Department Highlights
Page 1
Promotions and
Faculty Highlights
Page 2-3
Grant Administration
Page 4
SURP and CMP
Grad Program
Page 5
PIRRT
Page 6—8
New Faculty
Page 9
Pathology
News
V O L U M E
8
I S S U E
2
MAY
Publications
Page 11-20
Presentations
Page 21
Observer’s Policy
CAP INSPECTION—APRIL 2, 2014
On April 2, Dr. James Wisecarver from the University of Nebraska School of Medicine in Omaha, led a team of 20 professionals to inspect the pathology and laboratory services of the
CLB, PUH, SHY and CHP. This was a peer-to-peer evaluation on
behalf of CAP, mandated biannually for CLIA certification. All
aspects of diagnostic services were covered including general
clinical pathology, histopathology, molecular pathology, tissue
typing, point of care as well as ancillary testing, ophthalmic
microbiology, and the immune function laboratory. The two
day inspection also delved into support areas of laboratory LIS
and HR.
On the whole, the inspectors were impressed with our breadth
and depth of services and expertise at both the faculty and
technical levels. A few deficiencies were noted, that were
readily addressed on site or subsequently, and recommendations were made. The inspectors brought home a number of
best practices from all areas of the laboratories, as well as
insights on how to move forward with integrating and standardizing a much smaller network that they are building there.
All of us here were positively impacted by our interactions and
appreciated the professionalism and insights of the inspectors. — Alan Wells, M.D., DMS
Page 22
Personal
Page 23
Seminars
Page 24
Administrative
Updates
Page 25
ECU Update
Page 26
2014
D E PA R T M E N T H I G H L I G H T S
Residency/Fellowship
Page 10
1,
I would like to thank everyone who participated in the
inspection to make it a successful event. —
George K. Michalopoulos, M.D., Ph.D.
“In three
words I can
sum up
everything
I've learned
about life:
it goes on.”
Robert Frost
American Poet
1874-1963
Holiday Reminders
The University of Pittsburgh and UPMC will be closed Monday, May 26, 2014
in observation of Memorial Day
The University of Pittsburgh and UPMC will be closed Friday, July 4, 2014
in observation of Independence Day.
The University of Pittsburgh and UPMC will be closed on Monday, September 1, 2014
in observation of Labor Day.
PAGE
Promotions
Rohit Bhargava, M.D., promoted to Professor of Pathology
Simion Chiosea, M.D., promoted to Associate Professor of Pathology
Sanja Dacic, M.D., promoted to Professor of Pathology
Michael Shurin, M.D., Ph.D., promoted to Professor of Pathology
Faculty Highlights
Peter Lucas, M.D., Ph.D. and Linda McAllister-Lucas received a $250,000 grant as co-Principal Investigators from the Hyundai Hope on Wheels Foundation for Pediatric Cancer Research.
Trevor Macpherson, M.D. elected Member-at-Large for PRODS Council.
George K. Michalopoulos, M.D., Ph.D., President-Elect of ASIP for a three year
term starting June, 2014.
Satdarshan (Paul) Monga, M.D. American Society of Investigative Pathology
Outstanding Investigator Award, April 2014
Jeffrey S. Nine, M.D. received the Excellence in Education Award from the School of
Medicine Class of 2015 and 2016 in appreciation for his contribution and dedication to
teaching in the fundamentals of the organ systems block and basic science block.
Darrell Triulzi, M.D. has been election to represent the School of Medicine on Faculty Assembly for the
three years, beginning July 1, 2014.
American Society of Clinical Pathology ‘s 40 under 40 http://www.ascp.org/40under40
Three of our former trainees were listed in the top 40 under 40. See link above for more
info. Sara Monaco, M.D. , Rama Gullapalli, M.D., Gaurav Sharma, M.D.
CONGRATULATIONS!
Best wishes to Dr. Mohamed Virji
on his retirement from the University of
Pittsburgh. He was honored at the
Department’s faculty meeting on
February 21, 2014.
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3
Faculty Highlights
Parmjeet Randhawa, M.D.
 Visiting Professor, Department of Microbiology and Immunology, Hershey Medical Center,
Hershey, PA
 Chair Finance Committee, and Member Board of Advisors, The Renal Pathology Society, 2014.
 Chair, Cytomegalovirus End Point Adjudication Committee, CMX 001-301 Trial In Hematopoietic Stem
Cell Transplant Recipients, Chimerix, Inc, Raleigh, NC, 2014.
 Pathology Consultant, LCP-Tacro 3002 Trial in Kidney Transplant Patients, Veloxis Inc., Horsholm,
Denmark.
 Co-Chair, Banff Working Group on T-cell mediated acute rejection, 2014.
 Abstract Reviewer, for Clinical Kidney Transplantation-Polyomavirus and Clinical Kidney
Transplantation-Other Complications. World Transplant Congress, San Francisco, July 2014.
 Faculty recognition, University of Pittsburgh Honors Convocation, February 2014.
 Faculty at The Microscopy Room for course titled “Renal Biopsy: Clinical Correlations”. American Society of Nephrology Meeting, Atlanta, GA, November 8, 2013.
Congratulations ! Charleen T. Chu, MD, PhD
delivered the Provost’s Inaugural Lecture for the A.
Julio Martinez Chair in Neuropathology on March 31,
2014, entitled "SOS: Mitochondrial Distress Signals in
Parkinson's Disease."
Children’s Hospital Highlights
Dr. Reyes-Múgica received notification of a $40,000 donation from a generous family, who lost a child to Neurocutaneous Melanocytosis in 2013. This donation was also
sponsored by and Nevus Outreach, Inc., and will support the COND-BANK (tissue
repository for the study of Congenital Nevi and Other Neurocristopathies), housed in
Dr. Reyes’s lab at the Rangos Research Center, Children’s Hospital of
Pittsburgh.
Presidential award was presented to Dr. Reyes-Múgica by the Society for Pediatric
Pathology March, 2014.
PAGE
Grant Administration
“Question
everything
Learn
Something
Answer
Nothing”
NEW PRE-AWARD STAFF – Please welcome April Lehman as our new
Pre-Award Grants and Contracts Administrator. April will work with all
faculty whose last name falls within A-M for grant submissions and she will
process contracts for all faculty whether federal or industry. The processing of research visas and Material Transfer Agreements (MTAs) will be
shared with Mary Lou Benedetti and April for this initial training period.
April comes to the department with prior University experience and a very
welcomed addition to the research administration staff.
COI – The following are extremely important compliance reminders for all
PIs, CO-Is and anyone participating in the design of sponsored research projects. These compliance modules and forms are necessary in order for the
Office of Research to process proposals of not only Pathology faculty but
any proposals involving your participation.
All investigators planning to participate in or who is currently participating
in a PHS-funded research project (i.e. NIH) must complete:
COI Superform for PHS Funded Researchers
CITI Conflict of Interest Module (Basic Course)
Euripides
Greek Poet
480-406 BC
Also, effective March 31, 2013, PIs and CO-Is conducting research projects
involving human subjects must also complete the following:
CITI Responsible Conduct of Research
CITI Human Subjects Training
The above CITI module requirements for human subject research are in addition to the current requirements to complete the CITI COI and the COI
Superforms. If the training requirements are not completed, access to OSIRIS (IRB on-line application) will also be blocked. Go to www.citi.pitt.edu
for detailed information. Do not go directly to the CITI website as you are
required to use the special Pitt Access login portal: www.citi.pitt.edu in order to link your completion with Pitt.
THE OFFICE OF RESEARCH WILL NOT SUBMIT ANY PROPOSAL
THAT INVOLVES FACULTY WHO ARE NON-COMPLIANT. CONTINUING PROJECTS WILL NOT BE PROCESSED UNTIL THE
REQUIRED COMPLIANCE MODULES AND FORMS ARE COMPLETE. NON-COMPLIANCE WILL DELAY ASSIGNMENT OF AN
ACCOUNT NUMBER AND DISPURSEMENT OF FUNDS FOR YOUR
GRANT.
Mary Lou Benedetti, MHR/IR
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SURP AND CMP GRADUATE PROGRAM
From the desk of Dr. Wendy M. Mars ….
The numbers are in! This year there will be 26 students matriculating to the IBGP program in the fall so
soon we will be ACTIVELY seeking mentors who wish to host a graduate student in their lab next
year. To assure that the students know you are interested, be sure to register with the NEW web site:
https://somgrad.wufoo.com/forms/update-faculty-information/
The old listing of rotation opportunities has gone away so this is currently the best way for the students to find you. It only takes a minute so if you want a student, please register your rotation project.
Since December, we have had a RECORD number of students graduate from the program. In no particular order they are: Jonathan Proto (Johnny Huard), Evan Delgado (Paul Monga), Joshua Jamison
(Alan Wells), Brian Sicari (Steve Badylak), Matt Brown (Jian Yu), Julie Cramer (Eric Lagasse),
Katy Sobek (Denise O’Keefe) and Dee Seneviratne (Reza Zarnegar). This fall, although it is still too
early to tell, we hope to add 5 new students from the MSTP and IBGP parent programs.
The Pathology Research Seminar and Retreat will be held this year on Wednesday, May 28, 2014 from
12-7:30 PM. Our keynote speaker will be Dr. Jon Stanley Morrow from Yale University, Yale-New
Haven Hospital who will speak on “From Ghosts to Skeletons: Function and Dysfunction of the
Membrane Scaffold”. ECU credits will be offered for the oral presentation portion of the meeting.
The poster session will be held at the University Club. Please make sure to register online.
The CMP arm of the Summer Undergraduate Research Program (SURP) will run from May 27 until
August 1 this year. We have a total of 9 students participating from across the country.
SURP isn’t the only summer program in the Pathology Department! This summer we will have several
other students working with Pathology faculty. There will be five first year medical students working on their summer research projects, four of them funded through the Klionsky fellowship. Additionally, the Klionsky fellowships will be offered to another 2-3 undergraduates who plan to attend
medical school and have an interest in Pathology. Finally, two undergraduates are going to be sponsored by moneys from ASIP. All in all, our summer experiences are growing!
If you are interested in having issues brought before the CMP committee, please share them with our
CMP administrator, Tara Rohall (rohallta@upmc.edu), or me (wmars@pitt.edu). Also, please continue to make
me aware of any outstanding faculty members who are not currently members of CMP but who would be eligible
and have a possible interest in joining our program.
Thanks so much!
Wendy M. Mars, Ph.D.
Director, Pathology SURP and CMP graduate program
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Pathologist Investigator Residency-Research Training (PIRRT) Program:
Pioneering advances in molecular pathology – Basic and Applied
The PIRRT program allows Pathology residents, and now fellows, at the University of Pittsburgh to
construct individualized research training experiences with the goal of “fast-tracking” to combined diagnostic and independent research faculty positions. Trainees are generally admitted to the program as
first year residents, electing to take their research year after PGY1 or PGY2, or before continuing on to
diagnostic fellowship training here. While most of our recruitment continues to be at the residency level, this year, we are pleased to announce two new PIRRT trainees, one joining as a PGY1 trainee and
the other as a multi-year fellow.
Charleen T. Chu and Tim Oury
PIRRT Co-Directors
Please join us in welcoming our new PIRRT trainees in July!
Grzegorz (Greg) Gurda, MD, PhD (University of Michigan
2010) – AP/CP Resident, PGY4, at Johns Hopkins Hospital –
Greg plans to pursue fellowship training in Breast/Gyn pathology as a clinical instructor in 2014-15, followed by
the Molecular Genetic Fellowship in 2015-2016, and the
PIRRT research year in 2016-2017.
“My interests lie at the intersection of endocrinology, metabolism and neoplasia. My work addresses diet and
hormonal milieu as important components of diagnosis,
prognosis and treatment/treatment-resistance within cancer subtypes specific to gastroenterology and women’s
health."
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Thomas Pearce, MD, PhD (Washington University in St. Louis, expected 2014)
“My scientific interests are centered around understanding how the
brain processes information, which underlies many behaviors critical to every-day life such as learning, memory, perception, and
control of movement. I study these processes using electrophysiological recordings of neural activity paired with concurrent
measures of behavior.
Clinically, I find the diagnostic process of Pathology interesting; and
given my love of the brain, I am unsurprisingly planning to specialize further with a fellowship in Neuropathology.
Outside of the lab/hospital, I love outdoor activities like hiking, biking, golf, tennis, and team sports of
all varieties. My wife and I have two dogs that love to play outside; our yellow lab is truly OCD
about his tennis balls. Computer programming, cooking and brewing beer are some of the other hobbies I enjoy pursuing.”
Updates on current PIRRT trainees:
Jason Cheng-Hsuan Chiang, MD (National Taiwan University 2003), PhD (Hopkins 2010)
Jason will graduate from AP training and take the board exam this June, followed by Neuropathology
fellowship training.
His PIRRT Phase II proposal was approved by the steering committee this spring. He initiated the project using AP research elective time and will continue with his PIRRT research year in Dr. Charleen
Chu’s laboratory.
“My PIRRT research direction is focused on mitochondrial function and metabolism in human induced
pluripotent stem cell-derived neurons with a Parkinson disease associated LRRK2 G2019S mutation.”
Rebecca Leeman-Neill, MD, PhD (University of Pittsburgh, 2010)
Rebecca will graduate from the AP-only track of the residency program this June.
She pursued her PIRRT research with Dr. Yuri Nikiforov, investigating the molecular genetic features
of papillary thyroid carcinoma. Some of this work has recently been published (Leeman-Neill et al,
Cancer, March 2014; Leeman-Neill et al, Cancer, May 2013).
She will be staying at UPMC for a two-year fellowship in hematopathology, the second year of which
will be devoted to pursuing new research interests in mechanisms of lymphomagenesis in the laboratory of Dr. Daniel Johnson.
Rebecca, her husband Daniel and son Adam recently welcomed a second son, Ari Evan Neill, born
9/8/13.
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Alumni Updates:
Our graduates have been successful at transitioning to faculty positions as board certified, practicing pathologists
with independent lab space and start-up support, acquiring external grant funding at their new institutions.
Craig Horbinski, MD, PhD. Associate Professor of Pathology, University of Kentucky
Named Director of Biospecimen and Tissue Procurement Shared Resource Facility at the Markey Cancer Center at the University of Kentucky in 2013
Named Director of Molecular Anatomic Pathology in the Department of Pathology and Laboratory Medicine at
the University of Kentucky in 2013
Recently reached 50 peer-reviewed papers in PubMed
Supported by six active grants, including an NCI K08 and an NCI P30
Mentored seven medical or pathology trainees on a variety of research projects
On the editorial board of Acta Neuropathologica, Brain Pathology, and Journal of Neuropathology and Experimental Neurology
Regular reviewer for multiple journals, including Clinical Cancer Research, Autophagy, Journal of Molecular Diagnostics, Neuro-Oncology, PLoS One, and Human Mutation
Became a member of the Judging Committee for the American Association of Neuropathologists Diagnostic Slide
Session at their Annual Meeting
One of three central pathology reviewers for the national clinical trial ACNS1221, “A Phase II Study For The
Treatment Of Non-Metastatic Desmoplastic Medulloblastoma In Children Less Than 4 Years Of Age”
Invited to deliver a platform presentation at the International Conference on Brain Tumor Research and Therapy,
an invitation-only meeting of the world’s top brain cancer scientists
Featured in the University of Kentucky Healthcare OnCall Magazine (“Bench to bedside: Translational science
improves patient care, outcomes” April 2014, Issue 5, pages 16-22
Julia Kofler, MD, Assistant Professor of Pathology, University of Pittsburgh
Director, Neuropathology Core, Alzheimer’s Disease Research Center, University of Pittsburgh (supported by NIA
P50)
Project Leader “Alterations in microglial phenotype and function in aging and Alzheimer’s disease (Alzheimer’s
Disease Research Center NIA P50)
Elected member of National Alzheimer Disease Center Neuropathology Core Steering Committee
Assistant director, ALS Research Center, University of Pittsburgh
Neuropathologist for ALS Research Center, Movement Disorder Brain Bank and Late Life Mood Disorder Brain
Bank
Grant review panel member for American Institute of Biological Sciences (FY12 Militarily Relevant Peer Reviewed Alzheimer’s Disease Research Program)
“My research interests focus on the role of microglial cells and inflammatory processes in aging and Alzheimer’s
disease. I am also studying the impact of polymorphisms in Alzheimer’s disease risk genes and inflammationassociated genes on the pathology of Alzheimer’s disease”
Ed Plowey, MD, PhD, Assistant Professor of Pathology, Stanford University School of Medicine
Associate Director of Neuropathology for Ophthalmic Pathology, 2012
Director of Stanford Hospital and Clinics Brain Bank, 2013
New Investigator in Alzheimer Disease Award from American Federation for Aging Research, 2012
2013-14 publications in Autophagy, Human Pathology and Clinical Neuropathology
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9
NEW FACULTY
Let’s welcome the following to the Department .
Michael S. Landau, M.D., Assistant Professor of Pathology, July 1, 2014. Dr. Landau will finish a fellowship in GI Pathology at UPMC.
Changqing Ma, M.D., Ph.D., Assistant Professor of Pathology, July 1, 2014. Dr. Ma will finish a fellowship in gastrointestinal and liver pathology at Johns Hopkins in June.
Somak Roy, M.D., Assistant Professor of Pathology, July 1, 2014. Dr. Roy will join the Division of Molecular and Genomic Pathology as the Assistant Director of the MGP Laboratory. He is currently a clinical fellow in urologic and surgical pathology at UPMC.
Claudia M. Salgado, M.D., Ph.D., Research Assistant Professor of Pathology, July 1, 2014. at Children’s
Hospital. Dr. Salgado has an extensive amount of research experience and will focus on the tissue biology of
melanocytes and the biology of melanocytic lesions, benign or malignant.
Juan Xing, M.D., Assistant Professor of Pathology, will join the Division of Anatomic Pathology at
Shadyside Hospital July 21, 2014. Dr. Xing is currently at the Cleveland Clinic finishing a cytopathology
fellowship.
CLINICAL INSTRUCTORS
Justin D. Fender, M.D., will join the Division of Anatomic Pathology July 1. Dr. Fender will complete a
Pathology residency at the Mount Sinai Medical Center in June. He will join the Gastrointestinal
Pathology Center of Excellence at PUH.
Grzegorz T. Gurda, M.D., will join Magee Womens Hospital July 1. Dr. Gurda will complete an AP/CP
residency at Johns Hopkins Hospital in June.
Jennifer M. Leidy, M.D., will join Magee Womens Hospital July 1. Dr. Leidy will complete an AP/CP
residency at the University of Massachusetts in June.
Jenny Mas-Moya, M.D. will join the Division of Anatomic Pathology July 1. Dr. Mas-Moya will complete an AP/CP residency from Emory University in June.
David Webb, M.D. will join Magee Womens Hospital July 1. Dr. Webb is currently a resident physician
at the University of Virginia.
PAGE
RESIDENCY AND FELLOWSHIP
From the desk of Dr. Trevor Macpherson…..
Residency Program
 We matched 8 of 8 slots in the match with 6 APCP track, 1 CP track and 1 AP track recruit.
One candidate was recruited for the PIRRT program. Nationally 31 pathology programs did not
fill all their slots.
 The ASCP is introducing a First-RISE examination for PGY-1’s which we will administer for
our new PGY-1’s in early July 2014 as part of orientation. It is intended to provide programs
and PGY-1’s residents with a measure of their basic pathology knowledge.
 In July 2014 the ACGME milestones kick in for the residency program. New forms will be used
in MedHub for faculty to evaluate residents that will align with milestones. Faculty education
will follow.
 The Clinical Competency Committees – one for AP and one for CP are in place as is the Program Evaluation Committee.
 The first ACGME residency program faculty survey was launched in March 2014 – results will
only be available in mid-June. We had an 80% completion rate (60/69).
Fellowship Program
 The first ACGME individual fellowship faculty surveys were launched in March 2014 - results
will be made available in mid-June for fellowship program that had at least 1 60% faculty completion rate.
 We have not been informed of our number of slots for July 2016. Written offers will not be
made before November 1, 2014.
 Informatics is now a board certification program and we will be applying for ACGME accreditation for our Informatics Fellowship.
 Each fellowship director was given the opportunity to revise their individual fellowship ICPI
book information.
Medical Students
 28 faculty, 15 residents and 3 fellows were laboratory instructors in our Pathobiology Course in
January 2014. The course including lectures and small group laboratory sessions continue to
receive high ratings by the medical students.
 The ECU Tracking software program went live late last year. Faculty are to enter their medical
student and graduate student teaching hours to enable the department to get ECU credits from
the SOM.
th
 The Pathology Medical Student Interest Group (PMSIG) for the 5 consecutive year was awarded a $1,000 grant from The Intersociety Council for Pathology Information (ICPI).
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11
PUBLICATIONS
Lethal Outcomes in Klippel Trenauny Weber Syndrome. Karunamurthy A, Pantanowitz L, Lepe JG, ReyesMúgica M. Pediatr Dev Pathol. 2013 Sep-Oct;16(5):337-42.PMID: 23915076
Evaluation of Endobronchial Ultrasound-guided Fine Needle Aspirations (EBUS-FNA): Correlation with Adequacy and Histological Follow-up. Karunamurthy A, Pantanowitz L, Dacic S, Cai G, Khalbuss W, Monaco
S. Cancer Cytopathol. 2014 Jan;122(1):23-32.PMID: 24127207.
Liu Z, Zhan Y, Tu Y, Chen K, Liu Z, Wu C. PDZ and LIM domain protein 1(PDLIM1)/CLP36 promotes
breast cancer cell migration, invasion and metastasis through interaction with α-actinin.
Oncogene. 2014 Mar 24;0. doi:10.1038/onc.2014.64. [Epub ahead of print]
Cui X, Zhao Z, Liu D, Guo T, Li S, Hu J, Liu C, Yang L, Cao Y, Jiang J, Liang W, Liu
W, Li S, Wang L, Wang L, Gu W, Wu C, Chen Y, Li F. Inactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma. J Exp Clin
Cancer Res. 2014 Feb 17;33:20. doi: 10.1186/1756-9966-33-20.
Teräväinen TP, Myllymäki SM, Friedrichs J, Strohmeyer N, Moyano JV, Wu C, Matlin
KS, Muller DJ, Manninen A.. αV-integrins are required for mechanotransduction
in MDCK epithelial cells. PLoS One. 2013 Aug 19;8(8):e71485. doi: 10.1371/
journal.pone.0071485. eCollection 2013.
Norris, C.A., He, M., Kang, L.-I., Ding, M. Q., Radder, J.E., Haynes, M.M., Yang, Y., Paranjpe, S., Bowen,
W.C., Orr, A., Michalopoulos, G.K., Stolz, D. B. and Mars, W.M. Synthesis of IL-6 by hepatocytes as a
frequent response to common hepatic stimuli. (in press, PLoS ONE)
Song C, Zhu S, Wu C, Kang J. Histone deacetylase (HDAC) 10 suppresses cervical cancer metastasis through
inhibition of matrix metalloproteinase (MMP) 2 and 9 expression. Biol Chem. 2013 Sep 27;288(39):28021-33.
doi: 10.1074/jbc.M113.498758. Epub 2013 Jul 29.
Somak Roy M.D., Ph.D.
Received a Young Investigator Award for work in Genomics Informatics
and Next Generation Sequencing at the Association for Molecular Pathologists (AMP) 2013 Annual Meeting, Phoenix, AZ.
Received the Intersociety Council for Pathology Information (ICPI) Trainee Travel Award for abstract
presentation at the United States and Canadian Academy of Pathology (USCAP) annual meeting 2014.
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PUBLICATIONS
Basu D, Lettan R, Damoderan K, Strellec S, Reyes-Mugica M, Rebbaa A. Identification, Mechanism of
Action and Anti-Tumor Activity of a Small Molecule Inhibitor of Hippo, TGF Beta, and WNT Signaling
Pathways. Mol Cancer Ther. 2014 Apr 2. [Epub ahead of print]
Trejo-Bittar HE, Radder JE, Ranganathan S, Srinivasan A, Madan-Khetarpal S, Reyes-Múgica M. Clear
Cell Sarcoma of the Kidney in a Child with Fanconi Anemia. Pediatr Dev Pathol. 2014 Apr 15. [Epub
ahead of print]
“Accurate diagnosis of thyroid follicular lesions from nuclear morphology using supervised learning” was accepted for publication to the journal Medical Image Analysis. The authors are John A.
Ozolek, Akif Burak Tosun, Wei Wang, Cheng Chen, Soheil Kolouri, Saurav Basu, Hu Huang, Gustavo
K. Rohde.
"Images as occlusions of textures: a framework for segmentation” by authors McCann MT, Mixon DG,
Fickus MC, Castro CA, Ozolek JA, Kovacevic J. was published in the IEEE Transactions of Image
Processing.
Roy S, Durso MB, Wald A, Nikiforov YE, Nikiforova MN. SeqReporter: Automating next generation
sequencing result interpretation and reporting workflow in a clinical laboratory. J Mol Diagn. 2014
Jan;16(1):11-22 (Featured article of journal’s Jan 2014 issue).
Jain S, Roy S, Amin M, Acquafondata M, Yin M, Laframboise W, Bastacky S, Pantanowitz L, Dhir R,
Parwani A. Amylase α-1A (AMY1A): A Novel Immunohistochemical Marker to Differentiate Chromophobe Renal Cell Carcinoma From Benign Oncocytoma. Am J Surg Pathol. 2013;37:1824-30.
Nikiforova MN, Wald A, Roy S, Durso MB, Nikiforov YE. Targeted next-generation sequencing panel
(ThyroSeq) for detection of mutations in thyroid cancer. J Clin Endocrin Metab 2013 Aug 26 (Epub
ahead of print).
Roy S, Parwani AV, Dhir R, Yousem SA, Kelly SM, Pantanowitz L. Frozen section diagnosis: Is there
discordance between what pathologists say and what surgeons hear? Am J Clin Pathol. 2013;140:363-9.
The solstice heralds the beginning of summer in the Northern
Hemisphere. In 2014, the solstice falls on June 21
at 6:51 A.M. EDT.
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PUBLICATIONS
Hirsch H, Babel N, Commoli P, Friman V, Ginervri F, Jardine A, Lautenschlager I, Legendre C, Midtvedt K,
Munoz P, Randhawa P, Wiecek A: European perspective on human polyomavirus infection, replication and
disease in solid organ transplantation. Clin Microbiol Infect. 2014 Jan 29. doi: 10.1111/1469-0691.12538.
[Epub ahead of print]
Zeng Q, Sheriff KA, Ng Y-H, Zahalka S, Li Q, Ramaswami B, Randhawa P, Hoffman R, Lund FE, Chalasani G: B cells mediate chronic allograft rejection independent of antibody production. J Clin Invest. 2014,
124: 1052-56.
Randhawa PS: The expanding role of proteasome inhibtiors in the treatment of renal diseases. Pathology of
nephrotoxicity associated with monoclonal antibodies. 2013.
http://ajkd.org/?s=randhawa
Junyan Tao, Diego F. Calvisi, Sarangarajan Ranganathan, Antonio Cigliano, Lili Zhou, Sucha Singh, Lijie
Jiang, Biao Fan, Luigi Terracciano, Sorin Armeanu-Ebinger, Silvia Ribback, Frank Dombrowski, Matthias
Evert, Xin Chen, Monga SP. Wnt/β-catenin and Yap pathways synergize to promote hepatoblastoma development in mice and men. Gastroenterology (In Press).
Evan Delgado, Jing Yang, Juhoon So, Stephanie Leimgruber, Michael Kahn, Tohru Ishitani, Donghun Shin,
Gabriela Mustata Wilson, Monga SP. Identification and characterization of a novel small molecule inhibitor
of beta-catenin signaling. American Journal of Pathology (In Press).
Jing Yang, Laura E. Mowry, Kari Nichole Nejak-Bowen, Hirohisa Okabe, Cassandra R. Diegel, Richard A.
Lang, Bart O. Williams, Monga SP. Beta-catenin signaling in murine liver zonation and regeneration: A Wnt
-Wnt situation. Hepatology (In Press).
Book chapters:
Roy S, Parwani AV, Pantanowitz L. Bioinformatics. In: Practical Informatics for
Cytology (Springer). Eds. Dr A.V. Parwani, Dr L. Pantanowitz. 2014
Roy S, Parwani AV, Pantanowitz L. Research informatics. In: Practical Informatics
for Cytology (Springer). Eds. Dr A.V. Parwani, Dr L. Pantanowitz. 2014
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PUBLICATIONS
Barron S, Li Z, Austin RM, Zhao C. Low-grade squamous intraepithelial lesion/cannot exclude high-grade
squamous intraepithelial lesion (LSIL-H) is a unique category of cytologic abnormality associated with distinctive HPV and histopathologic CIN 2+ detection rates. Am J Clin Pathol. 2014 Feb;141(2):239-46
Boichuk S, Parry JA, Makielski KR, Litovchick L, Baron JL, Zewe JP, Wozniak A, Mehalek KR, Korzeniewski N, Seneviratne DS, Schöffski P, Debiec-Rychter M, DeCaprio JA, Duensing A. The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis. Cancer Res. 2013; 73:5120-5129.
Kelly L, Bryan K, Kim SY, Janeway KA, Killian JK, Schildhaus HU, Miettinen M, Helman L, Meltzer PS,
van de Rijn M, Debiec-Rychter M, O'Sullivan M; NIH Pediatric and wild-type GIST Clinic (Antonescu C,
Demetri G, Duensing A, George S, Jose-Dizon JM, Khan J, Kummar S, LaQuaglia M, Lodish M, MacArthur G, Pappo A, Raygada M, Schiffman J, Stratakis CA, Trent J, von Mehren M, Weldon C, Wright J).
Post-transcriptional dysregulation by miRNAs is implicated in the pathogenesis of gastrointestinal stromal
tumor (GIST). PLoS One 2013; 8(5): e64102.
Kapur P, Christie A, Raman J, Then M, Nuhn P, Buchner A, Bastian P, Zeitz C, Shariat S, Bensalah K, Rioux-Leclercq N, Xie X, Lotan Y, Margulis V, Brugarolas J. BAP1 Immunohistochemistry Predicts Outcomes in a Multi-Institutional Cohort with Clear Cell Renal Cell Carcinoma. J Urol 2014; 191:603-610.
López-Terrada D, Alaggio R, de Dávila MT, Czauderna P, Hiyama E, Katzenstein H, Leuschner I, Malogolowkin M, Meyers R, Ranganathan S, Tanaka Y, Tomlinson G, Fabrè M, Zimmermann A, Finegold MJ.
Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles
COG liver tumors symposium. Mod Pathol. 2014 Mar;27(3):472-91 PMID: 24008558.
Singhi AD, Goyal A, Davison JM, Regueiro MD, Roche RL, Ranganathan S. Pediatric autoimmune enteropathy: an entity frequently associated with immunodeficiency disorders. Mod Pathol. 2014 Apr;27(4):54353. PMID: 24051695
Ranganathan S, Schmitt LA, Sindhi R. Tufting enteropathy revisited: the utility of MOC31 (EpCAM) immunohistochemistry in diagnosis. Am J Surg Pathol. 2014 Feb;38(2):265-72. PubMed PMID: 24418860
Venkat VL, Ranganathan S, Mazariegos GV, Sun Q, Sindhi R. Recurrence of primary sclerosing cholangitis in pediatric liver transplant recipients. Liver Transpl. 2014 Feb 24. doi: 10.1002/lt.23868. [Epub ahead of
print] PMID: 24634351
Ma J, Zou C, Guo L, Seneviratne DS, Tan X, Kwon YK, An J, Bowser R, Defrances MC, Zarnegar R. A novel
death defying domain in met entraps the active site of caspase-3 and blocks apoptosis in hepatocytes.
Hepatology (October 3rd 2013). doi: 10.1002/hep.26769. [Epub ahead of print].
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PUBLICATIONS
Bowen WC, Michalopoulos AW, Orr A, Ding MQ, Stolz DB, Michalopoulos GK. Development of a
Chemically Defined Medium and Discovery of New Mitogenic Growth Factors for Mouse Hepatocytes: Mitogenic Effects of FGF1/2 and PDGF. PLoS One. 2014 Apr 17;9(4):e95487. doi: 10.1371/
journal.pone.0095487. eCollection 2014. PubMed PMID: 24743506; PubMed Central PMCID:
PMC3990636.
Michalopoulos GK. NRF2, not always friendly but perhaps misunderstood. Hepatology. 2014 Feb 23.
doi: 10.1002/hep.27090. [Epub ahead of print] PubMed PMID: 24700292.
Michalopoulos GK. The Liver Is a Peculiar Organ When It Comes to Stem Cells. Am J Pathol. 2014
Mar 27. pii: S0002-9440(14)00173-4. doi: 10.1016/j.ajpath.2014.02.020. [Epub ahead of print] PubMed PMID: 24681248.
Davison JM, Yee M, Krill-Burger JM, Lyons-Weiler MA, Kelly LA, Sciulli CM, Nason KS, Luketich
JD, Michalopoulos GK, LaFramboise WA. The degree of segmental aneuploidy measured by total
copy number abnormalities predicts survival and recurrence in superficial gastroesophageal adenocarcinoma. PLoS One. 2014 Jan 16;9(1):e79079. doi: 10.1371/journal.pone.0079079. eCollection 2014.
PubMed PMID: 24454681; PubMed Central PMCID: PMC3894223.
Yu YP, Ding Y, Chen R, Liao SG, Ren BG, Michalopoulos A, Michalopoulos G, Nelson J, Tseng
GC, Luo JH. Whole-genome methylation sequencing reveals distinct impact of differential methylations on gene transcription in prostate cancer. Am J Pathol. 2013 Dec;183(6):1960-70. doi: 10.1016/
j.ajpath.2013.08.018. Epub 2013 Oct 8. PubMed PMID: 24113458.
Donthamsetty S, Bhave VS, Mars WM, Bowen WC, Orr A, Haynes MM, Wu C, Michalopoulos GK.
Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis.
PLoS One. 2013 Sep 18;8(9):e74625. doi: 10.1371/journal.pone.0074625. eCollection 2013. PubMed
PMID: 24058607; PubMed Central PMCID: PMC3776730.
Michalopoulos GK, Grompe M, Theise ND. Assessing the potential of induced liver regeneration.
Nat Med. 2013 Sep;19(9):1096-7. doi: 10.1038/nm.3325. PubMed PMID: 24013747.
Michalopoulos GK. Principles of liver regeneration and growth homeostasis. Compr Physiol. 2013
Jan;3(1):485-513. doi: 10.1002/cphy.c120014. Review. PubMed PMID: 23720294.
Bhave VS, Mars W, Donthamsetty S, Zhang X, Tan L, Luo J, Bowen WC, Michalopoulos GK. Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex. Am J Pathol. 2013 Jul;183(1):1539. doi: 10.1016/j.ajpath.2013.03.013. Epub 2013 May 8. PubMed PMID: 23665349; PubMed Central
PMCID: PMC3702736.
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PUBLICATIONS
Zhou L, Li Y, Zhou D, Tan RJ, and Liu Y. 2013. Loss of klotho contributes to kidney injury by derepression
of Wnt/β-catenin signaling. J. Am. Soc. Nephrol. 24: 771-785.

Featured on JASN cover;

Featured on Editorial: Klotho to treat kidney fibrosis. JASN 24: 687-689, 2013;

Featured on Faculty of 1000 Prime, DOI: 10.3410/f.717997088.793478199.
Zhou D, Tan RJ, Lin L, Zhou L, and Liu Y. 2013. Activation of hepatocyte growth factor receptor, c-met, in
renal tubules is required for renoprotection after acute kidney injury. Kidney Int. 84: 509-520.
Zhou D, Tan RJ, Zhou L, Li Y, and Liu Y. 2013. Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication. Sci. Rep. 3, 1878; DOI:10.1038/srep01878.
Cheng A, Dong Y, Zhu F, Liu Y, Hou FF, and Nie J. 2013. AGE-LDL activates Toll Like receptor 4 pathway and promotes inflammatory cytokines production in renal tubular epithelial cells. Int. J. Biol. Sci. 9: 94107.
Wei X, Xia Y, Li F, Tang Y, Nie J, Liu Y, Zhou Z, Zhang H, Hou FF. 2013. Kindlin-2 mediates activation
of TGF-β/Smads signaling and renal fibrosis. J. Am. Soc. Nephrol. 24: 1387-1398.

Featured on Editorial: Kindlin-2: A new player in renal fibrogenesis. JASN 24: 1339-1340.
Tan RJ, Zhou L, Zhou D, Lin L, and Liu Y. 2013. Endothelin Receptor A blockade is an ineffective treatment for adriamycin nephropathy. PLoS One. 8: e79963.
Tan RJ, and Liu Y. 2013. Macrophage-derived TGF-β in renal fibrosis: not a macro-impact after all. Am. J.
Physiol. Renal Physiol. 305: F821-F822.
Xiao L, and Liu Y. 2013. Chronic Kidney Disease: Fibrosis and anemia in CKD -- two beasts, one ancestor.
Nat. Rev. Nephrol. 9: 563-565.
Tan RJ, and Liu Y. 2014. Arrestin(g) podocyte injury with endothelin antagonism. J. Am. Soc. Nephrol. 25:
423-425.
Chu GCY, Zhau HE, Wang R, Rogatko A, Feng X, Zayzafoon M, Liu Y, Farach-Carson MC, You S, Kiam J,
Freeman MR, Chung LWK. 2014. RANK- and c-Met-mediated signal network amplification promotes prostate cancer metastatic colonization. Endocr-Relat Cancer. 21: 311-326
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PUBLICATIONS
Zhou D, Li Y, Zhou L, Tan RJ, Xiao L, Liang M, Hou FF, and Liu Y. 2014. Sonic hedgehog is a novel tubule-derived growth factor for interstitial fibroblasts after kidney injury. J. Am. Soc. Nephrol. 25: 000000, in press.
 Selected for JASN cover
Zhou L, Li Y, Hao S, Zhou D, Tan RJ, Nie J, Hou FF, Kahn M, and Liu Y. 2014. Multiple genes of the renin-angiotensin system are novel targets of Wnt/β-catenin signaling. J. Am. Soc. Nephrol. 25: 000-000, in
press.
Yovchev MI, Xue Y, Shafritz DA, Locker J, Oertel M. Repopulation of the fibrotic/cirrhotic rat liver by transplanted hepatic stem/progenitor cells and mature hepatocytes. Hepatology 2014; 59: 284-295
αV-integrins are required for mechanotransduction in MDCK epithelial cells.
Teräväinen TP, Myllymäki SM, Friedrichs J, Strohmeyer N, Moyano JV, Wu C, Matlin KS, Muller DJ, Manninen A. PLoS One. 2013 Aug 19;8(8):e71485. doi: 10.1371/journal.pone.0071485.
eCollection 2013.
Histone deacetylase (HDAC) 10 suppresses cervical cancer metastasis through inhibition of matrix metalloproteinase (MMP) 2 and 9 expression. Song C, Zhu S, Wu C, Kang J. J Biol Chem. 2013 Sep 27;288(39):2802133. doi: 10.1074/jbc.M113.498758. Epub 2013 Jul 29.
Kurinna S, Stratton SA, Coban Z, Schumacher JM, Grompe M, Duncan AW*, Barton MC*. p53 regulates
a mitotic transcription program and determines ploidy in normal mouse liver. Hepatology. 2013;57(5):200413. PMCID: PMC3632650. * Co-senior/corresponding authors.
Duncan AW*, Soto-Gutierrez A*. Liver repopulation and regeneration: new approaches to old questions. Curr Opin Organ Transplant. 2013;18(2):197-202. PMCID: PMC3700618. * These authors conributed equally.
Duncan AW. Aneuploidy, polyploidy and ploidy reversal in the liver. Semin Cell Dev Biol. 2013;24(4):34756.
Prior High-Risk Human Papillomavirus Testing and Papanicolaou Test Results of 70 Invasive Cervical Carcinomas Diagnosed in 2012: Results of a Retrospective Multicenter Study. Zhao C, Li Z, Nayar R, Levi AW,
Winkler BA, Moriarty AT, Barkan GA, Rao J, Miller F, Fan F, Zhou Z, Si Q, Fischer AH, Sturgis CD, Jing
X, Marshall CB, Witt BL, Birdsong GG, Crothers BA.Arch Pathol Lab Med. 2014 Apr 2. [Epub ahead of
print]
Molecular characterization of undifferentiated carcinoma associated with endometrioid carcinoma.Kuhn E,
Ayhan A, Bahadirli-Talbott A, Zhao C, Shih IeM. Am J Surg Pathol. 2014 May;38(5):660-5. doi: 10.1097/
PAS.0000000000000166.
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PUBLICATIONS
Low-grade squamous intraepithelial lesion/cannot exclude high-grade squamous intraepithelial lesion (LSILH) is a unique category of cytologic abnormality associated with distinctive HPV and histopathologic CIN
2+ detection rates.Barron S, Li Z, Austin RM, Zhao C. Am J Clin Pathol. 2014 Feb;141(2):239-46. doi:
10.1309/AJCPM9X5RCZYEQJQ.
Automated cell block system for atypical glandular cells of cervical cytology: is it feasible?
Zhao C, Li Z. Cancer Cytopathol. 2014 Jan;122(1):5-7. doi: 10.1002/cncy.21368. Epub 2013 Dec 3. No abIncidental atypical proliferative lesions in reduction mammoplasty specimens in patients with a history of
breast cancer. Li Z, Fadare O, Hameed O, Zhao C, Desouki MM. Hum Pathol. 2014 Jan;45(1):104-9. doi:
10.1016/j.humpath.2013.08.010. Epub 2013 Oct 31.
Coassembly of amphiphilic peptide EAK16-II with histidinylated analogues and implications for functionalization of beta-sheet fibrils in vivo. Wen Y, Roudebush SL, Buckholtz GA, Goehring TR, Giannoukakis N,
Gawalt ES, Meng WS. (2014) Biomaterials, doi: 10.1016/j.biomaterials.2014.03.009
Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1
diabetes in NOD mice, Valentina Di Caro, Brett Phillips, Carl Engman, Jo Harnaha, Massimo Trucco and
Nick Giannoukakis, (2014) PLoS One, 9(1): e83575.
Retinoic acid-producing, ex vivo-generated human tolerogenic dendritic cells induce the proliferation of suppressive regulatory B-lymphocytes, Valentina Di Caro, Brett Phillips, Carl Engman, Jo Harnaha, Massimo
Trucco and Nick Giannoukakis (2013) Clin Exp Immunol. 174(2): 302-317
Retaining antibodies in tumors with a self-assembling injectable system. Wen Y, Kolonich HR, Kruszewski
KM, Giannoukakis N, Gawalt ES, Meng WS. (2013) Mol Pharmacol. 4;10(3):1035-1044.
It's Time to Bring Dendritic Cell Therapy to Type 1 Diabetes, Remi J. Creusot, Nick Giannoukakis, Massimo
Trucco, Michael J. Clare-Salzler, and C. Garrison Fathman (2014) Diabetes, 63: 20-30.
Ranirestat: Pharmacokinetic and Pharmacodynamic Properties and Update on Clinical Status. Nick Giannoukakis (2014) Expert Opinion on Drug Metabolism and Toxicology, IN PRESS.
Tolerogenic dendritic cells for type 1 diabetes, Nick Giannoukakis (2013) Immunotherapy, 5: 569-571.
A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease. Nishikawa T, Bellance N, Damm A, Bing H, Zhu Z, Handa K, Yovchev
MI, Sehgal V, Moss TJ, Oertel M, Ram PT, Pipinos II, Soto-Gutierrez A*, Fox IJ, Nagrath D. J Hepatol. 2014
Feb 26. pii: S0168-8278(14)00120-2. doi: 10.1016/j.jhep.2014.02.014. [Epub ahead of print]
* Corresponding Author
Assembly of human organs from stem cells to study liver disease.Handa K, Matsubara K, Fukumitsu K, Guzman-Lepe J, Watson A, Soto-Gutierrez A*. Am J Pathol. 2014 Feb;184(2):348-57. * Corresponding Author
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19
PUBLICATIONS
A nonhuman primate model of human radiation-induced venocclusive liver disease and hepatocyte injury.Yannam GR, Han B, Setoyama K, Yamamoto T, Ito R, Brooks JM, Guzman-Lepe J, Galambos C,
Fong JV, Deutsch M, Quader MA, Yamanouchi K, Kabarriti R, Mehta K, Soto-Gutierrez A, RoyChowdhury J, Locker J, Abe M, Enke CA, Baranowska-Kortylewicz J, Solberg TD, Guha C, Fox IJ. Int
J Radiat Oncol Biol Phys. 2014 Feb 1;88(2):404-11.
Increased reprogramming of human fetal hepatocytes compared with adult hepatocytes in feeder-free
conditions.Hansel MC, Gramignoli R, Blake W, Davila J, Skvorak K, Dorko K, Tahan V, Lee BR, Tafaleng E, Guzman-Lepe J, Soto-Gutierrez A, Fox IJ, Strom SC. Cell Transplant. 2014 Jan;23(1):27-38.
Tkach AV., Yanamala N., Stanley S., Shurin MR., Shurin GV., Kisisn ER., Murray AR., Pareso S., Khaliullin T., Kotchey GP., Castranova V., Mathur S., Fadeel B., Star A., Kagan VE., Shvedova AA. Graphene Oxide, but not Fullerenes, targets immunoproteasomes and suppresses antigen presentation by
dendritic cells. Small, 9:1686-90, 2013.
Shvedova AA., Tkach AV., Kisisn ER., Khaliullin T., Stanley S., Gutkin DW., Star A., Chen Y., Shurin
GV., Kagan VE., Shurin MR. Carbon nanotubes enhance metastatic growth of lung carcinoma via upregulation of myeloid-derived suppressor cells. Small, 9:1691-95, 2013.
Sevco A., Michels T., Vrohlings M., Umansky V., Beckhove P., Kato M., Shurin GV., Shurin MR.,
Umansky V. J. Antitumor effect of paclitaxel is mediated by inhibition of myeloid-derived suppressor
cells and chronic inflammation in the spontaneous melanoma model. J. Immunol. 190(5):2464-2471,
2013.
Ustinova EE., Shurin GV., Gutkin DW., Shurin MR. The role of TLR4 in the paclitaxel effects on neuronal growth in vitro. PloS One, 8(2):e56886, 2013.
Shurin GV., Ma Y., Shurin MR. Immunosuppressive mechanisms of regulatory dendritic cells in cancer.
Cancer Microenvironment, 6(2):159-67, 2013.
Barbeau DJ., La KT., Kim DS., Kerpedjieva SS., Shurin GV., Tamama K. Early Growth response -2 Signaling Mediates Immunomodulatory Effects of Human Multipotential Stromal Cells. Stem Cells Dev, 23
(2):155-166, 2014.
Zhong H., Gutkin DW., Han B., Ma Y., Keskinov AA., Shurin MR., Shurin GV. Origin and Pharmacological Modulation of tumor-associated regulatory dendritic cells. Int. Journal of Cancer, 134(11):26332645, 2014.
Landreneau JP., Shurin MR., Agassandian MV., Keskinov AA., Ma Y., Shurin GV. Immunological
Mechanisms of Low and Ultra-Low Dose Cancer Chemotherapty. Cancer Microenvironment, in press.
DEPARTMENT OF PATHOLOGY FACULTY MEETING
Friday, June 20, 2014
12:00 noon
1104 Scaife Hall
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20
PUBLICATIONS
Jing Yang, Laura E. Mowry, Kari Nichole Nejak-Bowen, Hirohisa Okabe, Cassandra R. Diegel, Richard A.
Lang, Bart O. Williams, Monga SP. Beta-catenin signaling in murine liver zonation and regeneration: A
Wnt-Wnt situation. Hepatology (In Press).
Fanti M, Singh S, Ledda-Columbano GM, Columbano M, Monga SP. Triiodothyronine induces hepatocyte
proliferation by protein kinase A-dependent b-catenin activation in rodents. Hepatology 2013, Oct. 07.
Lee JM, Yang J, Newell PN, Singh S, Parwani A, Friedman SL, Nejak-Bowen KN, Monga SP. Betacatenin signaling in hepatocellular cancer. Implications in inflammation, fibrosis and proliferation. Cancer
Letters, 2013, Sep. 23.
Delgado E, Bahal R, Yang J, Lee JM, Ly DH, Monga SP. β-Catenin Knockdown in Liver Tumor Cells by a
Cell Permeable Gamma Guanidine-based Peptide Nucleic Acid. Curr Cancer Drug Targets. 2013 Oct;13
(8):867-78
Criscimanna A, Duan D, Rhodes JA, Fendrich V, Wickline ED, Hartman DJ, Monga SP, Lotze M, Gittes
GK, Fong GH, Esni F. PanIN-specific regulation of Wnt signaling by HIF2. Cancer Res. 2013 Aug 1;73
(15):4781-90
Nakamura I, Fernandez-Barrena MG, Ortiz-Ruiz MC, Almada LL, Hu C, Elsawa SF, Mills LD, Romecin
PA, Gulaid KH, Moser CD, Han JJ, Vrabel A, Hanse EA, Akogyeram NA, Albrecht JH, Monga SP, Sanderson SO, Prieto J, Roberts LR, Fernandez-Zapico ME. Activation of the Transcription Factor GLI1 by WNT
Signaling Underlies the Role of SULFATASE 2 as a Regulator of Tissue Regeneration. J Biol Chem. 2013
Jul 19;288(29):21389-98.
Wickline E, Du Y, Stolz DB, Kahn M, Monga SP. g-Catenin at adherens junctions: Mechanism and biological implications in hepatocellular cancer after b-catenin knockdown. Neoplasia. 2013 Apr;15(4):421-34.
Awuah P, Nejak-Bowen KN, Monga SP. Role and regulation of PDGFRa in liver development and regeneration. Am J Pathol. 2013 May;182(5):1648-58
Pullara F, Guerrero-Santoro J, Calero M, Zhang Q, Peng Y, Spahr H, Kornberg GL, Cusimano A, Stevenson
HP, Santamaria H, Reynolds SL, Brown IS, Monga SP, Houten BV, Rapic-Otrin V, Calero G, Levine AS. A
general path for large-scale solubilization of cellular proteins: From membrane receptors to multiprotein
complexes. Protein Expr Purif. 2013 Feb;87(2):111-9.
Nejak-Bowen KN, Kikuchi A, Monga SP. b-Catenin-NF-kB interactions in murine hepatocytes: A complex
to die for. Hepatology 2013 Feb;57(2):763-74.
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PRESENTATIONS
George K. Michalopoulos, M.D., Ph.D.
“Liver Regeneration, Liver Cancer and Regenerative Responses in Liver Failure,” University of Virginia,
Richmond, VA January 13, 2014.
“Liver Regenerative and Pathways Associated with Liver Cancer,” Loyola University, Chicago, IL
March 17, 2014.
Satdarshan (Paul) Monga, M.D.
 ‘Cellular and Molecular Circuitry of Wnt Signaling in Liver Regeneration” Digestive Health Center
Seminar, Cincinnati Children’s, Cincinnati, OH, January, 2014

“Wnt signaling in Health and Disease”, University of Tokyo, Tokyo, Japan. January, 2014
 “Beta-catenin signaling in liver regeneration: A Wnt-Wnt situation”
Choshu International Liver Symposium, Yamaguchi University, Japan, January, 2014.
 “b-Catenin and Personalized Medicine in HCC”, EASL HCC Summit, Geneva, Switzerland, February,
2014.
 “Yap and Wnt signaling in liver tumorigenesis: Novel Role”, PLUTO, Grand Cayman Island., March,
2014.
 “b-Catenin signaling in liver regeneration and homeostasis: A Wnt-Wnt Situation”, University of California, Riverside, CA, April, 2014.
 “b-Catenin signaling in liver pathobiology: You Wnt some, you lose some”. ASIP Outstanding Investigator Award Lecture, San Diego, CA, April, 2014.
 b-Catenin signaling in liver regeneration and homeostasis: A Wnt-Wnt Situation”, University of California, San Diego, CA, April, 2014.
John Ozolek , M.D.
 With Dr. Lisa Teot from Boston Children’s Hospital at the workshop “The Cytopathology of Pediatric
Non-Thyroidal Head and Neck Masses with Histologic Correlates” at the Society for Pediatric Pathology Annual Meeting on March 2, 2014.
 A poster “Correlation of Clinicopathological Features and Molecular Genetics in Pediatric Thyroid Carcinoma” by authors Picarsic J, Buryk M, Ozolek J, Ranganathan S, Monaco S, Gurtunca, N, Joyce
J, Simons J, Witchel S, Mehta D, and Nikiforov Y at the Society for Pediatric Pathology Annual
Meeting on March 2, 2014.
 “Automated tissue screening: A challenging prospect in digital image analysis” at the Carnegie Mellon
University Annual Bioimaging Day on February 26, 2014.
Parmjeet Randhawa, M.D.
 BK Polyoma virus nephropathy. Indian Society of Renal and Transplant Pathology Meeting, New
Delhi, India, Sept 13,2013.
 Epstein-Barr virus infection and post-transplant lymphoproliferative disease. Indian Society of Renal
and Transplant Pathology Meeting, New Delhi, India, Sept 14, 2013.
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Parmjeet Randhawa, M.D., cont’d
 Uncommon but important infections of the renal allograft BK Polyoma virus nephropathy. Indian
Society of Renal and Transplant Pathology Meeting, New Delhi India, Sept 14, 2013.
 Inhibiton of large T antigen ATPase activity as a potential strategy to develop anti-JCV drugs. Pittsburgh Workshop on Quantitative and Systems Pharmacology in Personalized Medicine. November
12, 2013.
 Masutani K, Ninomiya T, Randhawa P. HLA-A2, HLA-B44, and HLA-DR-DR15 associated with
lower risk of BK viremia, while BK viruria is HLA-independent. Am Society of Nephrology, Atlanta, GA, November 9, 2013.
 Immune Response to Polyomavirus BK. Hershey Medical Center, Hershey, PA, December 12, 2013.
 Diagnosis and management of post-transplant lymphoproliferative disease in kidney transplant patients. The Kidney and Urology Institute, Medanata Multi-Superspecialty Hospital, Gurgaon, National Capital Region, India. March 21, 2014.
Arivarasan Karunamurthy, M.D. PGY-4 Resident, received the "JORGE L SANCHEZ Award " for
the Best Oral Abstract at International Society of Dermatopathology, ISDP 17th Annual Meeting held at
Denver, March 2014 for his oral presentation on " Cytogenetic Analysis Of Fibroepithelioma Of Pinkus
Supports Clear Differences To Basal Cell.”
Policy for Observers at University of Pittsburgh
and UPMC
All requests/applications for observers (trainees and others) for more than one week duration need to go through the Residency and Fellowship Program Office. As the Director, I
been asked to review and approve all observer requests for the Department of Pathology.
In addition to my approval, UPMC approval is also required. The Observer Policy has
been distributed to all Division Directors which includes an application form that needs to be signed by the applicant, a faculty
sponsor, the division director and me.
Electives requests from ACGME accredited residency or fellowship programs are
handled separately.
Medical Student elective requests go through the School of Medicine.
Research observer requests go through the department’s research office (Mary Lou
Benedetti).
If any questions, please feel free contact me at tmacpherson@mail.magee.edu.
Trevor Macpherson, M.D.
Vice Chair, Medical Education Program
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23
VISAS and/or VISA UPDATES
The number of visa applications in the Department of Pathology
has grown considerably over the past several years; in addition,
Federal and University requirements concerning the applications
have become more involved. The once paper process is now an
electronic submission to the Office of International Services.
Time is still of the essence and if you plan to bring on a foreign
national Visiting Scholar or Post Doc, please allow at least three (3) months for the internal
approval process, exchange of visitor information, submission and flow of paperwork
through OIS. If you have specific questions concerning visas, the application process or policies for the department, please contact Mary Lou Benedetti (benedettim@upmc.edu) or
April Lehman (lehmanad@upmc.edu).
Personal Highlights
Kate Serdy, M.D. (PGY-2) and husband Andrew are proud
parents of a baby boy, Andrew Robert Serdy,
born on October 31, 2013 weighing 9 lbs.
Christine Garcia Roth, M.D. and husband Stephan welcomed a son,
Matthew, October 12, 2013 weighing 8 lbs and 1 oz.
CONGRATULATIONS!
Donald Kelley, MD, MDiv, MBA, Clinical Assistant Professor,
Division of Transfusion Medicine and Anne Windus, MDiv, DMin, PhD, Adjunct
Professor of Counseling at the North Georgia Hub of the New Orleans Baptist
Theological Seminary were married on September 21, 2013 in Toccoa, GA. The
couple currently resides in Sarver, PA.
Eileen V. Misencik, Dr. Dhir’s assistant at Shadyside Hospital, was engaged on December 28,
2013 and getting married on October 18, 2014. Future husband is Robert A. Krecek, Jr.
PAGE
Wednesday, May 7, 2014 - noon - 1:00 p.m.
1104 Scaife Hall
Thursday, May 29, 2014 8:00 a.m. - 9:00 a.m.
Children's Hospital, Rangos Research Building
Main Conference Room, 3rd floor
"Evidence Based Pathology"
ANNUAL FETTERMAN LECTURE
Alberto Marchevsky, M.D.
Director, Pulmonary and Mediastinal Pathology
Cedars-Sinai
Los Angeles, CA
____________________________________________
Wednesday, May 14, 2014 - noon - 1:00 pm.
1104 Scaife Hall
"The Molecular Basis of FTD and ALS"
Ian R.Z. Mackenzie, M.D.
Professor, Neuropathology
Department of Pathology and Laboratory Medicine
University of British Columbia
Canada
_______________________________________
Wednesday, May 21, 2014 - noon - 1:00 p.m.
1104 Scaife Hall
"Prostate Cancer Genome"
Jianhua Luo, M.D., Ph.D.
Professor of Pathology
Department of Pathology
University of Pittsburgh
___________________________________________
Wednesday, May 28, 2014 - noon - 1:00 p.m.
S100A Biomedical Science Tower
ANNUAL DEPARTMENT RETREAT
"From Ghosts to Skeletons: Function and Dysfunction
of the Membrane Scaffold"
Jon S. Morrow, Ph.D., M.D.
Raymond Yesner Professor of Pathology
Chair, Department of Pathology
Yale School of Medicine
New Haven, CT
"Current Achilles and the Tortoise: Zeno's Paradox in the
Universe of Pediatric Small Round Cell Tumors"
Rita Alaggio, M.D.
Professor of Pediatric Pathology and Surgical Pathology
Department of Pathology
University of Padua
Padua, Italy
________________________________________________
Wednesday, June 4, 2014—noon—1:00 p.m.
1104 Scaife Hall
“A Culture of Quality and Safety: The Importance of Service
Excellence and Lean Thinking”
Jeffrey L. Myers, M.D.
Professor of Pathology
Department of Pathology
University of Michigan
Ann Arbor, MI
________________________________________________
Wednesday, June 11, 2014—noon—1:00 p.m.
1104 Scaife Hall
Title: TBA
Xin Chen, Ph.D.
Assistant Professor of Bioengineering and Therapeutic
Sciences
Department of Bioengineering and Therapeutic Sciences
University of California
San Francisco, CA
________________________________________________
Wednesday, June 18, 2014—noon—1:00 p.m.
1104 Scaife Hall
“miRNA-122: Nature’s Double-Edged Sword”
Kalapana Ghoshal, Ph.D.
Associate Professor of Pathology
Department of Pathology
The Ohio State University
Columbus, OH
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CME Credit Update
The University of Pittsburgh School of Medicine, Center for Continuing Education for the Health Sciences
CME transcripts can be obtained via the Internet at ccehs.upmc.edu. Click on link “Credit Transcripts” enter the required information (last name, last five digits of social security number). The transcript reflects
the American Medical Association Category 1 credits or the Continuing Education Units (CEUs) which have
been entered into the Center’s database. Credits from other institutions can be entered using the option
“add/modify” credit information. For questions about the Continuing Medical Education Credits, please
contact 412.647.8232.
Annual Report Update
The School of Medicine requests that an annual report be submitted every fall. An e-mail will be sent to
the faculty requesting individual information. The data needed includes a research summary paragraph,
Study Sections, Advisory Committees, honors, recognition and awards and a bibliography for the last three
years (2012, 2013, 2014). Collecting information from all members in the Department is time consuming
therefore we are asking you to please respond by the due date. Division Chiefs are asked to submit a
summary of their division’s activities. If you have any questions, please contact Shannon Hozinec at
hozinecs@upmc.edu. Thank you.
Educational Credit Unit Update
Just a reminder that the Educational Credit Units (ECUs) are being collected from every faculty member
who has been involved with teaching activities of the medical or graduate school programs from July 1,
2013 to June 30, 2014. We have initiated a web-page (see directions for access to page on Page 23) to
collect teaching as it happens. Please be sure to update your teaching data. The School of Medicine will
be asking for the information in July. If you have any questions please contact Chris Szalkuski at
szalkuskict@upmc.edu.
Publication Notification Process Update
This is a reminder the Dean has requested a Notification of Publication form for each manuscript accepted for publication in a peer-reviewed journal. The notification ensures compliance with human and animal
research policies, technology transfer/patent guidelines and the requirements for citation of grant support.
It also allows for newsworthy publications to be passed onto the University media. Please submit preprint
information via the website at: https://pnf.hs.pitt.edu . If you have any questions, please contact Chris
Szalkuski at szalkuskict@upmc.edu.
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FOR ACCESS TO WEB PAGE FOR ECU LOG ON
ECU data for the academic year July 1, 2013 to June 30, 2014 will be due soon. Please be
sure your info is entered via our Department’s web page link.
For faculty with a UPMC network ID, please use this link. Accessing this link off of the
UPMC network will bring up a login prompt:
https://epssecure.upmc.com/ECUAdmin/auth/index.cfm
For faculty without a UPMC ID, please use this link:
https://epssecure.upmc.com/ECUTrack/index.cfm
These links are also available on the Department of Pathology webpage under links at:
http://path.upmc.edu/links.htm
From the home page select which ECU activity is to be logged, and whether the activity is for
medical or graduate students. Then fill in all fields on the form with an option for a free-text
note at the end. Confirmation will be given and the activity will be entered into the database
for submission at the end of the academic term.
For questions or feedback, please contact Thomas Harper at ISD (harperth@upmc.edu).
Thank you.
Please send newsworthy items as they happen to
szalkuskict@upmc.edu.
Thank you.