Request for New Course
EASTERN MICHIGAN UNIVERSITY
DIVISION OF ACADEMIC AFFAIRS
REQUEST FOR NEW COURSE
DEPARTMENT/SCHOOL: ___CHEMISTRY__________________________________COLLEGE:
ARTS AND SCIENCES (CAS)
CONTACT PERSON: ____DEBORAH HEYL-CLEGG__________________________________________________________________
CONTACT PHONE:
487-2057
CONTACT EMAIL:
DHEYLCLE@EMICH.EDU
REQUESTED START DATE: TERM__WINTER_________YEAR___2015________
A. Rationale/Justification for the Course
This course has been taught as a special topics graduate level course in biochemistry and there has been demonstrated
student interest. It delves deeper into topics that are presented in general biochemistry courses and applies those
fundamental principles, and it includes student presentations and discussions of the current scientific literature. The
course provides important and relevant applications and skills for Biochemistry, Chemistry, and Biology majors/minors
who want to pursue graduate and professional studies and careers in medicine, dentistry, pharmacy, the pharmaceutical
industry, and other related disciplines. In addition, it is an appropriate course for undergraduates to take as it will serve
as an elective course for the proposed Neuroscience Interdisciplinary Program (NSIP), and in the General Biochemistry
and Professional Biochemistry majors.
B. Course Information
1. Subject Code and Course Number:
CHEM 457
2. Course Title:
Medicinal Chemistry and Drug Design
3. Credit Hours:
3
4. Repeatable for Credit? Yes_______
No___X___
If “Yes”, how many total credits may be earned?_______
5. Catalog Description (Limit to approximately 50 words.):
This course will cover principles of drug discovery (receptors and drug design) and various classes of pharmaceutical
agents. Topics include: drugs affecting neurotransmission; anesthetics and opioid analgesics; psychotherapeutic
(antipsychotic and antianxiety) drugs; renal, blood pressure and cardiovascular agents; steroids; antimicrobial and
antiviral drugs; and cancer chemotherapy. Emphasis will be placed on organic structure-biochemical activity
relationships (correlation of functional groups to pharmacological activity).
6. Method of Delivery (Check all that apply.)
a. Standard (lecture/lab) X
On Campus
X
Off Campus
b. Fully Online
c. Hybrid/ Web Enhanced
7. Grading Mode:
Normal (A-E)
X
Credit/No Credit
8. Prerequisites: Courses that MUST be completed before a student can take this course. (List by Subject Code, Number and Title.)
Miller, New Course
Sept. 09
New Course Form
CHEM 351 or CHEM 451
9. Concurrent Prerequisites:
Code, Number and Title.)
Courses listed in #5 that MAY also be taken at the same time as a student is taking this course. (List by Subject
10. Corequisites: Courses that MUST be taken at the same time as a student in taking this course.
(List by Subject Code, Number and
Title.)
11. Equivalent Courses. A student may not earn credit for both a course and its equivalent. A course will count as a repeat if an equivalent
course has already been taken. (List by Subject Code, Number and Title)
12. Course Restrictions:
a. Restriction by College. Is admission to a specific College Required?
College of Business
Yes
No
X
College of Education
Yes
No
X
b. Restriction by Major/Program. Will only students in certain majors/programs be allowed to take this course?
Yes
No
X
If “Yes”, list the majors/programs
c. Restriction by Class Level Check all those who will be allowed to take the course:
Undergraduate
Graduate
All undergraduates_______
All graduate students____
Freshperson
Certificate
Sophomore
Masters
Junior
Specialist
X
Senior X
Doctoral
Second Bachelor____X____
UG Degree Pending_____
Post-Bac. Tchr. Cert.__X___
Low GPA Admit_______
Note: If this is a 400-level course to be offered for graduate credit, attach Approval Form for 400-level Course for Graduate
Credit. Only “Approved for Graduate Credit” undergraduate courses may be included on graduate programs of study.
Note: Only 500-level graduate courses can be taken by undergraduate students. Undergraduate students may not register
for
600-level courses
d. Restriction by Permission. Will Departmental Permission be required?
Yes
No
(Note: Department permission requires the department to enter authorization for every student registering.)
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Sept. ‘09
X
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New Course Form
13. Will the course be offered as part of the General Education Program?
Yes
No
X
If “Yes”, attach Request for Inclusion of a Course in the General Education Program: Education for Participation in the Global Community
form. Note: All new courses proposed for inclusion in this program will be reviewed by the General Education Advisory Committee. If this
course is NOT approved for inclusion in the General Education program, will it still be offered? Yes
No
C. Relationship to Existing Courses
Within the Department:
14. Will this course will be a requirement or restricted elective in any existing program(s)? Yes
No
X
If “Yes”, list the programs and attach a copy of the programs that clearly shows the place the new course will have in the curriculum.
Program
Required
Restricted Elective
Program
Required
Restricted Elective
15. Will this course replace an existing course? Yes
No
X
16. (Complete only if the answer to #15 is “Yes.”)
a. Subject Code, Number and Title of course to be replaced:
b. Will the course to be replaced be deleted?
Yes
No
17. (Complete only if the answer #16b is “Yes.”) If the replaced course is to be deleted, it is not necessary to submit a Request for
Graduate and Undergraduate Course Deletion.
a. When is the last time it will be offered?
Term
Year
b. Is the course to be deleted required by programs in other departments?
Contact the Course and Program Development Office if necessary.
Yes
No
c. If “Yes”, do the affected departments support this change?
Yes
No
If “Yes”, attach letters of support. If “No”, attach letters from the affected department explaining the lack of support, if available .
Outside the Department: The following information must be provided. Contact the Course and Program Development office for
assistance if necessary.
18. Are there similar courses offered in other University Departments?
If “Yes”, list courses by Subject Code, Number and Title
Yes
No
X
19. If similar courses exist, do the departments in which they are offered support the proposed course?
Yes
No
If “Yes”, attach letters of support from the affected departments. If “No”, attach letters from the affected department explaining the lack of
support, if available.
D. Course Requirements
20. Attach a detailed Sample Course Syllabus including:
a.
b.
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Sept. ‘09
Course goals, objectives and/or student learning outcomes
Outline of the content to be covered
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New Course Form
c.
d.
e.
f.
g.
h.
Student assignments including presentations, research papers, exams, etc.
Method of evaluation
Grading scale (if a graduate course, include graduate grading scale)
Special requirements
Bibliography, supplemental reading list
Other pertinent information.
NOTE: COURSES BEING PROPOSED FOR INCLUSION IN THE EDUCATION FOR PARTICIPATION IN THE GLOBAL
COMMUNITY PROGRAM MUST USE THE SYLLABUS TEMPLATE PROVIDED BY THE GENERAL EDUCATION
ADVISORY COMMITTEE. THE TEMPLATE IS ATTACHED TO THE REQUEST FOR INCLUSION OF A COURSE IN THE
GENERAL EDUCATION PROGRAM: EDUCATION FOR PARTICIPATION IN THE GLOBAL COMMUNITY FORM.
E. Cost Analysis (Complete only if the course will require additional University resources.
Fill in Estimated Resources for the
sponsoring department(s). Attach separate estimates for other affected departments.)
Estimated Resources:
Year One
Year Two
Year Three
Faculty / Staff
$_________
$_________
$_________
SS&M
$_________
$_________
$_________
Equipment
$_________
$_________
$_________
Total
$_________
$_________
$_________
F. Action of the Department/School and College
1. Department/School
Vote of faculty: For ____18____
Against ____0_____
Abstentions ____1_____
(Enter the number of votes cast in each category.)
Department Head/School Director Signature
August 14, 2015
Date
2. College/Graduate School
A. College
College Dean Signature
Date
B. Graduate School (if Graduate Course)
Graduate Dean Signature
Date
G. Approval
Associate Vice-President for Academic Programming Signature
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Sept. ‘09
Date
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Request for New Course
Chemistry 457
Medicinal Chemistry and Drug Design
Tentative Syllabus
Text: Foye’s Principles of Medicinal Chemistry, 5th or 6th Edition, by Williams and Lemke
Some additional articles may be chosen as relevant research in the field.
Instructor: Dr. Deborah Heyl-Clegg Office: 501G Mark Jefferson
Phone: 487-2057 e-mail: dheylcle@emich.edu
Course Objectives:
1. Recognize how different functional groups contribute to
pharmacokinetic properties such as solubility, absorption, membrane
penetration, and duration of action.
2. Understand how ionization of drugs is influenced by pH.
3. Understand how physicochemical parameters (electronic character,
ionizability, lipophilicity, H-bonding, size/shape/steric constraints)
can be influenced and modified by structural changes.
4. Understand the different types of cellular receptors and associated
signal transduction and the concepts of agonists, antagonists, and
selectivity.
5. Understand the various mechanisms by which drugs act in different
physiological systems (for example, opening or closing ion channels,
inhibiting an enzyme, stimulating or blocking a receptor that regulates
a signaling cascade).
6. Be familiar with the basic pharmacophore of each class of drug
studied and the structure-activity relationships (how chemical
structure influences biological activity).
7. Understand why side effects occur in pharmacological intervention
and explore ways to minimize these.
8. Be able to read, understand, present, and discuss the current scientific
literature pertaining to the classes of drugs studied.
Course Format: The first two topics will be covered in a lecture format, followed by in-class case
study discussions that involve application of the material covered. During this time, students will
choose and sign up for one of the later topics to be covered. The student will be responsible for
choosing a relevant journal article from the current scientific literature on their selected topic that is
made available to the class prior to the scheduled day for that topic, and putting together a
presentation on that topic and paper. On the scheduled day, the instructor will first lecture on the
general topic, followed by the student’s Powerpoint journal article presentation to the class.
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Topics Covered:
Date
Chapter(s) 5th/6th
General Topic(s)
5/2
1-Drug Design and Structure-Activity Relationships
2/ 2
5/4
2-Receptors and Drug Action
4/ 4
5/9
3-Enzyme Inhibition
5/ 5
5/11, 5/16
4-Peptide and Protein Drugs
6/7
5/18
5-Local & Volatile Anesthetics; Hypnotics and Sleep Aids 13-15/ 16, 18, 19
5/23
6-Opioid Analgesics; Non-Steroidal Anti-Inflammatory Drugs 19, 32/ 24, 36
5/25
Midterm Exam
6/1
7-Cardiac Agents; Diuretics; Blood Pressure Drugs
21-24/ 26-29
6/6
8-Steroids
28, 29/ 33
6/8
9-Antibiotics and Antimicrobial Agents
34/ 38
6/13
10-Cancer Chemotherapy and Antiviral Agents
38, 39/ 42, 43
6/15
11-CNS Agents: Neurodegenerative and Psychotherapeutic 10- 12, 17/ 12-15, 21-22
(Cholinergic, Adrenergic, and Serotonergic Systems;
Depression/Anxiety)
6/20
Final Exam
Assignments and Grading:
Assignment/Exam
Date
Material Covered from topics:
Points
Ex I (midterm)
5/25
1-6
150
Ex II (final)
6/20
7-11
150
3-5-pg paper w/refs
5/18
Pharmaceutical Agent- structure,
mechanism, side effects, SAR
50
3-5-pg summary on 6/13
current literature article
Journal of Medicinal Chem. or
Bioorganic & Medicinal Chem.
50
Presentation of research paper
on assigned topic
TBD
15-20 min summary of article from
scientific journal critiqued by class 50
Group Participation
Assigned case studies or
discussions of presentations
throughout
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Sept. ‘09
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50
New Course Form
Exam questions will be based on the lecture material, including any additional material from nontext sources. Exams will be primarily essay and short answer in format and will require the
understanding and application of concepts explained in class (not solely memorization of facts) and
may have take-home sections that will involve further research into the problem.
Grades will be based on the following scale:
92 – 100% = A
86 – 88% = B+
76 – 78% = C+
66 – 68% = D+
89– 91% = A82– 85% = B
72– 75% = C
61– 65% = D
79 – 81% = B69 – 71% = C50 – 60% = D-
A failing grade (F) for the course is less than 50%.
Final grades will be determined by the total points earned as a percentage of 500. Make-up exams
and extensions will be given only for excused absences for truly extenuating circumstances; it is
your responsibility to notify the instructor BEFOREHAND. Unexcused late assignments will be
penalized at 5 points/day. Please be sure to come for help as soon as any problems arise (not just
before the exam) and feel free to ask any questions during class or outside of class during office
hours or via e-mail.
Class material including lecture notes, answers to in class or homework assignments, journal
articles, study guides, and sample exam questions will be posted on the e-reserves system. Further
instructions on the assigned papers can be found on the following page.
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