Eighth Irving Shain
Chemistry Colloquium
Karl Barry Sharpless
The Scripps Research Institute
Friday, April 15, 2011; 3:30 PM
Room 1315 Chemistry
“Click” Chemistry Evolving –
Destinations Unknown
•“Click” Chemistry is a modular approach that utilizes only the
most practical and reliable chemical transformations. Its
applications are increasingly found in all aspects of drug
discovery, ranging from lead finding through combinatorial
Chemistry and target-templated in situ Chemistry, to
proteomics and DNA research utilizing bioconjugation
reactions. The Huisgen 1,3-dipolar cycloaddition is a
particularly powerful linking reaction, due to its high degree
of dependability, complete specificity, and the biocompatibility of the reactants.
•The triazole products are more than just passive linkers; they
readily associate with biological targets through hydrogen
bonding and dipole interactions.
Nobel Laureate K. Barry Sharpless and his lab have pioneered the
concept and application of "Click" Chemistry, which consists of a set of
powerful, virtually 100% reliable, selective chemical reactions for the
rapid synthesis of new compounds via the formation of carbonheteroatom bonds. Applications of "click" reaction are vast and their use
continues to expand throughout the fields of chemistry and biology.
Please stay for refreshments in the Shain Tower Atrium at 4:30