Request for New Course
EASTERN MICHIGAN UNIVERSITY
DIVISION OF ACADEMIC AFFAIRS
REQUEST FOR NEW COURSE
DEPARTMENT:
BIOLOGY
DEPARTMENT CONTACT:
COLLEGE:
DANIEL CLEMANS
ARTS & SCIENCES
CONTACT PHONE:
487-4242
CONTACT EMAIL:
DCLEMANS@EMICH.EDU
A. Rationale/Justification for the Course
Bacterial Pathogenesis has been taught for years at the 400-level as BIO(L)429. This course is approved for
graduate credit and frequently appears on graduate programs of study. Because it looks odd on our program to
have a 400-level restricted elective, we propose to create a new 500-level Bacterial Pathogenesis course that
will be cross-listed with the 400-level course. This will allow access for both populations of students, our
master’s students and our upper-level undergraduates. We have attached the syllabus for BIO429 and BIO529
to highlight the differing expectations for the two groups of students.
B. Course Information
1. Subject Code and Course Number:
BIO529
2. Course Title:
Bacterial Pathogenesis
3. Credit Hours:
3
4. Catalog Description (Limit to approximately 50 words.):
A lecture course involving the descriptive and historical aspects of plant and animal distribution and the basic
principles governing their natural distribution in both space and time.
5. Prerequisites: (List by Subject Code, Number and Title.) Students MUST complete prerequisites before they can take this course.
6. Corequisites: (List by Subject Code, Number and Title.) Students MUST take corequisites at the same time as they are taking this course.
7. Concurrent Prerequisites: (List by Subject Code, Number and Title.) Students MUST take concurrent prerequisites EITHER before or at
the same time as they are taking this course.
8. Equivalent Courses: (List by Subject Code, Number and Title) Students may not earn credit for both a course and its equivalent.
BIO429
9. Course Restrictions:
Miller, New Course
Sept. 05
New Course Form
a. Academic/Class Level (Check all those who will be allowed to take the course for credit within their academic program.):
Undergraduate
Graduate
Freshperson
Certificate
X
Sophomore
Masters
X
Junior
Specialist
Senior
Doctoral
Note: Only 400-level undergraduate courses can be taken by graduate students for credit within their graduate program. Only
Certificate and Masters students may take these courses. If this is a 400-level course to be offered for graduate credit, attach Approval
Form for 400-level Course for Graduate Credit.
Note: Only 500-level graduate courses can be taken by undergraduate students.
b. Will only students in certain majors/programs be allowed to take this course?
Yes
X
No
If yes, list the majors/programs
MS in General Biology
MS in Ecology & Organismal Biology
MS in Molecular, Cellular & Developmental Biology
c. Will Departmental Permission be Required?
Yes
No
X
(Note: Department permission requires the department to enter authorization for every student registering.)
d. Is admission to a specific College Required?
College of Business
Yes
No
X
College of Education
Yes
No
X
10. Will the course be offered as part of the General Education Program?
Yes
No
X
If yes, attach Request for Inclusion of a Course in the General Education Program: Education for Participation in the Global Community form.
Note: All new courses proposed for inclusion in this program will be reviewed by the General Education Advisory Committee. If this course
is NOT approved for inclusion in the General Education program, will it still be offered? Yes
No
C. Relationship to Existing Courses
Within the Department:
11. Will this course will be a requirement or restricted elective in any existing program(s)? Yes
No
X
If yes, list the programs and attach a copy of the programs that clearly shows the place the new course will have in the curriculum.
**Note that this course is already a restricted elective on our program at the 400-level. We do not propose to change the position of this course
in the program rather to make a direct swap of the 500-level course for the 400-level course. We have not, therefore, attached the program.
Program
Required
Restricted Elective
Program
Required
Restricted Elective
12. Will this course replace an existing course? Yes
No
X
NOTE: Complete #13 only if the answer to #12 is “Yes.” Complete #14 only if the answers to #12 and #13b are both “Yes.”
13. (Complete only if the answer to #12 is “Yes.”)
a. Subject Code, Number and Title of course to be replaced:
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New Course Form
b. Will the course to be replaced be deleted?
Yes
No
14. (Complete only if the answers to #12 and #13b are both “Yes.”) If the replaced course is to be deleted, it is not necessary to submit
a Request for Graduate and Undergraduate Course Deletion.
a. When is the last time it will be offered?
Term
Year
b. Is the course to be deleted required by programs in other departments?
Contact the Course and Program Development Office if necessary.
Yes
No
c. If yes, do the affected departments support this change?
Yes
No
If yes, attach letters of support. If no, attach letters from the affected department explaining the lack of support, if available.
Outside the Department: The following information must be provided. Contact the Course and Program Development office for
assistance if necessary.
15. Are there similar courses offered in other University Departments?
If yes, list courses by Subject Code, Number and Title
Yes
No
X
16. If similar courses exist, do the departments in which they are offered support the proposed course?
Yes
No
If yes, attach letters of support from the affected departments. If no, attach letters from the affected department explaining the lack of support,
if available.
D. Course Requirements
17. Attach a detailed Sample Course Syllabus including:
a.
b.
c.
d.
e.
f.
g.
h.
Course goals, objectives and/or expected student outcomes
Outline of the content to be covered
Student assignments including presentations, research papers, exams, etc.
Method of evaluation
Grading scale (if a graduate course, include graduate grading scale)
Special requirements
Bibliography, supplemental reading list
Other pertinent information.
NOTE: COURSES BEING PROPOSED FOR INCLUSION IN THE EDUCATION FOR PARTICIPATION IN THE GLOBAL
COMMUNITY PROGRAM MUST USE THE SYLLABUS TEMPLATE PROVIDED BY THE GENERAL EDUCATION
ADVISORY COMMITTEE. THE TEMPLATE IS ATTACHED TO THE REQUEST FOR INCLUSION OF A COURSE IN THE
GENERAL EDUCATION PROGRAM: EDUCATION FOR PARTICIPATION IN THE GLOBAL COMMUNITY FORM.
E. Cost Analysis (Complete only if the course cannot be implemented without additional University resources.
Fill in Estimated
Resources for the sponsoring department(s). Attach separate estimates for other affected departments.)
Estimated Resources:
Year One
Year Two
Year Three
Faculty / Staff
$_________
$_________
$_________
SS&M
$_________
$_________
$_________
Equipment
$_________
$_________
$_________
Total
$_________
$_________
$_________
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New Course Form
F. Action of the Department/College
1. Department
Vote of department faculty:
For _____14_____
Against ____0______
(Enter the number of votes cast in each category.)
Department Head Signature
Date
Abstentions ______0____
2. College/Graduate School
A. College
College Dean Signature
Date
B. Graduate School (if Graduate Course)
Graduate Dean Signature
Date
G. Approval
Associate Vice-President for Academic Programming Signature
Date
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COURSE SYLLABUS
BACTERIAL PATHOGENESIS (MICR455; CRN:26940)
WINTER 2008
TUESDAY/THURSDAY 2:00 PM TO 3:15 PM
ROOM 311 MARK JEFFERSON
Instructor:
Daniel Clemans, 412 Mark Jefferson
Office Phone: (734) 487-1110
Email: daniel.clemans@emich.edu
Office hours: Monday/Wednesday, 10:00 am to 12:00 pm, or by appointment.
Cell Phones/Pagers/Electronic Devices:
Please turn off all cell phones, pagers, and other electronic devices BEFORE coming to class.
Course Objectives:
The objectives of this course are to better understand the structural and functional attributes of bacteria as they relate to
their ability to live in intimate associations with their hosts (i.e., humans, animals, & plants), including their potential to
cause infectious diseases. From the standpoint of practicality, knowledge of this material can be related to
understanding the molecular and cellular basis of bacterial pathogenesis.
Specific Goals of the Course:
1) Be able to derive and assimilate the basic concepts of bacterial pathogenesis by reading multiple forms of the
scientific literature (textbooks, journal articles, reviews, online resources, etc.).
2) Be able to read and understand a primary journal article and communicate it to the instructor and to the class using
the form of a written brief.
3) Be able to communicate succinctly the main points of a scientific article to the class and instructor in an oral
format.
4) Be able to derive answers to broad questions on certain aspects of bacterial pathogenesis from several sources and
communicate them effectively through a clear and concise written format.
5) Be able to research and assemble a presentation on an emerging infectious disease and present it to the class in the
form of a 20-minute mini-lecture.
6) Be able to work as a group toward a common goal.
Instructor Philosophy:
This course will be taught by a series of lectures that will follow a Socratic pattern of delivery (i.e., I like to ask a lot of
questions!). Intermixed with the lectures, I will have a series of group discussions based on questions or research
papers relevant to the daily topic. These questions will be handed out before the particular session and should be
completed before the class period in which they will be discussed. A copy of your answers will be handed in to me
before class starts! There will be occasional short pop quizzes on the readings for the day. Please Be Prepared for
Each Class! I expect class participation in class and in discussions and, hence, I will learn everyone’s name! My hope
is that everyone is an active participant in learning this material and that we all learn together!
Required textbook:
This year, instead of the bug-of-the-week club, I am taking a different approach. We will be using the textbook entitled
Cellular Microbiology, 2nd Edition, edited by P. Cossart, P. Boquet, S. Normark, & R. Rappuoli (ASM Press,
Washington, D.C., 2005; ISBN 1-55581-302-X). This book looks at bacterial pathogenesis in the context of how the
bacterial alter the host cell anatomy and physiology. We will by no means be comprehensive in our study of bacterial
pathogenesis. Instead, we will look at paradigm organisms and how they affect host-cell function.
Web-based texts:
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The required textbook will be supplemented with online textbooks, literature reviews, and the primary literature.
Please pay attention to the syllabus and the ERes site (see “Communications” section) for what is happening and the
location of readings for the course. I have listed several helpful websites below (in “Other Resources”) as resources for
various topics. I encourage you to visit these sites often to see how they can help us understand the world of bacterial
pathogenesis. Also, please feel free to bring to my attention any new sites that you discover!
1) Dr. Kenneth Todar's Online Textbook of Bacteriology by Kenneth Todar, University of Wisconsin-Madison,
http://www.textbookofbacteriology.net.
2) General Immunology, Medical Microbiology Textbook from Dr. Douglas Fix, University of Illinois Carbondale,
http://www.cehs.siu.edu/fix/medmicro/genimm.htm.
3) Microbiology & Bacteriology, The World of Microbes by Dr. Timothy Paustian, University of Wisconsin – Madison,
http://www.bact.wisc.edu/Microtextbook/index.php. This one costs $30.00 to access.
Other Resources:
Websites:
1) Cells Alive: http://www.cellsalive.com/index.htm
2) The Center for Disease Control: http://www.cdc.gov
3) KEGG: Kyoto Encyclopedia of Genes and Genomes PATHWAY Database:
http://www.genome.jp/kegg/regulation.html#cellular
4) PubMed: http://www.ncbi.nlm.nih.gov
5) Medscape: http://www.medscape.com/px/registration/profileindex
6) Neal Chamberlain's Microbesite: http://www.microbesite.com
7) Neal Chamberlain's Medical Microbiology Site: http://www.geocities.com/CapeCanaveral/3504/index.html
8) Medical Microbiology Textbook from Dr. Douglas Fix, University of Illinois Carbondale
http://www.cehs.siu.edu/fix/medmicro/
Journals, Books, and Databases:
1) Emerging Infectious Diseases: http://www.cdc.gov/ncidod/EID/index.htm
2) Morbidity and Mortality Weekly Report: http://www.cdc.gov/mmwr
3) The Journal of Bacteriology: http://jb.asm.org
4) Infection and Immunity: http://iai.asm.org
5) Dennis Kunkel Microscopy, Inc.: A database of bacterial photos – say cheese!
http://www.denniskunkel.com/index.php?osCsid=73d9d9bd60c1c6bca3b84579aac057ac&cPath=3
6) Microbiology & Immunology Resources. A site that lists several helpful databases for Microbiology,
Immunology, Virology, & Parasitology: http://pathmicro.med.sc.edu/links/bact-link.htm
7) The USDA “Bad Bug Book!” http://vm.cfsan.fda.gov/~MOW/intro.html
8) The Theriot lab movie collection – you gotta check this one out!: http://cmgm.stanford.edu/theriot/movies.htm
9) Immunobiology, By C.A. Janeway, P. Travers, M. Walport, and M. Shlomchik.
http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?call=bv.View..ShowTOC&rid=imm.TOC&depth=2
10) Medical Microbiology, By S. Baron.
http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?call=bv.View..ShowTOC&rid=mmed.TOC&depth=2
11) Molecular Biology of the Cell 4th ed. By Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin;
Roberts, Keith; Walter, Peter, New York: Garland Publishing; c2002.
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowTOC&rid=mboc4.TOC&depth=2
12) Several great reference textbooks on the NCBI Bookshelf
(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Books).
13) Databases available from the Halle Library (http://www.brand.emich.edu.ezproxy.emich.edu/indexde.php):
Writing & Organizational Resources:
1) The Writing Center: http://www.wisc.edu/writing/Handbook/Assignments.html
2) How to Write & Publish a Scientific Paper, 5th Edition, By Robert A. Day ($27.95 from Amazon;
http://www.amazon.com/exec/obidos/tg/detail/-/1573561657/002-8232239-0516830?v=glance).
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3) Scientific Papers and Presentations, By Martha Davis ($29.95 from Amazon;
http://www.amazon.com/exec/obidos/tg/detail/-/0122063708/002-8232239-0516830?v=glance).
4) A “How to” Guide to Concept Maps: http://www.pbcc.edu/faculty/johnsonp/TeachingLearning/CMinfo.htm
5) The Concept Map Homepage: http://users.edte.utwente.nl/lanzing/cm_home.htm
6) Graphic Organizers: http://www.sdcoe.k12.ca.us/score/actbank/torganiz.htm.
Communications:
I will post most of the course material onto the Halle Library Electronic Reserves
(http://reserves.emich.edu/courseindex.asp). The password for this site is "badbugs08." This website contains links to
important websites, lecture outlines, assignments, review articles and original papers, and many other items necessary
for success in this course. You will need to visit this website often to stay updated with the course.
Grading:
The course grade will be based upon a total of 224 points (undergraduate students), or 254 points (graduate students).
There will be 12 homework assignments/short oral presentations (each worth 10 points), 12 discussion sections (each
worth 2 points), a take-home midterm (30 points), and a research paper on a selected bacterial pathogen (worth 50
points). Graduate students will also be required to present a 20-minute oral presentation on the bacterial/microbial
pathogen they adopted during the semester (worth 38 points). Directions for the written paper and the presentation are
on separate forms. The course grade will be determined on a straight scale as outlined below.
Undergraduates:
C
73 to 76%
A
93 to 100%
AB+
B
BC+
90 to 92%
87 to 89%
83 to 86%
80 to 82%
77 to 79%
CD+
D
DE
70 to 72%
67 to 69%
63 to 66%
60 to 62%
59% or less
Graduate Students:
Graduate student grading policies will apply in this course. Final course percentages less than 70% will result in a final
course grade of “E”.
Extra Credit Opportunities:
1) 1% will be added to the course grade for attending the Michigan Branch ASM meeting on Saturday, April 12, 2005
at Central Michigan University (http://mi-asm.org/). An additional 1% will be added for writing a lucid and
appropriate short paper (1-2 pages) summarizing an oral or poster presentation at the meeting. Registration and further
information will be online at www.mi-asm.org.
2) 2% will be added to the course grade for helping to run the "Disease Detectives" events at the Wayne County
Science Olympiad at the University of Michigan – Dearborn (http://scienceolympiad.umd.umich.edu/). The event will
be on Saturday, March 1, 2008.
Conduct:
Unless otherwise stated, all work is expected to be your own. The first appearance of plagiarism will prompt a verbal
warning. Further evidence of plagiarism or other forms of cheating will result in dismissal from the class.
Attendance:
Attendance at student presentations and on discussion days is required. Each unexcused absence will result in a 3-point
deduction from the final grade average!
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One unexcused absence is allowed for the remainder of class. Any further unexcused absences from class will result in
a 3-point deduction from the final grade average!
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New Course Form
Tentative Lecture Schedule:
Date
Jan. 8
Lecture
1
Topic
Normal Flora of Humans
10
2
15
3
Discussion of Normal Flora of
Humans
Bacterial Pathogenesis
17
4
22
24
5
6
29
7
31
8
Extracellular Matrix & Host Cell
Surfaces: Potential Sites of
Pathogen Interaction
Discussion of ECM assignment
Feb. 5
9
Bacterial Adherence
7
10
Discussion
12
11
14
12
Bacterial Pathogenesis
Discuss Topics
Cell Biology: an Overview
Lipid rafts presentations
BACTERIAL SIGNALING TO
HOST CELLS THROUGH
ADHESION MOLECULES &
LIPID RAFTS
DISTRIBUTE MID-TERM
ASSESSMENT
19
13
#WCSO PREPARATION
21
14
WCSO PREPARATION
Feb. 25 to
March 2
March 1
4
WINTER RECESS
15
WAYNE COUNTY SCIENCE
OLYMPIAD AT UM-DEARBORN
INTRACELLULAR
Assignment Text
#1 assigned *KT: The Bacterial Flora
of Humans
#1 due
#2 assigned
#2 due
KT: Mechanisms of
Bacterial Pathogenicity &
Bacterial Structure in
Relationship to
Pathogenicity
#3 assigned
Topics due
#3 due
**CM: Chapter 3
#3 due
#4 assigned
CM: Chapter 4
#4 due
#5 assigned
#5 due
#6 assigned
#6 due
Outline/Ref
erences due
Work on
WCSO
event #7
Complete
WCSO
event #7
Rest &
Relax
Midterm
Due
CM: Chapter 5
KT: Colonization and
Invasion by Bacterial
Pathogens; individual
pathogens; Bacterial
Structure in Relationship to
Pathogenicity
CM: Read & Review
Chapter 6
CM: Chapter 7
See last year’s event &
http://www.cdc.gov/EXCI
TE/index.htm
See last year’s event &
http://www.cdc.gov/EXCI
TE/index.htm
CM: Read & Review
Chapters 8/9 (Yah Right!)
CM: Chapter 10
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PATHOGENESIS
6
11
13
16
17
18
18
19
20
20
25
21
Adaptive Immune Response
(Dr. Mike Angell)
27
22
April 1
3
8
10
April 12
23
24
25
26
15
17
27
28
Discussion
(Dr. Mike Angell)
Apoptosis
Discussion
Secretion systems (I-III)
Secretion systems (IV-V)
Spring Meeting of the Michigan
Branch of the ASM
(http://mi-asm.org)
Discussion
Graduate Student Presentations
INVASION
DISCUSSION
BACTERIAL TOXINS
(D. BRAD RABQUER)
Discussion
(Dr. Brad Rabquer)
Innate Immune Response
Draft of
paper to a
peer
#8 assigned
#8 due
CM: Chapters 11/12
#9 assigned
CM: Chapter 13
#9 due
#10 assigned
Paper due
#10 due
#11 assigned
#11 due
#12 assigned
CM: Chapter 18
KT: Immune Defense
against Microbial
Pathogens: Innate
Immunity
CM: Chapter 18
KT: Immune Defense
against Microbial
Pathogens: Adaptive
Immunity
CM: Chapter 16
CM: Chapter 17
CM: Chapter 15
CM: Chapter 16
Central Michigan
University
#12 due
Graduate Student
Presentations
22
29
Final Exam Period (1:30pm to
Graduate Student
3:00pm)
Presentations
*KT: Ken Todar's Textbook of Bacteriology (http://www.textbookofbacteriology.net/).
** Cellular Microbiology, 2nd Edition, edited by P. Cossart, P. Boquet, S. Normark, & R. Rappuoli
#Wayne County Science Olympiad
Instructions for Writing a Paper Summary
Each summary should be limited to 500 to 1000 words. Elements that might be included in such a paper are: 1) the title
and authors of the paper; 2) the major goal(s) of the paper; 3) the hypothesis (i.e., working model); 4) a summary of the
results and major findings; 5) a summary of the conclusions; 6) what the next step should be in the research, and 7) a
critique of the paper. In addition, please include any questions you may have on the paper. With this word limit, you
need to be very selective on what to include and what not to include.
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