20.201 Drug Metabolism Problem Set 1
Hydrolysis
O
1.
O
O
2.
Oxidation
NH2
O
3.
GST/GSH
NH2
NH2
N N
4.
H2N
Reduction
S
O
NH2
Oxidation
5.
N
Oxidation
6.
O
N
7.
O
Oxidation
N O
Oxidation
8.
N
H
1
Hypoperamericillin
O
F
HO
F
N
HO
N
S
H
N
OH
O
There are 3 sites in this molecule that can be activated to electrophilic intemediates. Each electrophile in
turncanbedeactivatedbymorethanonePhase2enzyme.Identifythesitesanddrawthestructuresof
theelectrophiles.ThenidentifythePhase2enzmesforeachdetoxicationreaction,anddrawthefinal
detoxified products.
2
MIT OpenCourseWare
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20.201 Mechanisms of Drug Actions
Fall 2013
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