SEPTEMBER/OCTOBER 2005 Volume 7, Number 5 GRID COMPUTING Guest Editors' Introduction: Scientific Applications of Grid Computing Copublished by the IEEE Computer Society and the American Institute of Physics Bruce Boghosian and Peter V. Coveney 10 Cross-Site Computations on the TeraGrid Statement of Purpose Computing in Science & Engineering Suchuan Dong, George Em Karniadakis, and Nicholas T. Karonis 14 aims to support and promote the emerging discipline of computational Scientific Grid Computing: The First Generation science and engineering and to Jonathan Chin, Matthew J. Harvey, Shantenu Jha, and Peter V. Coveney foster the use of computers and 24 computational techniques in scientific research and education. Every issue contains broad-interest theme articles, departments, news reports, and editorial comment. Collateral materials such as source code are made available electronically over the Internet. The intended audience comprises physical scientists, engineers, mathematicians, and computer scientists who would benefit from computational methodologies. All theme and feature articles in CiSE are peer-reviewed. Cooperating Services for Data-Driven Computational Experimentation Beth Plale, Dennis Gannon, Yi Huang, Gopi Kandaswamy, Sangmi Lee Pallickara, and Aleksander Slominski 34 Toward Ecosystem Modeling on Computing Grids Dali Wang, Eric Carr, Louis J. Gross, and Michael W. Berry 44 FEATURE ARTICLE Anisotropic Nonlinear Filtering of Cellular Structures in Cryoelectron Tomography Cover illustration: Dirk Hagner José-Jesús Fernández and Sam Li 54