi Z, Zarnani F, Tober G, West R (2012) Behaviour change techniques to reduce excessive alcohol use and their associations with outcome. Addiction, 107, 1431-1440. doi: 10.1111/j.1360-0443.2012.03845.x. 122. Zatonski W, Przewozniak K, Sulkowska U, West R, Wojtyla A (2012) Tobacco smoking in countries of the European Union. Annals of Agricultural and Environmental Medicine, 19, 181-192. 123. Kotz D, Fidler J, West R (2012) Very low rate and light smokers: smoking patterns and cessation-related behaviour in England, 20062011. Addiction, 107, 995-1002. doi: 10.1111/j.1360-443.2011.03739.x.* 124. Shahab L, West R (2012) Differences in happiness between smokers, ex-smokers and never smokers: cross-sectional findings from a national household survey. Drug and Alcohol Dependence, 121, 38-44. doi:10.1016/j.drugalcdep.2011.08.011.* Programme grant 2007-2011 125. West R, Zatonski W, Cedzynska M, Lewandowska D, Pazik J, Aveyard P, Stapleton J (2011) Randomised placebocontrolled trial of cytisine for smoking cessation. New England Journal of Medicine, 365 (13), 1193-200. 126. Hajek P, McRobbie H, Myers K, Stapleton JA, Dhanji AR (2011) Use of varenicline for 4 weeks before quitting smoking: decrease in ad lib smoking and increase in smoking cessation rates. Archives of Internal Medicine, 171(8), 770-7. doi:10.1001/archinternmed.2011.138. 127. Batty D, Shipley M, Kivimaki M, Dzvey Smith G, West R (2011) Impact of smoking cessation advice on future smoking behaviour, morbidity and mortality: up to 40 years of follow-up of the first randomised controlled trial of a general population sample. Archives of Internal Medicine, 171(21), 1950-1951. doi:10.1001/archinternmed.2011.543. 128. Brose L, West R, McDermott M, Fidler J, Croghan E, McEwen A (2011) What UTARG Output benefit. There are significant deficiencies in training and supervision of Stop-Smoking Practitioners in England, more so for ‘community’ (for whom smoking cessation is a small part of their role) than ‘specialist’ practitioners. It is possible to identify reliably specific behaviour change techniques recommended for interventions to reduce excessive alcohol consumption. Of these, promoting self-monitoring emerges from randomised trial evidence as an important factor in effectiveness. Restricting the analysis to daily smokers aged 20-64 produces a map of Europe in which variation in prevalence between individual countries within regions is as important as variation across regions. Survey methods need to be harmonised across countries to enable comparisons involving all ages and non-daily as well as daily smoker. Very low rate (<1cpd) and light (1-9cpd) smokers in England are at least as motivated to quit as heavier smokers. Although they use cessation medication less than heavier smokers and are more likely to succeed, they still use such medication and fail in quit attempts to a substantial degree. After a year of abstinence, ex-smokers report similar level of happiness and life satisfaction to neversmokers and considerably higher than current smokers. Cytisine is an effective aid to smoking cessation which because of its very low cost could advance smoking cessation globally. Using varenicline for four weeks prior to a quit attempt can reduce the enjoyment of smoking and smoke intake during the pre-quit period and increase the 12-week abstinence rate. A 40-year follow up of mortality in smokers who took part in an RCT of brief advice from a physician to promote smoking cessation gives a point estimate of the effect of the intervention of a increase in life expectancy of 0.4 life years. Routine clinic data support findings from randomised controlled trials that smokers receiving Page 16 makes for an effective stop-smoking service? Thorax. 66(10), 924-6. doi:10.1136/thoraxjnl-2011-200251.^ 129. Kotz D, Stapleton J, Owen L, West R. (2011). How cost-effective is "No Smoking Day"? Tobacco Control, 20(4), 302-4. Doi: 10.1136/tc.2009.034397* 130. Michie S, M van Stratten, West R (2011) The behaviour change wheel: A new method for characterising and designing behaviour change interventions. Implementation Science, 6, 42. doi:10.1186/1748-5908-6-42. 131. Stapleton JA, Sutherland G (2011) Treating heavy smokers in primary care with the nicotine nasal spray: randomized placebo-controlled trial. Addiction, 106(4), 824-32. doi: 10.1111/j.13600443.2010.03274.x. 132. Beard E, McNeill A, Aveyard P, Michie S, West R. (2011) Use of Nicotine Replacement Therapy for smoking reduction and during enforced temporary abstinence: a national survey of English smokers. Addiction, 106 (1), 197-204. doi:10.1111/j.1360-0443.2010.03215.x.* 133. Wee LH, Shahab L, Bulgiba A, West R (2011) Conflict About Quitting Predicts the Decision to Stop Smoking Gradually or Abruptly: Evidence From Stop Smoking Clinics in Malaysia. Journal of Smoking Cessation, 6, 37-44. doi: 10.1375/jsc.6.1.37. 134. Vangeli E, Stapleton J, Smit E, Borland R, West R (2011) Predictors of attempts to stop smoking and their success: A systematic review. Addiction, 106 (12), 2110-21. doi: 10.1111/j.1360-443.2011.03565.x. 135. Carpenter M, Sterba K, Boatright A, West R (2011) ‘Closet’ Quit Attempts: Prevalence, Correlates and Association with Outcome. Addiction, 106(12):2214-20. doi: 10.1111/j.1360-0443.2011.03538.x. 136. Fidler J, Shahab L, West O, Jarvis M, McEwen A, Stapleton J, Vangeli E, West R (2011) ‘The Smoking Toolkit Study’: A national study of smoking and smoking cessation in England. BMC Public Health, 11, 479. doi:10.1186/1471-2458-11-479.* 137. Beard E, Fidler J, West R (2011) Is use of nicotine replacement therapy while continuing to smoke associated with increased nicotine UTARG Output stop-smoking support from specialist clinics, treatment in groups and varenicline or combination NRT are more likely to succeed than those receiving treatment in primary care, one-toone and single NRT. From the increase in rate of quit attempts made during the month in which No Smoking Day occurs relative to months either side, it can be estimated that this event contributes about 6,000 long-term ex-smokers each year with a discounted cost per resulting life year gained of less than £100. Interventions and policies to change behaviour can be usefully characterised by means of a ‘Behaviour Change Wheel’ comprising: a ‘behaviour system’ at the hub, encircled by intervention functions and then by policy categories. Nicotine nasal spray is effective when given in primary care. The benefit appears to be lower than in a specialist clinic but similar to that with the nicotine patch. Nicotine nasal spray appears to be especially helpful for more dependent smokers. Continuing treatment of those initially failing doers is not beneficial. Use of nicotine replacement therapy (NRT) to aid smoking reduction and in situation of enforced abstinence is common in England and is strongly associated with a recent history of quit attempts. Nicotine patch and gum are the most commonly used forms of NRT for these purposes. Conflict about quitting appears to be measurable as a single dimension and is associated with a greater likelihood of trying to quit gradually rather than abruptly. Studies from a number of countries have shown that motivation to stop and past quit attempts strongly predict attempts to stop while measures of nicotine dependence strongly predict failure of those attempts; thus different mechanisms largely underlie quit attempts and success of quit attempts and policies to enable these need to address this. Attempting to quit smoking without telling anyone in advance appears common and does not appear to impede success. These findings do not support blanket advice to smokers to tell others about their quit attempts in advance. There is reason to believe that the STS findings (see www.smokinginengland.info) are generalisable to the adult population of England. Nicotine intake in smokers using nicotine replacement therapy for smoking reduction or to aid temporary abstinence is similar to that in smokers not doing so, Page 17 intake? Evidence from a population sample. Psychopharmacology, 218 (3), 609-610. doi: 10.1007/s00213-011-2359-4.* 138. West R, Evans A, Michie S (2011) Behaviour change techniques used in groupbased behavioural support by the English StopSmoking Services and preliminary assessment of association with short-term quit outcomes. Nicotine & Tobacco Research, 13, 1316-1320. doi: 10.1093/ntr/ntr120. ^ 139. Vangeli E, West R (2012) Transition towards a ‘non-smoker’ identity following smoking cessation: An interpretative phenomenological analysis. British Journal of Health Psychology, 17, 171-184. doi: 10.1111/j.2044-8287.2011.02031.x. 140. Fidler J, Stapleton J, West R (2011) Variation in saliva cotinine as a function of self-reported attempts to reduce cigarette consumption. Psychopharmacology, 217(4), 587-93. doi: 10.1007/s00213-011-2317-1.* 141. Stapleton JA, Sutherland G, O’Gara C, Spirling LI, Ball D. (2011) Association between DRD2/ANKK1 Taq1A Genotypes, Depression and Smoking Cessation with Nicotine Replacement Therapy. Pharmacogenetics and Genomics, 21(8):44753. doi: 10.1097/FPC.0b013e328347473a. 142. Kotz D, Fidler J, West R (2011) Did the introduction of varenicline in England substitute for or add to the use of other smoking cessation medications? Nicotine & Tobacco Research, 13(9): 793-9. doi: 10.1093/ntr/ntr075. * 143. Shahab L, McEwen A, West R (2011) Acceptability and effectiveness for withdrawal symptom relief of a novel oral nicotine delivery device: a randomised crossover trial. Psychopharmacology, 216(2), 187-96. doi: 10.1007/s00213-011-2204-9. 144. Bolam B, Gunnall D, West R (2011) Does smoking cessation cause depression and anxiety? Findings from the ATTEMPT cohort. Nicotine and Tobacco Research, 13 (3), 209214. doi: 10.1093/ntr/ntq244. 145. Ussher M, Aveyard P, Reid F, West R, Evans P, Clow A, Hucklebridge F, Fuller J, Ibison J, Steptoe A (2011) A randomised placebo-controlled trial of oral hydrocortisone for treating tobacco withdrawal symptoms. Psychopharmacology. 216, 43-51. doi: 10.1007/s00213-011-2191. 146. Wee LH, Shahab L, Bulgiba A, West R UTARG Output despite no difference in cigarette consumption. This suggests that smokers using nicotine replacement therapy while smoking smoke each cigarette less intensively. It is possible to code reliably group-specific behaviour change techniques for smoking cessation. Fourteen such techniques are present in guideline documents of which two appear to be associated with higher shortterm self-reported quit rates when included in treatment manuals of English Stop-Smoking Services. It appears useful to distinguish two levels of ‘nonsmoker’ identity: a surface level comprising the simple label and a deep level made up of often conflicting thoughts and feelings about oneself in relation to smoking. An absolute ‘non-smoker’ identity does not appear to be necessary for long-term abstinence. Saliva cotinine concentrations show moderate-to-high stability within subjects over a 3-month period. Smokers’ reports of attempting to cut down their smoking are associated with small decreases in this daily cigarette consumption but no detectable change in nicotine intake. Those having a Taq1A variant allele and a history of depression are likely to experience particular difficulty when trying to stop smoking and may require treatment other than standard doses of nicotine replacement. This finding might explain previous conflicting results for Taq1A and smoking cessation in studies where depression history was not measured, and may help explain the underlying link between depression and smoking. Use of varenicline increased substantially after it was approved by NICE and added to, rather than substituted for, use of other prescription medications, but this was against a background of a reduced incidence of quit attempts over the study period. A novel nicotine delivery system, the Nicotine Cannon, appears to provide at least a good relief from acute craving and withdrawal symptoms, as the comparable licensed NRT product but with higher levels of acceptability to users. Stopping smoking does not appear to increase the risk of symptoms of depression and anxiety in those free from symptoms when they were smoking. Hydrocortisone does not appear to be effective in relieving urges to smoke or withdrawal symptoms in abstaining smokers. Success rates of smokers attending smokers clinics in Page 18 (2011) Stop smoking clinics in Malaysia: characteristics of attendees and predictors of success. Addictive Behaviors, 36, 400-403. doi:10.1016/j.addbeh.2010.11.011. 147. Ussher M, Doshi R, Sampuran A, West R (2011) Cardiovascular risk factors in patients with schizophrenia receiving continuous medical care. Community Mental Health Journal, 47(6), 688-693. doi: 10.1007/s10597011-9376-y. 148. Michie S, Hyder N, Walia A, West R (2011) Development of a taxonomy of behaviour change techniques used in individual behavioural support for smoking cessation. Addictive Behaviors, 36 (4), 315-319. doi: 10.1016/j.addbeh.2010.11.016.^ 149. Wee LH, West R, Awang B, Shahab L (2011) Predictors of 3-month abstinence in smokers attending stop-smoking clinics in Malaysia. Nicotine and Tobacco Research, 13 (2), 151-6. doi: 10.1093/ntr/ntq221. 150. Smit, E, Fidler J, West R (2011) The role of desire, duty and intention in predicting attempts to quit smoking. Addiction, 106 (4), 844-51. doi: 10.1111/j.13600443.2010.03317.x.* 151. Kotz D, Fidler JA, West R. (2011) Estimating the rate of usage of varenicline and other medication for smoking cessation. Addiction, 106, 1868-1869. doi: 10.1111/j.1360-0443.2011.03486.x. 152. Fidler J, West R (2011) Enjoyment of smoking and urges to smoke as predictors of attempts and success of attempts to stop smoking: a longitudinal study. Drug and Alcohol Dependence. 115, 30-34. doi:10.1016/j.drugalcdep.2010.10.009.* 153. Fidler J, Shahab L, West R (2010) Strength of urges to smoke as a measure of severity of cigarette dependence: comparison with the Fagerstrom Test for Nicotine Dependence and its components. Addiction, 106 (3), 631-638. doi: 10.1111/j.1360-0443.2010.03226.x.* 154. Shahab L, West R, McNeill A (2011) A randomised controlled trial of adding expired carbon-monoxide feedback to brief stop smoking advice: evaluation of cognitive and behavioural effects. Health Psychology, 30, 4957. doi: 10.1037/a0021821. 155. Moody C, Mackintosh A, West R (2010) Adolescents’ awareness of, and involvement UTARG Output Malaysia are higher in those who are older, and have previously managed to stop for longer and lower in those who have higher baseline expired-air CO concentrations. Adjusting for these variables there remain large differences in the success rates of different clinics. Scores on the Fagerstrom Test for Cigarette Dependence do not appear to be related to success. Patients receiving continuous psychiatric care have very high levels of cardiovascular risk, particularly high rates of smoking and low rates of physical activity. It is possible to develop a reliable taxonomy of behaviour change techniques used in behavioural support for smoking cessation which can provide a starting point for investigating the association between intervention content and outcome and can form a basis for determining competences required to undertake the role of stop smoking specialist. Unlike in western samples, strength of motivation to stop appears to predict success of quit attempts in Malaysian smokers attending smokers clinics whereas the Fagerstrom Test for Cigarette Dependence, the most commonly used measure of nicotine dependence, does not. Desire and intention and intention to stop smoking independently positively predict quit attempts while sense that one ought to stop appears to undermine their effect. The introduction of varenicline did not reduce prescription NRT use but only appeared to in a paper by Langley et al because there was a coincident but unrelated decrease in the overall incidence of attempts to stop smoking. Enjoyment appears to be the major barrier to attempts to stop whereas cigarette dependence as indexed by strength of urges to smoke on normal smoking days is the main barrier to success of later quit attempts. A simple rating of strength of urges to smoke during a normal smoking day predicts success of subsequent quit attempt better than the Fagerstrom Test for Cigarette Dependence which is the current measure of choice for cigarette dependence. Expired-air carbon-monoxide concentration feedback enhances the effect of brief quit advice on cognitive antecedents of behaviour change and smoking cessation rates but further research is required to confirm the longevity of this effect and its applicability to smokers with low self-efficacy. Even in a country, such as the UK, that is purported to have a comprehensive, well-resourced illicit tobacco Page 19 with, illicit tobacco in the United Kingdom. Tobacco Control, 19(6), 521-522. doi: 10.1136/tc.2009.034967. Online. 18/11/2010. 156. Berg C, An L, Kirch M, Guo H, Thomas J, Patten C, Ahluwalia J, West R (2010) Failure to report quit attempts: Implications for research and clinical practice. Addictive Behaviors, 35, 900-904. doi:10.1016/j.addbeh.2010.06.009.* 157. Michie S, Churchill S, West R (2011) Identifying evidence-based competences required to deliver behavioural support for smoking cessation. Annals of Behavioral Medicine, 41(1), 59-70. doi: 10.1007/s12160010-9235-z.^ 158. Fidler JA, West R. (2010) Changes in smoking prevalence in 16-17 year old versus older adults following a rise in legal age of sale: findings from an English population study. Addiction, 105(11), 1984-8. doi: 10.1111/j.1360-0443.2010.03039.* 159. McEwen A, West R (2010) The PRIME approach to giving up smoking. Practice Nursing, 21(3): 145 - 153 160. Coleman, T., Agboola, S., Leonardi-Bee, J., Taylor, M., McEwen, A. & McNeill, A. (2010) Relapse Prevention in UK Stop Smoking Services: Current Practice, Systematic Reviews of Effectiveness and Cost Effectiveness Analysis. Health Technology Assessment, 14, 1-181. doi:10.3310/htal14490.^ 161. Agboola, S.A., Coleman, T.J., LeonardiBee, J.A., McEwen, A. & McNeill, A.D. (2010) Provision of relapse prevention interventions in UK NHS Stop Smoking Services: a survey. BMC Health Services Research, 10, 214. doi: 10.1186/1472-6963-10214.^ 162. Vangeli E, Stapleton J, West R (2010) Smoking intentions and mood preceding lapse after completion of treatment to aid cessation. Patient Education and Counselling, 81(2), 267271. doi:10.1016/j.pec.2010.01.024. 163. Powell J, Dawkins L, West R, Powell J, Pickering A (2010) Relapse to smoking during unaided cessation: Clinical, cognitive, and motivational predictors. Psychopharmacology, 212, 537–549. doi: 10.1007/s00213- 010-19758. 164. Bobrova N, West R, Bobak M (2010) UTARG Output strategy high numbers of youth are both aware of and involved with the illicit tobacco trade, which threatens to undermine the progress made in reducing smoking prevalence Failed quit attempts are quickly forgotten if they last only a short period of time. Almost two thirds of quit attempts that last between one day and one week fail to be reported after 3 months. It is possible to identify competences recommended for behavioural support for smoking cessation and subsets of these supported by different types of evidence. This approach can form the basis for development of assessment and training of stop smoking specialists. Following an increase in the legal age of sale from age 16 to age 18 in England a greater fall in prevalence was observed among 16-17 year olds than in older age groups, suggesting that such legislation may significantly reduce smoking prevalence. Most smokers experience discomfort about their smoking and at various times switch between not planning to stop, planning to stop, attempting to stop and thinking of themselves as having stopped. Transitions can occur between any of these states and any other very rapidly. Extending pharmacotherapy treatment (such as nicotine replacement therapy, bupropion or varenicline) after smokers have stopped smoking using these drugs, is both effective and cost effective for preventing relapse to smoking. Many English StopSmoking Services are using relapse prevention interventions for which there is no evidence of benefit. Most NHS Stop-Smoking Services appear to provide relapse prevention interventions for clients despite there being no evidence that these are effective Relapse to smoking appears to occur mostly in the context of negative rather than positive mood, and immediate urges to smoke. The intention is usually only to smoke for a limited time but buying cigarettes to relapse is common. Saliva cotinine functions better than the Fagerstrom Test for Cigarette Dependence as a measure of dependence in predicting short- and medium-term abstinence in unaided quitters. In addition, attentional bias to smoking cues and anti-saccade errors (a measure of ability to control impulses) predict shortterm abstinence. Low impulse control and cue reactivity also predict medium-term abstinence. Large differences exist between Russian men’s and Page 20 Gender differences in drinking practices in middle aged and older Russians. Alcohol and Alcoholism, 45, 573-580. doi: 10.1093/alcalc/agq069. 165. McEwen, A., Condliffe, L. & Gilbert, A. (2010) Promoting engagement with a Stop Smoking Service via pro-active telephone calls. Patient Education and Counselling, 80: 277-279. doi: 10.1016/j.pec.2009. 11.009.^ 166. Vangeli E, Stapleton J, West R (2010) Residual attraction to smoking and smoker identity following smoking cessation. Nicotine and Tobacco Research, 12, 865-865. doi: 10.1093/ntr/ntq104. 167. West R, Walia A, Hyder N, Shahab L, Michie S (2010) Behaviour change techniques used by the English Stop Smoking Services and their associations with short-term quit outcomes. Nicotine and Tobacco Research, 12, 742-747. doi:10.1093/ntr/ntq074.^ 168. Shahab L, Mindel J, Poulter S, West R (2010) Hypertension and its identification among current, past and never smokers in an English population sample. European Journal of Cardiovascular Prevention and Rehabilitation, 17, 63-70. doi: 10.1097/HJR.0b013e32832f3b42. 169. West R, Ussher M (2010) Is the 10-item Questionnaire of Smoking Urges (QSU-brief) more sensitive to abstinence than shorter craving measures? Psychopharmacology, 208, 427-432. doi: 10.1007/s00213-009-1742-x. 170. Gardner B, West R. (2010) Public support in England for raising the price of cigarettes to fund tobacco control activities. Tobacco Control, 19, 331-333. doi:10.1136/tc.2009.033274.* 171. Ashley,D.L.,O'Connor,R.J., Bernert,J.T, Watson,C.H., Polzin,G.M., Jain,R.B., Hammond,D., Hatsukami,D., Giovino,G.A., Cummings,K.M., McNeill,A., Shahab,L., King,B., Fong,G.T., Zhang,L., Xia,Y., Yan,Z., McCraw,J.M. (2010). Effect of Differing Levels of Tobacco-Specific Nitrosamines in Cigarette Smoke on the Levels of Biomarkers in Smokers. Cancer Epidemiology Biomarkers and Prevention, 19, 1389-98. doi: 10.1158/1055-9965.EPI-10-0084. 172. Shahab L, West R. (2010). Public support in England for a total ban on the sale of tobacco products. Tobacco Control, 19, 143-7. doi:10.1136/tc.2009.033415.* UTARG Output women’s drinking patterns; these differences may be largely explained by gender roles. Telephoning smokers from GP lists is a cost-effective method of prompting quit attempts using NHS StopSmoking Services. A significant minority of smokers who stop with the aid of group support in a smokers clinic report an attraction to smoking years after they have quit and some retain elements of a smoker identity. Identity change appears in many cases to be gradual rather than abrupt. There is wide variability in the behaviour change techniques used by the English Stop-Smoking Services and this, and the number of sessions scheduled for treatment explains a significant proportion of the variation in success rates. In particular, emphasis in service treatment manuals on measuring expired-air carbon monoxide concentrations, advising on use of medication, relapse prevention and coping and helping the smoker develop an ex-smoker identity are associated with higher success rates. Hypertension is detected less frequently among smokers than nonsmokers. Receiving a diagnosis seems to motivate cessation. Single item ratings of craving perform at least as well as the 10-item Questionnaire on Smoking Urges in terms of sensitivity to abstinence and reliability. 70% of English adults are in favour of raising the price of cigarettes with funds going towards tobacco control. Lowering the levels of tobacco-specific nitrosamines in the mainstream smoke of cigarettes through the use of specific tobacco types and known curing practices can significantly reduce the exposure of smokers to this known carcinogen and thus possibly harm caused by smoking. Nearly half of the English adult population support a movement towards a complete ban of the sale of tobacco in England with younger, female non-smokers in London expressing the greatest level of support. Page 21 173. Raupach T, Shahab L, Eimer S, Puls M, Hasenfuß G, Andreas S. (2010). Increasing use of nicotine replacement therapy by a simple intervention: An exploratory trial. Substance Use and Misuse, 45, 403-13. doi: 10.3109/10826080903452496. 174. Hackshaw L, McEwen A, West R, Bauld L. (2010) Quit attempts in response to smokefree legislation in England. Tobacco Control, 19, 160-4. doi:10.1136/tc.2009.032656.* 175. West R, May S, McEwen A, McRobbie H, Hajek P, Vangeli E. (2010) A randomised trial of glucose tablets to aid smoking cessation. Psychopharmacology, 207:631-5. doi: 10.1007/s00213-009-1692-3. 176. Georgiades C, West R. (2009). Time spent with urges to smoke and strength of urges as independent predictors of self-rated difficulty not smoking during abstinence. Journal of Smoking Cessation, 4, 48–51. doi: 10.1375/jsc.4.1.48. 177. Jarvis MJ, Mindell J, Gilmore A, Feyerabend C, West R. (2009). Smoke-free homes in England: prevalence, trends and validation by cotinine in children. Tobacco Control, 18, 491-5. doi:10.1136/tc.2009.031328. 178. McEwen A, Straus L (2009) Counterfeit tobacco in London: local crime needs an international solution. Trends in Organized Crime, 12, 251-259. doi: 10.1007/s12117-0099068-y. 179. Shahab L, McEwen A. (2009). Online support for smoking cessation: a systematic review of the literature. Addiction, 104, 1792804. doi: 10.1111/j.1360-0443.2009.02710.x. 180. van Jaarsveld C, Fidler J, Steptoe A, Boniface D, Wardle J. (2009). Perceived stress and weight gain in adolescents: A longitudinal analysis. Obesity, 17, 2155-61. doi:10.1038/oby.2009.183. 181. West R (2009). The multiple facets of cigarette addiction and what they mean for encouraging and helping smokers to stop. COPD: The Journal of Chronic Obstructive Disease, 6, 277-83. doi:10.1080/15412550903049181. 182. Aubin H-J, Berlin I, Smadja E, West R. (2009) Factors Associated with Higher Body Mass Index, Weight Concern, and Weight Gain in a Multinational Cohort Study of Smokers Intending to Quit. International Journal of Environmental and Public Health Research, 6, 943-57. doi:10.3390/ijerph6030943. UTARG Output An intervention aimed at increasing knowledge of nicotine dependence among participants of a cognitive-behavioural smoking cessation programme can lead to increased use of nicotine products. The implementation of Smoke-Free was associated with a temporary increase in attempts to stop smoking that was similar across the social gradient. Chewing glucose tablets may aid long-term cessation in smokers who are also using nicotine replacement therapy or bupropion. Time spent with urges to smoke and strength of urges are both independently associated with perceived difficulty not smoking during an attempt at smoking abstinence, whereas other withdrawal symptoms such as irritability are not. Even before the smoke-free legislation was enacted in England in 2007, smokers and non-smokers were increasingly making their homes smoke-free and this led to a reduction in smoke exposure to young children in those households. Local initiatives to deal with Kurdish refugee street sellers of counterfeit tobacco in Islington, North London, have been ineffective, with little agreement amongst local agencies as to what constitutes the ‘problem’, and with local shoppers giving a higher priority to other neighbourhood issues. Web-based, tailored, interactive smoking cessation interventions are effective compared with noninteractive, untailored booklet or email interventions but there are large variations in effectiveness across interventions studied. Stress in early childhood may lead to higher BMI during adolescence. Cigarette addiction involves several components relating to different parts of the motivational system: cues driven urges to smoke, a need to smoke arising from ‘nicotine hunger’ and withdrawal symptoms, wanting to smoke because of anticipated pleasure, positive evaluations of smoking including beliefs that it helps with stress, and a positive smoker identity. High baseline BMI appears to be associated with recent quit attempts, high weight concerns and high cigarette consumption. Weight gain is associated with low income, being single and number of cigarette-free days, but not with baseline weight concerns and confidence in preventing weight gain. Quit attempts are more frequent in smokers with a high BMI and low Page 22 183. Dawkins L, Powell JH, Pickering A, Powell J, West R (2009) Patterns of change in withdrawal symptoms, desire to smoke, reward motivation and response inhibition across 3 months of smoking abstinence. Addiction, 104, 850-8. doi: 10.1111/j.1360-0443.2009.02522.x. 184. Etter J-F, Stapleton J. (2009) Citations to trials of nicotine replacement therapy were biased toward positive results and high-impactfactor journals. J Clin Epidemiol, 62, 831-7. doi: 10.1016/j.jclinepi.2008.09.015. 185. Ferguson S, Shiffman S.Gitchell J, Sembower M.A. West R (2009) Unplanned quit attempts--results from a U.S. sample of smokers and ex-smokers. Nicotine and Tobacco Research, 11, 827-32 doi: 10.1093/ntr/ntp072. 186. Fidler J, West R (2009) Self-perceived smoking motives and their correlates in a general population sample. Nicotine and Tobacco Research, 11, 1182-8. doi: 10.1093/ntr/ntp120.* 187. Grainge M, Shahab L, Hammond D, O’Connor R, McNeill A. (2009). First Cigarette on Waking and Time of Day as Predictors of Puffing Behaviour in UK Adult Smokers. Drug & Alcohol Dependence, 101, 191-195. doi: 10.1016/j.drugalcdep.2009.01.013. 188. Kotz D, Fidler J, West R. (2009) Factors associated with the use of aids to cessation in English smokers. Addiction, 104, 1403-10. doi: 10.1111/j.1360-0443.2009.02639.x.* 189. Kotz D, Schayck O, West R, Huibers M. (2009) What mediates the effect of confrontational counselling on smoking in smokers with COPD? Patient Education and Counselling, 76, 16-24. doi:10.1016/j.pec.2008.11.017. 190. Kotz D, West R. (2009) Explaining the social gradient in smoking cessation: It's not in the trying, but in the succeeding. Tobacco Control, 18, 43-6. doi: 10.1136/tc.2008.025981.* 191. May S, Arnoldi H, Bauld L, Ferguson J, Stead M, McEwen A. (2009) How to measure client satisfaction with Stop Smoking Services: a pilot project in the NHS. Journal of Smoking Cessation, 4, 52-58. doi:10.1375/jsc.4.1.52. 192. McEwen A, West R (2009) Do implementation issues influence the UTARG Output weight concerns. Appetitive processes and related affective states appear to improve in smokers who remain nicotinefree for 3 months, whereas ability to inhibit responding does not. Poor inhibitory control may constitute a long-term risk factor for relapse and could be a target for intervention. Trials of nicotine replacement therapies with statistically significant results tend to be published in journals with higher impact factors than trials with non-significant results. Approximately half of quit attempts made in the US do not involve any pre-planning and people who report unplanned quit attempts are more likely still to be abstinence at the time of being surveyed than those who report pre-planning Enjoyment and stress relief are the most common reasons given for continued smoking by smokers in the general population, with men more likely to report enjoyment and women tending to cite stress relief. Smokers who report enjoying smoking and liking being a smoker are less likely to make a quit attempt. Contrary to what is commonly assumed, the first cigarette of the day is smoked less, not more, intensively than subsequent cigarettes. In England, half of all attempts to quit smoking are aided by some form of pharmacological or behavioural treatment. However, the use of the most effective treatment option (the NHS Stop-Smoking Services) is low, despite it being free of charge. Factors associated with an increased use of aids to cessation are being female, older, and smoking more cigarettes smoked per day. Confrontational counselling increases risk perceptions and self-efficacy, and decreases risk denial in smokers with previously undetected chronic obstructive pulmonary disease. These changes in mediators are associated with a higher likelihood of smoking cessation. Smokers from lower social grades in England are no less likely to try to stop smoking than those from higher social grades but they are less likely to succeed if they try. Satisfaction with stop-smoking services can be reliably assessed using a newly developed scale designed for that purpose Making it more effortful and time-consuming to get a smoking cessation medication can substantially reduce Page 23 effectiveness of medications? The case of nicotine replacement therapy and bupropion in UK Stop Smoking Services. BMC Public Health, 21, 28. doi:10.1186/1471-2458-9-28. 193. McEwen A, West R, Gaiger M (2009) Nicotine absorption from seven current nicotine replacement products and new widebore nicotine delivery device. Journal of Smoking Cessation, 3, 117-123. doi:10.1375/jsc.3.2.117. 194. McEwen A, Straus L, Croker H. (2009) Dietary beliefs and behaviour of a UK Somali population. Journal of Human Nutrition and Dietetics, 22, 116-21. doi: 10.1111/j.1365277X.2008.00939.x. 195. Raupach T, Shahab L, Baetzing S, Hoffmann B, Hasenfuss G, West R, Andreas S. (2009) Medical students lack basic knowledge about smoking: findings from two European medical schools. Nicotine and Tobacco Research, 11, 92-8. doi:10.1093/ntr/ntn007. 196. Sanderson S, Waller J, Jarvis M, Humphries S, Wardle J. (2009) Awareness of lifestyle risk factors for cancer and heart disease among adults in the UK. Patient Educ Couns, 74, 221-7. doi:10.1016/j.pec.2008.08.003. 197. Shahab L, Hammond D, Borland R, Cummings K, West R, McNeill A. (2009). The impact of changing nicotine replacement therapy licensing laws in the United Kingdom: findings from the International Tobacco Control Four Country Survey Addiction, 104, 1420-1427. doi: 10.1111/j.13600443.2009.02641.x. 198. Shahab L, West R. (2009) Do ex-smokers report feeling happier following smoking cessation? Evidence from a cross-sectional survey. Nicotine and Tobacco Research, 11, 553-557. doi: 10.1093/ntr/ntp031.* 199. Shahab L, West R, McNeill A. (2009). A comparison of exposure to carcinogens among roll-your-own and factory-made cigarette smokers. Addiction Biology, 14, 315-20. doi: 10.1111/j.1369-1600.2009.00157.x. 200. Stapleton J. (2009) Do the 10 UK suicides among those taking the smoking cessation drug varenicline suggest a causal link? Addiction, 104, 864-5. doi: 10.1111/j.13600443.2009.02567.x. 201. Stapleton J, Keaney F, Sutherland G. (2009) Illicit drug use as a predictor of smoking cessation treatment outcome. Nicotine Tob Res, 11, 685-689. doi: 10.1093/ntr/ntp050. 202. Straus L, McEwen A. (2009) Somali women’s experience of childbirth in the UK: UTARG Output its effectiveness. A new nicotine delivery device that allows improved inhalation of nicotine vapour can provide high doses of nicotine with a rate of absorption slightly slower than nicotine nasal spray. Fruit and vegetable consumption is low in the Somali population in London and there is uncertainty about what constitutes a healthy diet. Cultural factors such as the traditional Somali diet, social associations of food and lack of appropriate information may play a role in this. Medical students in both the UK and Germany lack relevant basic information about smoking and health and the effectiveness of cessation methods. In the UK, public awareness of the links between lifestyles and commonly feared diseases is inadequate. Extending the licence for nicotine replacement therapy products to include their use for gradual cessation had minimal impact on usage for this purpose. Ex-smokers overwhelmingly report being happier than when they were smoking. There appear to be no differences in the toxin intake between manufactured and hand-rolled cigarette smokers but women have higher concentrations of these toxins in their system irrespective of the cigarette type smoked. The reported rate of suicides while using varenicline is no higher than would expected in smokers in general. Illicit drug use appears to have a significant detrimental effect on the success of an attempt to stop smoking. Mismanagement of female circumcision leads to problems at birth for many Somali women; the Page 24 the views of Somali health workers. Midwifery, 25, 181-6. doi:10.1016/j.midw.2007.02.002. 203. Ussher M, Cropley M, Playle S, Mohidin R, West R (2009) Effect of isometric exercise and body scanning on cigarette cravings and withdrawal symptoms. Addiction, 104, 1251-7 doi: 10.1111/j.1360-0443.2009.02605.x. 204. Zhou X, Nonnemaker J, Sherrill B, Gilsenan A, Coste F, West R (2009) Attempts to quit smoking and relapse: factors associated with success or failure from the ATTEMPT cohort study. Addictive Behaviours, 34, 36573. doi:10.1016/j.addbeh.2008.11.013. 205. Fidler J, Jarvis M, Mindell J, West R (2008) Nicotine intake in cigarette smokers in England: distribution and demographic correlates. Cancer Epidemiology Biomarkers and Prevention, 17, 3331-6. doi: 10.1158/10559965.EPI-08-0296. 206. Fidler J, West R, van Jaarsveld C, Jarvis MJ, Wardle J. (2008) Smoking status of step parents as a risk factor for smoking in adolescence. Addiction, 103, 496-501. doi: 10.1111/j.1360-0443.2007.02086.x. 207. Jarvis MJ, Fidler J, Mindell J, Feyerabend C, West R (2008) Assessing smoking status in children, adolescents and adults: cotinine cutpoints revisited. Addiction, 103, 1553-61. doi: 10.1111/j.1360-0443.2008.02297.x. 208. McEwen A, West R, McRobbie H (2008) Motives for smoking and their correlates in clients attending Stop Smoking treatment services. Nicotine and Tobacco Research, 10, 843-50. doi: 10.1080/14622200802027248. 209. McEwen A, Straus L, Ussher M. (2008) Physical inactivity of a Somali population in London. Journal of Public Health, 30, 110. doi:10.1093/pubmed/fdm075. 210. McEwen A, West R, Gaiger M. (2008) Nicotine absorption from seven current nicotine replacement products and a new widebore nicotine delivery device. Journal of Smoking Cessation, 3, 117-23. doi: 10.1375/jsc.3.2.117. 211. O’Gara C, Knight J, Stapleton JA. Luty J, Neale B, Nash M, Heuzo-Diaz P, Hoda F, Cohen S, Sutherland G, Collier D, Sham P, Ball D, McGuffin P, Craig I. (2008) Association of serotonin transporter genes, neuroticism and smoking behaviours. Journal of Human Genetics, 53, 239-46. doi: 10.1007/s10038-007-0243-1. UTARG Output importance of Somalia’s oral culture is not recognised when addressing communication barriers and continuity of care is lacking. Isometric exercise, and a mental exercise that involves focusing attention on breathing and on different parts of the body while relaxing, reduces desire to smoke compared with sitting doing nothing. Quit attempts are less likely to succeed if they are made within 3 months of an earlier attempt. After adjusting for cigarette consumption, nicotine intake in English adults is greatest in middle age, males and those with highest levels of economic deprivation. Smoking behaviour of step-fathers is at least as strong a risk factor for smoking initiation as smoking behaviour of natural fathers. The optimal cutpoint for saliva cotinine varies with sociodemographic group but overall is around 13ng/ml Enjoyment and stress relied are important self-reported motives for smoking in smokers clinic clients but they do not predict relapse following attempts to stop. Low levels of physical activity are reported among Somalis in London; apparently due to changes in lifestyle since immigration and a misperception that ‘sweating’ has health benefits irrespective of whether it is produced through exercise or not (e.g. using a sauna). Of current acute delivery nicotine replacement therapy products currently on the market, the 4mg lozenge appears to produce the highest per unit plasma nicotine concentrations, the 2mg gum delivers the lowest concentrations and the nicotine nasal spray delivers nicotine the fastest. A new inhalation device, the Nicotine Cannon, could deliver nicotine rapidly in a manner that may be readily tolerated by users. Although neuroticism appears to be significantly associated with cigarette consumption and failure to stop smoking, genotype does not affect this relationship. This does not support initial interest in utilising 5HTTLPR genotypes in combination with neuroticism ratings for predicting outcome in smoking cessation clinical settings. Page 25 212. Raupach T, Shahab L, Neubert K, Hasenfuß G, Andreas S. (2008). Implementing a hospital-based smoking cessation programme: evidence for a learning effect. Patient Education & Counselling, 70, 199-204. doi: 10.1016/j.pec.2007.10.005. 213. Sanderson S, Humphries S, Hubbart C, Hughes E, Jarvis MJ, Wardle J. (2008) Psychological and behavioural impact of genetic testing smokers for lung cancer risk: a phase II exploratory trial. J Health Psychol, 13, 481-94. doi: 10.1177/1359105308088519. 214. Shahab L, West R, McNeill A. (2008) The feasibility of measuring puffing behaviour in Roll-Your-Own cigarette smokers. Tobacco Control, 17 Suppl 1, 17-23. doi:10.1136/tc.2007.021824. 215. Shahab L, Hammond D, O’Connor R, Cummings K, Borland R, King B, McNeill A. (2008) The reliability and validity of selfreported puffing behaviour: evidence from a cross-national study. Nicotine & Tobacco Research, 10, 867-74. doi: 10.1080/ 14622200802027156 . 216. Stapleton JA, Watson L, Spirling LI, Smith R, Milbrandt A, Radcliffe M, Sutherland G. (2008) Varenicline in the routine treatment of tobacco dependence: a pre-post comparison with Nicotine Replacement Therapy and an evaluation in those with mental illness. Addiction, 103, 146-54. doi: 10.1111/j.13600443.2007.02083.x. 217. Thyrian J, Panagiotakos D, Polychronopoulos E, West R, Zatonski W, John U. (2008) The relationship between smokers´ motivation to quit and intensity of tobacco control at the population level; a comparison of five European countries. BMC Public Health, 8, 2. doi: 10.1186/1471-2458-82. 218. Ussher M, Aveyard P, Coleman T, Straus L, West R, Marcus B, Lewis B, Manyonda I. (2008) Physical activity as an aid to smoking cessation during pregnancy: two feasibility studies. BMC Public Health, 8, 328. doi: 10.1186/1471-2458-8-328. 219. Vangeli E, West R. (2008) Sociodemographic differences in triggers to quit smoking: Findings from a national survey. Tobacco Control, 17, 410-415. doi:10.1136/tc.2008.025650.* 220. Vogt F, McEwen A, Michie S. (2008) What GPs can do to deliver more brief smoking cessation advice: an exploratory study. Journal of Smoking Cessation, 3, 10-6. doi: 10.1375/jsc.3.2.110. UTARG Output Stop-smoking practitioners appear to show a learning effect with time that leads to better smoking cessation rates. Research into the risks and benefits for individuals of emerging lifestyle-related genetic susceptibility tests is important and feasible to carry out. The measurement of puffing behaviour using a topography device is feasible, but is less practicable for roll-your-own than factory-made cigarettes. Smokers have a more accurate perception of the puffing time and number of puffs taken than the intensity and depth of each puff or their actual smoke exposure. With group support varenicline appears to improve success rates over those achieved with nicotine replacement therapy, and is equally effective and safe in those with and without a mental illness. Extent of tobacco control activity in countries in Europe varies considerably, as does population-level motivation to stop. However, there does not appear to be a direct association between the two. Pregnant smokers are likely to take up the offer of exercise classes and advice as a way of helping them stop smoking There are significant differences in reported triggers for quit attempts as a function of sociodemographic factors; smokers with higher SES are more likely to report concern about future health whereas those from lower SES are more likely to cite cost and current health problems. GPs appear to judge approximately a quarter of smokers they see in routine consultations as being in a state where it would be inappropriate to raise the topic of smoking. Page 26 221. West R, Baker CL, Cappelleri JC, Bushmakin AG. (2008) Effect of varenicline and bupropion SR on craving, nicotine withdrawal symptoms, and rewarding effects of smoking during a quit attempt. Psychopharmacology, 197, 371-7 doi:10.1007/s00213-007-1041-3. 222. West R, Stapleton J. (2008) Clinical and public health significance of treatments to aid smoking cessation. European Respiratory Review, 17, 1-6. doi: 10.1183/09059180.00011005. 223. West R, Townsend J, Joossens L, Arnott D, Lewis S (2008) Why combating tobacco smuggling is a priority: Tobacco smuggling is killing many times more people in the UK than smuggling of all illicit drugs put together. British Medical Journal, 337, 1933. doi:10.1136/bmj.a1933. 224. West R, West A (2008) Vers un modèle synthétique de la motivation (théorie PRIME) et son application dans la compréhension des addictions. Alcoologie et Addictologie, 30, 3745. 225. Dawkins L, Powell JH, West R, Powell J, Pickering A. (2007) A double-blind placebo controlled experimental study of nicotine: II effects on response inhibition and executive functioning. Psychopharmacology, 190, 45767. doi: 10.1007/s00213-006-0634-6. 226. Etter JF, Burri M, Stapleton JA (2007) The impact of pharmaceutical company funding on results of randomized trials of nicotine replacement therapy for smoking cessation: a meta-analysis. Addiction, 102, 815-22. doi: 10.1111/j.1360-0443.2007.01822.x. 227. Fidler JA, West R, Van Jaarsveld CH, Jarvis MJ, Wardle J. (2007) Does smoking in adolescence affect body mass index, waist or height? Findings from a longitudinal study. Addiction. 102, 1493-501. doi: 10.1111/j.13600443.2007.01910.x. 228. Holloway E, West R (2007) Integrated breathing and relaxation training (the Papworth Method) for adults with asthma in primary care: a randomised controlled trial. Thorax. 62, 1039-42. doi:10.1136/thx.2006.076430. 229. May S, West R, Hajek P, McEwen A, McRobbie H (2007) Social support and success at stopping smoking. Journal of Smoking Cessation. 2, 47-53. doi: 10.1375/jsc.2.2.47. 230. O’Gara C, Stapleton JA, Sutherland G, Guindalini C, Neale B, Breen G, Ball D (2007) Dopamine transporter polymorphisms associated with short-term response to smoking cessation treatment. Pharmacogenetics and Genomics. 17, 61-7. doi: 10.1097/01.fpc. UTARG Output Varenicline’s superiority over bupropion in aiding cessation may be linked to its superior effect on craving relief and stronger action in blocking the rewarding effect of smoking should a lapse occur. Failure of a quit attempt after the mid-30s can be expected to cost 6-7 years of life. Smuggling of tobacco and cigarettes is estimated to be leading to the death of some 4 times more people than smuggling of all illicit drugs put together, because of its effect in keeping the price down. Understanding addiction requires a model that combines learning theory, decision theory and selfcontrol theory. PRIME Theory offers such a model using terms that are close to ones used in everyday discourse. Nicotine withdrawal impairs capacity voluntarily to inhibit low level impulses. Published trials of nicotine replacement therapy funded by pharmaceutical companies have significantly larger effect sizes than others but all show clear evidence of effectiveness. Taking up smoking in adolescence is associated with a lower body mass index subsequently. The Papworth Method of breathing control and relaxation reduces symptoms of hyperventilation and breathing disorder in adults with asthma. There is no evidence to date that social support plays a significant role in aiding smoking cessation. There is modest evidence of a medium-sized effect of DAT1 genotype on the ability to stop smoking early in a smoking cessation attempt. If the effect is real this suggests that the primary utility of DAT1 screening in this field will be in the identification of those most at risk of early relapse after quitting. Page 27 0000236328. 18928.4c. 231. Shahab L, Hall S, Marteau TM (2007) Showing smokers with vascular disease images of their arteries to motivate cessation: a pilot study. British Journal of Health Psychology. 12, 275-83. doi: 10.1348/135910706X109684. 232. Stapleton JA, Sutherland G, O’Gara C (2007) Association between dopamine transporter genotypes and smoking cessation: A meta analysis. Addiction Biology. 12, 221-6. doi: 10.1111/j.1369-1600.2007.00058.x. 233. Straus L, McEwen A. & Croker H. (2007) Smoking prevalence and attitudes of a Somali population in London. Journal of Smoking Cessation, 2, 68-72. doi: 10.1375/jsc.2.2.68. 234. Aveyard P, West R (2007) Management of smoking cessation. BMJ. 335, 37-41. doi:10.1136/bmj.39252.591806.47. 235. Tonnesen P, Carrozzi L, Fagerstrom KO, Gratziou C, Jimenez-Ruiz C, Nardini S, Viegi G, Lazzaro C, Campell IA, Dagli E, West R. (2007) Smoking cessation in patients with respiratory diseases: a high priority, integral component of therapy. European Respiratory Journal. 207, 390-417. doi: 10.1183/?09031936.00060806. 236. Ussher M, West R, McEwen A, Taylor A, Steptoe A. (2007) Randomized controlled trial of physical activity counseling as an aid to smoking cessation: 12 month follow-up. Addictive Behaviors. 32, 3060-4. doi:10.1016/j.addbeh. 2007.04.009. 237. van Jaarsveld CH, Fidler, JA, Simon AE, Wardle, J (2007) Persistent impact of pubertal timing on trends in smoking, food choice, activity, and stress in adolescence. Psychosomatic Medicine. 69, 798-806. doi: 10.1097/PSY.0b013e31 81576106. 238. West R, Zatonski W, Przewozniak K, Jarvis M (2007) Can we trust national smoking prevalence figures? Discrepancies between biochemically-assessed and self-reported smoking rates in three countries. Cancer Epidemiology Biomarkers & Prevention. 16, 820-2. doi: 10.1158/1055-9965.EPI-06-0679. 239. West R, Zhou X (2007) Is nicotine replacement therapy for smoking cessation effective in the "real world"? Findings from a prospective multinational cohort study. Thorax. 62, 998-1002. doi:10.1136/thx.2007.078758. UTARG Output Personalised biomarker feedback can increase intentions to stop smoking and motivate smokers to engage in various smoking cessation behaviours if they have high self-efficacy. The DAT1 3'UTR VNTR polymorphism appears to be associated with an increased probability of smoking cessation. One or more variant 9-repeat alleles relative to the more common 10-repeat allele confers a greater likelihood of cessation, indicative of lower dependence on tobacco. Smoking rates in the Somali population appear to be higher than in the UK general population and higher still among men over 40 years old and those that regularly use qat; there is little knowledge of smoking cessation services. The combination of behavioural support and medication such as varenicline or nicotine replacement therapy improves the chances of success of quit attempts by 300%; a smoker who tries to stop at least once a year using this method at the age of 20 has an 80% chance of becoming a permanent ex-smoker by the age of 40. Clinicians treating smokers with chronic obstructive pulmonary disease should regard treatment for nicotine dependence as an integral and continuing part of their care plan, repeatedly offering behavioural support and medication. Establishing a plan with smokers to increase physical activity as part of behavioural support for smoking cessation appears to have no effect on long-term cessation rates. Early maturing adolescents are more likely to exhibit unhealthy behaviours, especially smoking. This increased risk is maintained throughout adolescence. Self-reported smoking prevalence in national surveys underestimates true smoking prevalence by different amounts in different countries. When adjusting for likely confounding factors such as nicotine dependence, use of nicotine replacement therapy without formal behavioural support is associated with an increased probability of long-term abstinence from cigarettes in smokers not taking part in clinical trials. Page 28 Editorials, trial protocols and opinion pieces in refereed journals 1. 2. Beard E, Brown J, West R, Acton C, Brennan A, Drummond C, Hickman M, Holmes J, Kaner E, Lock K, Walmsley M, Michie S (2015) Protocol for a national monthly survey of alcohol use in England: ‘The Alcohol Toolkit Study’. BMC Public Health, 15, 230. doi: 10.1186/s12889-015-1542-7. EQUIPT Project Team EQUIPT: protocol of a comparative effectiveness research study evaluating cross-context transferability of economic evidence on tobacco control. (2014) BMJ Open, 4, 11, e006945. doi: 10.1136/bmjopen-2014006945. 3. 4. 5. Fucito L, Bars M, Forray A, Rojewski A, Shiffman S, Selby P, West R, Foulds J, Toll B (2014) Addressing the evidence for FDA nicotine replacement therapy label changes: A policy statement of the association for the treatment of tobacco use and dependence and the society for research on nicotine and tobacco. Nicotine & Tobacco Research, 16, 909-914. doi: 10.1093/ntr/ntu087. Courtney R, Bradford D, Martire K, Bonevski B, Borland R, Doran C, Hall W, Farrell M, Siapush M, Sanson-Fisher R, West R, Mattick R (2014) A randomized clinical trial of a financial education intervention with nicotine replacement therapy (NRT) for low socio-economic status Australian smokers: A study protocol. Addiction, 109, 1602-11. doi: 10.1111/add.12669. West R, Brown J (2014) Electronic cigarettes: fact and faction. British Journal of General Practice, 64, 442-3. doi: 10.3399/bjgp14X681253. 6. Brown J, West R (2014) Animal farm must give way to doublethink when studying addiction. Addiction, 109, 1214-5. doi: 10.1111/add.12553. 7. Sarkar B, Shahab L, Arora M, Lorencatto F, Reddy S, West R (2013) A cluster randomised controlled trial of a brief tobacco cessation intervention for low income communities in India: Study Protocol. Addiction, 109, 371-8. doi: 10.1111/add.12420. Aveyard P, West R (2013) Cytisine and the failure to market and regulate for human health. Thorax, 68, 989. doi: 10.1136/thoraxjnl-2013-203246. 8. UTARG Output The Alcohol Toolkit Study will improve understanding of population level factors influencing alcohol consumption and be an important resource for policy evaluation and planning This study develops and evaluates a Europe-wide model and tool for calculating return on investment from tobacco control interventions. This report summarizes the FDA announcement, reviews the evidence for further revisions to current FDA NRT guidelines, and makes recommendations for over-the-counter (OTC) NRT labeling to allow for (1) combined use of faster-acting NRT medications with nicotine patch, (2) nicotine patch use prior to quit date or NRT for smoking reduction as part of a quit attempt, and (3) prolonged NRT for up to 6 months without healthcare provider consultation. This is the first intervention study to evaluate the potential of co-managing financial stress as a means of enhancing smokers' capacity to quit smoking. Such an intervention may provide a scalable intervention to help low SES smokers to quit. Data are being misinterpreted and imprecise and misleading language being used to describe results in order to support fixed positions on electronic cigarettes. Public health and the reputation of public health science is undermined by this kind of behaviour. Characterising addiction as a ‘brain disorder’, as proposed in a recent Nature editorial, is as limiting and problematic as characterising it as a ‘social problem’. Modern models of addiction have been formulated that allow the multiple facets of addiction to be integrated and these should be used. The first ever randomised trial of brief opportunistic advice for tobacco cessation in a low or middle income country will be carried out, If the intervention is successful it could provide a basis for adoption in India and beyond of a low-cost high-reach public health intervention that could save many thousands of lives. With a rational drug regulatory system, cytisine would be licensed for sale worldwide without the requirement for further studies, but failing that the UK government should fund the one further study Page 29 9. 10. Brown, J., Michie, S., Raupach, T., & West, R. (2013). Should public health bodies stop commissioning research from market research companies that serve the tobacco industry? Addiction, 109, 1-2. doi: 10.1111/add.12302. West R (2013) Addiction: a global problem requiring a global science. International Journal of Prevention and Treatment of Substance Use Disorders. doi: http://dx.doi.org/10.4038/ijptsud.v1i1.5906. 11. Cattaruzza M, West R (2013) Why do doctors and medical students smoke when they must know how harmful it is? European Journal of Public Health, 23, 188-9. doi: 10.1093/eurpub/ckt001. 12. West R, Marteau T (2013) The commercial determinants of health. Addiction, 108, 686687. doi: 10.1111/add.12118. Michie S, Spring B, West R (2013) Moving from theory to practice and back in social and health psychology. Health Psychology, 32, 581-585. doi: 10.1037/a0030205. 13. 14. Michie S, West R. (2013). Behaviour change theory and evidence: a presentation to government. Health Psychology Review. 7,122. doi:10.1080/17437199.2011.649445. 15. Brown J, Michie S, West R (2013) The case of stop smoking services in England. British Journal of Psychiatry, 202, 74. doi: 10.1192/bjp.202.1.74. 16. Michie S, Brown J, Geraghty AWA, et al. A randomised controlled trial of a theory-based interactive internet-based smoking cessation UTARG Output that is required and so save itself tens of millions of pounds each year in stop-smoking medicine costs. Market research companies who do work for tobacco industry clients should not be used by public health organisations. Research into understanding, preventing and treating addiction has focused on western, English-speaking cultures. Yet addiction is a global problem. There is an urgent need for studies that test western models and assumptions in order to arrive at a truly global science that is relevant to the majority of the world’s population. Smoking prevalence in doctors in countries such as Italy is high. Surprising as it may seem knowledge of the harms of smoking is low and may be one factor. A simple ‘risk acceptance’ ladder could be a useful tool in identifying what kind of intervention is needed to reduce such risky behaviour. It starts with ‘I did not know’, then goes through ‘I heard but did not believe’, and then ‘I believed but did not care very much’ all the way through to ‘I cared and want to change but find it very hard’. The profit motive arguably has a more pervasive and damaging influence on public health than social status. For advances in social psychology to translate into progressive improvements in interventions and realized gains in public health, theories should: 1) be explicitly linked to the major theories from which they draw; 2) reflect the context-sensitivity and dynamic nature of the intervention target; 3) show convincing evidence of improved effectiveness of interventions they spawn according to rigorous criteria; and 4) address the full translation process, including implementation by healthcare providers and engagement by the target population. Government policies relating to behaviour change need to go beyond the ‘nudge’ doctrine’ and embrace a comprehensive analysis of what is required for change to occur linked to selection from the full range of intervention functions and policies available in the Behaviour Change Wheel. The English stop smoking services are an example of an evidence-based individual level behaviour change intervention implemented at a population level – treating more than 600,000 smokers each year. Performance is variable but the National Centre for Smoking Cessation and Training has a run a successful programme of establishing best practice, disseminating it and evaluating the effects of this dissemination. Protocol for a trial to assess a new interactive internet-based intervention (StopAdvisor) for smoking cessation that was designed with particular Page 30 17. 18. 19. intervention (‘StopAdvisor’): Study protocol. Journal of Smoking Cessation. 2013;8(02):63-70. doi: 10.1017/jsc.2013.21. Ussher M, Aveyard P, Manyonda I, Lewis S, West R, Lewis B, Marcus B, Taylor A, Barton P, Coleman T (2012) Trials, 13, 186 Raupach T, Brown J (2012) Treatment of tobacco addiction and the cardiovascular specialist. Current Opinion in Cardiology, 27, 525-532. doi: 10.1097/HCO.0b013e328356db00. Sarkar B, Reddy S (2012) Priorities for tobacco control research in India. Addiction, 107, 2066-2068. doi: 10.1111/j.13600443.2012.03942.x. 20. Brown J, Raupach T, West R (2012) GPs have a key role to play in helping patients to stop smoking. The Practitioner, 256, 23-25 21. Lingford-Hughes A, Welch A, Peters L, Nutt D, Ball D, Buntwal N, Chick J, Crome I, Daly C, Dar K, Day E, Duka T, Finch E, Law F, Marshall E, Munafo M, Myles J, Porter S, Raistrick D, Reed L, Reid A, Sell L, Sinclair J, Tyrer P, West R, Williams T, Winstock A (2012) BAP updated guidelines: evidencebased guidelines for the pharmacological management of substance abuse, harmful use, addiction and comorbidity: recommendations from BAP. Journal of Psychopharmacology, 26, 899-952. doi: 10.1177/0269881112444324. Hughes J, Cummings K, Foulds J, Shiffman S, West R (2012) Effectiveness of nicotine replacement therapy: a rebuttal. Addiction, 107, 1527-1528. doi: 10.1111/j.13600443.2012.03925.x. 22. attention directed to people with low socioeconomic status. LEAP is a pragmatic randomised controlled trial to assess the effect of exercise counselling to help pregnant smokers to stop. Treatment tobacco addiction in smokers with cardiovascular disease is one of the most important interventions available in terms of preventing acute cardiac events. Effective treatments are available but often not used. The enormity of the tobacco epidemic in India, which has a population greater than the United States and Europe combined, merits a huge scaling-up of research efforts that can inform, support and evaluate tobacco control. Research is needed to underpin all the World Health Organization’s MPOWER recommendations. Prioritization and coordination of the research efforts are critical to success and ensuring value for money. Apart from the sheer size of the country and its population, its cultural and regional diversity present particular challenges. A review of the evidence suggests that GPs should offer help to all smokers without first asking them whether they are interested in quitting or advising them to stop. There is strong evidence for a range of pharmacological and psychological interventions to help people recover from substance abuse problems and addiction. In the case of cigarette addiction these include: nicotine replacement therapy, bupropion, varenicline, nortriptyline and cytisine, face-to-face individual and group-based behavioural support, telephone support, text messaging and websites. A recent study by Alpert did not, as the authors claimed, find that nicotine replacement therapy is ineffective in the long term. If it found anything, it confirmed that once people have quit for several months using a given method, the rate of relapse after that is roughly constant so that any gains achieved by a particular method in the arly months are preserved proportionately. The Dutch government should reconsider its decision to reverse tobacco control legislation and cut back on tobacco control activities; the Netherlands is already on one the worst European countries in terms of smoking prevalence and ignorance of the harmfulness of tobacco. Arnott D, Berteletti F, Britton J, Cardone A, Clancy L, Craig L, Fong G, Glantz S, Joossens L, Rudolphie M, Rutger M, Smith S, Stam H, West R, Willemsen M (2012) Can the Dutch government really be abandoning smokers to their fate? Lancet, 9811, 121-122. doi: 10.1016/S0140-6736(11)61855-2. Programme grant 2007-2011 24. West R (2011) Preventing tobacco companies There is good reason to believe that preventing from advertising using their packaging could tobacco companies to advertise their products through 23. UTARG Output Page 31 be an important component of comprehensive tobacco control. Drug and Alcohol Review, 30, 681-682. doi: 10.1111/j.14653362.2011.00369.x. 25. West R (2011) ‘Payment by results’ and smoking cessation support. Addiction, 106, 1730-1731. doi: 10.1111/j.13600443.2011.03541.x. 26. Bonevski B, Paul C, D'Este C, Sanson-Fisher R, West R, Girgis A, Siahpush M, Carter R (2011) RCT of a client-centred, caseworkerdelivered smoking cessation intervention for a socially disadvantaged population. BMC Public Health, 11, 70. doi: 10.1186/14712458-11-70. 27. West R, Miller P (2011) What is the purpose of diagnosing addiction or dependence and what does this mean for establishing diagnostic criteria? Addiction. 106(5), 863-5. doi: 10.1111/j.1360-0443.2011.03377.x. 28. Britton J, McNeill A, Arnott D, West R, Godfrey C Drugs and harm to society. Lancet, 377(9765), 551. doi:10.1016/S01406736(11)60192—x. 29. West R (2010) The potential contribution of health psychology to developing effective interventions to reduce tobacco smoking. Psychology and Health, 25(8), 889-892. doi: 10.1080/08870446.2010.523991. 30. West R, McNeill A, Britton J, Bauld L, Raw M, Hajek P, Arnott D, Jarvis M, Stapleton J (2010) Should smokers be offered assistance with stopping? Addiction. 105, 1867-2040. doi: 10.1111/j.1360-0443.2010.03111.x. UTARG Output their packaging will significantly reduce the attractiveness of cigarettes. Data arising from implementation of this policy in Australia will be helpful in determining how much effort and resource other countries should put into it given all the other policies they could be pursuing. Payment by results for smoking cessation support will lead to a serious deterioration in service provision without a set of key safeguards: only paying for successes above what could have been achieved by medication alone, varying the tariff to take account of differences in quit rates of different types of smoker, and only using providers that have been through an accreditation process which demonstrates that they offer optimal evidence-based support and their claimed quit rates are accurate A trial will be conducted to assess the effectiveness of a client-centred, caseworker-delivered intervention in helping smokers from socially disadvantaged populations in NSW Australia to stop. Given that the main purpose of diagnosing people as ‘addicted’ is to enable them to receive appropriate treatment, such a diagnosis should be applied to anyone who is engaging in, or at high risk of returning to, a behaviour known to have significant addictive potential in a way that is causing or likely to cause harm. Current and proposed diagnostic DSM criteria are arguably overly complex and do not meet the clinical or public health need. The ranking of drugs in terms of harm proposed by David Nutt and colleagues is fundamentally flawed in failing to account for the harms from tobacco, which is not surprising given the subjective nature of the process leading to the rankings and the lack of a tobacco expert on the panel. The field of Health Psychology is rich in innovative ideas and theories that can help explain smoking behaviour and develop interventions but as yet has not yielded interventions that are better than can be achieved by a simple model of smoking as involving a balance between concerns about the harms and costs of smoking and the desire (sometimes very strong) to smoke driven by pharmacological and social reward and punishment. Systematic reviews of key issues are needed to establish a firm evidence base on which to move theory and practice forward. There are several fallacies in arguments against helping smokers to stop such that it is unnecessary because most smokers stop without help, findings from randomised trials do not generalise to the ‘real world’ and aiding cessation is less cost-effective than other tobacco control measures. These are easily dealt with and once this is done it is possible to have a Page 32 31. Aveyard P, Amos A, Bauld L, Britton J, Coleman T, Cocherty G, Godfrey C, Hajek P, Hastings G, McNeill A, Lewis S, Munafo M, West R (2010) Is the UK’s coalition Government serious about public health? Lancet, 376, 589. doi:10.1016/ S01406736(10)61288-3. 32. Stapleton JA (2010) The Scandal of Smoking and Mental Illness. Addiction 105: 11901. doi: 10.1111/j.1360-0443.2010.03025.x. Abraham C, Kelly M, West R, Michie S. (2009) The UK National Institute for Health and Clinical Excellence (NICE) Public Health Guidance on Behaviour Change: A Brief Introduction, Psychology, Health & Medicine, 14, 1-8. doi: 10.1080/13548500802537903. 33. Arnott D, McEwen A. (2009) Illicit tobacco: An international problem with an international solution. Addiction, 104, 155-7. doi: 10.1111/j.1360-0443.2008.02407.x. 34. Coleman T, McEwen A, Bauld L, Ferguson J, Lorgelly P, Lewis S. (2009) Protocol for the Proactive Or Reactive Telephone Smoking CeSsation Support (PORTSSS) trial. Trials, 10, 26. doi: 10.1186/1745-621510-26. 35. Edwards G, Babor T, Darke S, Hall W, Marsden J, Miller P, West R. (2009) Drug trafficking: time to abolish the death penalty. Addiction, 104, 1267-9. doi: 10.1111/j.13600443.2009.02625.x. 36. Gilmore A, Britton J, Arnott D, Ashcroft R, Jarvis M. (2009) The place for harm reduction and product regulation in UK tobacco control policy. J Public Health 31, 310. doi:10.1093/pubmed/fdn105. Lindson N, Aveyard P, Ingram J, Inglis J, Beach J, West R, Michie S. (2009) Rapid reduction versus abrupt quitting for smokers who want to stop soon: a randomised controlled non-inferiority trial. Trials, 10, 69 doi:10.1186/1745-6215-10-69. 37. UTARG Output constructive debate about the role of cessation assistance in a comprehensive tobacco control strategy. The UK’s tobacco control strategy is evidence based and has yielded a 25% reduction in prevalence in the past 10 years but there is a risk that this is now being undermined by government cuts. People with mental illness have been neglected in tobacco control policies. The prevalence of smoking among people with mental illness is about 3 times higher than in the general population and dependence levels are also higher. Cessation efforts need to be redirected to provide more help to those with mental illness. Based on an analysis of the limitations of the available evidence base, research recommendations advise researchers on how to improve the quality of research into behaviour change interventions (including evaluations) and thereby advance the science of behaviour change. Trade in illicit tobacco results from a lack of control on the international movement of cigarettes and is run by criminal organisations with relatively sophisticated systems for distributing smuggled cigarettes. An effective solution to such a sophisticated international criminal trade will be provided by a protocol to the WHO Framework Convention on Tobacco Control (FCTC). The PORTSSS trial will provide high quality evidence to determine the most appropriate kind of counselling which should be provided via the NHS Smoking Helpline and also whether or not an additional offer of cost-free nicotine replacement therapy is effective and cost effective for smoking cessation. There are no moral or empirical grounds for retaining the death penalty for drug trafficking; it is important for researchers to join a concerted campaign to end this practice. For harm reduction to work in the UK, a nicotine product regulation authority is first needed. The public health community needs to drive this debate because failure to do so would let the tobacco industry gain the upper hand. A non-inferiority randomised trial of rapid reduction versus standard abrupt cessation will be conducted among smokers who want to stop smoking. In the reduction arm, participants will be advised to reduce smoking consumption by half in the first week and to 25% of baseline in the second, leading up to a quit Page 33 38. 39. McEwen A, Percival J. (2009) Interventions to trigger quit attempts. Practice Nursing, 20, 120-5. Stapleton JA (2009) Trial comes too late as psychiatric side effects end hope for rimonabant. Addiction 104, 277-8. doi: 10.1111/j.1360-0443.2008.02487.x. 40. McEwen A, Vangeli E. (2008) The Prescriber’s role in Smoking Cessation. Prescriber, 19, 48-56. 41. Spirling L, Stapleton JA, Sutherland G. (2008) Suicidal ideation and varenicline: a possible case of mistaken adverse drug reaction? Clin. Psychiatry, 69, 1834-5. Etter J-F, Lukas R, Benowitz N, West R, Dresler C. (2008) Cytisine for smoking cessation: a research agenda. Drug and Alcohol Dependence, 92, 3-8. doi:10.1016/j.drugalcdep.2007.06.017. 42. 43. 44. 45. 46. 47. 48. day at which participants will stop smoking completely. This will be assisted by nicotine patches and an acute form of nicotine replacement therapy. Unsolicited practice nurse advice can be important in triggering quit attempts. The first published trial of rimonabant for smoking cessation leaves many unanswered questions regarding efficacy that now may never be answered due to a significant incidence of psychiatric side effects. Prescribers need not engage in lengthy counselling sessions to help smokers to stop. They need only give very brief advice to stop accompanied by a referral to the NHS Stop Smoking Service. If that is not acceptable to the smoker then a prescription for medication should be offered. Suicidal ideation while taking varenicline to stop smoking is likely to be attributable to tobacco withdrawal rather than an adverse drug reaction. New studies are necessary to define the nicotinic receptor interaction profile of cytisine, to establish its pharmacokinetics and pharmacodynamics in humans, to determine whether animals self-administer cytisine, and to ascertain whether cytisine is safe and effective as a smoking cessation drug. West R. (2008) Finding better ways of The Tobacco Research Group carries out a wide motivating and assisting smokers to stop: range of studies aimed at finding better ways of Research at the CRUK Health Behaviour encouraging and helping smokers to stop. These Research Centre. European Health include epidemiological studies looking at smoking Psychologist, 10, 54-8. and smoking cessation in the general population, clinical trials of smoking cessation aids, experimental studies looking at craving and withdrawal symptoms and how these can be mitigated, and qualitative research examining the process of smoking cessation. Stapleton JA (2008) Breaking away from a Since first introduced in the early 1980s the narrow prescribing protocol for medicinal prescribing protocol for nicotine replacement has nicotine Addiction 103(4):564-565. remained unchallenged and under-researched. New doi: 10.1111/j.1360-0443.2008.02170.x. data should promote further research to optimise smoking cessation with nicotine replacement. Hall W, West R (2008) Thinking about the Whereas a simple ban on the sale of smoked tobacco unthinkable a de facto prohibition on smoked may be unthinkable, a de facto ban is achievable and tobacco products. Addiction. 103, 873-874. a worthwhile goal by making use of smoked tobacco doi: 10.1111/j.1360-0443.2007.02129.x. expensive, unrewarding and inconvenient and facilitating use of much safer alternatives. Stapleton JA. (2008) Breaking away from a Variations to the standard treatment protocols for narrow prescribing protocol for medicinal nicotine replacement therapies have the potential to nicotine. Addiction, 103, 564-66. doi: considerably improve smoking cessation rates. 10.1111/j.1360-0443.2008.02170.x. Britton J, McNeill A, Arnott D, West R, Nicotine use, in the form of cigarette smoking, merits Godfrey C. (2007) Assessing drug-related a higher ranking in the league table of addictive drugs harm. Lancet, 369, 1856-7. than was proposed by David Nutt and colleagues in doi:10.1016 /S0140-6736(07)60842-3. an article in the Lancet. West R (2007) Interventions to promote smoking cessation. BMJ Health Intelligence UTARG Output A range of interventions have proven effectiveness and cost-effectiveness in aiding smoking cessation Page 34 49. 50. http://healthintelligence.bmj.com West R (2007) The clinical significance of ‘small’ effects of smoking cessation treatments. Addiction. 102, 506-9. doi: 10.1111/j.1360-0443.2007.01750.x. West R (2007) What lessons can be learned from tobacco control for combating the growing prevalence of obesity? Obesity Reviews. 8 (Suppl 1), 145-50. doi: 10.1111/j.1467-789X.2007.00334.x. and these should be routinely offered to all smokers An increase of as little as 1 percentage point in abstinence for 6 months (which would translate to 0.5 percentage points permanent cessation) is highly clinically significant . There may be scope to make a significant impact through providing better information and campaigns designed to change norms and raise public concerns about patterns of behaviour that lead to over-eating. However, even if that is successful, it is unlikely that the problem will be adequately addressed without more coercive measures directed either at consumers or suppliers, or both. Book chapters, books and published reports Current programme grant 1. West R (2015) The importance of maintaining downward pressure on smoking prevalence through comprehensive tobacco control. Report to All Party Parliamentary Group on Smoking and Health. London: ASH. 2. Christmas S, Michie S, West R (2015) Thinking About Behavior Change. London: Silverback Publishing. 3. Michie S, Atkins L, West R (2015) The Behaviour Change Wheel: A Guide to Designing Interventions. London: Silverback Publishing. 4. Michie S, West R, Campbell R, Brown J, Gainforth H (2014) ABC of Behaviour Change Theories. London: Silverback Publishing. 5. West R, Hajek P, McNeill A, Brown J, Arnott D. Electronic cigarettes: what we know so far. Briefing report to UK All-Party Parliamentary Group on Pharmacy2014. 6. West R (2013) The SmokeFree Formula. London: Orion. 7. Arnott D, McIlvar M, Mcewen A (2013) Tobacco Use in Gerada C, RCGP Guide to the Management of Substance Misuse in Primary Care. London: Royal College of General practitioners. 8. West R, Brown J (2013) Theory of Addiction. 2nd Edition. Oxford: Wiley-Blackwell. 9. Attwood, A., Aveyard, P., Bauld, L., Britton, J., Hajek, P., Hastings, G., McNeill, A., Munafò, M., Murray, R., Shahab, L., West, R., (2013) Tobacco. In: Principles of Addiction: Comprehensive Addictive Behaviors and Disorders. Elsevier Inc., San Diego: Academic Press, pp. 767–776. 10. West R (2013) Models of Addiction. Lisbon: EMCDDA. 11. McIlvar M, Williams I, McEwen A, West R (2012) Development of an Independent Audit Process for Providers of Stop Smoking Support. London: NCSCT. Programme grant 2007-2011 12. Shahab L, Beard E, Gardner B (2012) BCT analysis of existing cost-effective interventions. Report to the NICE Behaviour Change Programme Guidance Committee. 13. West R (2011) Overcoming state addiction to tobacco. In H Ghodse, H Herman, M Maj, N Sartorius (Eds) Substance Abuse Disorders Edited by Hamid Ghodse, Helen Herrman, Mario Maj and Norman Sartorius. London: Wiley 14. West R, Michie S (2010) Behaviour change: the importance of seeing the whole picture and a critique of ‘Nudge’. Evidence to House of Lords Behaviour Change Inquiry. 15. Michie S, West R (2010) Behaviour change interventions: evidence and applications Evidence to House of Lords Behaviour Change Inquiry: Follow-up to 16 November Evidence Session 16. Shahab L, West R. (2010) Smoking. In: D. French, A.A. Kaptein, K. Vedhara, & J. Weinman (Eds) Health Psychology. Oxford, UK: Wiley-Blackwell. 17. Shahab L, Fidler J. (2010). Tobacco-related disorders. in P Sturmey, M Hersen M. (Eds) Handbook of Evidence-Based Practice in Clinical Psychology. New York: Wiley. 18. West R, Shahab L (2010) Smoking cessation. In Killoran A & Kelly M (Eds) Effectiveness and efficiency in public health: systematic approaches to evidence and practice. Oxford University Press UTARG Output Page 35 19. West R (2010) Why is it so hard to quit? The Advisor. Autumn 2010 20. West R (2010) The role of mass media campaigns in evidence-based tobacco control. In Arnott D (Ed) All Party Parliamentary Group Report on Tobacco Control in England. London: ASH. 21. West R (2010) Evidence-based tobacco control: why England still needs it and what it is. In Arnott D (Ed) All Party Parliamentary Group Report on Tobacco Control in England. London: ASH. 22. Amos A, Angus K, Bostock Y, Fidler J, Hastings G (2009) A Review of Young People and Smoking in England. Public Health Research Consortium, http://www.york.ac.uk/phrc/papers.htm 23. West R. (2009) Experimental design issues in addiction. In Miller P, Strang J & Miller P (Eds) Addiction Research Methods. London: Wiley. 24. West R. (2009) Possible application of PRIME Theory of motivation to promote safer driving. In Behavioural Studies in Road Safety 17. London: DfT 25. West R, Stenius K (2008) Use and abuse of citations. In Babor T, Stenius K, Savva S, O’Reilly J (Eds) Publishing Addiction Science. London: ISAJE. 26. May S, McEwen A. (2008) NHS Stop Smoking Service CO-verification Project - A Report for the Department of Health. London: Smoking Cessation Service research network (SCSRN). 27. McEwen A, Arnoldi H, Bauld L, May S, Ferguson J, Stead L. (2008) Client satisfaction survey: pilot project report. London: Smoking Cessation Service research network (SCSRN). 28. McEwen A, McRobbie H, Preston A. (2008) The Stop Smoking Handbook. Dorchester, Exchange Supplies. 29. Shahab L, McEwen A. (2008) Online Support for Smoking Cessation - A Report for the Department of Health. London: Smoking Cessation Service research network (SCSRN). 30. Shahab L. (2008). Epidemiology of tobacco smoking – a growing concern. In M. Miravitlles (Ed) Hot topics in respiratory medicine (Issue 8). Modena, Italy: FB Communications. 31. Owen L (Chair), Beal J, Collett S, Fullard B, Kay E, MacDonald S, McEwen A. (2007) NICE – Smoking cessation training resource for the dental teams. CD-ROM. London: National Institute for Health and Clinical Excellence. 32. Shahab L. (2007) Socioeconomic status and health. In S Ayers et al (Eds) Cambridge Handbook of Health Psychology (2nd Edition). Cambridge: Cambridge University Press. 33. Watt R, Andrews F, Beal J, Bose A, Dyer T, Jenner T, Lowe C, McEwen A, Owen L, Read J, Slater M, Zoitopoulos L. (2007) Smokefree and smiling: helping dental patients to quit tobacco. London: Department of Health.West R, Shiffman S (2007) Smoking Cessation (2nd Editions). Oxford: Health Press. 34. West R. (2007) The PRIME Theory of motivation as a possible foundation for addiction treatment. In J Henningfield, P Santora and W (Eds) Drug Addiction Treatment in the 21st Century: Science and Policy Issues. Baltimore: John’s Hopkins University Press. 35. West R, Hardy A (2007) Stigma. In S Ayers et al (Eds) Cambridge Handbook of Psychology Health and Medicine (2nd Edition). Cambridge: Cambridge University Press. 36. West R, Hardy A (2007) Tobacco use. In S Ayers et al (Eds) Cambridge Handbook of Psychology Health and Medicine (2nd Edition). Cambridge: Cambridge University Press. UTARG Output Page 36