Product datasheet
Anti-Glycerol kinase antibody (Biotin) ab193514
Overview
Product name
Anti-Glycerol kinase antibody (Biotin)
Description
Rabbit Polyclonal to Glycerol kinase (Biotin)
Conjugation
Biotin
Tested applications
WB
Species reactivity
Reacts with: Escherichia coli
Immunogen
Recombinant full length protein corresponding to Escherichia coli Glycerol kinase aa 2-502.
Sequence:
TEKKYIVALDQGTTSSRAVVMDHDANIISVSQREFEQIYPKPGWVEHDPM
EIWATQSSTLVEVLAKADISSDQIAAIGITNQRETTIVWEKETGKPIYNA
IVWQCRRTAEICEHLKRDGLEDYIRSNTGLVIDPYFSGTKVKWILDHVEG
SRERARRGELLFGTVDTWLIWKMTQGRVHVTDYTNASRTMLFNIHTLDWD
DKMLEVLDIPREMLPEVRRSSEVYGQTNIGGKGGTRIPISGIAGDQQAAL
FGQLCVKEGMAKNTYGTGCFMLMNTGEKAVKSENGLLTTIACGPTGEVNY
ALEGAVFMAGASIQWLRDEMKLINDAYDSEYFATKVQNTNGVYVVPAFTG
LGAPYWDPYARGAIFGLTRGVNANHIIRATLESIAYQTRDVLEAMQADSG
IRLHALRVDGGAVANNFLMQFQSDILGTRVERPEVREVTALGAAYLAGLA
VGFWQNLDELQEKAVIEREFRPGIETTERNYRYAGWKKAVKRAMAWEEHD
E
Database link: P0A6F3
Run BLAST with
Run BLAST with
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long
term. Avoid freeze / thaw cycle. Store In the Dark.
Storage buffer
pH: 7.40
Preservative: 0.03% Proclin
Constituents: 49% PBS, 50% Glycerol
Purity
Caprylic Acid - Ammonium Sulfate precipitation
Clonality
Polyclonal
Isotype
IgG
1
Applications
Our Abpromise guarantee covers the use of ab193514 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
Abreviews
WB
Notes
1/50 - 1/200. Predicted molecular weight: 56 kDa.
Target
Function
Key enzyme in the regulation of glycerol uptake and metabolism.
Tissue specificity
Highly expressed in the liver, kidney and testis. Isoform 2 and isoform 3 are expressed
specifically in testis and fetal liver, but not in the adult liver.
Pathway
Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate
from glycerol: step 1/1.
Involvement in disease
Defects in GK are the cause of GK deficiency (GKD) [MIM:307030]. This disease can be either
symptomatic with episodic metabolic and CNS decompensation or asymptomatic with
hyperglycerolemia and hyperglyceroluria only.
Sequence similarities
Belongs to the FGGY kinase family.
Cellular localization
Mitochondrion outer membrane. Cytoplasm. In sperm and fetal tissues, the majority of the
enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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