SUPPORTING INFORMATION Supplemental Methods R-Scripts used for microarray image analysis and analysis of gene transcription profiles of salmon juveniles from enriched and unenriched hatchery rearing envrionments. Microarray data acquisition (scripts adapted from Booman et al. 2011) 1. Images exported from the ScanArray Gx Plus scanner and ScanExpress v4.0 software were visualized using Imagene. In Imagene, manual flagging was used to exclude spots of poor quality. 2. Further processing of the data was done in R: # Script based on 'script 110327.R' # Script written and executed over multiple days January 24-25 2013 # Load marray package # Read in array info to make object of class marrayInfo targets_fam_trmt_melissa <- read.marrayInfo(fname="targets_fam_trmt.txt",info.id=NULL, labels=NULL, notes="targets_fam_trmt_melissa", sep="\t", skip=0, quote="\"") # Read in gal file info indicating Name and ID columns and columns containing layout info to make object of class marrayInfo galinfoAgilent <- read.Galfile("025055_D_20090817_AID.gal", path=".", info.id=c("Name","Annotation ID","ID","ControlType"), layout.id=c(Block="Block", Row="Row", Column="Column"), labels="Name", notes="", sep="\t", skip=NULL, ncolumns=1) # Create vector of array names arrayNames <- targets_fam_trmt_melissa@maLabels # Read in, summarize and display intensity data for all arrays mrawMedian <- read.marrayRaw(fnames=arrayNames, path=".", name.Gf="Signal Median 2", name.Gb="Background Median 2", name.Rf="Signal Median 1", name.Rb="Background Median 1", name.W="Flag", layout=galinfoAgilent$layout, gnames=galinfoAgilent$gnames, targets=targets_fam_trmt_melissa, notes=NULL, skip=NULL, sep="\t", quote="\"", DEBUG=FALSE) summary(mrawMedian) # Check if order of intensities and target are the same checkTargetInfo(mrawMedian) # Remove control spots 1 mrawMedianNoControl <- subset(mrawMedian,!(mrawMedian@maGnames@maInfo$ControlType %in% c("ignore","pos","neg"))) # Calculate summary stats and cutoff levels # Create separate object for this, and remove manual flagged spots (flag 1) # Manually flagged spots are removed to prevent blowing up the background SD because of dust etc. mrawMedianStats <- mrawMedianNoControl for (i in 1:32){ mrawMedianStats@maGf[,i][mrawMedianStats@maW[,i]==1]<-NA mrawMedianStats@maGb[,i][mrawMedianStats@maW[,i]==1]<-NA mrawMedianStats@maRf[,i][mrawMedianStats@maW[,i]==1]<-NA mrawMedianStats@maRb[,i][mrawMedianStats@maW[,i]==1]<-NA } # Calculate average (avg), standard deviation (sd), signal/background ratio (sbr) and cutoffs avgGf <- colMeans(mrawMedianStats@maGf, na.rm=TRUE) avgGb <- colMeans(mrawMedianStats@maGb, na.rm=TRUE) avgRf <- colMeans(mrawMedianStats@maRf, na.rm=TRUE) avgRb <- colMeans(mrawMedianStats@maRb, na.rm=TRUE) sdGf <- apply(mrawMedianStats@maGf,2,sd, na.rm=TRUE) sdGb <- apply(mrawMedianStats@maGb,2,sd, na.rm=TRUE) sdRf <- apply(mrawMedianStats@maRf,2,sd, na.rm=TRUE) sdRb <- apply(mrawMedianStats@maRb,2,sd, na.rm=TRUE) sbrG <- avgGf/avgGb sbrR <- avgRf/avgRb cutoffs <- matrix(0,32,2) for (i in 1:32){ cutoffs[i,1] <- avgGb[i] + (2*sdGb[i]) cutoffs[i,2] <- avgRb[i] + (2*sdRb[i]) } # To export cutoffs into text file, add column and row names cutoffsExport <- cbind(arrayNames,cutoffs) cutoffsExport <- rbind(c('ArrayID','Green cutoff','Red cutoff'),cutoffsExport) write.table(cutoffsExport,"cutoff levels.txt",quote=FALSE,sep="\t") # To export summary statistics to text file, add column and row names statsExport <- cbind(avgGf,sdGf,avgRf,sdRf,avgGb,sdGb,avgRb,sdRb,sbrG,sbrR) write.table(statsExport,"summary statistics.txt",quote=FALSE,sep="\t") # Continue with normalizing dataset, using the mrawMedianNoControl object # (which has only control spots removed) # Normalize using printtip Loess 2 mnormMedianNoControl <- maNormMain(mrawMedianNoControl,echo=TRUE) summary(mnormMedianNoControl) # Plot boxplots to check normalization for (i in 1:32){ pdf(paste("RawMedianBoxPlots",targets_fam_trmt_melissa@maInfo[i,2],".pdf", sep=""), paper="letter") boxplot(mrawMedianNoControl[, i], xvar = "maPrintTip", yvar = "maM") dev.off() pdf(paste("NormMedianBoxPlots",targets_fam_trmt_melissa@maInfo[i,2],".pdf", sep=""), paper="letter") boxplot(mnormMedianNoControl[, i], xvar = "maPrintTip", yvar = "maM") dev.off() } pdf("RawMedianBoxPlotsAllArrays.pdf", paper="letter") boxplot(mrawMedianNoControl, yvar = "maM") dev.off() pdf("NormMedianBoxPlotsAllArrays.pdf", paper="letter") boxplot(mnormMedianNoControl, yvar = "maM") dev.off() # Plot scatterplots; example MA plots with LowessLines for (i in 1:32){ pdf(paste("RawMedianScatterPlot",targets_fam_trmt_melissa@maInfo[i,2],".pdf", sep=""), paper="letter") defs <- maDefaultPar(mrawMedianNoControl[, i], x = "maA", y = "maM", z = "maPrintTip") legend.func <- do.call("maLegendLines", defs$def.legend) lines.func <- do.call("maLowessLines", c(list(TRUE, f = 0.3), defs$def.lines)) plot(mrawMedianNoControl[, i], xvar = "maA", yvar = "maM", zvar = "maPrintTip", lines.func, text.func = maText(), legend.func) dev.off() pdf(paste("NormMedianScatterPlot",targets_fam_trmt_melissa@maInfo[i,2],".pdf", sep=""), paper="letter") defs <- maDefaultPar(mnormMedianNoControl[, i], x = "maA", y = "maM", z = "maPrintTip") legend.func <- do.call("maLegendLines", defs$def.legend) lines.func <- do.call("maLowessLines", c(list(TRUE, f = 0.3), defs$def.lines)) plot(mnormMedianNoControl[, i], xvar = "maA", yvar = "maM", zvar = "maPrintTip", lines.func, text.func = maText(), legend.func) dev.off() } # Create array data where values below specific cutoff are replaced by NA after normalization # Create different datasets # And one with only cutoff for Green used (i.e. to prevent loss of genes that are switched off in a subgroup of samples) 3 mnormCutoffBoth <- mnormMedianNoControl for (i in 1:91){ removeG <- mrawMedianNoControl@maGf[,i]<cutoffs[i,1] removeR <- mrawMedianNoControl@maRf[,i]<cutoffs[i,2] mnormCutoffBoth@maM[,i][removeG]<-NA mnormCutoffBoth@maM[,i][removeR]<-NA mnormCutoffBoth@maA[,i][is.na(mnormCutoffBoth@maM[,i])]<-NA } mnormCutoffGreen <- mnormMedianNoControl for (i in 1:32){ removeG <- mrawMedianNoControl@maGf[,i]<cutoffs[i,1] mnormCutoffGreen@maM[,i][removeG]<-NA mnormCutoffGreen@maA[,i][is.na(mnormCutoffGreen@maM[,i])]<-NA } # Make a count of the Imagene quality flags remaining after removal of controls # (since spots below cutoff are not removed but rather replaced by NA, a count after cutoff levels is useless) flags <- mrawMedianNoControl@maW flags1 <- flags == 1 flags2 <- flags == 2 flags3 <- flags == 3 flagcounts <- matrix(0,32,3) flagcounts[,1] <- apply(flags1,2,sum) flagcounts[,2] <- apply(flags2,2,sum) flagcounts[,3] <- apply(flags3,2,sum) write.table(flagcounts,"flagcounts after control removal.txt",quote=FALSE,sep="\t") # Remove all flagged spots mnormCutoffBothrmFlagAll <- mnormCutoffBoth for (i in 1:1){ mnormCutoffBothrmFlagAll@maM[,i][mnormCutoffBothrmFlagAll@maW[,i]==1]<-NA [mnormCutoffBothrmFlagAll@maW[,i]==2]<-NA mnormCutoffBothrmFlagAll@maA[,i][is.na(mnormCutoffBothrmFlagAll@maM[,i])]<-NA } mnormCutoffBothrmFlagAll.table <cbind(mnormCutoffBothrmFlagAll@maGnames@maInfo$ID,mnormCutoffBothrmFlagAll@maM) write.table(mnormCutoffBothrmFlagAll.table,"mnormCutoffBothrmFlagAll_ratios.txt",quote=FALSE,sep ="\t") mnormCutoffGreenrmFlagAll <- mnormCutoffGreen for (i in 1:32){ mnormCutoffGreenrmFlagAll@maM[,i][mnormCutoffGreenrmFlagAll@maW[,i]==2]<-NA mnormCutoffGreenrmFlagAll@maA[,i][is.na(mnormCutoffGreenrmFlagAll@maM[,i])]<-NA } for (i in 1:32){ 4 mnormCutoffGreenrmFlagAll@maM[,i][mnormCutoffGreenrmFlagAll@maW[,i]==1]<-NA mnormCutoffGreenrmFlagAll@maA[,i][is.na(mnormCutoffGreenrmFlagAll@maM[,i])]<-NA } mnormCutoffGreenrmFlagAll.table <cbind(mnormCutoffGreenrmFlagAll@maGnames@maInfo$ID,mnormCutoffGreenrmFlagAll@maM) write.table(mnormCutoffGreenrmFlagAll.table,"mnormCutoffGreenrmFlagAll_ratios.txt",quote=FALSE,s ep="\t") # Make new tables removing spots with >=25% NA (32 arrays, 8 NA, so 8 and smaller allowed) mnormCutoffGreenrmFlagAllNACount <- rowSums(is.na(mnormCutoffGreenrmFlagAll.table)) mnormCutoffGreen.NA <cbind(mnormCutoffGreenrmFlagAll.table,mnormCutoffGreenrmFlagAllNACount) write.table(mnormCutoffGreen.NA,file="mnormCutoffGreenNACount.txt",quote=FALSE,sep="\t") mnormCutoffGreen.full <read.table("mnormCutoffGreenNACount.txt",header=TRUE,sep="\t",row.names=1,fill=TRUE) mnormCutoffGreen.NA25 <- subset(mnormCutoffGreen.full,mnormCutoffGreen.full[,34]<9) mnormCutoffGreen.NA25 <- mnormCutoffGreen.NA25[,1:33] write.table(mnormCutoffGreen.NA25,"Green_avg_NACutoff_25percent.txt",quote=FALSE,sep="\t") # Impute missing data using EMarray from LSimpute applet # Adapt LSimpute commands to new files and folders # Do not forget to change text files first to insert a tab at the beginning and remove './' and '.txt' 5 Siggenes analysis (scripts adapted from Booman et al. 2011) 1. As part of the previous script, all probes for which the log2 ratio was missing (NA) in more than 25% of arrays were removed from the normalized and thresholded log transcription data. This resulted in a final dataset comprised of 21,117 probes. 2. Missing data in the new dataset were imputed using the EM_array algorithm from the LSimpute package as described by Bø et al., Nucleic Acids Research 2004, 32:e34. 3. Imputed data were read into R and two-class comparison analysis was performed with the package ‘siggenes’: #Read in imputed data table.melissa.avg.25.imputed.full <read.table("Green_avg_NACutoff_25percent_imputed_EMarray_repl_rem.txt",header=TRUE,sep="\t",r ow.names=1,fill=TRUE) table.25imputed_all_families_NG_vs_G <cbind(table.melissa.avg.25.imputed.full[,1:5],table.melissa.avg.25.imputed.full[,11:15],table.melissa.avg .25.imputed.full[,21:25],table.melissa.avg.25.imputed.full[,6:10],table.melissa.avg.25.imputed.full[,16:2 0],table.melissa.avg.25.imputed.full[,26:30]) write.table(table.25imputed_all_families_NG_vs_G, "all_families_NG_vs_G_25_percent_imputed.txt",quote=FALSE, sep="\t") #assign classes to each treatment zero is control (No gravel) and 1 is treatment (Gravel) in this case and which is analogous to U and I respectively in Fig.1 from Tusher et al. 2001 #Run SAM class comparison in siggenes all_families_data<- table.25imputed_all_families_NG_vs_G class.melissa <- rep(c(0,1),c(15,15)) all_families.out <sam(all_families_data,class.melissa,method=d.stat,var.equal=FALSE,B=2000,B.more=0.1,B.max=30000, med=TRUE,gene.names=dimnames(all_families_data)[[1]],use.dm=FALSE,R.unlog=TRUE,na.replace=FAL SE,rand=12345) #View SAM output: all_families.out summary(all_families.out) summary(all_families.out,delta=seq(0.5,1.2,0.1)) plot(all_families.out) plot(all_families.out,0.9) sum.all_families <- summary(all_families.out,0.9) siggenes.melissa <- sum.all_families@mat.sig write.table(siggenes.melissa,"all_families_averaged_FDR_0p012_255.txt",quote=FALSE,sep="\t") 6 Figure A. Midsaggital histological cross-section of a juvenile Atlantic salmon head at emergence. The dashed line in the picture indicates where the head was severed from the body in our study of gene transcription patterns in juvenile salmon. The location of the heart, regions of the brain, and muscle tissue are also indicated. Picture provided by J. Winkowski and I. Fleming. 7 Table A. Atlantic salmon microarray probes identified as differentially transcribed between juveniles reared in enriched and unenriched (traditional) hatchery environments. The results shown follow the analysis of gene transcription patterns across the three families (X11, X22, X35) in a total of 15 complex and 15 simple individuals using the cGRASP-designed Agilent 4×44K salmon gene microarray. Differentially transcribed genes were identified using a FDR of 5% in siggenes. The fold-change in gene transcription levels found in enriched/unenriched environments are indicated. Probe ID Best BLASTx hit* C067R138 C204R103 C237R040 C205R145 C211R110 C258R138 C051R138 C211R161 C026R035 C001R030 C155R133 C166R069 C172R070 C135R135 C215R100 C036R160 C258R048 C085R160 C022R025 C124R148 protein-glutamine gamma-glutamyltransferase e-like cytochrome p450 2m1 PREDICTED: hypothetical protein LOC324610 claudin-10-like complement receptor type 1-like UNKNOWN hypothetical protein MTR_5g050970 metalloproteinase inhibitor 2 precursor protein phosphatase 1 regulatory subunit 14b metalloproteinase inhibitor 2 precursor gtpase imap family member 7 uroplakin-1a cytochrome p450 2m1 ornithine decarboxylase antizyme transmembrane protein 106b atpase h+ transporting v1 subunit g isoform 1 zinc finger protein zic 4 phosphorylase b kinase gamma catalytic testis liver isoform udp-n-acetylhexosamine pyrophosphorylase-like myelin and lymphocyte protein Fold-change (all families) 8.55 4.23 2.87 2.41 2.26 2.13 2.05 2.05 1.90 1.89 1.87 1.81 1.80 1.78 1.77 1.76 1.75 1.73 1.73 1.72 Fold-change (X11) 4.21 5.37 3.40 3.92 1.99 6.88 2.22 2.76 2.82 2.12 2.20 2.10 1.79 1.75 2.60 2.61 2.29 2.05 2.53 1.74 Fold-change (X22) 20.72 4.99 2.66 1.38 2.87 1.30 1.92 2.51 1.43 2.02 1.40 1.49 1.62 2.11 1.21 1.78 1.13 1.77 1.44 2.23 Fold-change (X35) 2.21 3.06 2.58 2.48 2.12 1.39 2.09 1.32 1.52 1.60 2.49 2.26 2.02 1.41 1.73 1.05 2.26 1.33 1.35 1.33 8 C104R034 C024R096 C025R093 C051R009 C066R122 C177R030 C045R110 C147R126 C076R102 C032R048 C255R108 C257R146 C182R144 C088R165 C128R109 C086R164 C078R052 C083R166 C138R056 C025R107 C157R083 C138R082 C081R073 C147R039 C195R042 C196R170 C023R126 C069R110 C196R097 migration and invasion enhancer 1 hypoxanthine-guanine phosphoribosyltransferase protein eva-1 homolog c-like protein fam181a-like vacuolar proton pump subunit e 1 ras-related c3 botulinum toxin substrate 1 purpurin precursor prodynorphin precursor cyclin-g2-like bcl2 adenovirus e1b 19 kda protein-interacting protein 3 peptidyl-prolyl cis-trans isomerase c embigin precursor pyridoxal kinase-like UNKNOWN dynein light chain cytoplasmic teashirt homolog 1 integral membrane protein 2c sodium-coupled neutral amino acid transporter 7-like envoplakin-like zinc finger protein 512b UNKNOWN cerebellin-1-like phosphatidylinositol transfer protein alpha isoform neuritin gdp-mannose dehydratase myelin and lymphocyte protein 5 -amp-activated protein kinase subunit beta-1 UNKNOWN bccip homolog 1.71 1.69 1.67 1.66 1.65 1.65 1.62 1.62 1.60 1.59 1.56 1.55 1.55 1.55 1.54 1.53 1.53 1.53 1.52 1.52 1.51 1.50 1.50 1.50 1.49 1.48 1.48 1.47 1.47 2.13 2.32 1.78 2.69 1.86 1.78 1.74 2.37 1.82 2.01 1.51 2.57 2.61 2.34 1.91 1.74 1.70 1.80 1.84 1.01 1.28 2.43 1.87 1.83 1.87 1.29 1.69 1.74 1.61 1.79 1.36 1.65 1.08 1.78 1.59 1.77 1.53 1.43 1.48 1.37 0.99 1.04 1.10 1.41 1.05 1.34 1.55 1.28 1.48 1.67 1.39 1.33 1.20 1.26 2.04 1.39 1.18 1.50 1.34 1.54 1.58 1.64 1.27 1.55 1.44 1.18 1.56 1.42 1.94 1.79 1.50 1.39 1.29 2.32 1.58 1.23 1.49 2.08 1.63 1.07 1.36 1.57 1.43 1.27 1.36 1.58 1.32 9 C141R027 C086R033 C122R157 C262R103 C082R123 C091R079 C075R036 C113R065 C243R121 C155R148 C064R164 C028R051 C120R154 C023R052 C048R158 C024R036 C032R036 C207R079 C080R142 C023R047 C128R096 C042R122 C238R108 C181R097 C032R066 C207R063 C136R151 C089R127 C154R165 transcription factor sox-2 gamma-crystallin m2-like aspartyl asparaginyl beta-hydroxylase-like transcription factor jun-d polycomb complex protein bmi-1-a probable g-protein coupled receptor 88 envoplakin-like chromosome 11 open reading frame 87 peroxisome proliferator-activated receptor beta synaptic vesicle 2-related protein schwannomin-interacting protein 1-like claudin-4 ras-related protein rab-25 hydroxyacylglutathione hydrolase scel protein proteasome assembly chaperone 1 btb poz domain-containing protein kctd5 hcls1-associated protein x-1 guanine nucleotide-binding protein subunit alpha-14-like calpain-2 catalytic subunit-like UNKNOWN UNKNOWN hydroxyacylglutathione hydrolase transmembrane protein 199 UNKNOWN UNKNOWN UNKNOWN adipocyte plasma membrane-associated protein cyclin-dependent kinase 4 inhibitor b 1.46 1.46 1.46 1.45 1.45 1.45 1.44 1.44 1.44 1.43 1.43 1.42 1.42 1.41 1.40 1.39 1.39 1.38 1.38 1.38 1.37 1.37 1.37 1.37 1.36 1.36 1.36 1.35 1.35 1.70 1.31 1.28 2.52 1.79 1.64 1.27 1.57 1.75 1.51 1.78 1.74 1.38 1.66 1.57 1.46 1.64 1.47 1.28 1.55 1.42 1.28 1.55 1.53 1.23 1.53 1.16 1.46 1.56 1.36 1.72 1.70 1.15 1.18 1.55 1.94 1.44 1.47 1.62 1.29 1.31 1.49 1.15 1.22 1.31 1.24 1.33 1.65 1.27 1.26 1.50 1.19 1.29 1.63 1.35 1.41 1.23 1.29 1.38 1.37 1.41 1.13 1.39 1.18 1.28 1.29 1.18 1.19 1.29 1.26 1.37 1.51 1.43 1.41 1.27 1.35 1.23 1.32 1.46 1.32 1.41 1.31 1.25 1.21 1.55 1.38 1.23 10 C074R167 C002R100 C084R110 C131R046 C135R166 C043R087 C185R128 C031R158 C078R140 C048R097 C118R132 C188R163 C203R062 C080R079 C068R076 C115R053 C030R156 C224R065 C138R068 C031R128 C184R075 C195R152 C050R102 C030R160 C215R130 C062R103 C219R070 C103R116 C135R126 protein manbal pol-like protein hypothetical protein PCYB_123530 n-acylneuraminate cytidylyltransferase insulinoma-associated protein 1-like low quality protein: ornithine decarboxylase antizyme 2 calpain (m ii) large subunit plasminogen activator inhibitor 1 rna-binding protein isoform 4 p53 apoptosis effector related to pmp-22 transmembrane protein 50a cyclin i UNKNOWN scel protein cyclin-dependent kinase 4 inhibitor b dopachrome tautomerase udp-n-acetylhexosamine pyrophosphorylase-like phosphorylase b kinase gamma catalytic skeletal muscle isoform envoplakin-like small g protein signaling modulator 1-like transmembrane and coiled-coil domain-containing protein 1 protein fam3c-like scel protein upf0414 transmembrane protein c20orf30 homolog translocator protein ras-related protein rab-25 UNKNOWN transmembrane protein 60 transmembrane emp24 domain-containing protein 4 UNKNOWN 1.35 1.35 1.35 1.34 1.33 1.33 1.33 1.32 1.32 1.32 1.32 1.32 1.32 1.32 1.32 1.31 1.31 1.30 1.30 1.30 1.30 1.30 1.29 1.28 1.28 1.27 1.27 1.27 1.26 1.61 1.46 1.25 1.43 1.36 1.25 1.49 1.50 1.16 1.68 1.44 1.37 1.67 1.55 1.23 1.24 1.20 1.47 1.45 1.40 1.31 1.51 1.47 1.40 1.53 1.22 1.39 1.41 1.20 1.35 1.34 1.35 1.23 1.49 1.28 1.37 1.36 1.53 1.15 1.27 1.34 1.07 1.15 1.55 1.58 1.34 1.32 1.16 1.23 1.31 1.08 1.32 1.28 1.15 1.27 1.20 1.23 1.22 1.14 1.25 1.44 1.40 1.15 1.48 1.14 1.14 1.26 1.19 1.23 1.25 1.30 1.29 1.21 1.14 1.39 1.17 1.32 1.28 1.27 1.34 1.11 1.18 1.20 1.33 1.20 1.19 1.38 11 C045R094 C105R094 C168R138 C229R087 C150R077 C154R123 C253R055 C115R023 C139R132 C146R131 C161R096 C075R094 C144R110 C232R114 C231R113 C107R039 C144R089 C151R102 C059R097 C012R051 C182R064 C129R072 C101R057 C223R091 C132R061 C159R165 C101R107 C149R114 C229R153 mitochondrial fission process protein 1 dehydrogenase reductase sdr family member 1 sodium- and chloride-dependent taurine transporter mrna turnover protein 4 homolog rwd domain-containing protein 1 wd repeat domain 46 26s protease regulatory subunit 8 wd repeat-containing protein 75 dna (cytosine-5)-methyltransferase 1-like small nuclear ribonucleoprotein sm d3 nuclear pore complex protein nup160 phosphoribosylaminoimidazole phosphoribosylaminoimidazole UNKNOWN translation initiation factor eif-2b subunit delta-like ribosomal rna small subunit methyltransferase nep1-like 39s ribosomal protein mitochondrial precursor upf0609 protein c4orf27 homolog UKNOWN UNKNOWN steroid receptor rna activator 1 transposable element tcb1 transposase adenylosuccinate lyase delta-like protein b-like lamin-b receptor dna (cytosine-5)-methyltransferase 1 atp synthase-coupling factor mitochondrial precursor h aca ribonucleoprotein complex subunit 1 general transcription factor 3c polypeptide 6 endoplasmin precursor 1.26 1.24 1.23 0.87 0.86 0.86 0.85 0.85 0.85 0.84 0.84 0.84 0.84 0.84 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.83 0.82 0.82 1.31 1.36 1.19 0.84 0.80 0.92 0.76 0.87 0.86 0.79 0.74 0.80 0.70 0.72 0.71 0.74 0.71 0.77 0.75 0.69 0.70 0.75 0.87 0.63 0.76 0.92 0.72 0.77 0.76 1.13 1.23 1.24 0.87 0.85 0.84 0.89 0.81 0.86 0.89 0.93 0.89 0.98 0.85 0.87 0.87 0.93 0.89 1.01 0.94 0.83 0.88 0.81 1.01 0.88 0.82 0.94 0.93 0.84 1.34 1.14 1.27 0.89 0.94 0.82 0.91 0.86 0.82 0.86 0.87 0.84 0.85 0.95 0.95 0.90 0.86 0.83 0.73 0.90 0.96 0.86 0.80 0.87 0.85 0.76 0.83 0.79 0.87 12 C153R084 C205R011 C042R030 C026R007 C147R098 C155R025 C237R086 C148R030 C056R087 C148R076 C057R087 C131R041 C170R082 C163R052 C182R067 C221R081 C090R023 C007R133 C122R116 C011R073 C030R063 C259R138 C086R088 C131R042 C123R043 C258R130 C157R093 C194R147 C259R081 atp-dependent rna helicase dhx8 methylcrotonoyl- carboxylase beta mitochondrial tyrosine-protein kinase 223-like protein disulfide-isomerase a5-like tyrosine--trna cytoplasmic cell adhesion molecule 4-like guanine nucleotide-binding 3-like nostrin isoform 1 deoxycytidine kinase exportin-1 transposable element tcb1 transposase cell differentiation protein rcd1 homolog zinc finger protein 62 homolog UNKNOWN transcriptional repressor ctcf-like myosin light chain 3 eukaryotic initiation factor 4a-iii survival motor neuron protein 1 UNKNOWN UNKNOWN UNKNOWN nedd4-like e3 ubiquitin-protein ligase wwp2 acidic leucine-rich nuclear phosphoprotein 32 family member a monocarboxylate transporter 2-like prickle-like protein 2 protein smg8-like peptidyl-trna hydrolase mitochondrial precursor gmp reductase 1 proliferating cell nuclear antigen 0.82 0.82 0.82 0.82 0.82 0.82 0.82 0.82 0.82 0.82 0.82 0.82 0.81 0.81 0.81 0.81 0.81 0.81 0.81 0.81 0.81 0.81 0.81 0.81 0.81 0.81 0.81 0.81 0.81 0.64 0.82 0.63 0.69 0.77 0.71 0.82 0.84 1.00 0.79 0.65 0.75 0.75 0.68 0.74 0.87 0.77 0.73 0.79 0.66 0.83 0.78 0.63 0.68 0.79 0.69 0.74 0.81 0.79 1.02 0.72 0.89 0.88 0.85 0.87 0.85 0.84 0.71 0.87 0.95 0.83 0.80 0.76 0.90 0.75 0.91 0.90 0.75 0.96 0.90 0.65 0.88 0.96 0.87 0.86 0.97 0.72 0.81 0.86 0.94 0.96 0.93 0.84 0.90 0.80 0.78 0.77 0.80 0.88 0.90 0.89 1.01 0.81 0.83 0.77 0.81 0.88 0.84 0.71 1.02 0.90 0.82 0.77 0.90 0.75 0.90 0.82 13 C189R165 C200R099 C111R137 C210R031 C199R164 C146R082 C034R093 C089R012 C165R091 C122R068 C148R099 C109R127 C230R124 C080R163 C200R070 C204R141 C244R043 C157R127 C029R115 C162R085 C165R010 C227R073 C199R161 C031R022 C186R059 C208R015 C251R045 C097R015 C008R125 UNKNOWN pre-rrna-processing protein tsr1 homolog gmp reductase 1 tubulin alpha-1c chain- partial rrp12-like protein rna-binding protein 28 isoform 2 transmembrane and tpr repeat-containing protein 4 u5 small nuclear ribonucleoprotein 40 kda protein protein emsy ttnl protein sjchgc04011 protein placenta-specific protein 9-like nucleolar protein 14 importin subunit alpha-2 eh domain-binding protein 1-like protein 1 plastin-2 isoform 1 kinesin-like protein kif23 cytochrome c oxidase subunit mitochondrial precursor translational activator gcn1 coiled-coil domain-containing protein 43 poly lipoprotein lipase neuronal growth regulator 1-like sorbitol dehydrogenase reticulon 2 cytochrome b-c1 complex subunit mitochondrial precursor cyclin-dependent kinases regulatory subunit 2 dna replication licensing factor mcm3 lysine-specific histone demethylase 1a-like 0.81 0.81 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.80 0.59 0.73 0.68 0.76 0.92 0.78 0.68 0.92 0.62 0.76 0.74 0.68 0.70 0.70 0.85 0.81 0.79 0.73 0.70 0.78 0.73 0.65 0.79 0.79 0.90 0.88 0.81 1.01 0.65 0.94 0.85 0.84 0.76 0.82 0.81 1.02 0.67 0.85 0.75 0.75 0.89 0.93 1.02 0.62 0.76 0.80 0.82 0.91 0.85 0.72 0.92 0.83 0.86 0.69 0.64 0.78 0.69 0.81 0.92 0.85 0.89 0.90 0.69 0.82 0.71 0.80 0.94 0.90 0.91 0.86 0.80 0.69 0.92 0.82 0.81 0.84 0.80 0.77 0.96 0.85 0.78 0.75 0.82 0.87 0.81 0.73 0.95 14 C201R019 C208R145 C186R110 C154R024 C236R160 C177R153 C094R091 C234R130 C162R042 C161R086 C186R097 C078R131 C194R076 C202R064 C210R163 C236R099 C216R118 C045R038 C265R142 C112R036 C106R091 C089R007 C162R077 C038R017 C202R116 C167R146 C064R063 C266R147 C005R123 protein mon2 homolog glutamate-rich wd repeat containing 1 homeodomain protein 2b UNKNOWN cytochrome c oxidase polypeptide vic-2 structural maintenance of chromosomes protein 2 n-alpha-acetyltransferase auxiliary subunit dna mismatch repair protein msh6 isoform 2 cleavage and polyadenylation specificity factor subunit 6 small subunit processome component 20 homolog ctp synthase 1-like proteasome subunit beta type-7 precursor targeting protein for xklp2 nucleolar protein 6-like e3 sumo-protein ligase 2 nuclear autoantigenic sperm protein interferon-induced guanylate-binding protein 1 beta-parvin isoform x1 sjchgc04011 protein dna repair protein xrcc1-like UNKNOWN 39s ribosomal protein mitochondrial-like PREDICTED: uncharacterized protein LOC101166494 novel protein e-cadherin UNKNOWN cd83 cytoplasmic dynein 2 light intermediate chain 1-like importin 5 sjchgc09650 protein 0.80 0.80 0.80 0.80 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.79 0.78 0.60 0.77 0.73 0.70 0.86 0.67 0.88 0.76 0.61 0.74 0.68 0.70 0.88 0.78 0.88 0.80 0.78 0.59 0.78 0.80 0.75 0.75 0.75 0.65 0.61 0.76 0.67 0.59 0.73 0.99 0.84 0.71 0.81 0.79 0.81 0.81 0.81 0.72 0.78 1.02 0.91 0.77 0.90 0.81 0.74 0.75 0.76 0.85 0.85 0.78 0.84 0.91 0.88 0.95 0.71 0.70 0.90 0.87 0.83 0.78 0.92 0.87 0.74 0.92 0.71 0.81 1.03 0.84 0.74 0.78 0.73 0.71 0.69 0.83 0.84 1.02 0.73 0.73 0.85 0.78 0.73 0.86 0.84 0.90 1.02 0.91 15 C159R170 C165R160 C164R145 C007R074 C090R110 C098R134 C099R059 C226R078 C243R073 C003R029 C114R077 C194R145 C243R102 C011R098 C183R051 C169R012 C172R088 C083R023 C075R131 C174R122 C258R070 C120R007 C019R161 C142R018 C141R102 C169R045 C190R020 C042R058 C259R019 UNKNOWN 60s ribosomal protein l22-like 1-like enhancer of zeste homolog 2 (enx-1) isoform cra_a zw10 interactor-like ribose-5-phosphate isomerase bis(5 -nucleosyl)-tetraphosphatase 40s ribosomal protein s13 epidermal growth factor-like protein 7-like trimeric intracellular cation channel type a multidrug resistance-associated protein 1-like 14 kda phosphohistidine phosphatase 60s ribosomal protein l3-like g-protein coupled receptor 182 tropomodulin 4 cysteine-rich protein 1 UNKNOWN eukaryotic translation initiation factor 4e structural maintenance of chromosomes protein 2 uracil nucleotide cysteinyl leukotriene receptor-like UNKNOWN sjoegren syndrome scleroderma autoantigen 1 glutaminyl-peptide cyclotransferase-like probable cUNKNOWN UNKNOWN protein fam212a-like ribonucleoside-diphosphate reductase large subunit cytochrome c oxidase subunit vib isoform 1 UNKNOWN 0.79 0.79 0.79 0.79 0.79 0.79 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.63 0.81 0.60 0.87 0.90 0.70 0.80 0.74 0.80 0.62 0.77 0.91 0.60 0.74 0.93 0.54 0.70 0.92 0.65 0.86 0.64 0.79 0.85 0.67 0.52 0.73 0.97 0.67 0.79 0.87 0.69 1.01 0.85 0.75 0.86 0.80 0.81 0.75 0.88 0.78 0.66 1.05 0.77 0.67 0.74 0.95 0.73 0.69 0.71 0.80 0.68 0.88 0.72 0.92 0.76 0.62 0.99 0.77 0.86 0.85 0.80 0.62 0.70 0.80 0.76 0.80 0.81 0.89 0.80 0.80 0.73 0.84 0.77 1.10 0.73 0.68 1.05 0.78 0.92 0.88 0.62 0.94 0.89 0.86 0.80 0.76 0.78 16 C176R096 C184R019 C039R055 C229R033 C028R034 C238R056 C228R155 C013R120 C167R128 C266R135 C252R104 C030R134 C160R007 C200R114 C021R165 C229R095 C236R133 C200R073 C172R133 C199R053 C266R068 C131R120 C008R116 C255R041 C121R162 C103R142 C092R009 C128R054 C243R052 dna-directed rna polymerases and iii subunit rpabc5 UKNOWN aspartic acid-rich protein aspolin2 exosome complex exonuclease rrp44 nuclear transport factor 2 zinc finger protein 503 calsequestrin-1-like zinc finger protein 703-like protein-glutamine gamma-glutamyltransferase 2 hydroxyacid oxidase 2 hemoglobin subunit beta-1 UKNOWN UKNOWN transitional endoplasmic reticulum atpase-like kinesin-like protein kif11-like UKNOWN UNKNOWN drebrin-like protein epidermis-type lipoxygenase 3-like disabled homolog 2-interacting malcavernin-like protein calumenin isoform x1 beta-catenin-like protein 1 UNKNOWN nicotinamide riboside kinase 2 nidogen-1 low quality protein: dedicator of cytokinesis protein 10-like nucleolar protein 14 protein unc-79 homolog 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.64 0.61 0.62 0.73 0.63 0.78 0.76 0.50 0.76 0.90 0.67 0.61 0.75 0.59 0.70 0.62 0.61 0.67 0.62 0.68 0.53 0.60 0.77 0.70 0.65 0.78 0.71 0.70 0.74 0.88 0.92 0.93 0.68 0.93 0.81 0.70 0.93 0.76 0.63 0.73 0.90 0.73 0.78 0.94 0.88 0.76 0.72 0.77 0.83 0.76 0.90 0.80 0.90 0.80 0.77 0.70 0.86 0.69 0.86 0.86 0.82 0.93 0.87 0.73 0.87 0.95 0.82 0.84 0.95 0.85 0.86 0.97 0.72 0.85 0.93 0.95 0.93 0.82 1.06 0.88 0.76 0.74 0.88 0.76 0.92 0.78 0.90 17 C252R069 C158R131 C155R100 C016R017 C012R050 C017R158 C234R065 C118R070 C071R100 C206R043 C013R156 C147R067 C070R024 C053R114 C240R151 C065R122 C175R071 C248R116 C132R050 C147R022 C103R092 C209R016 C063R090 C154R066 C234R112 C262R052 C107R060 C014R147 C155R168 laminin subunit alpha-2 interferon-induced guanylate-binding protein 1 noggin-3 precursor filamin-c-like isoform 1 small glutamine-rich tetratricopeptide repeat-containing protein thioredoxin-like protein 1 wd repeat-containing protein 34 intracellular hyaluronan-binding protein 4 interleukin-1 receptor accessory protein isoform x2 probable atp-dependent rna helicase ddx27 receptor-type tyrosine-protein phosphatase c-like PREDICTED: ankyrin-1-like ran gtpase-activating protein 1-like doublesex- and mab-3-related transcription factor a1 conserved oligomeric golgi complex subunit partial rho-related gtp-binding protein protein transport protein sec61 subunit gamma phenylalanine--trna ligase alpha subunit enterin neuropeptide 28s ribosomal protein mitochondrial rotatin UNKNOWN centromere protein u-like nuclear pore complex protein nup107 dihydrolipoyllysine-residue acetyltransferase component of interferon-induced guanylate-binding protein 1 u6 snrna-associated sm-like protein lsm5 suppressor of g2 allele of skp1 homolog nuclear pore complex protein nup205 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.76 0.71 0.75 0.74 0.72 0.59 0.78 0.72 0.82 0.85 0.79 0.80 0.70 0.69 0.76 0.69 0.65 0.69 0.64 0.77 0.78 0.51 0.92 0.64 0.72 0.69 0.86 0.68 0.75 0.74 0.75 0.73 0.80 0.72 0.91 0.89 0.78 0.74 0.69 0.83 0.68 0.70 0.92 0.92 0.77 0.82 0.83 0.88 0.69 0.66 1.02 0.67 1.05 0.81 0.89 0.59 0.83 0.62 0.85 0.85 0.84 0.79 0.90 0.86 0.67 0.81 0.75 0.77 0.70 0.82 0.92 0.75 0.65 0.85 0.83 0.79 0.82 0.88 0.86 0.85 0.75 0.60 0.78 0.73 0.89 0.80 0.98 0.70 18 C200R015 C253R040 C199R103 C200R045 C179R059 C180R083 C161R031 C141R091 C187R119 C118R021 C149R123 C013R130 C207R017 C056R089 C099R054 C014R141 C124R010 C187R133 C229R119 C248R102 C263R100 C224R160 C147R120 C096R085 C255R076 C204R057 C177R137 C194R011 C124R049 UNKNOWN forkhead box protein d1-like UNKNOWN dna polymerase alpha subunit b UNKNOWN tropomodulin 4 breast cancer type 2 susceptibility kinesin-like protein kif2c tetratricopeptide repeat protein 4-like UNKNOWN nexilin zinc finger mym-type protein 1-like UNKNOWN troponin slow skeletal and cardiac muscles ribosome production factor 2 homolog dna-directed rna polymerase i subunit rpa43 mitochondrial inner membrane protease subunit 1 methionine synthase reductase protection of telomeres protein 1 26s proteasome non-atpase regulatory subunit 2 xin actin-binding repeat-containing protein 1-like intraflagellar transport protein 88 homolog tetratricopeptide repeat protein 40 ras-interacting protein 1 UNKNOWN lariat debranching enzyme 40s ribosomal protein s10 nuclear distribution protein nude homolog 1-like UNKNOWN 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.79 0.78 0.71 0.93 0.90 0.75 0.69 0.85 0.61 0.69 0.88 0.65 0.90 0.74 0.68 0.69 0.68 0.55 0.71 0.68 0.54 0.67 0.72 0.61 0.70 0.95 0.76 0.67 0.50 0.58 0.77 0.78 0.66 0.74 0.70 0.77 0.66 0.83 0.70 0.68 0.86 0.71 0.91 0.89 0.71 0.73 0.91 0.88 0.76 0.79 0.87 0.55 0.99 0.66 0.73 0.75 0.72 0.95 0.95 0.74 0.80 0.72 0.64 0.84 0.83 0.77 0.87 0.85 0.75 0.79 0.70 0.66 0.71 0.89 0.88 0.82 0.71 0.84 0.96 0.77 1.02 0.75 0.90 0.65 0.76 0.89 0.89 19 C120R070 C118R086 C206R024 C227R025 C098R135 C159R044 C128R056 C072R096 C248R039 C099R013 C264R020 C111R078 C243R144 C264R125 C010R028 C205R170 C083R044 C079R070 C059R005 C149R046 C147R007 C077R044 C266R051 C254R073 C068R013 C169R059 C085R023 C004R153 C179R095 endothelin-converting enzyme 2 nad mitochondrial-like dihydrofolate reductase regulator of g-protein signaling 5-like protein reticulon 2 epidermis-type lipoxygenase 3-like UNKNOWN UKNOWN UNKNOWN 4-hydroxyphenylpyruvate dioxygenase-like protein translation machinery-associated protein 16 UKNOWN haus augmin-like complex subunit 6-like nicotinamide riboside kinase 2 dna topoisomerase 2-alpha nebulin-related-anchoring protein lim-domain binding factor 3 dna topoisomerase 2-binding protein 1 trimeric intracellular cation channel type a transcription elongation regulator 1-like UNKNOWN UNKNOWN nucleolar protein 14 allograft inflammatory factor 1 immunoglobulin light chain dnaj homolog subfamily c member 25-like camp-regulated phosphoprotein 19 tropomodulin 4 cdkn2aip n-terminal-like protein 0.76 0.76 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.81 0.72 0.83 0.86 0.64 0.72 0.55 0.65 0.69 0.70 0.91 0.67 0.69 0.70 0.78 0.55 0.74 0.58 0.95 0.67 0.64 0.58 0.83 0.67 0.79 0.59 0.59 0.67 0.72 0.84 0.81 0.84 0.71 0.82 0.67 0.80 0.92 0.66 0.72 0.66 0.68 0.75 0.83 0.77 0.97 0.68 1.01 0.58 0.66 0.76 0.85 0.65 0.63 0.56 0.85 0.86 0.75 0.81 0.61 0.74 0.61 0.69 0.82 0.87 0.99 0.74 0.94 0.85 0.73 0.90 0.81 0.73 0.69 0.79 0.82 0.74 0.75 0.94 0.83 0.85 0.78 0.90 0.91 0.87 0.78 0.84 0.73 20 C052R082 C172R050 C209R138 C118R149 C124R008 C063R091 C159R115 C181R067 C244R015 C001R099 C003R047 C107R105 C006R050 C072R014 C258R021 C129R093 C151R012 C073R133 C055R090 C261R017 C142R098 C211R109 C157R015 C092R066 C207R016 C063R052 C206R027 C193R017 C263R062 elongation factor 2 protein cip2a homolog enhancer of rudimentary homolog UNKNOWN protein canopy homolog 4 homologous-pairing protein 2 homolog cytochrome c oxidase subunit 4 isoform mitochondrial precursor reticulon 2b homeobox protein 3ab UNKNOWN inner centromere protein cellular retinoic acid-binding protein 2-like inner centromere protein cholesteryl ester transfer protein UNKNOWN UKNOWN taxilin beta muscle-derived protein 77-like UNKNOWN rna-binding protein 38-like collagen alpha-3 chain-like UKNOWN UKNOWN aspartyl aminopeptidase interferon-related developmental regulator 2 39s ribosomal protein mitochondrial major egg antigen UNKNOWN general transcription factor iie subunit 1 ox-2 membrane glyco 0.75 0.75 0.75 0.75 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.72 0.80 0.61 0.62 0.66 0.52 0.67 0.73 0.69 0.59 0.75 0.62 0.82 0.81 0.78 0.57 1.03 0.80 0.60 0.65 0.62 0.76 0.75 0.63 0.85 0.70 0.64 0.63 0.97 0.67 0.78 0.89 0.84 0.70 0.85 0.74 0.63 0.62 0.73 0.73 1.03 0.64 0.51 0.66 1.19 0.46 0.65 0.79 0.75 0.69 0.69 0.61 0.97 0.78 0.71 0.75 0.68 0.78 0.85 0.67 0.78 0.79 0.94 0.89 0.82 0.92 0.91 0.90 0.75 0.66 0.79 0.94 0.81 0.62 0.84 0.77 0.89 0.82 0.90 0.78 0.87 0.68 0.63 0.83 0.83 0.91 0.48 21 C252R074 C094R014 C074R053 C021R144 C075R111 C143R060 C116R096 C216R131 C031R021 C250R019 C054R036 C176R122 C167R086 C166R008 C102R168 C201R166 C259R025 C066R097 C234R113 C202R083 C228R095 C159R030 C125R071 C255R047 C232R031 C255R040 C260R058 C115R138 C229R063 targeting protein for xklp2 nuclear transport factor 2 troponin slow skeletal and cardiac muscles UNKNOWN acyl- synthetase family member mitochondrial UNKNOWN 60s ribosomal protein l22-like 1-like triadin lumican small subunit processome component 20 homolog tsc22 domain family protein 3-like UNKNOWN rrna-processing protein fcf1 homolog low quality protein: coagulation factor viii-like vasorin-like isoform x1 solute carrier family facilitated glucose transporter member 3mrna turnover protein 4 homolog nicotinamide riboside kinase 2 chromosome-associated kinesin kif4a fatty acid-binding intestinal condensin complex subunit 1-like sulfotransferase 6b1 set and mynd domain-containing protein 1-like isoform 1 origin recognition complex subunit 5 UNKNOWN lim-domain binding factor 3 transmembrane protein 88-like myosin binding protein cardiac von willebrand factor d and egf domain-containing 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.72 0.72 0.61 0.59 0.60 0.48 0.79 0.61 0.46 0.65 0.66 0.64 0.78 0.78 0.44 0.60 0.76 0.53 0.60 0.63 0.87 0.62 0.69 0.71 0.60 0.87 0.55 0.75 0.81 0.83 0.71 0.98 0.80 0.92 0.76 0.67 0.84 0.80 0.64 0.72 0.86 0.74 0.58 1.02 0.86 0.71 0.94 0.96 1.00 0.69 0.76 0.64 0.82 0.56 0.66 0.79 0.72 0.64 0.66 0.79 0.69 0.82 0.72 0.95 0.73 0.77 1.02 0.88 0.84 0.74 0.70 0.84 0.84 0.75 0.73 0.81 0.70 0.66 0.66 0.85 0.85 0.67 0.96 0.69 0.87 0.71 0.74 22 C168R019 C157R071 C119R005 C201R116 C155R037 C138R131 C091R016 C077R054 C245R120 C144R062 C166R011 C129R146 C202R057 C230R011 C077R015 C021R009 C144R158 C214R057 C248R111 C142R031 C018R118 C213R105 C162R130 C232R021 C100R109 C230R162 C056R050 C231R007 C141R170 krueppel-like factor 11-like dna-directed rna polymerase i subunit rpa1 structural maintenance of chromosomes protein 4 dna repair protein rad51 homolog 1 basal cell adhesion molecule precursor von willebrand factor d and egf domain-containing probable ctransmembrane protein 131-like clip-associating protein 2-like nadp-dependent malic mitochondrial-like ran gtpase-activating protein 1-like catenin beta-1 nuclear autoantigenic sperm protein (histone-binding) neutral alpha-glucosidase ab-like UNKNOWN lim-domain binding factor 3 trans- -enoyl- reductase-like UNKNOWN dual specificity protein kinase ttk transforming growth factor-beta-induced protein ig-h3 fermitin family homolog 1 UNKNOWN protein regulator of cytokinesis 1 zinc finger protein 207 26s proteasome complex subunit dss1 cofilin-2 polyadenylate-binding protein 4 UNKNOWN tonsoku-like protein 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.59 0.61 0.75 0.76 0.64 0.75 0.78 0.44 0.44 0.69 0.67 0.72 0.68 0.70 0.46 0.66 0.66 0.66 0.70 0.62 0.46 0.65 0.67 0.58 0.68 0.56 0.77 0.63 0.65 0.73 0.80 0.65 0.85 0.75 0.75 0.62 0.92 0.90 0.66 0.66 0.75 0.82 0.63 0.82 0.60 0.62 0.79 0.67 0.81 0.93 0.78 0.92 0.79 0.73 0.78 0.71 0.71 0.62 0.87 0.80 0.79 0.58 0.80 0.69 0.79 0.89 0.91 0.85 0.88 0.72 0.70 0.87 1.01 0.94 0.88 0.73 0.83 0.77 0.94 0.76 0.60 0.83 0.77 0.85 0.70 0.82 0.88 23 C244R099 C207R024 C176R058 C039R082 C158R046 C199R109 C151R067 C244R012 C049R111 C106R090 C238R116 C048R037 C158R037 C135R063 C090R149 C125R039 C103R023 C085R011 C233R161 C260R098 C021R155 C120R115 C047R128 C169R048 C171R162 C177R128 C198R157 C204R020 C123R129 UNKNOWN UKNOWN disabled homolog 2 isoform 1 perforin-1-like myomesin-3 small nuclear ribonucleoprotein f musculoskeletal embryonic nuclear protein 1 t-box 1 acetolactate synthase-like protein high choriolytic enzyme 1 precursor ankyrin repeat domain-containing protein 1-like UNKNOWN histone-arginine methyltransferase carm1 zinc finger protein 135-like UNKNOWN laminin subunit beta-2-like UKNOWN UKNOWN kinesin-like protein kif11 procollagen c-endopeptidase enhancer 2-like smoothelin-like protein 2-like rho-related gtp-binding protein protein apcdd1-like heat shock cognate 71 kda ubiquitin-like modifier-activating enzyme 1-like UKNOWN UNKNOWN nipped-b-like protein fish virus induced trim protein 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.54 0.71 0.73 0.61 0.62 0.67 0.71 0.46 0.73 0.57 0.63 0.87 0.73 0.56 0.51 0.69 0.41 0.90 0.78 0.63 0.51 0.70 0.53 0.71 0.46 0.94 0.58 0.62 0.55 0.68 0.63 0.77 0.69 0.64 0.88 0.62 0.78 0.87 0.80 0.85 0.90 0.61 0.90 0.84 0.63 0.83 0.38 0.78 0.86 0.79 0.72 1.08 0.56 0.88 0.82 0.67 0.74 0.87 0.91 0.84 0.69 0.83 0.90 0.67 0.88 0.98 0.63 0.85 0.68 0.49 0.81 0.78 0.83 0.84 0.92 0.88 0.62 0.69 0.85 0.73 0.69 0.90 0.83 0.47 0.88 0.78 0.81 24 C260R062 C178R073 C154R042 C062R074 C186R121 C181R064 C120R016 C122R078 C021R017 C232R006 C224R013 C056R114 C122R121 C209R137 C238R022 C026R169 C148R122 C108R169 C165R019 C104R068 C264R138 C233R116 C245R019 C066R037 C148R165 C155R170 C137R058 C018R027 C112R163 mitotic checkpoint serine threonine-protein kinase bub1 dep domain-containing protein 7-like UNKNOWN kinesin-like protein kif20b complement c4-like guanidinoacetate n-methyltransferase liprin-beta-2- partial UNKNOWN cytoskeleton-associated protein 2 UNKNOWN forkhead box protein n3-like heat repeat-containing protein 3 tyrosyl-dna phosphodiesterase 2-like UNKNOWN histone-arginine methyltransferase carm1-like fanconi anemia group d2 protein ect2-like solute carrier family 30 (zinc transporter) member 1 sodium channel subunit beta-1-like myozenin 1 nucleosome-remodeling factor subunit bptf transferrin precursor pleckstrin homology domain-containing family m member 1 thrombospondin-3 isoform 3 mitotic spindle assembly checkpoint protein mad2a homeobox protein hox-b2a-like inhibitor of nuclear factor kappa-b kinase-interacting protein UNKNOWN serine threonine-protein kinase 35-like 0.72 0.72 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.70 0.61 0.83 0.62 0.88 0.35 0.75 0.57 0.39 0.66 0.72 0.54 0.61 0.54 0.57 0.60 0.67 0.77 0.64 0.58 0.59 0.49 0.73 0.62 0.59 0.75 0.58 0.58 0.76 0.69 0.84 0.89 0.71 0.61 0.95 0.61 0.83 1.02 0.79 0.55 0.72 0.78 0.83 0.79 0.81 0.83 0.81 0.83 0.71 0.70 0.77 0.49 0.64 0.77 0.97 0.89 0.76 0.71 0.73 0.70 0.52 0.82 0.70 0.96 0.78 0.75 0.89 0.71 0.89 0.88 0.78 0.80 0.73 0.76 0.67 0.57 0.71 0.89 0.85 0.90 0.97 0.83 0.77 0.46 0.70 0.83 0.64 0.69 25 C138R017 C154R064 C184R049 C161R007 C118R080 C250R023 C020R012 C194R062 C221R097 C241R063 C150R052 C169R060 C176R150 C263R149 C138R160 C142R032 C140R003 C213R109 C122R033 C203R016 C125R129 C102R043 C232R118 C224R128 C183R018 C188R033 C260R027 C110R010 C205R023 b-cell receptor-associated protein 29 macrophage receptor marco translation initiation factor eif-2b subunit delta-like forkhead box protein l1-like protein polybromo-1 probable phospholipid-transporting atpase vd-like solute carrier family 41 member 3-like isoform 1 mitochondrial nadh-ubiquinone oxidoreductase 75 kda subunit far upstream element-binding protein 2-like cysteine and histidine-rich domain-containing protein 1-like 40s ribosomal protein s10 UNKNOWN non-syndromic hearing impairment protein 5 cd3 epsilon lim-domain binding factor 3 cysteine and histidine-rich domain-containing protein 1-like lysozyme g kinesin-like protein kif23 whey acidic protein precursor n-acetyltransferase esco2-like plastin-1 myozenin 1-like rna-binding protein fus UNKNOWN UNKNOWN zinc finger and scan domain-containing protein 25-like isoform tetratricopeptide repeat protein 39a-like actin-related protein 2 3 complex subunit 2 dna mismatch repair protein msh2-like 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.71 0.65 0.47 0.72 0.57 0.48 0.80 0.43 0.45 0.78 0.60 0.67 0.66 0.80 0.58 0.72 0.65 0.91 0.71 0.89 0.46 0.67 0.43 0.67 0.63 0.52 0.48 0.58 0.98 0.56 0.72 0.97 0.57 0.73 0.80 0.55 1.08 0.79 0.55 0.67 0.62 0.68 0.57 0.78 0.57 0.64 0.61 0.48 0.61 0.89 0.58 0.88 0.81 0.52 0.82 0.64 0.61 0.56 0.83 0.73 0.86 0.87 0.81 0.86 0.75 0.85 0.89 0.79 0.88 0.81 0.74 0.75 0.75 0.80 0.79 0.60 0.87 0.64 0.85 0.85 0.85 0.61 0.90 0.78 0.95 1.01 0.55 26 C166R010 C249R065 C020R060 C251R131 C043R036 C157R055 C045R067 C136R130 C207R092 C154R022 C153R133 C118R101 C156R042 C159R032 C213R078 C074R021 C170R129 C187R163 C039R096 C029R028 C027R031 C257R035 C233R016 C178R159 C030R055 C099R026 C229R120 C175R061 C249R024 plac8-like protein 1 ankyrin repeat and socs box protein 14-like nck-associated protein 1-like serine threonine-protein kinase greatwall-like splicing factor 3b subunit 1 UNKNOWN transporter-associated with antigen processing 1 telomeric repeat-binding factor 2 nuclear transport factor 2 non-syndromic hearing impairment protein 5 UNKNOWN protein-tyrosine kinase 2-beta-like dna-directed rna polymerases and iii subunit rpabc4 rotatin UNKNOWN UNKNOWN atp-dependent dna helicase q4 cell division control protein 2 homolog myogenin adenylosuccinate lyase UNKNOWN atp-binding cassette sub-family f member 3-like pcna-associated factor alpha-aminoadipic semialdehyde dehydrogenase atpase family aaa domain-containing protein 2 esophageal cancer-related gene 4 protein precursor centrosomal protein of 135 kda cytochrome c oxidase polypeptide vic-2 lim-domain binding factor 3 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.62 0.53 0.42 0.55 0.51 0.51 0.60 0.39 0.55 0.60 0.52 0.51 0.56 0.53 0.51 0.64 0.51 0.69 0.44 0.52 0.74 0.93 0.73 0.45 0.63 0.67 0.37 0.49 0.80 0.53 0.74 0.83 0.73 0.89 0.65 0.76 0.91 0.86 0.58 0.83 0.74 0.87 0.69 0.77 0.64 0.81 0.75 0.92 0.71 0.62 0.60 0.66 0.86 0.75 0.59 0.71 0.78 0.71 0.86 0.81 0.95 0.79 0.79 0.89 0.72 0.81 0.75 0.84 0.76 0.83 0.70 0.84 0.81 0.79 0.75 0.61 0.73 0.93 0.70 0.54 0.65 0.77 0.68 0.80 0.98 0.89 0.53 27 C076R085 C135R074 C215R147 C221R127 C181R072 C064R015 C020R126 C056R003 C071R076 C118R014 C073R026 C233R147 C137R035 C116R024 C014R096 C062R112 C112R081 C084R013 C185R072 C137R043 C094R043 C161R081 C071R116 C063R169 C059R123 C080R082 C147R057 C111R080 C010R015 isotocin precursor kelch repeat and btb domain-containing protein 10-like UKNOWN tripartite motif-containing protein 16-like filamin a-interacting protein 1-like UNKNOWN dual specificity protein kinase ttk-like traf family member-associated nf-kappa-b activator-like zz-type zinc finger-containing protein 3 t-complex protein 1 subunit theta dna damage-inducible transcript 4-like myb-binding protein 1a very long-chain specific acyl- mitochondrial isoform 1 gonadotropin-releasing hormone 2 -deoxynucleoside 5 -phosphate n-hydrolase 1 phosphatidylinositol- -bisphosphate 3-kinase catalytic subunit e3 ubiquitin-protein ligase rnf130 cleavage and polyadenylation specificity factor subunit 7 adenylosuccinate lyase UNKNOWN trans- -dihydrobenzene- -diol dehydrogenase-like atp-binding cassette sub-family b member 9-like UNKNOWN dna mismatch repair protein msh2-like sperm-associated antigen 5 cyclin b alpha cardiac muscle 1 tumor necrosis factor ligand superfamily member 13b cd276 antigen-like 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.71 0.58 0.56 0.61 0.55 0.43 0.57 1.06 0.43 0.51 0.69 0.62 0.53 0.50 0.89 0.57 0.55 0.57 0.60 0.41 0.44 0.49 0.47 0.56 0.69 0.85 0.52 0.53 0.70 0.90 0.67 0.84 0.45 0.72 0.66 0.76 0.42 0.77 0.85 0.71 0.72 0.62 0.93 0.61 0.63 0.81 0.62 0.60 0.59 0.92 0.79 0.80 0.79 0.82 0.62 0.70 0.95 0.52 0.47 0.79 0.71 0.94 0.77 0.90 0.74 0.63 0.93 0.73 0.61 0.68 0.91 0.74 0.58 0.81 0.69 0.88 0.89 1.34 0.80 0.74 0.88 0.68 0.53 0.55 0.82 0.65 0.80 28 C165R066 C094R030 C245R046 C263R056 C221R134 C084R169 C052R059 C040R096 C186R010 C019R035 C099R123 C148R007 C072R114 C219R038 C094R169 C227R008 C107R024 C011R044 C175R023 C058R127 C229R038 C111R089 C145R103 C012R013 C156R098 C135R061 C182R034 C223R122 C088R014 rho gtpase-activating protein 24 isoform 2 UNKNOWN mucosa associated lymphoid tissue lymphoma translocation neuralized-like protein 2 inter-alpha-trypsin inhibitor heavy chain h3-like a2 protein UNKNOWN UNKNOWN eukaryotic peptide chain release factor subunit 1 f-box wd repeat-containing protein 5 phosducin-like protein rho-related gtp-binding protein UKNOWN UKNOWN myomesin-1 isoform 1 platelet-derived growth factor receptor beta hypothetical protein BRAFLDRAFT_86387 centromere protein m rna binding protein fox-1 homolog 1-like desmin heat shock protein hsp 90-alpha 1-like UKNOWN sperm-associated antigen 5 cardiac muscle alpha actin 1 beta-taxilin immunoglobulin superfamily member 10 isoform 1 si:dkeyp- protein heat shock protein beta-7 UNKNOWN 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.60 0.69 0.55 0.75 0.38 0.43 0.56 0.42 0.51 0.54 0.46 0.85 0.51 0.53 0.48 0.81 0.42 0.60 0.55 0.58 0.63 0.54 0.97 0.45 0.64 0.42 0.61 0.46 0.42 0.68 0.74 0.72 0.49 0.75 0.80 0.63 0.78 0.64 0.63 0.90 0.43 0.80 0.64 0.56 0.45 0.75 0.72 0.62 0.50 0.78 0.64 0.44 0.79 0.52 0.69 0.62 0.75 0.72 0.74 0.60 0.77 0.76 0.90 0.87 0.80 0.89 0.96 0.84 0.72 0.78 0.74 0.76 0.94 0.81 0.93 0.68 0.84 0.86 0.58 0.78 0.72 0.85 0.81 0.86 0.74 0.83 0.92 29 C160R061 C088R033 C003R061 C156R013 C140R150 C130R051 C035R018 C079R047 C178R138 C014R159 C004R141 C165R018 C161R016 C238R137 C208R126 C183R130 C261R094 C116R033 C155R048 C146R035 C259R049 C179R074 C157R130 C254R151 C110R033 C103R046 C071R019 C123R012 C006R012 protein unc-45 homolog b macrophage receptor marco aurora kinase b-like nuclear transport factor 2 UNKNOWN prostaglandin e synthase 3 acidic leucine-rich nuclear phosphoprotein 32 family member b smad nuclear-interacting protein 1 UNKNOWN ephrin type-a receptor 2-like UNKNOWN ubiquitin carboxyl-terminal hydrolase 28-like UKNOWN bchain human vinculin head (1-258) in complex with human UNKNOWN UNKNOWN platelet-derived growth factor receptor beta kelch repeat and btb domain-containing protein 12-like UNKNOWN condensin-2 complex subunit g2 leucine-rich repeat and wd repeat-containing protein 1 gmp reductase 1 UNKNOWN UKNOWN UKNOWN UNKNOWN t-complex protein 1 subunit theta UNKNOWN UNKNOWN 0.66 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.74 0.67 0.63 0.60 0.59 0.61 0.62 0.42 0.42 0.65 0.41 0.44 0.53 0.35 0.42 0.49 0.58 0.40 0.68 0.52 0.70 0.60 0.56 0.56 0.66 0.54 0.41 0.60 0.47 0.56 0.57 0.67 0.59 0.66 0.67 0.61 1.08 0.82 0.60 0.87 0.50 0.78 0.79 1.16 0.56 0.59 0.82 0.64 0.71 0.56 0.66 0.83 0.68 0.57 0.70 0.86 0.61 0.54 0.68 0.69 0.67 0.80 0.69 0.67 0.71 0.68 0.79 0.69 0.72 1.03 0.65 0.81 0.62 0.78 0.81 0.79 0.61 0.74 0.70 0.67 0.62 0.72 0.69 0.73 0.79 0.74 0.96 30 C256R034 C247R129 C013R125 C246R044 C099R024 C173R066 C084R051 C017R024 C002R144 C114R088 C174R024 C165R011 C099R030 C057R043 C239R104 C082R133 C100R002 C093R148 C108R133 C149R067 C114R022 C125R109 C253R006 C221R048 C137R106 C074R025 C201R124 C128R044 C009R091 lim-domain binding factor 3 nucleoprotein tpr glutathione peroxidase 4a chromosome transmission fidelity protein 8 homolog ap-3 complex subunit delta-1 muscle-related coiled-coil myomesin 2 p2y purinoceptor 8 myoblast determination protein 2 alpha-actinin-2 isoform 2 UNKNOWN abnormal spindle-like microcephaly-associated protein homolog pogo transposable element with krab domain-like disintegrin and metalloproteinase domain-containing protein 33 kinesin-like protein kif20b-like UNKNOWN matrix-remodeling-associated protein 8-like dna polymerase delta catalytic subunit-like alpha-ketoglutarate-dependent dioxygenase alkb homolog 2 selenoprotein p novel protein vertebrate nebulin acidic coiled-coil containing protein 3 tripartite motif-containing protein 16-like upf0193 protein evg1 isoform 2 UNKNOWN gonadotropin-releasing hormone sumo-activating enzyme subunit 2 PREDICTED: uncharacterized protein C1orf112 homolog isoform fibulin-1 precursor 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.62 0.62 0.62 0.62 0.45 0.59 0.43 0.53 0.44 0.53 0.53 0.57 0.37 0.42 0.50 0.77 0.36 0.42 0.57 0.39 0.45 0.62 0.50 0.53 0.41 0.69 0.68 0.40 0.38 0.56 0.49 0.43 0.43 0.81 0.53 0.76 0.76 0.71 0.70 0.61 0.45 0.82 0.86 0.58 0.51 0.77 0.82 0.69 0.87 0.84 0.65 0.97 0.72 0.74 0.66 0.34 1.14 0.73 0.95 0.89 0.93 0.73 0.68 0.78 0.88 0.62 0.95 0.68 0.79 0.82 0.94 0.77 0.91 0.62 0.86 0.74 0.65 0.75 0.73 0.63 0.55 0.65 0.80 0.53 0.89 0.62 0.84 0.52 0.56 0.63 0.83 31 C065R038 C160R062 C157R060 C065R162 C179R010 C118R056 C153R058 C164R085 C228R010 C016R137 C237R008 C204R156 C062R015 C169R125 C203R027 C256R075 C213R107 C241R010 C153R037 C152R011 C146R110 C073R043 C233R067 C145R100 C118R069 C264R139 C061R059 C089R008 C206R039 nadh dehydrogenase subunit 3 mothers against decapentaplegic homolog 1 ataxin-2-like isoform x4 set and mynd domain-containing protein 1-like isoform 2 light chain 12 tyrosine-protein kinase transforming protein fps-like dep domain-containing protein 1a isoform 2 prolyl endopeptidase-like integrator complex subunit 4 thyroglobulin protein casc5-like swi snf-related matrix-associated actin-dependent regulator of chromatin subfamily a-like protein 1 UNKNOWN nucleoprotein tpr complement component c1q receptor sarcosine mitochondrial cell division control protein 6 homolog t-cell surface glycoprotein cd3 zeta chain precursor alpha cardiac muscle 1 collagen alpha-1 chain myosin binding protein cardiac tetraspanin-3-like isoform 1 protein dpy-30 homolog myosin heavy chain UNKNOWN desmin protein kinase c and casein kinase substrate in neurons protein myosin-binding protein fast-type-like UNKNOWN 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.61 0.61 0.39 0.33 0.38 0.68 0.43 0.35 0.50 0.50 0.55 0.68 0.49 0.66 0.69 0.85 0.65 0.51 0.57 0.96 1.02 0.76 0.56 0.61 0.56 0.69 0.92 0.94 0.90 0.68 0.99 0.78 0.46 0.65 0.73 0.58 0.82 0.51 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.60 0.60 0.60 0.60 0.60 0.59 0.49 0.43 0.53 0.45 0.55 0.54 0.52 0.62 0.28 0.41 0.46 0.37 0.54 0.38 0.53 0.49 0.43 0.76 0.52 0.56 0.84 0.52 0.52 0.53 0.49 0.96 0.98 0.64 0.72 0.48 1.03 0.41 0.74 0.82 0.68 0.97 0.70 0.63 0.71 0.77 0.75 0.69 0.72 0.66 0.74 0.91 0.76 0.75 0.89 0.59 32 C217R085 C118R155 C018R051 C167R014 C046R150 C241R059 C047R111 C252R013 C099R019 C236R043 C067R162 C148R140 C084R162 C246R074 C090R041 C263R059 C072R005 C264R084 C139R165 C013R148 C030R046 C047R107 C198R110 C106R087 C135R056 C193R122 C224R069 C023R031 C125R078 UNKNOWN s-antigen partial endoplasmin- partial PREDICTED: uncharacterized protein LOC101486179 heat shock protein beta-1 matrilin-2 precursor myotilin isoform 1 c14orf159 protein UNKNOWN interferon inducible mx protein cyclic amp-dependent transcription factor atf-4 e3 ubiquitin-protein ligase synoviolin-like c-c motif chemokine 19 precursor zinc finger protein 51 fatty-acid amide hydrolase 2 ubiquitin-associated protein 2 UNKNOWN protein fam117a-like actinin alpha 2 UNKNOWN prostaglandin e synthase 3 lymphocyte-specific protein tyrosine kinase rrna methyltransferase mitochondrial myocilin-like actin-binding rho-activating lymphocyte-specific protein tyrosine kinase tho complex subunit 5 homolog mhc class ii alpha partial svil protein 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.57 0.39 0.57 0.62 0.54 0.57 0.42 0.25 0.39 0.61 0.53 0.38 0.29 0.60 0.55 0.54 0.35 0.58 0.56 0.41 0.61 0.61 0.37 0.36 0.49 0.39 0.26 0.31 0.41 0.39 0.65 0.81 0.70 0.43 0.52 0.61 1.10 0.41 0.50 0.83 0.67 0.70 0.39 0.63 0.64 0.65 0.41 0.47 0.77 0.56 0.48 0.78 0.62 0.59 0.49 1.01 0.91 0.66 0.69 0.75 0.52 0.45 0.76 0.74 0.82 0.76 1.02 0.67 0.48 0.77 0.89 0.67 0.63 0.60 0.81 0.73 0.73 0.72 0.58 0.64 0.71 0.74 0.66 0.81 0.65 0.68 0.65 0.85 33 C163R131 C227R065 C057R111 C064R032 C257R041 C138R009 C052R118 C169R047 C240R162 C252R157 C172R117 C260R032 C064R027 C124R109 C013R158 C098R103 C200R010 C077R041 C073R023 C107R140 C213R128 C243R086 C226R125 C044R040 C011R090 C160R142 C063R031 C254R062 C242R008 myogenin nadh dehydrogenase cysteine and glycine-rich protein 3 UNKNOWN UNKNOWN UNKNOWN UNKNOWN myocilin-like alpha cardiac muscle 1 troponin slow skeletal and cardiac muscles calcineurin b homologous protein 2 t-cell surface glycoprotein cd5-like myogenic factor 5 UNKNOWN set and mynd domain-containing protein 1-like isoform 2 fibroblast growth factor 1 t-cell receptor gamma yth domain family protein 2-like cysteine and glycine-rich protein 3 UKNOWN asc-type amino acid transporter 1-like UNKNOWN isoform cra_a ubiquitin-associated protein 1-like serine threonine-protein kinase pak 2-like caveolin-2-like ras gtpase-activating-like protein iqgap3-like inter-alpha-trypsin inhibitor heavy chain h3 UNKNOWN 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.55 0.55 0.55 0.55 0.54 0.54 0.54 0.54 0.54 0.53 0.55 0.46 0.44 0.53 0.57 0.26 0.29 0.30 0.51 0.42 0.42 0.49 0.47 0.44 0.55 0.42 0.59 0.34 0.52 0.39 0.43 0.40 0.41 0.26 0.24 0.40 0.33 0.36 0.35 0.67 1.03 0.62 0.48 0.47 0.63 1.17 0.77 0.74 0.77 0.62 0.22 0.55 0.48 0.53 0.66 0.27 0.59 0.51 0.66 0.60 0.43 0.56 0.94 1.39 0.61 0.44 0.59 0.45 0.52 0.49 0.65 0.70 0.66 0.98 0.52 0.67 0.51 0.59 0.70 0.84 0.66 0.75 0.62 0.65 0.82 0.90 0.65 0.68 0.65 0.76 0.61 0.61 0.58 0.63 0.96 0.74 0.88 34 C062R056 C116R108 C260R055 C266R127 C238R102 C206R009 C237R046 C101R089 C050R154 C010R106 C231R077 C025R008 C246R022 C100R025 C157R006 C200R008 C132R101 C197R155 C131R010 C244R017 C103R085 C164R059 C094R067 C214R036 C152R152a C147R072 C228R108 C233R135 C211R037 rna binding protein fox-1 homolog 1-like mkl myocardin-like protein 1 myosin binding protein cardiac set and mynd domain-containing protein 1-like isoform 2 beta-crystallin b3 UNKNOWN prostaglandin e synthase 3 thimet oligopeptidase UNKNOWN UNKNOWN structural maintenance of chromosomes protein 4 tropomyosin 4 inter-alpha-trypsin inhibitor heavy chain h3-like telomere-associated protein rif1 isoform x2 solute carrier family 43 member 3-like parvalbumin-7-like isoform x1 replication factor c subunit 3 UNKNOWN UNKNOWN cysteine and glycine-rich protein 3 e3 ubiquitin-protein ligase trim21-like protein UNKNOWN heat shock protein beta-1 ependymin-1 precursor asph protein ttd non-photosensitive 1 protein homolog myosin heavy chain ubiquitin thioesterase partial 0.53 0.53 0.53 0.52 0.52 0.52 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.50 0.50 0.49 0.49 0.49 0.48 0.48 0.48 0.47 0.47 0.47 0.46 0.46 0.46 0.45 0.44 0.44 0.30 0.39 0.67 0.29 0.38 0.44 0.30 0.27 0.27 0.29 0.48 0.40 0.47 0.54 0.42 0.15 0.40 0.34 0.43 0.24 0.11 0.25 0.66 0.20 0.25 0.25 0.33 0.23 0.48 0.75 0.62 0.41 0.78 0.46 0.75 0.97 0.63 0.68 0.71 0.49 0.45 0.53 0.36 0.35 1.38 0.58 0.53 0.46 0.56 0.88 0.60 0.28 0.57 0.51 0.49 0.68 0.43 0.78 0.60 0.63 0.54 0.62 0.72 0.36 0.60 0.77 0.83 0.77 0.58 0.68 0.52 0.59 0.68 0.62 0.51 0.59 0.56 0.66 0.83 0.64 0.52 0.69 0.78 0.95 0.46 0.79 35 C113R135 C074R049 C020R131 C176R119 C251R080 C086R103 * regulator of chromosome condensation UNKNOWN phosphatidylinositol transfer protein beta isoform isoform 2 apolipoprotein a-i precursor myosin regulatory light chain atrial isoform myosin light polypeptide 4 0.44 0.43 0.31 0.15 0.10 0.06 0.23 0.30 0.22 0.16 0.06 0.04 0.60 0.54 0.46 0.07 0.12 0.08 -6 0.75 0.49 0.42 0.59 0.13 0.08 Significantly differentially transcribed genes were annotated in Blast2GO using the BLASTx algorithm and the best BLASTx hit (E-value < 10 ) is presented. a While this gene was initially annotated as ependymin-1, further analyses suggest that microarray contig C152R152 is chimeric (data not shown). 36 Table B. Overrepresented Gene Ontology (GO) terms associated with the 808 genes differentially transcribed between juvenile Atlantic salmon reared in unenriched and enriched hatchery environments. Significantly over- or under-represented GO terms were identified using a Fisher’s exact test in Blast2GO. Gene parent ontology category (P: biological process; C: cellular component; F: molecular function) and the number of genes (i.e. microarray features) associated with each of the GO terms is indicated. Significance of the Fisher’s exact test (assessed at < 5% FDR) of over- or under-representation of the GO term in the test gene set compared to the reference gene set is also shown. GO ID GO Term GO:0030017 GO:0030016 GO:0044449 GO:0043292 GO:0030239 GO:0031674 GO:0055001 GO:0055002 GO:0031032 GO:0042692 GO:0048738 GO:0055003 GO:0030018 GO:0061061 GO:0051146 GO:0010927 GO:0000279 GO:0008307 sarcomere myofibril contractile fiber part contractile fiber myofibril assembly I band muscle cell development striated muscle cell development actomyosin structure organization muscle cell differentiation cardiac muscle tissue development cardiac myofibril assembly Z disc muscle structure development striated muscle cell differentiation cellular component assembly involved in morphogenesis M phase structural constituent of muscle GO Category C C C C P C P P P P P P C P P P P F FDR 1.23E-12 1.23E-12 1.23E-12 5.91E-12 5.9E-11 9E-11 1.29E-10 2.42E-10 4.72E-10 5.9E-09 7.02E-09 1.24E-08 1.66E-08 1.79E-08 7.35E-08 1.11E-07 1.38E-07 1.47E-07 No. Genes 51 54 52 54 32 36 49 46 32 62 38 18 29 76 52 36 66 22 Representation over over over over over over over over over over over over over over over over over over 37 GO:0031143 GO:0007507 GO:0055013 GO:0055006 GO:0060537 GO:0014706 GO:0022402 GO:0007517 GO:0000087 GO:0022403 GO:0045214 GO:0030049 GO:0033275 GO:0070252 GO:0006936 GO:0007010 GO:0048285 GO:0007067 GO:0000280 GO:0043232 GO:0043228 GO:0000278 GO:0003012 GO:0060048 GO:0007049 GO:0030048 GO:0003015 GO:0060047 GO:0007059 GO:0005856 pseudopodium heart development cardiac muscle cell development cardiac cell development muscle tissue development striated muscle tissue development cell cycle process muscle organ development M phase of mitotic cell cycle cell cycle phase sarcomere organization muscle filament sliding actin-myosin filament sliding actin-mediated cell contraction muscle contraction cytoskeleton organization organelle fission mitosis nuclear division intracellular non-membrane-bounded organelle non-membrane-bounded organelle mitotic cell cycle muscle system process cardiac muscle contraction cell cycle actin filament-based movement heart process heart contraction chromosome segregation cytoskeleton C P P P P P P P P P P P P P P P P P P C C P P P P P P P P C 1.74E-07 2.49E-07 2.63E-07 3.35E-07 4.5E-07 8.4E-07 9.22E-07 1.08E-06 1.2E-06 1.31E-06 1.31E-06 1.38E-06 2.03E-06 3.44E-06 4.25E-06 4.58E-06 1E-05 1.02E-05 1.03E-05 1.13E-05 1.13E-05 1.42E-05 1.88E-05 2.08E-05 5.29E-05 6.15E-05 6.35E-05 6.35E-05 6.35E-05 8.02E-05 12 63 19 20 58 56 106 58 50 90 20 20 20 21 43 92 48 46 46 248 248 86 44 19 122 22 31 31 25 128 over over over over over over over over over over over over over over over over over over over over over over over over over over over over over over 38 GO:0009888 tissue development GO:0000967 rRNA 5'-end processing GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0034471 ncRNA 5'-end processing GO:0000775 chromosome, centromeric region GO:0055007 cardiac muscle cell differentiation GO:0030029 actin filament-based process GO:0008092 cytoskeletal protein binding GO:0030688 preribosome, small subunit precursor GO:0044427 chromosomal part GO:0048513 organ development GO:0030036 actin cytoskeleton organization GO:0005694 chromosome GO:0030274 LIM domain binding GO:0006941 striated muscle contraction GO:0035051 cardiac cell differentiation GO:0051983 regulation of chromosome segregation GO:0048747 muscle fiber development GO:0031034 myosin filament assembly GO:0000966 RNA 5'-end processing GO:0016020 membrane GO:0060538 skeletal muscle organ development GO:0055008 cardiac muscle tissue morphogenesis GO:0048644 muscle organ morphogenesis GO:0044085 cellular component biogenesis GO:0005859 muscle myosin complex GO:0005643 nuclear pore P P P 8.06E-05 9.03E-05 9.03E-05 131 5 5 over over over P 9.03E-05 5 over P C P P F C C P P C F P P P P P P C P P P P C C 9.03E-05 9.15E-05 0.00011 0.00014 0.000152 0.000162 0.000162 0.00018 0.000206 0.000242 0.000315 0.000388 0.000404 0.000492 0.00053 0.000539 0.000665 0.000732 0.000741 0.000841 0.000841 0.000869 0.000937 0.000999 5 26 19 61 71 5 58 200 57 64 7 23 22 10 25 10 5 207 36 18 19 139 9 17 over over over over over over over over over over over over over over over over over under over over over over over over 39 GO:0072359 GO:0072358 GO:0060415 GO:0000776 GO:0005865 GO:0031033 GO:0016460 GO:0005080 GO:0010669 GO:0032971 GO:0006996 GO:0019901 GO:0000236 GO:0071690 GO:0019900 GO:0014866 GO:0007519 GO:0005198 GO:0010032 GO:0014705 GO:0000819 GO:0000447 GO:0019855 GO:0044089 GO:0017022 GO:0046930 GO:0031090 GO:0016459 circulatory system development cardiovascular system development muscle tissue morphogenesis kinetochore striated muscle thin filament myosin filament organization myosin II complex protein kinase C binding epithelial structure maintenance regulation of muscle filament sliding organelle organization protein kinase binding mitotic prometaphase cardiac muscle myosin thick filament assembly kinase binding skeletal myofibril assembly skeletal muscle tissue development structural molecule activity meiotic chromosome condensation C zone sister chromatid segregation endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) calcium channel inhibitor activity positive regulation of cellular component biogenesis myosin binding pore complex organelle membrane myosin complex P P P C C P C F P P P F P P F P P F P C P P 0.001284 0.001284 0.001284 0.001307 0.001499 0.001499 0.001638 0.001736 0.001996 0.002332 0.002482 0.002625 0.002692 0.002796 0.002836 0.002887 0.004007 0.004241 0.004303 0.004654 0.004923 0.006405 80 80 18 19 14 10 10 13 8 6 161 44 15 4 48 10 33 58 4 3 12 5 over over over over over over over over over over over over over over over over over over over over over over F P F C C C 0.006405 0.006429 0.006983 0.007541 0.007541 0.007541 5 8 12 17 68 14 over over over over under over 40 GO:0045132 meiotic chromosome segregation GO:0045445 myoblast differentiation GO:0016657 oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor GO:0003920 GMP reductase activity GO:0030692 Noc4p-Nop14p complex GO:0048769 sarcomerogenesis GO:0000070 mitotic sister chromatid segregation GO:0051096 positive regulation of helicase activity GO:0000226 microtubule cytoskeleton organization GO:0003007 heart morphogenesis GO:0000796 condensin complex GO:0032040 small-subunit processome GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000478 endonucleolytic cleavage involved in rRNA processing GO:0000469 cleavage involved in rRNA processing GO:0015629 actin cytoskeleton GO:0048646 anatomical structure formation involved in morphogenesis GO:0071670 smooth muscle cell chemotaxis GO:0007062 sister chromatid cohesion GO:0001533 cornified envelope GO:0032991 macromolecular complex GO:0043234 protein complex GO:0044430 cytoskeletal part GO:0030689 Noc complex GO:0071840 cellular component organization or biogenesis GO:0035994 response to muscle stretch GO:0044428 nuclear part GO:0032405 MutLalpha complex binding P P F 0.007541 0.009075 0.010116 7 12 3 over over over F C P P P P P C C P 0.010116 0.010116 0.011275 0.011529 0.011897 0.012123 0.012801 0.012876 0.012876 0.012876 3 3 6 11 4 36 30 5 5 5 over over over over over over over over over over P P C P P P C C C C C P P C F 0.012876 0.012876 0.01376 0.014465 0.014832 0.015028 0.01528 0.01528 0.016561 0.01675 0.01675 0.01711 0.017395 0.018189 0.018189 5 5 45 128 4 9 6 246 211 91 3 263 5 196 4 over over over over over over over over over over over over over over over 41 GO:0032135 GO:0071897 GO:0016571 GO:0055010 GO:0035019 GO:0010564 GO:0008200 GO:0007051 GO:0003779 GO:0003229 GO:0005863 GO:0006200 GO:0000466 GO:0005721 GO:0000462 GO:0007267 GO:0048741 GO:0032982 GO:0005768 GO:0048468 GO:0007076 GO:0048856 GO:0048739 GO:0070626 GO:0004018 GO:0031260 GO:0048731 DNA insertion or deletion binding DNA biosynthetic process histone methylation ventricular cardiac muscle tissue morphogenesis somatic stem cell maintenance regulation of cell cycle process ion channel inhibitor activity spindle organization actin binding ventricular cardiac muscle tissue development striated muscle myosin thick filament ATP catabolic process maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) centromeric heterochromatin maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) cell-cell signaling skeletal muscle fiber development myosin filament endosome cell development mitotic chromosome condensation anatomical structure development cardiac muscle fiber development (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4carboxamido)succinate AMP-lyase (fumarate-forming) activity N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity pseudopodium membrane system development F P P P P P F P F P C P P 0.018189 0.018189 0.018189 0.018189 0.019612 0.019709 0.020332 0.020527 0.021132 0.021492 0.022191 0.022191 0.02581 4 8 13 12 9 45 6 18 38 12 4 25 5 over over over over over over over over over over over over over C P 0.02581 0.02581 5 5 over over P P C C P P P P F 0.02601 0.027079 0.030051 0.030995 0.033736 0.033871 0.033878 0.037095 0.037095 20 18 7 9 117 6 261 6 3 under over over under over over over over over F C P 0.037095 0.037364 0.037364 3 2 230 over over over 42 GO:0030686 GO:0031023 GO:0007098 GO:0044431 GO:0005884 GO:0008016 GO:0030490 GO:0031672 GO:0016248 GO:0007052 GO:0022607 GO:0006189 GO:0032404 GO:0010831 GO:0051095 GO:0007268 GO:0051297 GO:0012506 GO:0030261 GO:0032357 GO:0032301 GO:0032143 GO:0032142 GO:0032139 GO:0032356 90S preribosome microtubule organizing center organization centrosome cycle Golgi apparatus part actin filament regulation of heart contraction maturation of SSU-rRNA A band channel inhibitor activity mitotic spindle organization cellular component assembly 'de novo' IMP biosynthetic process mismatch repair complex binding positive regulation of myotube differentiation regulation of helicase activity synaptic transmission centrosome organization vesicle membrane chromosome condensation oxidized purine DNA binding MutSalpha complex single thymine insertion binding single guanine insertion binding dinucleotide insertion or deletion binding oxidized DNA binding C P P C C P P C F P P P F P P P P C P F C F F F F 0.037682 0.037682 0.037865 0.039215 0.0407 0.040885 0.042061 0.04291 0.04291 0.045086 0.045086 0.046067 0.046067 0.046067 0.046067 0.046862 0.046982 0.046982 0.046982 0.046982 0.046982 0.046982 0.046982 0.046982 0.046982 5 12 9 10 15 18 5 10 6 12 119 4 4 4 4 11 11 4 8 3 3 3 3 3 3 over over over under over over over over over over over over over over over under over under over over over over over over over 43 Table C. Atlantic salmon microarray probes identified as differentially transcribed by juveniles reared in enriched and unenriched hatchery environments and that corresponded to the GO terms “heart development” and “cell cycle” in a Blast2GO gene enrichment analysis. Differentially transcribed genes were identified using a FDR of 5% in siggenes. The fold-change in gene transcription levels found in enriched/unenriched hatchery environments are indicated and reported for all families and for each of the three examined families individually. GO Term Probe ID Best BLASTx hit* Heart development (GO:0007507) C045R110 C080R142 Purpurin precursor Guanine nucleotide-binding protein alpha-14 subunit Protein FAM3C precursor Delta-like protein B precursor Proliferating cell nuclear antigen Thiamine-triphosphatase Beta-parvin Cysteine-rich protein 1 FK506-binding protein 1B Malcavernin Noggin-3 precursor Nexilin Troponin C, slow skeletal and cardiac muscles Intraflagellar transport protein 88 homolog Endothelin-converting enzyme 2 Dihydrofolate reductase LIM domain-binding protein 3 NOGO isoform A2 C184R075 C101R057 C259R081 C122R068 C045R038 C183R051 C184R019 C266R068 C155R100 C149R123 C056R089 C224R160 C120R070 C206R024 C083R044 C181R067 Fold-change (all families) 1.62 1.38 Fold-change (X22) 1.77 1.65 Fold-change (X11) 1.74 1.28 Fold-change (X35) 1.44 1.23 1.30 0.83 0.81 0.80 0.79 0.78 0.78 0.77 0.77 0.76 0.76 0.76 0.76 0.75 0.75 0.74 1.31 0.81 0.81 0.75 0.75 0.67 0.92 0.76 0.80 0.68 0.91 0.87 0.84 0.84 0.68 0.63 1.31 0.87 0.79 0.76 0.78 0.93 0.61 0.53 0.74 0.88 0.74 0.67 0.81 0.83 0.74 0.73 1.27 0.80 0.82 0.90 0.84 0.77 0.86 1.06 0.79 0.75 0.66 0.77 0.61 0.61 0.82 0.92 44 C142R098 C074R053 C125R071 C255R040 C115R138 C129R146 C021R009 C244R012 C238R116 C085R011 C204R020 C118R080 C138R160 C203R016 C020R060 C187R163 C249R024 C147R057 C227R008 C175R023 C012R013 C160R061 C261R094 C256R034 C173R066 C009R091 C160R062 C065R162 LIM domain-binding protein 3 Troponin C, slow skeletal and cardiac muscles SET and MYND domain-containing protein 1 LIM domain-binding protein 3 Myosin-binding protein C, cardiac-type Catenin beta-1 LIM domain-binding protein 3 T-box transcription factor TBX1 Ankyrin repeat domain-containing protein 1 RuvB-like 2 Nipped-B-like protein Protein polybromo-1 LIM domain-binding protein 3 N-acetyltransferase ESCO1 Nck-associated protein 1-like Cell division control protein 2 homolog LIM domain-binding protein 3 Actin, alpha cardiac muscle 1 Beta-type platelet-derived growth factor receptor precursor Fox-1 homolog-like protein 1 Actin, alpha cardiac muscle 1 UNC45 homolog B Beta-type platelet-derived growth factor receptor precursor LIM domain-binding protein 3 PTRF/SDPR family protein Fibulin-1 precursor Mothers against decapentaplegic homolog 5 SET and MYND domain-containing protein 1 0.74 0.74 0.73 0.73 0.73 0.73 0.73 0.72 0.72 0.72 0.72 0.70 0.70 0.70 0.69 0.68 0.68 0.67 0.66 0.69 0.98 0.64 0.66 0.72 0.75 0.60 0.78 0.85 0.38 0.74 0.73 0.78 0.61 0.83 0.75 0.71 0.70 0.45 0.62 0.61 0.69 0.87 0.75 0.72 0.66 0.46 0.63 0.90 0.62 0.57 0.58 0.89 0.42 0.69 0.80 0.52 0.81 0.90 0.69 0.85 0.69 0.71 0.72 0.94 0.98 0.68 0.88 0.78 0.81 0.75 0.64 0.95 0.61 0.53 0.82 0.81 0.66 0.66 0.66 0.65 0.62 0.79 0.56 0.59 0.55 0.45 0.74 0.58 0.84 0.85 0.68 0.81 0.64 0.64 0.62 0.62 0.62 0.81 0.70 0.73 0.85 0.51 0.45 0.53 0.43 0.33 0.68 0.68 0.68 0.83 0.94 0.68 45 Cell cycle (GO:0007049) C153R037 C146R110 C145R100 C057R111 C240R162 C252R157 C013R158 C098R103 C073R023 C062R056 C260R055 C266R127 C025R008 C244R017 C233R135 C251R080 C086R103 C211R161 C076R102 C128R109 C023R126 C196R097 C141R027 C154R165 C080R079 C253R055 C146R131 C161R096 C075R094 C107R039 Actin, alpha cardiac muscle 1 Myosin-binding protein C, cardiac-type Myosin-6 Cysteine and glycine-rich protein 3 Actin, larval muscle Troponin C, slow skeletal and cardiac muscles SET and MYND domain-containing protein 1 Putative heparin-binding growth factor 1 Cysteine and glycine-rich protein 3 Fox-1 homolog-like protein 1 Myosin-binding protein C, cardiac-type SET and MYND domain-containing protein 1 Tropomyosin alpha-4 chain Cysteine and glycine-rich protein 3 Myosin-2 Myosin regulatory light chain 2, atrial isoform Myosin light chain 4 Metalloproteinase inhibitor 2 precursor Cyclin-G2 Dynein light chain 2, cytoplasmic 5'-AMP-activated protein kinase subunit beta-1 Protein BCCIP homolog Transcription factor Sox-2 Cyclin-dependent kinase 4 inhibitor B Cyclin-dependent kinase 4 inhibitor B 26S protease regulatory subunit 8 Small nuclear ribonucleoprotein Sm D3 Nuclear pore complex protein Nup160 Multifunctional protein ADE2 39S ribosomal protein L41, mitochondrial 0.61 0.61 0.61 0.57 0.56 0.56 0.56 0.56 0.56 0.53 0.53 0.52 0.51 0.48 0.45 0.10 0.06 2.05 1.60 1.54 1.48 1.47 1.46 1.35 1.32 0.85 0.84 0.84 0.84 0.83 0.52 0.49 0.64 0.62 0.74 0.77 0.53 0.66 0.51 0.48 0.62 0.41 0.49 0.46 0.68 0.12 0.08 2.51 1.43 1.41 1.39 1.50 1.36 1.29 1.15 0.89 0.89 0.93 0.89 0.87 0.54 0.62 0.46 0.44 0.51 0.42 0.55 0.42 0.52 0.44 0.39 0.67 0.48 0.43 0.33 0.06 0.04 2.76 1.82 1.91 1.69 1.61 1.70 1.56 1.55 0.76 0.79 0.74 0.80 0.74 0.77 0.69 0.74 0.65 0.51 0.59 0.62 0.65 0.65 0.78 0.63 0.54 0.58 0.56 0.46 0.13 0.08 1.32 1.56 1.29 1.36 1.32 1.38 1.23 1.29 0.91 0.86 0.87 0.84 0.90 46 C237R086 C148R076 C182R067 C086R088 C259R081 C122R068 C080R163 C244R043 C251R045 C097R015 C177R153 C234R130 C078R131 C194R076 C210R163 C236R099 C164R145 C172R088 C083R023 C190R020 C200R114 C021R165 C016R017 C013R156 C070R024 precursor Guanine nucleotide-binding protein-like 3 Exportin-1 Transcriptional repressor CTCF Acidic leucine-rich nuclear phosphoprotein 32 family member A Proliferating cell nuclear antigen Thiamine-triphosphatase Importin subunit alpha-2 Kinesin-like protein KIF23 Cyclin-dependent kinases regulatory subunit 2 DNA replication licensing factor MCM3 Structural maintenance of chromosomes protein 2 DNA mismatch repair protein Msh6 Proteasome subunit beta type-7 precursor Targeting protein for Xklp2 E3 SUMO-protein ligase RanBP2 Protein HGV2 Enhancer of zeste homolog 2 Eukaryotic translation initiation factor 4E Structural maintenance of chromosomes protein 2 Ribonucleoside-diphosphate reductase large subunit Transitional endoplasmic reticulum ATPase Kinesin-related motor protein Eg5 2 Filamin-C Leukocyte common antigen precursor Ran GTPase-activating protein 1 0.82 0.82 0.81 0.81 0.85 0.87 0.90 0.88 0.82 0.79 0.74 0.63 0.80 0.80 0.81 0.90 0.81 0.80 0.80 0.80 0.80 0.80 0.79 0.81 0.75 1.02 0.80 0.78 0.69 0.79 0.79 0.76 0.70 0.79 0.81 1.01 0.86 0.82 0.90 0.69 0.81 0.81 0.73 0.74 0.79 0.79 0.79 0.79 0.79 0.79 0.78 0.78 0.81 1.02 0.91 0.90 0.81 1.01 0.95 0.73 0.88 0.68 0.70 0.78 0.88 0.60 0.70 0.92 0.71 0.74 0.78 0.71 0.69 0.80 0.73 0.68 0.78 0.62 0.97 0.80 0.78 0.78 0.77 0.77 0.77 0.78 0.94 0.72 0.68 0.92 0.59 0.70 0.72 0.80 0.69 0.97 0.72 0.90 0.82 0.75 47 C063R090 C154R066 C014R147 C200R045 C141R091 C248R102 C194R011 C206R024 C159R044 C243R144 C010R028 C079R070 C254R073 C085R023 C209R138 C063R091 C003R047 C006R050 C055R090 C252R074 C228R095 C255R047 C168R019 C119R005 C201R116 C245R120 C166R011 Centromere protein U Nuclear pore complex protein Nup107 Suppressor of G2 allele of SKP1 homolog DNA polymerase subunit alpha B Kinesin-like protein KIF2C 26S proteasome non-ATPase regulatory subunit 2 Nuclear distribution protein nudE homolog 1 Dihydrofolate reductase Arachidonate 12-lipoxygenase, 12R type Protein FAM29A DNA topoisomerase 2-alpha DNA topoisomerase 2-binding protein 1 Allograft inflammatory factor 1 cAMP-regulated phosphoprotein 19 Enhancer of rudimentary homolog Homologous-pairing protein 2 homolog Inner centromere protein Inner centromere protein RNA-binding protein 38 Targeting protein for Xklp2 Condensin complex subunit 1 Origin recognition complex subunit 5 Transforming growth factor-beta-inducible early growth response protein 3 Structural maintenance of chromosomes protein 4 DNA repair protein RAD51 homolog B CLIP-associating protein 2 Ran GTPase-activating protein 1 0.77 0.77 0.77 0.76 0.76 0.76 1.05 0.81 0.62 0.66 0.66 0.76 0.64 0.72 0.75 0.93 0.85 0.68 0.60 0.78 0.98 0.72 0.77 0.84 0.76 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.74 0.74 0.74 0.74 0.74 0.73 0.73 0.73 0.72 0.84 0.67 0.75 0.77 1.01 0.63 0.86 0.89 0.85 0.73 0.64 0.79 0.83 0.69 0.82 0.73 0.67 0.83 0.72 0.69 0.78 0.58 0.67 0.59 0.61 0.52 0.75 0.82 0.60 0.72 0.87 0.71 0.59 0.89 0.61 0.87 0.81 0.69 0.74 0.90 0.78 0.78 0.89 0.75 0.79 0.89 0.66 0.66 0.67 0.87 0.73 0.65 0.75 0.79 0.73 0.73 0.73 0.85 0.90 0.66 0.76 0.44 0.67 0.58 0.91 0.88 48 C129R146 C202R057 C248R111 C162R130 C233R161 C169R048 C177R128 C204R020 C260R062 C062R074 C021R017 C224R013 C026R169 C148R122 C148R165 C118R080 C241R063 C142R032 C213R109 C203R016 C205R023 C251R131 C170R129 C187R163 C233R016 C099R026 Catenin beta-1 Nuclear autoantigenic sperm protein Dual specificity protein kinase Ttk Protein regulator of cytokinesis 1 Kinesin-related motor protein Eg5 2 Heat shock cognate 71 kDa protein Centromere protein I Nipped-B-like protein Mitotic checkpoint serine/threonine-protein kinase BUB1 M-phase phosphoprotein 1 Cytoskeleton-associated protein 2 Forkhead box protein N3 Fanconi anemia group D2 protein Protein ECT2 Mitotic spindle assembly checkpoint protein MAD2A Protein polybromo-1 Cysteine and histidine-rich domain-containing protein 1 Cysteine and histidine-rich domain-containing protein 1 Kinesin-like protein KIF23 N-acetyltransferase ESCO1 DNA mismatch repair protein MSH2 Microtubule-associated serine/threonineprotein kinase-like ATP-dependent DNA helicase Q4 Cell division control protein 2 homolog PCNA-associated factor Esophageal cancer-related gene 4 protein 0.73 0.73 0.73 0.72 0.72 0.72 0.72 0.72 0.72 0.75 0.82 0.67 0.92 0.78 0.56 0.82 0.74 0.84 0.72 0.68 0.70 0.67 0.78 0.71 0.94 0.62 0.61 0.72 0.70 0.83 0.60 0.62 0.90 0.47 0.78 0.70 0.71 0.71 0.71 0.71 0.71 0.71 0.61 0.79 0.72 0.83 0.81 0.97 0.88 0.66 0.54 0.67 0.77 0.75 0.70 0.71 0.88 0.67 0.57 0.46 0.70 0.70 0.73 0.55 0.57 0.78 0.81 0.79 0.70 0.57 0.72 0.80 0.70 0.70 0.69 0.69 0.61 0.61 0.56 0.73 0.91 0.89 0.98 0.55 0.60 0.64 0.55 0.79 0.69 0.68 0.68 0.68 0.81 0.75 0.66 0.59 0.51 0.69 0.73 0.67 0.75 0.61 0.65 0.80 49 C229R120 C020R126 C233R147 C161R081 C063R169 C059R123 C080R082 C019R035 C227R008 C011R044 C145R103 C003R061 C165R018 C261R094 C259R049 C247R129 C246R044 C165R011 C239R104 C093R148 C125R109 C118R056 C237R008 C204R156 precursor Centrosomal protein of 135 kDa Dual specificity protein kinase Ttk Myb-binding protein 1A-like protein Multidrug resistance protein 1 DNA mismatch repair protein Msh2 Sperm-associated antigen 5 G2/mitotic-specific cyclin-B1 F-box/WD repeat-containing protein 5 Beta-type platelet-derived growth factor receptor precursor Centromere protein M Sperm-associated antigen 5 Serine/threonine-protein kinase 12 Ubiquitin carboxyl-terminal hydrolase 28 Beta-type platelet-derived growth factor receptor precursor Leucine-rich repeat and WD repeat-containing protein 1 Nucleoprotein TPR Chromosome transmission fidelity protein 8 Abnormal spindle-like microcephaly-associated protein M-phase phosphoprotein 1 DNA polymerase delta catalytic subunit CPEB-associated factor Maskin Proto-oncogene tyrosine-protein kinase FER Protein CASC5 SWI/SNF-related matrix-associated actindependent regulator of chromatin subfamily Alike protein 1 0.68 0.68 0.67 0.67 0.67 0.67 0.67 0.67 0.66 0.71 0.76 0.72 0.79 0.79 0.82 0.62 0.63 0.45 0.37 0.57 0.62 0.49 0.56 0.69 0.85 0.54 0.81 0.98 0.74 0.68 0.74 0.68 0.53 0.55 0.84 0.81 0.66 0.66 0.65 0.65 0.65 0.72 0.44 0.67 0.50 0.59 0.60 0.97 0.63 0.44 0.58 0.68 0.72 0.67 1.03 0.81 0.65 0.56 0.70 0.70 0.64 0.64 0.64 0.53 0.76 0.51 0.59 0.53 0.77 0.78 0.62 0.62 0.63 0.63 0.63 0.62 0.61 0.61 0.69 0.65 0.66 0.96 0.56 0.69 0.57 0.62 0.69 0.35 0.49 0.66 0.65 0.63 0.53 0.78 0.82 0.51 50 C169R125 C213R107 C160R142 C231R077 * C100R025 C132R101 C113R135 Nucleoprotein TPR Cell division control protein 6 homolog Caveolin-2 Structural maintenance of chromosomes protein 4 Telomere-associated protein RIF1 Replication factor C subunit 3 Regulator of chromosome condensation 0.61 0.61 0.54 0.51 0.76 0.84 0.61 0.71 0.49 0.45 0.40 0.29 0.68 0.63 0.63 0.77 0.50 0.49 0.44 0.53 1.38 0.60 0.47 0.15 0.23 0.52 0.62 0.75 -6 Significantly differentially transcribed genes were annotated in Blast2GO using the BLASTx algorithm and the best BLASTx hit (E-value < 10 ) is presented. 51 Table D. Atlantic salmon microarray probes showing differing patterns of gene transcription in juvenile salmon reared in unenriched and enriched environments. Gene transcription patterns were examined using the cGRASP-designed 4×44K salmon gene microarray and the analysis conducted separately for each of three families, X11, X22, and X35, using SAM. Results are shown for family X22 and X11 at a FDR of 5% and for family X35 at a FDR of 8%. The fold-change in gene transcription levels found in enriched compared to unenriched habitats are indicated. Family Probe ID Best Blastx hit* X22 C211R161§ C200R070 C028R014 C246R012 C065R063 C109R011 C102R006 C138R017 C010R015§ C233R116 C149R037 C148R007 C118R012 C085R011 C194R001 § C260R032 C173R009 C258R138 C076R113 C204R103 C067R138 C168R047 C205R145 C178R155 C243R111 C108R097 C177R022 C087R147 metalloproteinase inhibitor 2 precursor eh domain-binding protein 1-like protein 1 c3 and pzp-like alpha-2-macroglobulin domainserine protease htra1 precursor UNKNOWN outer dense fiber protein 3-like protein 2-like cklf-like marvel transmembrane domain-containing b-cell receptor-associated protein 29 cd276 antigen transferrin precursor shugoshin-like 1 rho-related gtp-binding protein probable d-lactate mitochondrial-like ruvb-like 2 transcription termination factor 1-like t-cell surface glycoprotein cd5-like atp-dependent rna helicase ddx1 UNKNOWN protein-glutamine gamma-glutamyltransferase 5-like cytochrome p450 2m1 protein-glutamine gamma-glutamyltransferase e-like chordin-like protein 2-like claudin-10-like type i cytoskeletal 13-like mhc class i antigen motile sperm domain-containing protein 2 ras-like protein family member 11b leucine-rich glioma-inactivated protein 1 precursor X11 Fold-change (enriched/unenriched) 2.51 0.62 0.62 0.61 0.60 0.59 0.58 0.56 0.52 0.49 0.45 0.43 0.42 0.38 0.32 0.22 0.15 6.88 5.80 5.37 4.21 4.08 3.92 3.90 3.78 3.76 3.75 3.59 52 C249R164 C185R152 C262R042 C237R040‡ C182R007 C079R001 C169R151 C091R002 C215R090 C071R117 C069R141 C039R004 C154R016 C198R002 C005R155 C132R081 C148R124 C081R005 C085R046 C170R024 C060R004 C082R055 C035R081 C179R004 C266R141 C026R035 C012R016 C185R057 C034R024 § C211R161 C106R002 C071R051 C154R021 C184R005 C203R098 C183R003 C181R010 C051R009 C210R133 C238R158 C120R101 C235R030 UNKNOWN nucleophosmin serine threonine protein kinase PREDICTED: hypothetical protein LOC324610 tripartite motif-containing protein 35-like UNKNOWN homeobox protein dlx-1 tax1-binding protein 1 homolog b-like UNKNOWN ras-related protein rab-7a protein atp1b4-like secreted frizzled-related protein 1 precursor follistatin-related protein 3 sodium potassium-transporting atpase subunit beta-3fatty acid binding protein h6-isoform ring finger protein 13 protein c-ets-2 e3 ubiquitin-protein ligase rfwd2 protein tyrosine phosphatase type iva 1 calcium-binding protein 39-like cation-independent mannose-6-phosphate receptor cytochrome c oxidase subunit 1 transmembrane emp24 domain-containing protein 4 transcription factor hes-5-like elongation of very long chain fatty acids protein 4-like protein phosphatase 1 regulatory subunit 14b ankyrin repeat domain-containing protein 22 heme oxygenase v-type proton atpase 21 kda proteolipid subunit-like metalloproteinase inhibitor 2 precursor seizure protein 6 homolog heme oxygenase hypothetical protein SGRA_3282 msx1 partial septin 5 carbohydrate sulfotransferase 12-like serine threonine-protein kinase pim-3 protein fam181a-like lysosomal thioesterase ppt2-a-like transmembrane protein 127 UNKNOWN protein disulfide-isomerase a6 3.56 3.48 3.45 3.40 3.35 3.33 3.28 3.26 3.19 3.14 3.11 3.09 3.07 3.05 3.05 3.00 2.99 2.98 2.96 2.96 2.95 2.92 2.91 2.91 2.86 2.82 2.80 2.80 2.77 2.76 2.76 2.74 2.73 2.73 2.71 2.70 2.69 2.69 2.68 2.67 2.66 2.65 53 C202R136 C154R002 C211R164 C175R004 C036R160 C182R144 C265R026 C215R100 C087R027 C196R032 C261R019 C257R146 C124R005 C145R007 C251R005 C084R127 C194R139 C048R030 C022R025 C070R087 C221R033 C262R103 C037R004 C069R069 C216R003 C201R046 C266R133 C217R035 C250R164 C044R019 C250R149 C032R163 C053R002 C125R006 C134R083 C120R054 C263R039 C255R093 C109R004 C138R082 C048R170 C247R004 collagen type iv alpha-3-binding cofilin-2 mhc class i lymphoid-specific helicase atpase h+ transporting v1 subunit g isoform 1 pyridoxal kinase-like elongation factor 1-gamma transmembrane protein 106b lim and sh3 domain protein 1 protein fam76b matrin 3-like embigin precursor phospholipid transfer protein precursor UNKNOWN dna chr wayne state university expressed forkhead box protein b1 heterogeneous nuclear ribonucleoprotein a1 stomatin-like protein 2 udp-n-acetylhexosamine pyrophosphorylase-like v-type proton atpase subunit c 1-a-like ras-related protein rab-3a transcription factor jun-d chromobox protein homolog 8-like ras-related protein ral-b ubiquitin carboxyl-terminal hydrolase 12 erlin-2 precursor wd repeat and socs box-containing protein 2 ras-related and estrogen-regulated growth inhibitor-like von willebrand factor type egf and pentraxin domaincatenin beta-1 wd repeat and socs box-containing protein 2 casein kinase i isoform alpha ammonium transporter rh type c 1-like protein dispatched homolog 2 synaptosomal-associated protein 25 ras-related protein rab-10 neuroplastin precursor transgelin-3 ap-1 complex subunit sigma-3 cerebellin-1-like homeobox protein orthopedia b-like isoform 2 upf0488 protein c8orf33 homolog 2.65 2.64 2.64 2.63 2.61 2.61 2.60 2.60 2.59 2.58 2.58 2.57 2.55 2.54 2.54 2.54 2.54 2.54 2.53 2.53 2.53 2.52 2.52 2.51 2.51 2.50 2.48 2.48 2.47 2.45 2.45 2.45 2.44 2.44 2.44 2.44 2.43 2.43 2.43 2.43 2.42 2.42 54 C225R166 C066R112 C237R002 C177R157 C175R096 C244R146 C118R006 C180R050 C030R163 C172R058 C144R105 C190R127 C193R041 C111R060 C112R019 C164R063 C184R003 C032R027 C019R080 C147R126 C263R137 C139R059 C183R086 C159R155 C195R164 C198R063 C088R165 C051R146 C169R002 C197R026 C024R096 C223R127 C145R138 C266R046 C104R055 C213R005 C172R005 C041R151 C258R048 C250R007 C217R156 C248R158 zinc finger protein zpr1 glutamate receptor 2 isoform x1 heterogeneous nuclear ribonucleoprotein u-like protein tyrosine-protein kinase frk sarcoplasmic endoplasmic reticulum calcium atpase 2 protein ndrg2-like germ cell-less 1 o-phosphoseryl-trna selenium transferase neuronal-specific septin-3 pituitary homeobox 2 isoform 1 v-type proton atpase subunit s1-like retinoic acid receptor rxr-beta-a mitochondrial import receptor subunit tom40 homolog pantothenate kinase 1 transcription factor jun-d alanyl-trna cytoplasmic water dikinase 1 brain protein 44 zinc finger protein c3h1 type-like 2 prodynorphin precursor iroquois-class homeodomain protein irx-3 ankyrin repeat domain-containing protein 9-like n-acylneuraminate cytidylyltransferase heterogeneous nuclear ribonucleoprotein r UNKNOWN ankyrin repeat family a protein 2 UNKNOWN transcription factor sox-14 phosphogluconate dehydrogenase grainyhead-like protein 3 homolog hypoxanthine-guanine phosphoribosyltransferase dead box atp-dependent rna UNKNOWN trna-splicing ligase homolog protein disulfide-isomerase a3-like UNKNOWN lysozyme c ii precursor protein sco1 mitochondrial-like UNKNOWN u4 tri-snrnp-associated protein 2 isoform 2 zinc finger protein 161 homolog fxyd domain-containing ion transport regulator 6 2.42 2.41 2.41 2.40 2.40 2.40 2.40 2.39 2.39 2.39 2.39 2.38 2.38 2.37 2.37 2.37 2.37 2.37 2.37 2.37 2.36 2.36 2.36 2.35 2.35 2.34 2.34 2.34 2.34 2.33 2.32 2.32 2.31 2.31 2.31 2.31 2.30 2.30 2.29 2.28 2.28 2.28 55 C039R087 C210R044 C084R142 C090R150 C189R078 C205R152 C142R144 C093R130 C018R117 C124R044 C044R163 C170R001 C026R095 C232R150 C150R011 C206R153 C040R018 C051R138 C198R026 C081R116 C075R168 C223R012 C089R062 C178R004 C068R154 C155R133 C042R094 C171R108 C048R162 C017R103 C240R004 C021R089 C112R086 C222R006 C150R003 C053R047 C190R032 C135R099 C253R111 C052R119 C256R101 C023R111 5 -3 exoribonuclease 2 biglycan precursor n-acylglucosamine 2-epimerase-like glycoprotein m6a dehydrogenase reductase sdr family member 1 matrilin-4 iroquois-class homeodomain protein irx-3 lanosterol 14-alpha demethylase-like glycogen liver form claudin-4 protein disulfide-isomerase precursor UNKNOWN sin3 histone deacetylase corepressor complex UNKNOWN kelch-like protein 26 probable palmitoyltransferase zdhhc12-like rho-related gtp-binding hypothetical protein MTR_5g050970 btb poz domain-containing protein kctd17 protein phosphatase 1g dual specificity mitogen-activated protein kinase kinase protein atonal homolog 1-like hydroxyacylglutathione hydrolase UNKNOWN pleiotrophic factor-alpha-2 precursor gtpase imap family member 7 leptin receptor gene-related protein 28s ribosomal protein mitochondrial-like 72 kda type iv collagenase sodium potassium-transporting atpase subunit beta-233 claudin-5-like eukaryotic translation initiation factor 1b UNKNOWN tomoregulin-1-like calcium calmodulin-dependent protein kinase ii inhibitor hig1 domain family member 1a sun domain-containing protein 1-like luc7-like protein 3 sox3 28 kda heat- and acid-stable phosphoprotein spermine oxidase-like UNKNOWN 2.28 2.28 2.27 2.26 2.26 2.26 2.25 2.25 2.24 2.24 2.24 2.24 2.24 2.24 2.23 2.23 2.22 2.22 2.22 2.22 2.21 2.21 2.21 2.21 2.20 2.20 2.19 2.19 2.19 2.19 2.19 2.19 2.19 2.19 2.19 2.19 2.18 2.18 2.18 2.18 2.18 2.17 56 C167R154 C039R050 C015R121 C246R112 C142R035 C244R004 C066R007 C159R075 C195R122 C079R156 C202R085 C187R065 C117R102 C051R003 C220R164 C161R093 C233R121 C080R151 C104R034 C192R001 C197R056 C101R141 C061R124 C045R014 C246R005 C120R004 C244R145 C187R170 C180R005 C159R071 C188R044 C213R141 C147R115 C018R006 C175R016 C205R133 C265R147 C105R004 C249R017 C056R146 C260R064 C175R128 headcase protein homolog zinc finger cchc domain-containing protein 4 heat shock protein hsp 90-alpha protein fam45a heme-binding protein 1 dna damage-inducible transcript 4-like metalloproteinase inhibitor 2 precursor amyloid beta a4 cd59 glycoprotein precursor spindlin-1 transcription factor sox-11 UNKNOWN myelin expression factor 2 UNKNOWN sphingosine 1-phosphate receptor 1 serine threonine-protein phosphatase 2a 65 kda UNKNOWN zinc finger protein 346-like migration and invasion enhancer 1 protein mal2 low quality protein: ankyrin-3-like toll-interacting protein ubiquitin carboxyl-terminal hydrolase 46 sex comb on midleg-like protein 4-like zinc finger protein c3h1 type-like 1 PREDICTED: hypothetical protein LOC100699190 microtubule-associated protein 1a ap-3 complex subunit mu-2 translocon-associated protein subunit delta precursor fibroblast growth factor 13 syndecan-4 geranylgeranyl diphosphate synthase 1 coatomer subunit gamma-2 zinc finger protein 25 gdnf family receptor alpha-1-like cub and lccl domain containing 2- partial protein fam76b adipocyte plasma membrane-associated protein UNKNOWN zinc finger protein 135- partial pyridoxal kinase-like novel alpha-globin 2.17 2.17 2.17 2.17 2.17 2.16 2.16 2.16 2.16 2.16 2.15 2.15 2.14 2.14 2.14 2.14 2.14 2.14 2.13 2.13 2.13 2.13 2.13 2.13 2.13 2.12 2.12 2.12 2.12 2.12 2.12 2.12 2.12 2.11 2.11 2.11 2.11 2.11 2.11 2.11 2.10 2.10 57 C166R069 C073R097 C035R062 C219R078 C058R115 C039R005 C143R012 C095R124 C069R056 C131R128 C223R103 C248R160 C077R062 C254R089 C038R003 C023R155 C083R075 C021R065 C164R036 C142R105 C060R028 C139R049 C062R120 C140R158 C133R143 C053R044 C016R072 C013R057 C199R049 C085R160 C051R140 C022R015 C148R111 C091R089 C202R062 C263R060 C152R041 C200R163 C056R005 C167R083 C059R041 C085R070 uroplakin-1a transcription factor jun-b-like neurolin-like cell adhesion molecule hexosaminidase d o-phosphoseryl-trna selenium transferase aspartate beta-hydroxylase domain-containing protein 2 ef-hand domain-containing family member a1-like galectin-8-like UNKNOWN na k atpase alpha subunit isoform 1c diphosphomevalonate decarboxylase tetraspanin-7 loc100127300 protein tropomyosin alpha-3 chain ubiquinone biosynthesis protein mitochondrial precursor mothers against decapentaplegic homolog 7-like programmed cell death protein 4 isoform 1 enoyl- hydratase domain-containing protein tsc22 domain member 1 n -dimethylarginine dimethylaminohydrolase 2 cd209 antigen-like mitochondrial precursor disulfide-isomerase a6 precursor charged multivesicular body protein 3 involucrin-like isoform x3 pleiotrophic factor-alpha-2 precursor nucleolysin tiar synaptosomal-associated protein 25 multiple inositol polyphosphate phosphatase 1-like phosphorylase b kinase gamma catalytic testis liver secreted frizzled-related protein 3-like mbd3 protein sideroflexin-4 type-1 angiotensin ii receptor-associated selenophosphate synthetase 2 alpha-n-acetylgalactosaminide alpha-sialyltransferase 3UNKNOWN UNKNOWN estrogen receptor binding site 9 v-type proton atpase subunit s1-like chloride intracellular channel protein 1 rna binding protein with multiple splicing 2 2.10 2.09 2.09 2.09 2.09 2.09 2.09 2.09 2.08 2.08 2.08 2.08 2.08 2.08 2.07 2.06 2.06 2.06 2.06 2.06 2.06 2.05 2.05 2.05 2.05 2.05 2.05 2.05 2.05 2.05 2.05 2.05 2.05 2.04 2.04 2.04 2.04 2.04 2.03 2.03 2.02 2.02 58 C096R075 C225R065 C203R023 C205R001 C047R087 C042R075 C160R072 C182R004 C248R006 C011R036 C032R048 C200R139 C193R045 C171R165 C151R001 C035R139 C153R160 C063R015 C027R094 C158R098 C077R036 C258R084 C126R082 C198R087 C172R123 C179R046 C154R104 C007R077 C200R067 C024R083 C035R055 C211R110‡ C208R062 C256R110 C178R006 C158R041 C119R045 C081R087 C048R135 C176R102 C122R045 C035R042 mothers against decapentaplegic homolog 3 isoform 2 transmembrane protein 59-like UNKNOWN n-lysine methyltransferase setd8-a-like protein sec13 homolog isoform 1 UNKNOWN tripartite motif-containing protein 35-like cd63 antigen 26s protease regulatory subunit 6a leucine-rich glioma-inactivated protein 1 precursor bcl2 adenovirus e1b 19 kda protein-interacting protein 3 septin 10 elongation of very long chain fatty acids protein 6-like upf0368 protein cxorf26-like u1 small nuclear ribonucleoprotein c claudin-like protein zf-a89 cell cycle control protein 50b na k atpase alpha subunit isoform 1c echinoderm microtubule associated protein like 1 rhomboid-related protein 2 cell division cycle protein 123 homolog ras-related protein rap-2c UNKNOWN alpha-synuclein fish virus induced trim protein serine threonine-protein kinase sgk3 cytosolic non-specific dipeptidase u4 tri-snrnp-associated protein 2 isoform 2 nuclear transcription factor y subunit alpha-like UNKNOWN repressor of rna polymerase iii transcription maf1 c4b-binding protein alpha chain precursor daz-associated protein 1 beta-galactosyltransferase 1 calpain small subunit 1 zinc finger protein zpr1 glutaminase kidney mitochondrial-like nucleolysin tia-1 isoform p40 isoform 2 max protein antizyme inhibitor 1 hcls1-associated protein x-1 v-maf musculoaponeurotic fibrosarcoma oncogene-like 2.02 2.02 2.02 2.02 2.02 2.02 2.02 2.02 2.01 2.01 2.01 2.01 2.01 2.01 2.01 2.01 2.01 2.00 2.00 2.00 2.00 2.00 2.00 2.00 1.99 1.99 1.99 1.99 1.99 1.99 1.99 1.99 1.98 1.98 1.98 1.98 1.98 1.98 1.97 1.97 1.97 1.97 59 C074R132 C127R002 C207R078 C008R077 C246R120 C238R011 C193R062 C070R056 C117R159 C084R102 C093R080 C106R060 C047R023 C246R145 C222R034 C165R131 C209R002 C251R060 C025R088 C167R129 C089R143 C057R004 C048R103 C209R004 C108R105 C079R071 C062R129 C166R060 C216R002 C021R131 C201R001 C157R099 C088R127 C161R139 C227R087 C024R163 C122R001 C206R080 C201R149 C197R044 C097R156 C263R038 e3 ubiquitin-protein ligase rnf146-like septin-6 isoform 1 nf-kappa-b inhibitor-interacting ras-like protein 2 prostaglandin e synthase 3 claudin-like protein zf-a89 adenosine kinase mitochondrial glutamate carrier 1-like tumor-associated calcium signal transducer 2 precursor spermidine synthase beta-glucuronidase precursor tgf-beta receptor type-2-like t-cell acute lymphocytic leukemia protein 2 calcium release-activated calcium channel protein 1 UNKNOWN serine threonine-protein phosphatase 2a 65 kda death-associated protein 1 wd repeat-containing protein 82 c4b-binding protein alpha chain precursor arrestin domain-containing protein 2 polycomb complex protein bmi-1 wd repeat-containing protein 92 maspardin isoform 1 nucleosome assembly protein 1-like 1 cd209 antigen-like protein a isovaleryl coenzyme a dehydrogenase profilin-2 inhibitor of growth protein 5 ras-related protein rab-3a zinc finger protein 850-like akt-interacting protein plastin-2 isoform 1 low quality protein: cell cycle control protein 50a protein yipf1-like neurogenic differentiation factor 2 protein atp1b4-like elav-like protein 1 retinoic acid receptor rxr-beta-a intraflagellar transport protein 52 homolog UNKNOWN solute carrier family 35 member f1 pyridoxal phosphate phosphatase UNKNOWN 1.96 1.96 1.96 1.96 1.96 1.96 1.96 1.96 1.96 1.96 1.96 1.95 1.95 1.95 1.95 1.95 1.95 1.94 1.94 1.94 1.94 1.94 1.94 1.94 1.94 1.93 1.93 1.93 1.93 1.93 1.93 1.92 1.92 1.92 1.92 1.92 1.92 1.92 1.92 1.92 1.91 1.91 60 C005R151 C164R004 C193R076 C240R056 C128R109 C015R021 C031R067 C209R041 C241R024 C264R151 C194R022 C012R108 C010R058 C240R105 C218R064 C104R163 C182R027 C021R083 C055R055 C213R030 C203R131 C239R088 C195R055 C237R056 C145R037 C137R144 C148R154 C101R117 C073R082 C048R100 C030R053 C231R149 C147R029 C117R002 C216R004 C258R035 C065R021 C116R085 C081R073 C012R079 C195R042 C005R076 probable bax inhibitor 1 ino80 complex subunit e UNKNOWN myosin regulatory light chain smooth muscle isoform dynein light chain cytoplasmic cytochrome b5 heterogeneous nuclear ribonucleoprotein q u4 tri-snrnp-associated protein 2 isoform 2 epithelial membrane protein 2 succinate dehydrogenase general transcription factor ii-i repeat domain-containing prostaglandin e synthase 3 g protein-activated inward rectifier potassium channel 3 fxyd domain-containing ion transport regulator 6 fish virus induced trim protein epoxide hydrolase 1-like heat shock protein hsp 90-alpha keratin 8 guanine nucleotide-binding protein g g g subunit beta-1eukaryotic translation initiation factor 3 subunit g UNKNOWN complexin-1 rna-binding protein 12b torsin-1b probable alpha-ketoglutarate-dependent dioxygenase riboflavin kinase cop9 signalosome complex subunit 2 isoform 1 UNKNOWN UNKNOWN UNKNOWN growth associated protein 43 calcineurin subunit b type 1 sun domain-containing protein 1 atp-dependent rna helicase tdrd9-like high affinity camp-specific 3 -cyclic phosphodiesterase 7a sal-like protein 4 probable bax inhibitor 1 mitochondrial-like phosphatidylinositol transfer protein alpha isoform transcription factor hes-5-like gdp-mannose dehydratase cell growth regulator with ring finger domain protein 1 1.91 1.91 1.91 1.91 1.91 1.91 1.90 1.90 1.90 1.90 1.90 1.90 1.90 1.90 1.90 1.89 1.89 1.89 1.89 1.88 1.88 1.88 1.88 1.88 1.88 1.88 1.88 1.88 1.88 1.88 1.88 1.88 1.87 1.87 1.87 1.87 1.87 1.87 1.87 1.87 1.87 1.87 61 C193R034 C118R084 C083R120 C212R032 C243R149 C011R155 C066R122 C089R121 C177R090 C194R037 C054R144 C174R012 C214R127 C232R100 C081R160 C109R033 C225R155 C065R151 C040R034 C035R050 C121R086 C250R065 C225R168 C190R001 C244R136 C043R134 C230R006 C170R106 C061R167 C220R076 C104R043 C143R026 C191R075 C244R038 C174R032 C246R138 C144R036 C160R170 C035R135 C134R084 C053R121 C215R086 diphthamide biosynthesis protein 2-like gtp-binding nuclear protein ran protein kinase c iota type vesicle transport protein got1b cerebellin- partial zinc finger ran-binding domain-containing protein 2 vacuolar proton pump subunit e 1 ring finger protein 11 protein mal2 sparc precursor transport and golgi organization 2 homolog unconventional myosin-ic glutamate decarboxylase 1-like neuronal calcium sensor 1 acidic fibroblast growth factor intracellular-binding uv excision repair protein rad23 homolog a-like protein fam60a-like double-strand-break repair protein rad21 homolog wd repeat-containing protein 1 UNKNOWN caspase 3 ig kappa chain v-iv region b17 precursor fish virus induced trim protein epithelial membrane protein 3-like glutamate decarboxylase 1 kinesin heavy chain isoform 5a isoform 2 btb poz domain-containing protein 6 cysteine mitochondrial UNKNOWN n-terminal ef-hand calcium-binding protein 1-like sh3 domain-containing protein 19-like UNKNOWN ubiquitin-like modifier-activating enzyme 5 multiple inositol polyphosphate phosphatase 1-like swi snf-related matrix-associated actin-dependent tumor-associated calcium signal transducer 2 precursor lim homeobox protein lhx9 isoform x1 40s ribosomal protein sa cln3 protein septin isoform cra_a UNKNOWN protein mab-21-like 1 1.87 1.87 1.87 1.87 1.87 1.86 1.86 1.86 1.86 1.86 1.86 1.86 1.86 1.86 1.86 1.86 1.85 1.85 1.85 1.85 1.85 1.85 1.85 1.85 1.85 1.85 1.84 1.84 1.84 1.84 1.84 1.84 1.84 1.84 1.84 1.84 1.84 1.84 1.84 1.84 1.84 1.84 62 C138R056 C060R006 C119R140 C109R067 C210R131 C254R126 C147R039 C179R138 C262R069 C067R055 C094R116 C076R127 C015R103 C258R045 C038R022 C143R089 C096R039 C062R155 C049R073 C221R021 C043R082 C194R070 C244R034 C076R102 C164R125 C168R046 C204R070 C127R145 C168R036 C179R034 C083R107 C021R127 C053R036 C218R126 C069R041 C041R006 C170R168 C072R052 C043R020 C037R006 C073R105 C113R034 envoplakin-like hemoglobin subunit beta-1 run and fyve domain containing 3 transmembrane 9 superfamily member 3 histone -like nicotinamide mononucleotide adenylyltransferase 2 neuritin protein fam60a-like sodium-coupled neutral amino acid transporter 2 proliferation-associated protein 2g4-like death-associated protein kinase 3 adp-ribosylation factor-like protein 9 methylosome protein 50 osteoblast specific factor electron transfer flavoprotein-ubiquinone mitochondrialsam domain and hd domain-containing protein 1 follistatin-related protein 1 precursor ornithine decarboxylase antizyme 1 protein kinase c and casein kinase substrate in neurons 3 nuclear prelamin a recognition factor protein mab-21-like 2 spermine oxidase-like phosphatidylinositol transfer protein beta isoform cyclin-g2-like cd99 antigen precursor transposable element tcb1 transposase vacuolar protein sorting-associated protein 41 homolog glutamate receptor 2 isoform x1 UNKNOWN cop9 signalosome complex subunit 2 isoform 1 solute carrier family 7 (cationic amino acid y+ system) matrix metalloproteinase 2 actin-related protein 2 wd repeat domain-containing protein 83 14-3-3 protein gamma UNKNOWN casein kinase i isoform alpha mitochondrial inner membrane protease subunit 2-like UNKNOWN UNKNOWN beta- -galactosyltransferase 2-like calpain-9 isoform 3 1.84 1.84 1.83 1.83 1.83 1.83 1.83 1.83 1.83 1.83 1.83 1.83 1.83 1.83 1.83 1.82 1.82 1.82 1.82 1.82 1.82 1.82 1.82 1.82 1.82 1.82 1.82 1.82 1.82 1.82 1.82 1.82 1.82 1.82 1.81 1.81 1.81 1.81 1.81 1.81 1.81 1.81 63 C176R005 C036R048 C031R083 C187R103 C039R151 C107R064 C117R012 C155R073 C141R110 C216R079 C058R138 C244R101 C065R158 C130R075 C079R106 C073R062 C184R151 C053R137 C250R018 C036R027 C177R020 C264R071 C174R039 C172R070 C082R123 C054R088 C266R103 C108R066 C036R074 C256R109 C151R038 C172R138 C193R140 C148R103 C199R003 C041R160 C089R133 C012R069 C261R067 C179R060 C177R030 C178R100 protein farnesyltransferase subunit beta-like protein max-like isoform 3 long-chain-fatty-acid-- ligase acsbg2-like lipoma hmgic fusion partner-like 3 akt-interacting protein u4 u6 small nuclear ribonucleoprotein prp31-like peptidyl-prolyl cis-trans isomerase-like 4 serine threonine-protein phosphatase 2a 55 kda tropomyosin alpha-4 chain isoform 8 protein set-like ring finger and spry domain-containing protein 1 atp-sensitive inward rectifier potassium channel 11-like membrane-associated progesterone receptor coup transcription factor 1 golgin subfamily a member 7 ring finger protein 223-like isoform x1 probable peptidyl-trna hydrolase guanine nucleotide-binding protein g g g subunit protein-coding gene cg057 like protein pith domain-containing protein 1-like apoptosis regulator bcl-x v-type proton atpase subunit d 1 homeobox protein dlx-1 cytochrome p450 2m1 polycomb complex protein bmi-1-a tubulin beta-2a chain oocyte zinc finger protein 6-like nedd4 family-interacting protein 1 novel protein heat shock protein 70 cell surface protein kh domain- rna- signal transduction-associated protein 1cystinosin methylosome protein 50 phosphatidylinositol 4-kinase type 2-alpha ras-related protein rab-11a insulin-like growth factor-binding protein 7-like choline ethanolaminephosphotransferase 1 UNKNOWN ubiquitin-conjugating enzyme e2 d2 ras-related c3 botulinum toxin substrate 1 (rho small gtp btb poz domain-containing protein kctd5 1.81 1.81 1.81 1.81 1.81 1.81 1.80 1.80 1.80 1.80 1.80 1.80 1.80 1.80 1.80 1.80 1.80 1.80 1.80 1.80 1.80 1.80 1.80 1.79 1.79 1.79 1.79 1.79 1.79 1.79 1.79 1.79 1.79 1.79 1.79 1.79 1.79 1.79 1.78 1.78 1.78 1.78 64 C111R044 C064R164 C200R084 C197R027 C035R071 C017R044 C133R097 C154R140 C085R067 C222R075 C216R005 C254R057 C005R051 C146R020 C244R049 C085R138 C083R101 C054R162 C093R073 C187R048 C096R128 C141R151 C127R006 C163R124 C211R019 C250R040 C081R019 C215R022 C007R036 C039R102 C149R126 C062R022 C214R086 C011R162 C212R001 C069R109 C199R067 C143R154 C170R046 C109R044 C186R054 C023R069 seizure protein 6 homolog schwannomin-interacting protein 1-like glutathione transferase omega-1 peptidyl-prolyl cis-trans isomerase fkbp4 cyclin-dependent kinase 5 activator 1-like cerebellin- partial myotubularin-related protein 13-like alpha- -sialyltransferase st8sia v cell division cycle-associated protein 4-like cyclin-g2-like protein hexim1 casein kinase i isoform alpha 5 -3 exoribonuclease 2 tubulin beta chain-like prothymosin alpha vacuolar protein sorting-associated protein 28 homolog sry-box containing gene 11a UNKNOWN calcium calmodulin-dependent protein kinase iv copine-2 bcl2 antagonist of cell death growth arrest and dna damage-inducible protein gadd45 mid1-interacting protein 1-b-like kh domain- rna- signal transduction-associated protein 1myosin-9-like secretogranin-2 precursor uncharacterized loc100912373 gamma-aminobutyric acid a receptor alpha 1 glutamate receptor u1-like probable atp-dependent rna helicase ddx49 c6orf64 homolog e3 ubiquitin-protein ligase rnf185 neuronal membrane glycoprotein m6-b-like biglycan precursor loc100137634 protein gpi-anchor transamidase-like retinol dehydrogenase 12 transcription factor sox-21 solute carrier family 25 member 40 acidic fibroblast growth factor intracellular-binding actin-related protein 3 glutaminase kidney mitochondrial-like 1.78 1.78 1.78 1.78 1.78 1.78 1.78 1.78 1.78 1.78 1.78 1.78 1.78 1.78 1.78 1.77 1.77 1.77 1.77 1.77 1.77 1.77 1.77 1.77 1.77 1.77 1.77 1.77 1.77 1.77 1.77 1.77 1.76 1.76 1.76 1.76 1.76 1.76 1.76 1.76 1.76 1.76 65 C212R037 C097R012 C145R143 C087R160 C215R001 C012R071 C249R094 C262R041 C197R104 C200R071 C197R114 C140R007 C091R055 C085R137 C092R099 C175R001 C031R110 C135R135 C180R109 C078R149 C085R077 C070R079 C243R121 C031R072 C177R166 C215R109 C121R100 C096R003 C167R153 C069R110 C192R157 C117R058 C232R001 C247R162 C121R058 C216R145 C236R146 C028R051 C182R085 C177R045 C091R069 C022R135 asparagine-trna cytoplasmic ras-related c3 botulinum toxin substrate 1 (rho small gtp UNKNOWN adenylosuccinate synthetase isozyme 2 UNKNOWN s-methyl-5 -thioadenosine phosphorylase sialic acid synthase nad-dependent deacetylase sirtuin-2 serine incorporator 1-like protein max-like isoform 3 peroxisomal coenzyme a diphosphatase nudt7 protein crumbs homolog 3-like mpn domain-containing protein translocon-associated protein subunit alpha-like lipopolysaccharide-induced tumor necrosis factor-alpha choline transporter-like protein 2-like microspherule protein 1 ornithine decarboxylase antizyme serine threonine-protein phosphatase 2a catalytic dual specificity protein phosphatase 6 cystinosin tubulin alpha-1a chain peroxisome proliferator-activated receptor beta adenylate kinase isoenzyme 6-like ring finger protein 122 calmodulin protein yipf3 vacuolar protein sorting-associated protein 41 homolog calreticulin precursor UNKNOWN metalloreductase steap2 cadherin-1 isoform 1 epididymal secretory protein e1 precursor actin-related protein 10 claudin-4 pescadillo homolog alpha-enolase-like isoform 1 claudin-4 short branched chain specific acyl- mitochondrial beta- partial synaptosomal-associated protein 25 serine hydrolase-like 1.76 1.76 1.76 1.76 1.76 1.76 1.76 1.76 1.76 1.76 1.76 1.76 1.75 1.75 1.75 1.75 1.75 1.75 1.75 1.75 1.75 1.75 1.75 1.75 1.75 1.75 1.75 1.74 1.74 1.74 1.74 1.74 1.74 1.74 1.74 1.74 1.74 1.74 1.74 1.74 1.74 1.74 66 C086R164 C019R119 C226R075 C073R164 C051R075 C084R005 C214R055 C192R050 C226R143 C112R151 C087R114 C193R026 C102R002 C067R103 C021R167 C084R083 C231R075 C141R149 C103R106 C007R104 C071R142 C177R025 C202R078 C229R008 C168R163 C232R008 C039R075 C016R005 C189R045 C113R002 C121R089 C211R168 C159R069 C200R033 C186R111 C210R115 C211R005 C186R064 C007R122 C168R064 C014R030 C108R131 teashirt homolog 1 ccaat enhancer-binding protein delta adp-ribosylation factor-like protein 4a regulator of nonsense transcripts 3b protein fam89a vesicle-associated membrane protein-associated protein high mobility group protein b3 transmembrane protein 120b 26s proteasome non-atpase regulatory subunit 9 elmo domain-containing protein 2 sodium channel subunit beta-3 annexin a13 annexin a2-a reticulon 4 UNKNOWN splicing arginine serine-rich 2 eukaryotic initiation factor 4a-i nitrilase homolog 1-like asporin isoform 2 denn domain-containing protein 2d neuronal migration protein doublecortin isoform 2 matrin 3-like jnk1 mapk8-associated membrane protein isoform 1 methyltransferase ddb_g0268948-like mannoside acetylglucosaminyltransferase isoform cra_a cation transport regulator-like protein 1 atp synthase mitochondrial f1 complex assembly factor 2 uba-like domain-containing protein 1 ankyrin repeat domain-containing protein 10-like UNKNOWN ubiquitin-conjugating enzyme e2 b zinc finger protein 3 inositol polyphosphate 1-phosphatase UNKNOWN protein ndrg3-like ependymin precursor gastrotropin claudin-5-like regulator of g-protein signaling 3-like protein sec13 homolog cell cycle control protein 50b zinc finger and btb domain-containing protein 17 1.74 1.73 1.73 1.73 1.73 1.73 1.73 1.73 1.73 1.73 1.73 1.73 1.73 1.73 1.73 1.73 1.73 1.73 1.72 1.72 1.72 1.72 1.72 1.72 1.72 1.72 1.72 1.72 1.72 1.72 1.72 1.72 1.72 1.72 1.72 1.71 1.71 1.71 1.71 1.71 1.71 1.71 67 C203R039 C226R013 C046R136 C080R070 C196R098 C175R161 C052R090 C140R106 C149R053 C097R097 C161R011 C014R020 C072R057 C266R090 C078R043 C156R020 C077R161 C078R052 C240R067 C154R068 C057R132 C235R046 C148R003 C086R158 C217R021 C005R149 C141R027 C009R149 C079R041 C023R044 C059R078 C112R147 C211R001 C086R100 C148R052 C023R126 C057R003 C067R010 C114R069 C182R066 C071R132 C244R148 cofilin-2 adp-ribosylation factor-like protein 2-binding protein btb poz domain-containing protein kctd9 UNKNOWN rna-binding protein 39 desmoplakin isoform x1 calcium-regulated heat stable protein 1 threonine-trna cytoplasmic probable rrna-processing protein ebp2 poly cd99 antigen precursor histone h5a something about silencing protein 10 protein lunapark-b 45 kda calcium-binding protein cofilin-2 heterochromatin protein binding protein isoform cra_a integral membrane protein 2c zinc finger protein zic 3 regulator of g-protein signaling 3-like kv channel-interacting protein 1 isoform 4 heterogeneous nuclear ribonucleoprotein r thymidine cytosolic katnb1-like protein 1 aryl hydrocarbon receptor nuclear translocator 2 guanine nucleotide-binding protein g subunit alpha transcription factor sox-2 UNKNOWN vacuolar protein sorting-associated protein 33b heterogeneous nuclear ribonucleoprotein a1 translin calcium calmodulin-dependent protein kinase ii inhibitor calmodulin PREDICTED: hypothetical protein LOC100002065 monocyte to macrophage differentiation protein 5 -amp-activated protein kinase subunit beta-1 inositol-3-phosphate synthase 1 occludin b mitochondrial atp synthase gamma chain calreticulin precursor UNKNOWN histidine triad nucleotide-binding protein 3 1.71 1.71 1.71 1.71 1.71 1.71 1.71 1.71 1.71 1.71 1.70 1.70 1.70 1.70 1.70 1.70 1.70 1.70 1.70 1.70 1.70 1.70 1.70 1.70 1.70 1.70 1.70 1.70 1.70 1.69 1.69 1.69 1.69 1.69 1.69 1.69 1.69 1.69 1.69 1.69 1.69 1.69 68 C171R008 C038R060 C175R123 C237R006 C040R107 C208R002 C240R041 C126R103 C217R118 C104R026 C240R097 C220R094 C134R096 C135R154 C103R033 C225R039 C238R029 C087R074 C185R023 C010R098 C048R097 C261R014 C183R048 C195R020 C231R106 C031R047 C169R037 C244R002 C188R055 C255R014 C252R159 C205R104 C216R115 C233R087 C250R160 C203R062 C095R034 C261R155 C227R082 C237R087 C014R099 C216R126 cornifelin homolog a 39s ribosomal protein mitochondrial bro1 domain-containing protein brox h aca ribonucleoprotein complex subunit 2-like protein pleckstrin homology domain-containing family f member actin-related protein 2 3 complex subunit 3 nucleolysin tia-1 isoform p40 isoform 2 epoxide hydrolase 1-like stannin serine arginine-rich splicing factor 11-like glutathione transferase omega-1 elav-like protein 1 vacuolar protein sorting-associated protein 41 homolog metalloproteinase inhibitor 3-like interleukin-4 receptor subunit alpha ribose-phosphate pyrophosphokinase 2 spindle and kinetochore-associated protein 2 transmembrane protein 54 isoform 2 nucleolar gtp-binding protein 1 inhibitor of growth protein 2 transmembrane protein 50a protein casein kinase ii subunit beta rhombotin-1 membrane protein mlc1-like zinc finger protein 596-like zinc finger protein 280d UNKNOWN synaptosomal-associated protein 23 neuron-specific protein family member 1 nicotinamide riboside kinase 2 repulsive guidance molecule a precursor bsg protein map kinase-activated protein kinase 2 cystathionine beta-synthase-like scel protein calcyphosin-like protein splicing factor 3a subunit 3 protein fam19a2 mannose-1-phosphate guanyltransferase alpha-a udp-glucose 4-epimerase superoxide dismutase 1.69 1.69 1.69 1.69 1.69 1.69 1.68 1.68 1.68 1.68 1.68 1.68 1.68 1.68 1.68 1.68 1.68 1.68 1.68 1.68 1.68 1.68 1.68 1.67 1.67 1.67 1.67 1.67 1.67 1.67 1.67 1.67 1.67 1.67 1.67 1.67 1.67 1.67 1.67 1.67 1.67 1.67 69 C087R011 C188R145 C128R106 C138R034 C034R147 C023R052 C255R075 C225R136 C071R040 C138R059 C229R074 C146R013 C187R075 C014R080 C082R009 C127R051 C112R097 C151R083 C093R089 C126R072 C040R003 C194R128 C006R031 C133R146 C216R102 C074R159 C182R118 C249R023 C020R096 C113R122 C096R028 C190R048 C114R149 C161R128 C079R100 C186R046 C264R056 C151R024 C054R089 C016R014 C159R026 C227R023 nicolin-1 pyridoxal phosphate phosphatase phospho2 actin-related protein 2 serine threonine-protein kinase rio1 glyoxylate reductase hydroxypyruvate reductase hydroxyacylglutathione hydrolase signal peptidase complex catalytic subunit sec11a voltage-dependent anion-selective channel protein 2 methyltransferase-like protein 5 wd repeat and socs box-containing protein 2 ist1 homolog srp72 protein UNKNOWN prostaglandin e synthase 3 dehydrogenase reductase sdr family member 11 purine nucleoside phosphorylase-like calcyclin-binding protein casein kinase i isoform epsilon-like ccr4-not transcription complex subunit 7 tetratricopeptide repeat protein mitochondrial haus augmin-like complex subunit 8-like p53 apoptosis effector related to pmp-22 dual specificity mitogen-activated protein kinase kinase 14-3-3 protein beta alpha 4f2 cell-surface antigen heavy chain btb poz domain-containing protein kctd17 follistatin-related protein 1 precursor calpain small subunit 1 oocyte zinc finger protein 6-like nuclease harbi1 lysosomal protective protein n-acetyltransferase nat13 protein set-like septin 5 ring finger protein 122 nf-kappa-b inhibitor-interacting ras-like protein 2 sept8a protein alpha-enolase ap-1 complex subunit sigma-2 receptor expression-enhancing protein 5 active breakpoint cluster region-related protein isoform dehydrogenase reductase sdr family member 12-like 1.67 1.67 1.66 1.66 1.66 1.66 1.66 1.66 1.66 1.66 1.66 1.66 1.66 1.66 1.66 1.66 1.66 1.66 1.66 1.65 1.65 1.65 1.65 1.65 1.65 1.65 1.65 1.65 1.65 1.65 1.65 1.65 1.65 1.65 1.65 1.65 1.65 1.65 1.65 1.65 1.64 1.64 70 C192R120 C050R160 C221R115 C245R113 C197R107 C081R018 C075R031 C023R075 C052R075 C053R065 C091R079 C255R113 C025R016 C032R036 C097R119 C207R080 C118R004 C205R088 C010R135 C005R058 C185R060 C061R161 C187R024 C196R072 C039R021 C140R157 C093R095 C083R135 C071R090 C175R003 C067R005 C061R129 C195R089 C220R128 C079R035 C069R043 C159R049 C162R086 C074R100 C092R059 C222R158 C094R026 synapsin-2-like isoform 1 glutamate decarboxylase 1 swi snf-related matrix-associated actin-dependent zinc finger protein 576 uridine-cytidine kinase 1 UNKNOWN protein fam199x transmembrane emp24 domain-containing protein 3 zinc finger protein 25 polyadenylate-binding protein 2 probable g-protein coupled receptor 88 transmembrane protein 9b precursor UNKNOWN btb poz domain-containing protein kctd5 l-seryl-trna kinase lysosomal protective protein UNKNOWN rna-binding protein musashi homolog 1 adaptin ear-binding coat-associated protein 1 ependymin precursor uv excision repair protein rad23 homolog b ubiquitin carboxyl-terminal hydrolase isozyme l3 tetratricopeptide repeat protein 32 protein fam50a c-x-c motif chemokine 14 precursor probable hydrolase pnkd isoform 2 ribosome biogenesis protein nsa2 homolog guanine nucleotide-binding protein g subunit alpha-2 casein kinase i isoform alpha isoform 1 loc553515 partial transmembrane protease serine 9-like actin-related protein 2 ras-related and estrogen-regulated growth inhibitor adp-ribosylation factor 1 probable saccharopine dehydrogenase hig1 domain family member 1a hematological and neurological expressed 1 26s protease regulatory subunit 6b isoform 1 septin-9-like isoform x2 eukaryotic initiation factor 4a-ii basic leucine zipper and w2 domain-containing protein oxidative stress responsive 1 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.64 1.63 1.63 1.63 1.63 1.63 1.63 1.63 1.63 1.63 1.63 1.63 1.63 1.63 1.63 1.63 1.63 1.63 1.63 1.62 1.62 71 C073R114 C069R144 C143R119 C028R044 C172R139 C218R079 C050R027 C243R154 C074R084 C120R116 C078R056 C112R139 C084R047 C154R168 C048R094 C057R130 C106R010 C145R165 C147R069 C057R148 C162R021 C145R034 C264R142 C047R034 C010R150 C196R097 C103R078 C142R151 C025R081 C201R005 C069R103 C209R067 C166R106 C067R160 C156R002 C040R125 C058R067 C174R015 C017R025 C074R167 C207R100 C150R009 t-complex protein 1 subunit delta ring finger protein 4 purpurin precursor protein lunapark-b platelet receptor gi24 v-type proton atpase 116 kda subunit a isoform 1-like protein lin-7 homolog c PREDICTED: hypothetical protein LOC100698742 probable palmitoyltransferase zdhhc16-like eukaryotic peptide chain release factor subunit 1 mitochondrial precursor zinc finger ran-binding domain-containing protein 2 lysophospholipase i transmembrane protein 59-like dehydrogenase reductase sdr family member 11-like upf0468 protein c16orf80 homolog caspase 3 3 -5 exoribonuclease 1-like atpase family aaa domain-containing protein 1 rho guanine nucleotide exchange factor 4 protein arginine n-methyltransferase 5 isoform 1 nucleosome assembly protein 1-like 1 tight junction protein zo-1-like ras-related protein rab-2a protein sys1 homolog bccip homolog protein mal2 fish virus induced trim protein multivesicular body subunit 12a type ii keratin e3 exocyst complex component 1 gap junction beta-4 protein serine threonine-protein phosphatase pp1-gamma UNKNOWN circularly permutated ras protein 1-like homeobox protein dlx-3 transcription initiation factor tfiid subunit 10 cap-specific mrna (nucleoside-2 -o-)-methyltransferase 1 beta-catenin-interacting protein 1 protein manbal dcn1-like protein 5 heat shock 70 kda protein 4l 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.62 1.61 1.61 1.61 1.61 1.61 1.61 1.61 1.61 1.61 1.61 1.61 1.61 1.61 1.61 1.61 1.61 1.61 1.61 1.61 1.61 72 C204R046 C199R025 C039R032 C069R127 C174R051 C146R061 C106R080 C061R103 C032R007 C096R080 C168R130 C258R155 C226R020 C259R150 C228R005 C051R123 C092R117 C172R085 C259R070 C039R084 C021R027 C096R044 C159R100 C026R074 C072R127 C114R059 C263R035 C223R038 C088R162 C214R069 C226R072 C194R054 C088R139 C248R022 C248R166 C195R092 C218R159 C188R035 C263R085 C098R105 C112R116 C226R146 tcf3 fusion partner homolog serine threonine-protein phosphatase 2a 65 kda phosphogluconate dehydrogenase UNKNOWN cytochrome b-c1 complex subunit 10 UNKNOWN insulin-like growth factor binding protein 5 vesicular glutamate transporter 1-like translocon-associated protein subunit alpha-like palmitoyltransferase zdhhc3-like beta-glucuronidase-like transcription initiation factor tfiid subunit 10 UNKNOWN cytochrome c oxidase subunit viia-related mitochondrial probable g-protein coupled receptor 116 tetraspanin-7 dna chr wayne state university expressed mki67 fha domain-interacting nucleolar phospho receptor expression-enhancing protein 5 rad51-associated protein 1 histone h5a regulator of g-protein signaling 5-like rna methyltransferase like 1 transcription initiation factor tfiid subunit 7 beta- partial bccip homolog charged multivesicular body protein 2a delta-6 fatty acyl desaturase endoplasmic reticulum resident protein 44 inositol monophosphatase 2 isoform a glutathione s-transferase ubiquitin carboxyl-terminal hydrolase 47 wnt1-inducible-signaling pathway protein 1-like glycogen liver form fructose- -bisphosphatase tigar b-like UNKNOWN hyaluronan and proteoglycan link protein 1 adp-ribosylation factor 1 nicotinamide riboside kinase 2 UNKNOWN u2 small nuclear ribonucleoprotein a 1.61 1.61 1.61 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.60 1.59 1.59 1.59 1.59 1.59 1.59 1.59 1.59 1.59 1.59 1.59 1.59 1.59 73 C141R030 C266R075 C246R123 C185R024 C115R006 C071R122 C016R043 C018R088 C203R089 C075R032 C216R024 C063R030 C094R097 C112R088 C024R015 C222R106 C081R161 C095R007 C147R046 C030R142 C240R118 C041R118 C065R084 C092R064 C084R155 C173R029 C022R055 C215R031 C173R060 C261R113 C017R145 C078R127 C112R150 C109R051 C180R157 C082R091 C054R157 C185R081 C245R010 C120R088 C240R094 C139R135 arrestin-c-like asparagine-trna cytoplasmic spry domain-containing protein 7 isoform 1 rna-binding protein nob1 farnesyl pyrophosphate synthase ras-related gtp-binding protein a calpain-1 catalytic subunit-like phosphoethanolamine n-methyltransferase 3 kinesin light chain 4 surfeit locus protein 6 dnaj homolog subfamily a member mitochondrial tumor-associated calcium signal transducer 2 precursor btb poz domain-containing protein kctd17 26s proteasome non-atpase regulatory subunit 7 hcls1-binding protein 3 lysine-specific demethylase 5b-like stathmin kiaa1143 homolog prefoldin subunit 4 btb poz domain-containing protein kctd20 atp-citrate synthase-like lipid phosphate phosphatase-related protein type 1 selenoprotein 1 ras-related protein rab-27a necap endocytosis associated 2 zinc finger ran-binding domain-containing protein 2 glucosamine 6-phosphate n-acetyltransferase dmx-like protein 2-like neighbor of cox4 protein kish-a histidine kinase- dna gyrase b- and hsp90-like domain 28 kda heat- and acid-stable phosphoprotein kxdl motif-containing protein 1 inhibitor of growth protein 4 mediator of rna polymerase ii transcription subunit 29 acidic coiled-coil containing protein 3 small ubiquitin-related modifier 3 precursor transmembrane 4 l6 family member 1-like protein pelota homolog krr1 small subunit processome component homolog o-phosphoseryl-trna selenium transferase carbonyl reductase 1.59 1.59 1.59 1.59 1.59 1.59 1.59 1.59 1.59 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.58 1.57 1.57 1.57 1.57 1.57 1.57 1.57 1.57 74 C140R044 C015R080 C048R158 C074R138 C061R058 C210R085 C218R083 C151R158 C238R026 C015R083 C181R051 C030R149 C009R089 C177R056 C264R017 C030R133 C113R065 C210R057 C039R048 C194R168 C036R041 C022R027 C202R040 C196R108 C177R058 C245R038 C248R031 C170R165 C246R076 C135R092 C029R069 C162R064 C063R006 C205R083 C192R042 C078R042 C019R145 C067R019 C057R031 C223R043 C041R055 C180R008 iroquois-class homeodomain protein irx-5 eh domain-containing protein 1 scel protein abhydrolase domain-containing protein 4 ras-related protein rab-27b general transcription factor iie subunit 2 h+ v1 subunit h transforming protein precursor solute carrier family 35 member b1 zinc finger protein 420-like stathmin serine threonine-protein phosphatase 2a 55 kda peroxisomal -dienoyl- reductase gem-associated protein 8-like cd59 glycoprotein precursor death-associated 1-a chromosome 11 open reading frame 87 inhibitor of growth member 5 dna-directed rna polymerase ii subunit rpb11-a proteasome activator complex subunit 3 cathepsin d trafficking protein particle complex subunit 2-like protein schwannomin-interacting protein 1 UNKNOWN probable ergosterol biosynthetic protein 28 UNKNOWN tho complex subunit 3 biglycan isoform 2 ubiquitin-conjugating enzyme e2 d2 adp-ribosylation factor-like protein 5a rna-binding protein 39 galectin-related protein b-like tetraspanin-7 cop9 signalosome complex subunit 2 isoform 1 alpha-aminoadipic semialdehyde dehydrogenase heat shock 70 kda protein 4-like protein tmed8 cop9 signalosome complex subunit 7a chaperonin containing subunit 7 protein max-like isoform 3 partner of y14 and mago vacuolar protein sorting-associated protein 28 homolog 1.57 1.57 1.57 1.57 1.57 1.57 1.57 1.57 1.57 1.57 1.57 1.57 1.57 1.57 1.57 1.57 1.57 1.57 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.56 1.55 1.55 75 C080R135 C239R049 C091R129 C187R166 C238R108 C089R095 C023R047 C042R106 C213R040 C225R080 C097R050 C082R029 C040R016 C062R096 C225R010 C048R080 C194R132 C080R079 C196R038 C175R070 C204R009 C243R047 C072R098 C005R042 C253R165 C263R125 C221R019 C074R069 C111R100 C045R006 C104R072 C086R157 C233R048 C170R037 C090R152 C255R154 C172R025 C027R097 C163R032 C172R131 C183R117 C171R007 transcription initiation factor tfiid subunit 4 sorting and assembly machinery component 50 homolog small nuclear ribonucleoprotein sm d2 mixed lineage kinase domain-like hydroxyacylglutathione hydrolase rna-binding protein musashi homolog 2 calpain-2 catalytic subunit-like serine incorporator 1 protein njmu-r1 translational activator of cytochrome c oxidase 1-like epidermal retinol dehydrogenase 2-like serine arginine-rich splicing factor 11-like UNKNOWN protein fam114a2-like carboxypeptidase e dual specificity protein phosphatase 22-a-like n-acetylglucosamine-1-phosphotransferase subunit cyclin-dependent kinase 4 inhibitor b heterogeneous nuclear ribonucleoprotein h ependymin precursor uba-like domain-containing protein 1 integral membrane protein 2b profilin-2 v-type proton atpase subunit f mrna export factor phytanoyl- hydroxylase-interacting protein rna binding protein with multiple splicing 2 gamma-glutamyl hydrolase transcription factor vbp-like ap-1 complex subunit sigma-3 iron-responsive element-binding protein 2 28s ribosomal protein mitochondrial-like mitochondrial-processing peptidase subunit beta-like calcipressin-1 14-3-3 protein beta alpha-2 26s protease regulatory subunit 8 gdp-mannose dehydratase ependymin precursor splicing arginine serine-rich 6 testis derived transcript elongation factor 2 er membrane protein complex subunit 1-like 1.55 1.55 1.55 1.55 1.55 1.55 1.55 1.55 1.55 1.55 1.55 1.55 1.55 1.55 1.55 1.55 1.55 1.55 1.55 1.55 1.55 1.54 1.54 1.54 1.54 1.54 1.54 1.54 1.54 1.54 1.54 1.54 1.54 1.54 1.54 1.54 1.54 1.54 1.54 1.54 1.54 1.54 76 C187R136 C175R062 C215R130 C116R019 C223R119 C226R129 C025R064 C181R097 C047R127 C085R130 C069R075 C163R010 C204R116 C116R118 C122R070 C109R041 C083R037 C207R063 C197R138 C035R124 C028R061 C015R093 C143R145 C251R100 C230R122 C202R166 C006R127 C058R091 C097R120 C186R135 C220R160 C092R127 C220R066 C047R073 C151R128 C154R036 C012R158 C071R011 C138R054 C092R037 C213R054 C179R155 cobw domain-containing protein 2-like probable phospholipid-transporting atpase iia-like ras-related protein rab-25 protein sco1 mitochondrial-like eukaryotic translation initiation factor 3 subunit l-like nad h dehydrogenase atp-binding cassette sub-family e member 1 transmembrane protein 199 glycylpeptide n-tetradecanoyltransferase 1 kunitz-type protease inhibitor 1-like interleukin-13 receptor subunit alpha-2-like ras-related protein rab-3b ump-cmp kinase septin-7 isoform 1 inactive dipeptidyl peptidase 10-like mitochondrial 2-oxoglutarate malate carrier protein cbp p300-interacting transactivator 2 UNKNOWN mixed lineage kinase domain-like alpha-mannosyl-glycoprotein 2-beta-ntransmembrane protein 68 serine protease 27-like methyl-binding domain protein 3 myb sant-like dna-binding domain-containing protein 3transmembrane protein 68 nop58 protein UNKNOWN leucine-rich repeat-containing protein 58-like ddb1- and cul4-associated factor 13 actin-related protein 2 dehydrogenase reductase sdr family member 13-like UNKNOWN sarcolemmal membrane-associated phosphoribosyl pyrophosphate synthase-associated breakpoint cluster region protein methyltransferase-like protein 5 coiled-coil domain-containing protein 71 lysosomal-associated transmembrane protein 4a protein kish-a endothelial differentiation-related factor 1 cyclin-dependent kinase 4 inhibitor b solute carrier family 31 (copper transporters) member 1 1.54 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.53 1.52 1.52 1.52 1.52 1.52 1.52 1.52 1.52 1.52 1.52 1.52 1.52 1.52 77 C205R049 C146R012 C184R082 C198R104 C071R039 C111R002 C075R068 C264R102 C036R029 C266R108 C015R122 C102R079 C065R130 C122R120 C148R073 C221R096 C140R032 C195R134 C096R108 C217R164 C098R054 C102R125 C059R006 C262R073 C155R142 C022R008 C036R076 C136R108 C155R148 C212R013 C067R022 C215R082 C127R081 C085R080 C072R008 C068R110 C047R041 C079R079 C019R054 C195R152 C132R086 C243R123 biogenesis of lysosome-related organelles complex 1 mitochondrial uncoupling protein 2 regulator of g-protein signaling 20 redox-regulatory protein fam213a queuine trna-ribosyltransferase integral membrane protein 2b adp-ribosylation factor 4 phosphoribosyl pyrophosphate synthase-associated charged multivesicular body protein 2b plasma alpha-l-fucosidase swi snf matrix actin dependent regulator of subfamily e3 ubiquitin-protein ligase hectd1 UNKNOWN cd9 antigen methyl- -binding domain protein 3 s-methyl-5 -thioadenosine phosphorylase palmitoyltransferase zdhhc15 UNKNOWN natterin-like protein dna-binding protein inhibitor id-1 anti-apoptotic protein nr13 bcl2 adenovirus e1b 19 kda protein-interacting protein 3collagen alpha-1 chain cell cycle progression protein 1 nedd4 family-interacting protein 1 ubiquitin carboxyl-terminal hydrolase isozyme l1 vacuolar protein sorting-associated protein 26b-like homolog subfamily c member 12 synaptic vesicle 2-related protein septin 6 activated rna polymerase ii transcriptional coactivator novel protein UNKNOWN UNKNOWN tomoregulin-1-like ectonucleoside triphosphate diphosphohydrolase 2 zinc finger protein 2 homolog zinc finger protein 830 cathepsin l scel protein bola-like protein 3-like heat shock protein 67b2 1.52 1.52 1.52 1.52 1.52 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 1.51 78 C110R020 C042R010 C216R067 C176R098 C067R034 C202R010 C141R031 C253R124 C019R095 C052R105 C005R114 C031R158 C252R149 C224R081 C143R111 C184R073 C201R007 C215R081 C235R012 C096R009 C064R008 C213R081 C065R149 C062R081 C097R051 C116R129 C200R006 C081R001 C073R072 C089R100 C161R159 C172R087 C237R136 C188R167 C075R115 C082R056 C082R150 C028R137 C091R023 C095R105 C097R083 C188R079 v-type proton atpase subunit s1-like cystathionine gamma-lyase probable hydrolase pnkd-like ewing sarcoma breakpoint region 1b dynein heavy chain axonemal-like guanine nucleotide-binding 3 peptidyl-prolyl cis-trans isomerase h stathmin-like 3 daz-associated protein 2 lupus la protein homolog elmo domain-containing protein 2 plasminogen activator inhibitor 1 rna-binding protein nedd4 family-interacting protein 1 protein fam98b protein fam219b lamina-associated polypeptide isoforms beta gamma epidermal growth factor-like protein 6 amphiphysin-like isoform x9 protein max-like isoform 3 ovarian cancer-associated gene 2 protein homolog tetraspanin-9 katnb1-like protein 1 chibby homolog 1 UNKNOWN hiv tat-specific factor 1 homolog protein manbal bccip homolog ets-related transcription factor elf-3 mediator of rna polymerase ii transcription subunit 29 n-terminal asparagine amidohydrolase UNKNOWN ras-related c3 botulinum toxin substrate 1 (rho small gtp v-type proton atpase proteolipid subunit-like protein UNKNOWN zinc finger protein zic 5-like jumping translocation breakpoint heme transporter hrg1 protein phosphatase catalytic gamma isoform lanosterol 14-alpha demethylase-like serine threonine-protein kinase pim-1-like twisted gastrulation protein homolog 1 coiled-coil domain-containing protein 23 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.49 1.49 1.49 1.49 1.49 1.49 1.49 1.49 1.49 1.49 1.49 1.49 1.49 1.49 1.49 1.49 1.49 1.49 1.49 1.49 1.48 79 C188R140 C086R085 C226R105 C032R033 C069R112 C092R122 C167R141 C219R055 C170R113 C241R107 C179R150 C089R053 C202R022 C055R051 C060R144 C210R072 C251R007 C083R080 C228R097 C173R086 C019R106 C092R167 C051R159 C191R103 C207R079 C069R079 C113R072 C143R165 C256R136 C090R167 C210R055 C087R106 C179R005 C061R101 C224R065 C025R133 C186R109 C197R083 C015R078 C081R124 C091R071 C060R016 max-like protein x chromobox protein homolog 1-like coatomer subunit delta proteasome subunit alpha type-1 programmed cell death protein 10 retinitis pigmentosa 9 protein homolog actin-related protein 3 scan domain-containing protein 3-like nucleolin-like isoform 2 zinc finger protein 2 homolog homeobox protein dlx-2 histone-binding protein rbbp4 nfu1 iron-sulfur cluster scaffold mitochondrial calmodulin protein max-like isoform 3 centrin-1 tetraspanin-8 transmembrane protein 9b protein fam115-like calumenin isoform 2 cop9 signalosome complex subunit 6 t-complex protein 1 subunit gamma actin-related protein 3 ldlr chaperone mesd hcls1-associated protein x-1 transmembrane emp24 domain-containing protein 4 chemokine-like receptor 1-like annexin a2-a eukaryotic translation initiation factor 3 subunit j growth arrest and dna damage-inducible protein gadd45 nedd4 family-interacting protein 1 mitochondrial mimitin v-type proton atpase proteolipid subunit-like protein eukaryotic translation initiation factor 3 subunit k envoplakin-like UNKNOWN cyclin-dependent kinase inhibitor 1c UNKNOWN translation initiation factor eif-2b subunit gamma-like cysteine and glycine-rich protein 2 beta-catenin-like protein 1 programmed cell death protein 10 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.48 1.47 1.47 1.47 1.47 1.47 1.47 1.47 1.47 1.47 1.47 1.47 1.47 1.47 1.47 1.47 1.47 1.47 1.47 1.47 1.47 80 C258R141 C057R159 C062R006 C106R071 C118R143 C259R074 C086R121 C231R024 C153R119 C024R036 C048R096 C064R020 C041R026 C216R105 C112R055 C171R095 C138R129 C091R101 C082R155 C264R036 C174R009 C089R127 C091R108 C114R058 C114R138 C167R045 C162R095 C160R127 C103R127 C071R153 C022R039 C098R033 C222R095 C059R036 C138R068 C104R085 C088R129 C058R147 C190R117 C193R137 C127R065 C185R119 UNKNOWN glutathione s-transferase a cystathionine gamma-lyase myosin regulatory light chain smooth muscle isoform tubulin-specific chaperone a casein kinase ii subunit beta 40s ribosomal protein s5 cat eye syndrome critical region protein 5 homolog ras-related protein rab-27a proteasome assembly chaperone 1 protein set-like bromodomain-containing protein 3 mitotic-spindle organizing protein 1 glutathione s-transferase theta-1 2-oxoglutarate and iron-dependent oxygenase domainphosphoserine phosphatase cathepsin l cysteine-rich protein 2 tm2 domain-containing protein 2 unknown UNKNOWN adipocyte plasma membrane-associated protein histone -like phosphate carrier mitochondrial precursor methyltransferase-like protein 6 claudin domain-containing protein 1-like microfibrillar-associated protein 1 beta-hexosaminidase subunit beta-like protein btg1 UNKNOWN low quality protein: methionine-r-sulfoxide reductase b1 homolog subfamily c member 12 t-complex protein 1 subunit alpha heat shock cognate 70 kda protein small g protein signaling modulator 1-like calpain-2 catalytic subunit-like adp-ribosylation factor-like protein 2-binding protein calpain-9 isoform 3 transmembrane and tpr repeat-containing protein 4 UNKNOWN ap-1 complex subunit mu-2 raf proto-oncogene serine threonine-protein kinase 1.47 1.47 1.47 1.47 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.46 1.45 1.45 1.45 1.45 1.45 1.45 1.45 1.45 1.45 1.45 1.45 81 C028R084 C242R107 C174R154 C019R081 C059R058 C229R066 C019R159 C220R142 C134R093 C199R116 C215R162 C088R157 C118R132 C175R058 C247R077 C185R068 C142R084 C082R117 C140R046 C070R045 C007R108 C225R104 C180R156 C253R038 C153R044 C122R036 C135R080 C244R024 C184R017 C169R036 C154R142 C194R105 C075R117 C203R166 C073R148 C134R102 C035R031 C058R160 C100R124 C079R086 C234R079 C042R014 guanine nucleotide-binding protein g subunit alpha-1 rrna-processing protein utp23 homolog serine incorporator 1 programmed cell death protein 10 mortality factor 4-like protein 1 UNKNOWN dna-binding protein inhibitor id-1 UNKNOWN src substrate protein p85-like serine threonine-protein phosphatase 2a catalytic protein set secretory carrier-associated membrane protein 4 cyclin i pax-6 protein calmodulin x-box binding protein 1 peroxiredoxin-1 transmembrane protein 109-like fun14 domain-containing protein 2 beta-2-microglobulin precursor neurogenic differentiation factor 2-like UNKNOWN protein pelota homolog lamin-b receptor interferon-induced guanylate-binding protein 1 actin-related protein 2 3 complex subunit 1a UNKNOWN argininosuccinate synthase nucleolar gtp-binding protein 1 choline transporter-like protein 2-like histone actin-related protein 2 3 complex subunit 3 trafficking protein particle complex subunit 3 aurora kinase b c-type natriuretic peptide 1 precursor retinaldehyde-binding protein 1-like protein fam219a isoform x1 cystatin precursor transmembrane protein 50a UNKNOWN tight junction protein zo-2-like signal peptidase complex catalytic subunit sec11a 1.45 1.45 1.45 1.45 1.45 1.45 1.45 1.45 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.44 1.43 1.43 1.43 1.43 1.43 1.43 1.43 1.43 1.43 1.43 1.43 1.43 82 C212R170 C225R159 C023R008 C251R024 C057R083 C053R020 C106R069 C190R015 C092R070 C129R086 C243R008 C170R110 C063R129 C138R146 C189R035 C150R072 C113R163 C039R103 C136R077 C089R033 C140R121 C063R126 C226R110 C148R048 C117R097 C182R097 C096R026 C059R055 C220R120 C174R079 C255R032 C265R107 C042R019 C209R092 C190R097 C144R053 C059R048 C103R116 C116R008 C035R109 C204R099 C158R156 prepro-thyrotropin-releasing hormone 14-3-3 protein zeta delta UNKNOWN sialic acid synthase UNKNOWN dual specificity protein kinase clk4 neuroendocrine protein 7b2 chromosome 6 open reading frame 106 mitochondrial-processing peptidase subunit beta-like dolichyl-diphosphooligosaccharide-protein homeobox protein otx2 krueppel-like factor 6 translationally-controlled tumor protein scinderin like a n-lysine methyltransferase setd8-a-like purine nucleoside phosphorylase-like riboflavin-binding protein UNKNOWN probable ergosterol biosynthetic protein 28 sideroflexin 2 chromobox protein homolog 1 glutathione s-transferase a paired box protein pax-6 isoform 2 glycerophosphodiester phosphodiesterase domaindna-binding protein inhibitor id-1 translation initiation factor eif-2b subunit alpha transmembrane protein 60 isovaleryl coenzyme a dehydrogenase transmembrane protein 9b splicing arginine serine-rich 2 occludin b UNKNOWN tumor necrosis factor receptor superfamily member 1a androgen-dependent tfpi-regulating protein er lumen protein retaining receptor 3 vacuolar protein sorting-associated protein 11 homolog n-acetylgalactosaminyltransferase 7-like transmembrane emp24 domain-containing protein 4 adenylate kinase isoenzyme 6-like 28s ribosomal protein mitochondrial-like annexin a11 gtpase imap family member 7-like 1.43 1.43 1.43 1.43 1.43 1.43 1.43 1.42 1.42 1.42 1.42 1.42 1.42 1.42 1.42 1.42 1.42 1.42 1.42 1.42 1.42 1.42 1.41 1.41 1.41 1.41 1.41 1.41 1.41 1.41 1.41 1.41 1.41 1.41 1.41 1.41 1.41 1.41 1.41 1.41 1.41 1.41 83 C057R094 C256R148 C151R170 C146R057 C245R110 C175R165 C140R114 C098R169 C180R149 C148R105 C200R092 C069R096 C043R093 C192R069 C190R017 C220R161 C213R085 C229R107 C090R155 C169R158 C042R044 C095R068 C170R155 C092R091 C014R064 C187R068 C191R091 C170R019 C095R091 C171R036 C205R046 C067R108 C144R073 C078R012 C142R057 C178R013 C189R069 C254R162 C251R052 C033R014 C178R139 C264R046 endothelial differentiation-related factor 1 UNKNOWN beta- -galactosyltransferase 1 rhombotin-1 UNKNOWN 15-hydroxyprostaglandin dehydrogenase 116 kda u5 small nuclear ribonucleoprotein component cyclin-d1-binding protein 1 homolog lim zinc-binding domain-containing nebulette isoform 2 rab gtpase-binding effector protein 2 ras gtpase-activating protein-binding protein 1-like protein cwc15 homolog phosphatidylinositol n-acetylglucosaminyltransferase nuclear receptor subfamily 1 group d member 2-like trna selenocysteine 1-associated protein 1-like malonyl-acyl carrier protein mitochondrial poly polymerase 12 ubiquitin-conjugating enzyme e2 d4 sialic acid synthase rna 3 -terminal phosphate cyclase cadherin type n-cadherin protein phosphoglycerate mutase 1 atlastin-3 kinesin-associated protein 3 x-box binding protein 1 splicing arginine serine-rich 2 nucleolar rna helicase 2-like apoptotic protease-activating factor 1-like gpn-loop gtpase 1-like er lumen protein retaining receptor 2 nucleolar gtp-binding protein 1 tubulin-specific chaperone e cathepsin z-like 4f2 cell-surface antigen heavy chain riboflavin transporter 2-like hydroxymethylglutaryl- mitochondrial-like lysyl-trna synthetase splicing arginine serine-rich 3 calmodulin retinol dehydrogenase 14-like aspartate mitochondrial-like h aca ribonucleoprotein complex subunit 3 1.41 1.40 1.40 1.40 1.40 1.40 1.40 1.40 1.40 1.40 1.40 1.40 1.40 1.40 1.40 1.39 1.39 1.39 1.39 1.39 1.39 1.39 1.39 1.39 1.39 1.39 1.39 1.39 1.39 1.38 1.38 1.38 1.38 1.38 1.38 1.38 1.38 1.38 1.38 1.37 1.37 1.37 84 C094R064 C182R063 C229R058 C093R009 C204R126 C170R065 C074R091 C072R069 C168R086 C078R065 C191R108 C068R020 C084R112 C056R016 C083R152 C070R142 C080R072 C179R162 C097R093 C089R075 C231R097 C045R105 C087R045 C238R054 C027R100 C090R049 C088R087 C095R071 C218R136 C201R094 C027R045 C097R066 C155R123 C189R102 C171R053 C257R024 C197R096 C114R052 C099R073 C076R007 C202R165 C189R140 comm domain-containing protein 7 translocon-associated protein subunit delta precursor transmembrane protein 93 26s protease regulatory subunit 6b isoform 1 pleiotrophic factor-alpha-2 precursor myelin transcription factor 1-like UNKNOWN transmembrane emp24 domain-containing protein 10 uv excision repair protein rad23 homolog a isoform 1 adenosine deaminase er lumen protein retaining receptor 3 calcium calmodulin-dependent protein kinase ii inhibitor alpha-aspartyl dipeptidase glutathione s-transferase theta-1 UNKNOWN serine threonine-protein kinase sgk1-like armadillo repeat-containing protein 6-like dual specificity protein phosphatase 14 u3 small nucleolar rna-interacting protein 2 ran-binding protein 3-like transcription initiation factor tfiid subunit 10 cytochrome b-c1 complex subunit 10 sjchgc03036 protein leucine-rich glioma-inactivated protein 1 precursor comm domain-containing protein 3 dehydrogenase reductase sdr family member 11 zgc:174935 protein protein kish-b retinol dehydrogenase 3 protein fam134a-like UNKNOWN myotubularin-related protein 7 x-box binding protein 1 eukaryotic translation initiation factor 3 subunit 6 mam domain-containing protein 2 ezrin isoform 2 cop9 signalosome complex subunit 5 voltage-dependent anion-selective channel protein 2-like zinc finger protein 185 isoform 6 coiled-coil domain-containing protein 94 transcription factor glutathione s-transferase theta-1 1.37 1.37 1.37 1.37 1.37 1.36 1.36 1.36 1.36 1.36 1.36 1.36 1.36 1.36 1.36 1.36 1.36 1.36 1.36 1.36 1.35 1.35 1.35 1.35 1.35 1.35 1.35 1.35 1.34 1.34 1.34 1.34 1.34 1.34 1.33 1.33 1.33 1.33 1.32 1.32 1.32 1.32 85 C073R056 C138R100 C234R085 C150R026 C091R091 C043R105 C078R114 C073R068 C001R059 C121R042 C234R122 C231R083 C059R084 C045R038 C124R077 C097R154 C181R144 C164R046 C153R142 C152R101 C015R047 C139R083 C001R052 C155R106 C046R069 C101R045 C130R104 C259R025 C241R069 C233R124 C253R055 C152R165 C229R153 C154R098 C121R027 C084R049 C130R070 C192R128 C095R021 C082R028 C232R041 C131R116 phytanoyl- hydroxylase-interacting protein UNKNOWN e3 ubiquitin-protein ligase arih1-like transposable element tcb2 transposase eukaryotic translation initiation factor 3 subunit j proactivator polypeptide precursor low density lipoprotein receptor adapter protein 1 ss18-like protein 2 glycogen muscle form xaa-pro aminopeptidase 1 hig1 domain family member 2a nedd4 family-interacting protein 2 transmembrane protein 182 beta-parvin-like isoform x1 kinase d-interacting substrate of 220 kda-like g kinase-anchoring protein 1 general transcription factor 3c polypeptide 6 amyotrophic lateral sclerosis 2 chromosomal region branched-chain-amino-acid cytosolic-like cytochrome b-c1 complex subunit mitochondrial-like gdp-l-fucose synthetase UNKNOWN cap-gly domain-containing linker protein 1 ubiquitin conjugation factor e4 a sjchgc03018 protein UNKNOWN transcription factor 20 isoform 2 mrna turnover protein 4 homolog interleukin-1 receptor-associated kinase 3 dnaj homolog subfamily c member 15 26s protease regulatory subunit 8 heterogeneous nuclear ribonucleoprotein k endoplasmin precursor UNKNOWN ribosomal protein s6 kinase beta-1-like UNKNOWN matrin-3 allograft inflammatory factor 1 c-c motif chemokine 20-like UNKNOWN UNKNOWN phosphorylase b kinase regulatory subunit beta-like 1.32 1.32 1.30 1.29 1.25 0.80 0.79 0.78 0.78 0.78 0.78 0.78 0.78 0.78 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.77 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 0.76 86 C190R116 C030R035 C252R092 C045R100 C014R130 C016R052 C026R129 C219R075 C170R082 C126R089 C083R028 C143R140 C059R097 C037R080 C219R071 C133R012 C173R100 C064R082 C158R131 C051R012 C131R041 C229R088 C103R108 C164R086 C211R107 C117R098 C096R068 C040R115 C155R071 C074R096 C182R067 C143R106 C107R039 C116R045 C053R015 C094R017 C160R059 C092R036 C154R121 C013R059 C112R095 C112R096 deoxyhypusine hydroxylase coiled-coil-helix-coiled-coil-helix domain containing 2 UNKNOWN na k atpase alpha subunit isoform 1c UNKNOWN casein kinase i isoform delta hypoxia-inducible factor 1 alpha atpase mitochondrial precursor zinc finger protein 62 homolog UNKNOWN ets translocation variant 4 UNKNOWN UNKNOWN UNKNOWN ubiquitin-conjugating enzyme e2 d2 cat eye syndrome critical region protein 5 homolog UNKNOWN UNKNOWN interferon-induced guanylate-binding protein 1 transposable element tcb1 transposase cell differentiation protein rcd1 homolog cdgsh iron-sulfur domain-containing protein 2 coiled-coil domain-containing protein 51-like tether containing ubx domain for glut4 peptidyl-trna hydrolase mitochondrial sphingomyelin phosphodiesterase 4 succinyl- ligase transmembrane protein 237a-like thrombospondin 2 chromosome-associated kinesin kif4a transcriptional repressor ctcf-like swi snf-related matrix-associated actin-dependent 39s ribosomal protein mitochondrial precursor hypoxia up-regulated protein 1-like UNKNOWN tfiih basal transcription factor complex helicase xpd mitogen-activated protein kinase kinase kinase kinase 3protein-tyrosine sulfotransferase 1 rna-binding protein 4b macrophage-capping protein UNKNOWN dna topoisomerase 1 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.75 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 87 C112R077 C112R070 C011R098 C200R141 C053R019 C161R096 C201R084 C111R069 C177R068 C072R039 C148R072 C070R109 C228R094 C157R093 C266R131 C166R036 C017R121 C175R139 C121R043 C186R097 C159R019 C063R011 C035R142 C125R130 C140R017 C173R150 C250R054 C214R162 C016R164 C028R058 C197R076 C078R022 C133R136 C145R083 C108R029 C169R045 C157R110 C191R124 C174R155 C180R140 C154R024 C209R139 camp-dependent protein kinase type ii-alpha regulatory intron-binding protein aquarius tropomodulin-4 tpm1 protein UNKNOWN nuclear pore complex protein nup160 membrane-spanning 4-domains subfamily a member 4a protoheme ix mitochondrial-like mannose-6-phosphate isomerase-like UNKNOWN UNKNOWN UNKNOWN UNKNOWN peptidyl-trna hydrolase mitochondrial precursor myeloid differentiation factor 88 UNKNOWN transmembrane protein 134-like cation-independent mannose-6-phosphate receptor neurofilament light polypeptide-like ctp synthase 1-like sororin pls3 protein cleft lip and palate transmembrane protein 1-like protein endothelin-converting enzyme 2-like major facilitator superfamily domain-containing protein UNKNOWN gdp dissociation inhibitor 2 kin of irre-like protein 1-like UNKNOWN ubiquitin-conjugating enzyme e2 d2 UNKNOWN cellular nucleic acid-binding protein protein yipf5 UNKNOWN UNKNOWN protein fam212a-like protein kish-a developmentally-regulated gtp-binding protein 1 26s proteasome non-atpase regulatory subunit 3 UNKNOWN UNKNOWN homocysteine-responsive endoplasmic reticulum- 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.74 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 88 C060R042 C157R127 C229R033 C014R125 C207R072 C188R115 C040R121 C139R127 C119R095 C075R082 C098R046 C104R078 C184R101 C034R074 C100R094 C097R085 C010R104 C240R060 C007R133 C140R088 C245R100 C178R061 C129R010 C111R160 C074R125 C157R166 C075R063 C031R117 C160R107 C229R126 C144R068 C043R081 C215R079 C157R158 C075R079 C131R090 C109R093 C101R107 C075R021 C151R058 C030R012 C229R019 arginyl-trna-protein transferase 1 cytochrome c oxidase subunit mitochondrial precursor exosome complex exonuclease rrp44 ubiquitin-conjugating enzyme e2 g1 uridine 5 -monophosphate synthase UNKNOWN neurochondrin isoform 1 UNKNOWN UNKNOWN UNKNOWN UNKNOWN cleavage stimulation factor subunit 3 UNKNOWN oocyte zinc finger protein 20 ring finger protein 170 transmembrane protein 39b gamma b (breast cancer-specific protein 1) component of gems 4 survival motor neuron protein 1 lysosomal thioesterase ppt2-a-like fructose -bisphosphatase 1-like rna-binding protein musashi homolog 2 isoform 1 ribosomal protein partial slit-robo rho gtpase-activating protein 3-like isoform x2 e3 ubiquitin-protein ligase march6 sodium potassium-transporting atpase subunit beta-233 bmp-binding endothelial regulator protein nuclear receptor coactivator 6-like vasculin-like protein 1 regulation of nuclear pre-mrna domain-containing ran-specific gtpase-activating protein cullin-3 isoform 2 calpain-3 isoform 3 UNKNOWN splicing factor 3a subunit 1 isoform 1 rho guanine nucleotide exchange factor 15-like transposase h aca ribonucleoprotein complex subunit 1 phytanoyl- dioxygenase domain-containing protein 1 v-set and transmembrane domain-containing protein 2UNKNOWN eukaryotic translation initiation factor 2 subunit 1 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.73 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 89 C040R043 C113R032 C160R104 C240R072 C205R156 C252R074 C171R089 C172R098 C255R123 C135R134 C171R059 C081R147 C081R106 C133R044 C167R022 C108R010 C172R142 C106R056 C126R044 C234R087 C182R121 C074R104 C111R056 C065R065 C127R128 C232R114 C200R100 C236R151 C221R094 C168R120 C013R122 C103R132 C075R073 C015R138 C150R071 C118R086 C230R126 C123R079 C252R069 C229R119 C214R165 C003R097 UNKNOWN UNKNOWN UNKNOWN replication protein a 14 kda subunit UNKNOWN targeting protein for xklp2 UNKNOWN lysyl-trna synthetase UNKNOWN dedicator of cytokinesis protein 2 UNKNOWN UNKNOWN nadh dehydrogenase UNKNOWN atp-binding cassette sub-family d member 3 isoform 2 e3 ubiquitin-protein ligase bre1a g-protein-signaling modulator 2 triadin UNKNOWN myocyte-specific enhancer factor 2c-like isoform 2 coagulation factor xiii a chain cytochrome c oxidase subunit vib isoform 1 cytochrome c oxidase subunit vib isoform 1 UNKNOWN b-cell cll lymphoma 9 protein translation initiation factor eif-2b subunit delta-like tropomyosin 4 UNKNOWN UNKNOWN polyhomeotic-like protein 1-like UNKNOWN keratinocyte-associated transmembrane protein 2-like UNKNOWN signal recognition particle 72 kda protein protein kinase c beta type-like nad mitochondrial-like proteasome subunit alpha type-6 UNKNOWN laminin subunit alpha-2 protection of telomeres protein 1 cytochrome b focal adhesion kinase partial 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.72 0.71 0.71 0.71 0.71 90 C121R065 C196R081 C117R126 C260R141 C053R033 C149R117 C229R065 C019R143 C177R120 C231R113 C162R114 C097R137 C171R066 C155R025 C120R045 C229R070 C046R169 C130R088 C015R042 C125R027 C144R089 C169R048 C204R088 C141R018 C259R042 C229R035 C063R095 C162R158 C044R022 C046R009 C139R096 C149R127 C165R058 C068R133 C230R035 C164R011 C066R062 C007R091 C199R146 C203R124 C260R080 C244R115 transmembrane protein 97 rna-binding protein 40 UNKNOWN pantophysin related to transposase UNKNOWN squalene synthase target of egr1 protein 1 t-complex protein 1 subunit gamma isoform 1 ribosomal rna small subunit methyltransferase nep1-like cell division cycle protein 27 homolog protein fam167a-like transmembrane protein c7orf23 homolog cell adhesion molecule 4-like UNKNOWN UNKNOWN integrin-linked protein kinase protein zwilch homolog proteasome maturation protein thioredoxin-like protein 1 upf0609 protein c4orf27 homolog heat shock cognate 71 kda PREDICTED: uncharacterized protein C9orf152-like UNKNOWN eukaryotic translation initiation factor 4e type 2 leucine-rich repeat flightless-interacting protein 2 c-x-c motif chemokine 10 precursor 26s proteasome non-atpase regulatory subunit 10 protein fem-1 homolog c-like dermatan 4 sulfotransferase 1 cdk5 regulatory subunit associated protein 1-like 1 tropomyosin alpha-1 chain isoform 4 UNKNOWN homeobox protein otx5-like UNKNOWN origin recognition complex subunit 3-like carboxy-terminal domain rna polymerase ii polypeptide arf-gap with sh3 ank repeat and ph domain-containing UNKNOWN histone-lysine n-methyltransferase ezh2-like ubiquitin-protein ligase e3a-like UNKNOWN 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 91 C112R112 C092R009 C255R047 C236R033 C127R087 C109R024 C059R016 C089R139 C142R125 C006R065 C086R070 C167R088 C145R062 C064R035 C253R043 C087R012 C157R038 C215R121 C108R041 C119R059 C144R159 C219R149 C250R114 C230R124 C177R146 C169R043 C194R076 C058R017 C187R117 C169R164 C157R131 C227R169 C208R092 C215R143 C165R135 C225R137 C046R076 C204R131 C140R092 C027R071 C098R134 C013R126 UNKNOWN low quality protein: dedicator of cytokinesis protein 10origin recognition complex subunit 5 UNKNOWN twinfilin-1 sjchgc04011 protein transmembrane protein 129 usp6 n-terminal-like UNKNOWN atp-binding cassette sub-family f member 2 UNKNOWN ubiquitin-associated protein 2-like isoform x1 f-box lrr-repeat protein 17 dual specificity protein phosphatase 14 acyl- dehydrogenase -like UNKNOWN mannosyltransferase-like ceramide kinase-like protein isoform 2 UNKNOWN tyrosine-protein kinase btk prefoldin subunit 4 UNKNOWN polyadenylate-binding protein 4 nucleolar protein 14 UNKNOWN nad-dependent deacetylase sirtuin-5 targeting protein for xklp2 UNKNOWN golgi resident protein gcp60 exportin-2 steroid receptor rna activator 1 39s ribosomal protein mitochondrial precursor sulfide:quinone mitochondrial nesprin- partial ntf2-related export protein 2 UNKNOWN novel protein xin actin-binding repeat-containing protein 2 isoform 3 vesicle-fusing atpase 14 kda phosphohistidine phosphatase bis(5 -nucleosyl)-tetraphosphatase UNKNOWN 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.71 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 92 C066R052 C021R165 C129R017 C153R053 C060R085 C225R072 C116R062 C095R169 C131R094 C242R073 C065R085 C123R081 C174R161 C128R054 C160R096 C208R109 C060R051 C093R033 C103R128 C076R167 C052R056 C204R087 C234R027 C255R076 C074R128 C061R078 C259R049 C146R120 C125R091 C191R144 C241R119 C018R152 C068R049 C080R021 C070R033 C155R053 C201R076 C144R110 C098R149 C090R106 C118R098 C243R094 g-protein coupled receptor 182 kinesin-like protein kif11-like phosphoglucomutase 1 protein fam184a rab3 gtpase-activating protein non-catalytic subunit transposase UNKNOWN UNKNOWN fructose-bisphosphate aldolase a acetyl-coenzyme a synthetase 2- mitochondrial-like tcb1 transposase gamma-crystallin m2-like UNKNOWN nucleolar protein 14 tyrosine-protein kinase jak1 UNKNOWN UNKNOWN UNKNOWN UNKNOWN choline transporter-like protein 2 leupaxin sra stem-loop-interacting rna-binding mitochondrial gelsolin isoform 1 UNKNOWN novel protein UNKNOWN leucine-rich repeat and wd repeat-containing protein 1 calumenin isoform 6 platelet-activating factor acetylhydrolase growth hormone receptor 2 UNKNOWN enolase 2 calmodulin-like protein 4 dymeclin-like isoform x1 nipped-b-like protein pleckstrin homology domain-containing family a member UNKNOWN UNKNOWN sterol regulatory element-binding protein 1 UNKNOWN proteasomal ubiquitin receptor adrm1-like UNKNOWN 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 93 C049R010 C080R163 C063R052 C134R147 C182R064 § C010R015 C239R124 C194R167 C094R101 C120R115 C172R088 C129R170 C104R018 C222R144 C116R135 C111R064 C129R061 C249R144 C147R067 C056R116 C105R066 C248R111 C112R115 C231R119 C085R139 C165R078 C141R137 C044R119 C158R050 C195R132 C092R140 C155R062 C043R061 C231R139 C049R077 C199R081 C030R115 C122R077 C219R095 C175R071 C130R125 C032R137 grb2-associated-binding protein 1 isoform 2 importin subunit alpha-2 major egg antigen metallothionein transposable element tcb1 transposase cd276 antigen-like UNKNOWN UNKNOWN UNKNOWN UNKNOWN eukaryotic translation initiation factor 4e tcb1 transposase u5 small nuclear ribonucleoprotein 40 kda protein UNKNOWN UNKNOWN UNKNOWN UNKNOWN UNKNOWN PREDICTED: ankyrin-1-like UNKNOWN ras-related protein rab-11b dual specificity protein kinase ttk UNKNOWN gigaxonin oocyte zinc finger protein 20 UNKNOWN tubulin epsilon chain atp-dependent rna helicase ddx18 UNKNOWN poly -binding protein 4-like transmembrane protein 237a-like thioredoxin domain-containing protein 15 adp-ribosylation factor-binding protein gga1-like transposable element tcb1 transposase UNKNOWN UNKNOWN UNKNOWN tetraspanin-5 aspartyl aminopeptidase protein transport protein sec61 subunit gamma canalicular multispecific organic anion transporter 2-like e3 ubiquitin-protein ligase arih2 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.70 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 94 C248R039 C082R087 C062R092 C187R163 C232R141 C126R076 C003R088 C208R104 C104R028 C234R112 C139R058 C012R051 C110R041 C150R154 C254R121 C220R165 C143R043 C154R109 C153R081 C051R026 C150R088 C067R008 C118R021 C068R036 C063R048 C213R134 C121R075 C021R057 C242R010 C135R066 C125R039 C055R024 C243R144 C265R143 C198R093 C210R034 C102R138 C123R128 C166R114 C059R026 C198R132 C142R132 UNKNOWN nadh dehydrogenase UNKNOWN cell division control protein 2 homolog cytoglobin thrombospondin 4 protein fam212a-like zinc finger protein 521 frizzled homolog 7a dihydrolipoyllysine-residue acetyltransferase component krueppel-like factor 11-like steroid receptor rna activator 1 glycine dehydrogenase fast kinase domain-containing protein 1 UNKNOWN UNKNOWN retinoic acid receptor rxr-alpha-like dual adapter for phosphotyrosine and 3mitochondrial ornithine transporter 1 UNKNOWN UNKNOWN mitochondrial 28s ribosomal protein s28 UNKNOWN target of rapamycin complex 2 subunit mapkap1-like UNKNOWN ras-related protein rab-32-like sun domain-containing protein 1 UNKNOWN UNKNOWN teashirt homolog 1-like laminin subunit beta-2-like mitochondrial nucleoid factor 1 haus augmin-like complex subunit 6-like spry domain-containing protein 4 pleckstrin homology domain-containing family a member splicing factor 45 t-cell surface glycoprotein cd4-2 atp-dependent zinc metalloprotease yme1l1-like dna damage-regulated autophagy modulator protein 2 syndecan-3 exocyst complex component 3 UNKNOWN 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 95 C057R104 C122R107 C014R141 C059R123‡ C186R134 C125R071 C167R099 C130R155 C090R060 C026R007 C242R080 C258R130 C052R015 C203R070 C019R142 C168R119 C070R024 C241R074 C149R028 C220R073 C073R044 C144R069 C218R134 C131R130 C195R106 C153R135 C193R154 C181R170 C132R049 C001R044 C242R086 C086R036 C199R092 C078R131 C180R063 C160R134 C082R020 C172R141 C089R086 C125R025 C131R042 C131R168 UNKNOWN UNKNOWN dna-directed rna polymerase i subunit rpa43 sperm-associated antigen 5 UNKNOWN set and mynd domain-containing protein 1 isoform x2 UNKNOWN UNKNOWN secretagogin protein disulfide-isomerase a5-like UNKNOWN protein smg8-like mitochondrial nucleoid factor 1 serine threonine-protein kinase ulk1 UNKNOWN transmembrane protein 100 ran gtpase-activating protein 1-like UNKNOWN proline-rich protein bca3 ubiquitin carboxyl-terminal hydrolase 28 UNKNOWN UNKNOWN UNKNOWN adenylosuccinate lyase UNKNOWN UNKNOWN UNKNOWN UNKNOWN UNKNOWN UNKNOWN dual specificity protein kinase clk2 UNKNOWN UNKNOWN proteasome subunit beta type-7 precursor pyruvate kinase UNKNOWN histone-lysine n-methyltransferase ehmt1 UNKNOWN nuclear pore complex protein nup98-nup96-like cholecystokinin monocarboxylate transporter 2-like UNKNOWN 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.69 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 96 C062R142 C256R106 C005R139 C028R083 C152R075 C115R125 C127R129 C199R053 C109R127 C075R144 C060R140 C124R010 C153R122 C007R090 C120R059 C202R159 C111R137 C001R055 C045R129 C140R018 C248R102 C210R050 C127R007 C020R091 C103R105 C253R006 C137R128 C174R113 C101R023 C150R163 C096R079 C033R119 C034R048 C200R164 C261R044 C079R150 C088R124 C232R081 C242R064 C107R060 C202R057 C017R054 UNKNOWN transcriptional regulator kaiso-like mature t-cell proliferation 1 neighbor exosome complex component mtr3-like transmembrane protein 184b ino80 complex subunit c UNKNOWN disabled homolog 2-interacting placenta-specific protein 9-like homeobox protein six3 UNKNOWN mitochondrial inner membrane protease subunit 1 ras-related protein rab-1a mediator of rna polymerase ii transcription subunit 13zinc finger protein 180 14-3-3 protein beta alpha-2 gmp reductase 1 UNKNOWN stress-associated endoplasmic reticulum protein 1 whey acidic protein precursor 26s proteasome non-atpase regulatory subunit 2 probable xaa-pro aminopeptidase 3 lysosomal protective pyrroline-5-carboxylate reductase 3 UNKNOWN tripartite motif-containing protein 16-like probable udp-sugar transporter protein slc35a4 UNKNOWN annexin max4-like methylmalonate-semialdehyde dehydrogenase UNKNOWN UNKNOWN kelch domain-containing protein 4 ictacalcin alpha-actinin-3-like isoform 2 stress-70 mitochondrial-like tight junction-associated protein 1 bladder cancer-associated protein cullin 4a isoform cra_a u6 snrna-associated sm-like protein lsm5 nuclear autoantigenic sperm protein (histone-binding) UNKNOWN 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 97 C163R052 C216R047 C205R125 C128R164 C135R033 C028R116 C239R126 C183R038 C194R142 C141R113 C178R144 C039R091 C114R013 C169R060 C204R086 C162R130 C087R053 C233R139 C033R012 C174R165 C085R088 C040R048 C142R018 C150R084 C242R103 C166R011 C200R073 C204R026 C097R086 C242R028 C088R033 C060R086 C016R109 C066R130 C056R047 C073R054 C037R057 C111R078 C090R044 C063R121 C078R130 C224R128 UNKNOWN iron-sulfur protein nubpl-like cytochrome c oxidase subunit mitochondrial-like UNKNOWN kelch domain-containing protein 3-like isoform x1 UNKNOWN transposable element tcb1 transposase trio and f-actin-binding solute carrier family 25 (mitochondrial carrier geranylgeranyl transferase type-2 subunit alpha adenosine 3 -phospho 5 -phosphosulfate transporter 2 cell differentiation protein rcd1 homolog beta-taxilin UNKNOWN cytochrome c oxidase subunit mitochondrial-like protein regulator of cytokinesis 1 xylose isomerase UNKNOWN ankyrin repeat domain-containing protein 13c-a-like UNKNOWN UNKNOWN UNKNOWN UNKNOWN UNKNOWN tax1-binding protein 3 ran gtpase-activating protein 1-like drebrin-like protein UNKNOWN zinc finger protein 408 UNKNOWN macrophage receptor marco ribosomal protein s18 3 -5 exoribonuclease 1-like UNKNOWN protein phosphatase 1 regulatory subunit 12c myozenin-2 UNKNOWN UNKNOWN dipeptidyl peptidase 9 40s ribosomal protein s5 endonuclease domain-containing 1 UNKNOWN 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.68 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 98 C094R091 C166R051 C064R074 C164R084 C263R129 C119R016 C246R089 C190R168 C010R019 C173R090 C093R156 C042R058 C103R111 C010R045 C161R085 C171R166 C252R104 C067R163 C071R069 C243R131 C242R044 C194R011 C224R160 C253R046 C189R096 C149R046 C159R146 C004R153 C102R043 C185R155 C133R153 C227R151 C019R079 C191R166 C122R089 C215R122 C140R045 C165R125 C001R105 C242R082 C254R117 C123R106 n-alpha-acetyltransferase auxiliary subunit UNKNOWN carbonyl reductase family member 4 UNKNOWN guanine nucleotide-binding protein g subunit gamma-t1 methylmalonic aciduria and homocystinuria type c UNKNOWN UNKNOWN protein dehydrogenase reductase sdr family member 4 UNKNOWN cytochrome c oxidase subunit vib isoform 1 14 kda phosphohistidine phosphatase prefoldin subunit 2 ras-related protein rab-5c UNKNOWN hemoglobin subunit beta-1 UNKNOWN gtpase imap family member 7-like UNKNOWN atp synthase subunit mitochondrial-like nuclear distribution protein nude homolog 1-like UNKNOWN UNKNOWN protein fam184a-like UNKNOWN UNKNOWN tropomodulin-4 myozenin 1-like suppression of tumorigenicity 5 e3 ubiquitin-protein ligase rnf25 UNKNOWN phospholipid scramblase 1 ribosomal large subunit pseudouridine synthase b endothelial cell-specific molecule 1-like UNKNOWN UNKNOWN ataxin-10 stress-70 mitochondrial membrane protein mlc1-like UNKNOWN UNKNOWN 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 99 C217R036 C261R133 C189R164 C162R135 C228R131 C191R116 C266R147 C164R056 C204R139 C242R087 C092R111 C254R073 C078R046 C224R086 C097R013 C166R137 C120R023 C127R016 C082R116 C077R080 C017R119 C164R128 C102R135 C065R083 C178R160 C097R043 C104R030 C021R009 C162R071 C022R034 C030R066 C138R113 C165R024 C221R109 C201R112 C156R101 C051R107 C013R145 C059R106 C054R036 C214R057 C112R053 sperm-associated antigen 7 tudor domain-containing protein 3-like acidic leucine-rich nuclear phosphoprotein 32 family UNKNOWN dna polymerase delta catalytic subunit trna selenocysteine 1-associated protein 1 importin 5 mitochondrial ribosomal protein s16 UNKNOWN oocyte zinc finger protein 20 UNKNOWN allograft inflammatory factor 1 hypoxia up-regulated isoform cra_a rnf213 protein UNKNOWN cyclic amp-dependent transcription factor atf-1 protein transport protein sec61 subunit gamma UNKNOWN sec23-interacting protein UNKNOWN UNKNOWN alkylated dna repair protein alkb homolog 1 39s ribosomal protein mitochondrial UNKNOWN UNKNOWN zinc finger protein 292 ran protein lim-domain binding factor 3 UNKNOWN mhc class i transposase UNKNOWN protein farnesyltransferase geranylgeranyltransferase protein dpy-30 homolog zinc finger bed domain-containing protein 1-like mediator of rna polymerase ii transcription subunit serologically defined colon cancer antigen 3 homolog ras-related protein rab-10 alpha- -mannosyl-glycoprotein 2-beta-ntsc22 domain family protein 3 isoform 1 UNKNOWN UNKNOWN 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.67 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 100 C039R041 C209R084 C087R035 C011R073 C145R053 C043R083 C077R088 C252R073 C208R159 C021R017 C107R035 C182R044 C124R145 C092R110 C230R085 C137R142 C009R108 C244R089 C246R046 C050R024 C019R094 C085R117 C227R116 C196R110 C016R116 C013R012 C229R057 C124R008 C110R033 C147R080 C197R093 C016R167 C173R075 C146R126 C041R034 C061R060 C109R061 C156R156 C234R101 C064R098 C104R157 C162R138 UNKNOWN protein pat1 homolog 1 oligosaccharyltransferase complex subunit ostc UNKNOWN unnamed protein product gastrula zinc finger UNKNOWN tumor suppressor candidate 4 cytosolic non-specific dipeptidase cytoskeleton-associated protein 2 yth domain family protein 3 isoform x4 UNKNOWN myelin basic 80 kda mcm3-associated protein serrate rna effector molecule homolog polyadenylate-binding protein 4 wd repeat-containing protein c2orf44 homolog UNKNOWN fibroblast growth factor 3 transmembrane and coiled-coil domain-containing UNKNOWN nucleosome-remodeling factor subunit bptf structural maintenance of chromosomes protein 5 c19orf29 partial gamma b (breast cancer-specific protein 1) poly -specific endoribonuclease-c-like UNKNOWN protein canopy homolog 4 ccr4-not transcription complex subunit 10-like dna repair protein complementing xp-a cells dolichyl-diphosphooligosaccharide--protein UNKNOWN UNKNOWN extracellular matrix protein 1 precursor histidine--trna cytoplasmic isoform 1 UNKNOWN cul2 protein UNKNOWN UNKNOWN UNKNOWN transcription factor cytochrome b-c1 complex subunit mitochondrial 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 0.66 101 C074R036 C213R045 C205R097 C052R006 C144R158 C235R017 C165R089 C187R110 C149R157 C141R134 C220R046 C171R124 C263R075 C008R125 C057R087 C116R127 C135R128 C158R102 C120R052 C259R056 C140R003 C047R145 C163R063 C085R147 C096R105 C223R153 C236R072 C252R089 C177R102 C065R101 C173R077 C231R060 C056R119 C133R077 C250R019 C169R150 C191R130 C088R055 C042R115 C154R064 C081R081 C147R125 UNKNOWN guanosine-3 -bis 3 -pyrophosphohydrolase mesh1 eomesodermin-like protein a-1 epoxide hydrolase 1-like trans- -enoyl- reductase-like amyloid beta a4 precursor protein-binding family a UNKNOWN zinc finger protein 782- partial phosphatidylinositol-binding clathrin assembly low quality protein: obscurin-like UNKNOWN UNKNOWN zinc finger protein 592 lysine-specific histone demethylase 1a-like transposable element tcb1 transposase adenylosuccinate lyase solute carrier organic anion transporter family member UNKNOWN proline-rich protein 5 UNKNOWN lysozyme g UNKNOWN fermitin family homolog 3 cleavage and polyadenylation specificity factor subunit 5 nadh dehydrogenase iron-sulfur protein 5 UNKNOWN g patch domain-containing protein 8-like isoform x1 oocyte zinc finger protein 20 UNKNOWN nesprin-1-like protein kinase c eta type phosphatidylinositol-4-phosphate 5-kinase type-1 beta UNKNOWN fas-associated factor 1 small subunit processome component 20 homolog glycogen debranching enzyme probable g-protein coupled receptor 148-like UNKNOWN UNKNOWN macrophage receptor marco complement c4-1 calpain-1 catalytic subunit 0.66 0.66 0.66 0.66 0.66 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 102 C132R072 C029R089 C121R162 C164R146 C036R042 C261R017 C121R090 C227R073 C198R126 C157R041 C009R039 C205R058 C231R059 C065R122 C109R134 C076R016 C155R077 C063R153 C257R103 C002R131 C006R113 C202R116 C208R057 C204R081 C218R035 C013R130 C114R169 C100R119 C072R096 C098R099 C018R137‡ C011R107 C156R070 C110R070 C170R088 C060R105 C119R065 C169R099 C250R053 C034R106 C157R147 C211R092 f-box only protein 46 bifunctional purine biosynthesis protein purh nicotinamide riboside kinase 2 tetratricopeptide repeat protein 5 actin-related protein 2 3 complex subunit 2 collagen alpha-3 chain-like eukaryotic translation initiation factor 4 gamma 2-like lipoprotein lipase UNKNOWN c-jun-amino-terminal kinase-interacting protein 1-like UNKNOWN periostin-like tubulin polyglutamylase complex subunit 2 rho-related gtp-binding protein UNKNOWN probable phosphatase phospho1-like angiotensin-converting enzyme-like UNKNOWN UNKNOWN UNKNOWN activator of 90 kda heat shock protein atpase homolog 1 UNKNOWN collagen alpha-3 chain-like mitochondrial import inner membrane translocase ice nucleation protein zinc finger mym-type protein 1-like nucleolar protein 8 caspase-1 precursor transmembrane protein 8c-like ribosomal protein s6 kinase beta-1-like heterogeneous nuclear ribonucleoprotein l UNKNOWN UNKNOWN e3 ubiquitin-protein ligase ubr3 pogo transposable element with znf domain a s-antigen partial collagen alpha-1 chain pleckstrin homology domain-containing family h sorbin and sh3 domain containing 3 insulin-like growth factor 1 receptor UNKNOWN transcriptional regulator erg isoform 1 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.65 0.64 103 C017R040 C188R066 C152R085 C034R116 C035R064 C001R106 C144R056 C079R009 C207R028 C214R075 C059R032 C248R116 C108R169 C066R103 C020R076 C035R077 C132R033 C095R143 C038R090 C207R155 C155R037 C191R120 C118R112 C013R085 C130R128 C156R084 C247R084 C258R070 C156R098 C111R139 C179R122 C239R132 C114R170 C183R145 C201R021 C066R096 C087R151 C127R070 C191R015 C014R091 C042R083 C171R064 thymosin beta-12 UNKNOWN UNKNOWN sickle tail protein homolog novel protein vertebrate nebulin cd81 antigen UNKNOWN nad mitochondrial-like isoform x1 zinc finger ccch domain-containing protein 18-like g patch domain-containing protein 8-like isoform x1 fish virus induced trim protein phenylalanine--trna ligase alpha subunit solute carrier family 30 (zinc transporter) member 1 UNKNOWN protein rft1 homolog UNKNOWN UNKNOWN UNKNOWN rap1 gtpase-gdp dissociation stimulator 1-like atp-dependent rna helicase dhx8 basal cell adhesion molecule precursor sodium potassium calcium exchanger 3-like UNKNOWN protein arginine n-methyltransferase 1 isoform 2 atpase family aaa domain-containing protein 3 protein virilizer homolog polymorphic mucin truncated splice variant ic6 2 sjoegren syndrome scleroderma autoantigen 1 beta-taxilin multidrug resistance protein 1-like zinc finger protein 214 digestive organ expansion factor homolog tropomodulin-4 UNKNOWN UNKNOWN protein mon2 homolog UNKNOWN pericentriolar material 1 protein UNKNOWN jmjc domain-containing protein 4-like protein tob1-like tbc domain-containing protein kinase-like partial 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 104 C220R077 C099R103 C064R084 C074R021 C206R027 C169R064 C160R139 C035R140 C098R135 C212R112 C228R127 C120R122 C022R038 C234R139 C176R096 C077R145 C141R020 C094R120 C230R079 C153R084 C082R105 C132R028 C144R042 C164R147 C147R007 C110R085 C176R122 C253R077 C075R155 C163R020 C182R122 C153R063 C106R123 C165R107 C063R090 C203R137 C110R165 C065R069 C068R056 C144R016 C025R075 C218R024 atr-interacting protein UNKNOWN ubiquitin carboxyl-terminal hydrolase 4 isoform 1 UNKNOWN UNKNOWN host cell factor 1 zinc finger protein 180 integrase core domain protein reticulon 2 myocyte-specific enhancer factor 2a UNKNOWN peroxisomal leader peptide-processing protease macrophage migration inhibitory factor zinc finger and btb domain-containing protein 17 dna-directed rna polymerases and iii subunit rpabc5 gtpase imap family member 7 UNKNOWN atp-dependent rna helicase dhx30-like structural maintenance of chromosomes protein 1a atp-dependent rna helicase dhx8 lymphocyte cytosolic protein 2 UNKNOWN UNKNOWN p53 and dna damage-regulated protein 1 UNKNOWN patched domain-containing protein 3-like UNKNOWN protein yippee-like 2 arf-gap with sh3 ank repeat and ph domain-containing gastrula zinc finger protein oxysterol-binding protein 6-like 60s ribosomal protein l8 eomesodermin homolog bone morphogenetic protein 3b-like centromere protein u-like probable e3 ubiquitin-protein ligase trim8 UNKNOWN cugbp elav-like family member 4-like metabotropic glutamate receptor 2 rna binding motif protein 14 guanine nucleotide exchange factor mss4 UNKNOWN 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.64 0.63 0.63 0.63 0.63 0.63 0.63 0.63 105 C040R163 C093R081 C131R073 C034R082 C078R033 C161R036 C132R029 C001R029 C041R146 C168R098 C164R113 C145R024 C255R052 C238R116 C061R128 C257R084 C030R055 C261R058 C051R162 C172R143 C217R065 C162R074 C054R121 C174R078 C090R075 C193R017 C187R156 C057R089 C092R066 C223R091 C070R091 C219R145 C242R141 C036R023 C017R086 C016R132 C215R110 C042R030 C146R147 C044R129 C099R121 C222R142 thioredoxin 2 UNKNOWN protein fam84a centrosomal protein of 70 kda-like UNKNOWN leucine-rich repeat and immunoglobulin-like domaincomplement component c1q receptor atp-dependent rna helicase dna topoisomerase 2-binding protein 1 f-box-like wd repeat-containing protein tbl1xr1-like zinc finger protein 423 UNKNOWN high mobility group-t protein ankyrin repeat domain-containing protein 1-like presenilin-2 UNKNOWN atpase family aaa domain-containing protein 2 zinc finger mym-type protein 1 UNKNOWN 26s proteasome complex subunit dss1 probable glutamyl-trna amidotransferase subunit s100-a1 disabled homolog 2 isoform 1 coiled-coil alpha-helical rod protein 1 transposase general transcription factor iie subunit 1 nadh dehydrogenase subunit 1 protein interferon-related developmental regulator 2 lamin-b receptor map kinase-activated protein kinase 3 UNKNOWN cytochrome b-c1 complex subunit 8 UNKNOWN ankyrin repeat and mynd domain-containing protein 2 serine threonine-protein kinase tousled-like 1-b-like nucleobindin 2a tyrosine-protein kinase 223-like UNKNOWN mitochondrial intermembrane space import and nuclear migration protein nudc eukaryotic peptide chain release factor subunit 1 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 106 C184R120 C118R067 C086R088 C186R049 C033R013 C230R150 C166R022 C233R131 C046R087 C132R124 C050R055 C122R035 C146R140 C018R079 C172R103 C246R053 C012R045 C188R100 C105R126 C068R077 C202R083 C028R034 C159R170 C178R120 C229R038 C128R066 C025R167 C108R062 C039R055 C130R039 C105R033 C122R111 C018R051 C154R042 C028R103 C229R095 C172R133 C206R148 C142R098 C025R170 C155R090 C130R143 zinc finger protein 451 isoform x1 interferon-stimulated 20 kda exonuclease-like 2 acidic leucine-rich nuclear phosphoprotein 32 family UNKNOWN UNKNOWN akirin 2 gon-4-like protein transmembrane protein mitochondrial-like cytochrome c oxidase subunit mitochondrial-like transforming protein tubulin-specific chaperone d mitochondrial intermediate peptidase transposable element tcb1 transposase UNKNOWN lissencephaly-1 homolog b UNKNOWN enolase 3-2 transmembrane protein 25-like UNKNOWN u2 small nuclear ribonucleoprotein b fatty acid-binding intestinal nuclear transport factor 2 UNKNOWN lymphocyte cytosolic protein 2 heat shock protein hsp 90-alpha 1-like UNKNOWN perforin-1-like wd repeat-containing protein mio-like sarcoplasmic reticulum histidine-rich calcium-binding glutathione s-transferase c-terminal domain-containing UNKNOWN UNKNOWN endoplasmin- partial UNKNOWN UNKNOWN zinc finger ccch domain-containing protein 7b-like epidermis-type lipoxygenase 3-like 14-3-3 protein beta alpha lim-domain binding factor 3 cellular tumor antigen p53 proprotein convertase subtilisin kexin type 6-like pyrroline-5-carboxylate reductase 2 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.63 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 107 C078R054 C237R079 C076R159 C035R072 C197R079 C202R103 C196R093 C245R019 C194R089 C172R016 C158R046 C080R046 C176R053 C131R077 C247R137 C012R007 C248R063 C163R045 C010R047 C093R148 C136R050 C190R075 C165R091 C183R031 C233R147 C168R102 C078R024 C129R107 C116R148 C163R082 C159R030 C119R035 C142R031 C023R036 C107R105 C009R095 C064R076 C227R061 C172R168 C019R107 C049R045 C166R010 exocyst complex component 6b pap-associated domain-containing protein partial ras and ef-hand domain-containing dapper homolog 1 nadh dehydrogenase subunit 4 huwe1 partial unconventional myosin-ic-like pleckstrin homology domain-containing family m UNKNOWN UNKNOWN myomesin-3 adipocyte enhancer-binding protein 1-like eosinophil peroxidase-like myosin light chain kinase 3 UNKNOWN peptide mitochondrial UNKNOWN phosphatidylinositol 3-kinase catalytic subunit type 3-like UNKNOWN dna polymerase delta catalytic subunit-like UNKNOWN type alpha partial protein emsy UNKNOWN myb-binding protein 1a-like tyrosine-protein kinase jak1-like mitochondrial sodium hydrogen exchanger 9b2 glutaminyl-peptide cyclotransferase-like protein cyclin-d-binding myb-like transcription factor 1 sulfotransferase 6b1 transcription factor 12-like isoform 1 transforming growth factor-beta-induced protein ig-h3 UNKNOWN cellular retinoic acid-binding protein 2-like phosphatidylinositol 5-phosphate 4-kinase type-2 beta UNKNOWN abl interactor 1 peroxisome proliferator-activated receptor beta UNKNOWN estrogen-related receptor gamma plac8-like protein 1 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 108 C153R029 C028R026 C141R061 C141R021 C183R057 C178R167 C003R029 C028R170 C035R018 C214R029 C146R110 C216R094 C109R148 C140R037 C039R082 C070R090 C128R158 C084R107 C034R073 C099R129 C013R148 C172R150 C074R053 C074R089 C080R134 C221R127 C217R034 C076R033 C207R139 C172R121 C096R085 C236R133 C161R086 C157R071 C030R134 C062R060 C014R145 C186R157 C130R051 C047R144 C253R060 C162R164 UNKNOWN kelch-like protein 31 protein tyrosine phosphatase type iva 3-like isoform 2 ring-box protein 1 fish virus induced trim protein transducin -like 2 multidrug resistance-associated protein 1-like transposase acidic leucine-rich nuclear phosphoprotein 32 family serine threonine-protein phosphatase pp1-alpha myosin binding protein cardiac UNKNOWN atp-dependent rna helicase dhx29 transposable element tc1 transposase perforin-1-like gamma-crystallin m2-like n-alpha-acetyltransferase auxiliary subunit unhealthy ribosome biogenesis protein 2 homolog UNKNOWN UNKNOWN UNKNOWN UNKNOWN troponin slow skeletal and cardiac muscles rac-alpha serine threonine-protein kinase UNKNOWN tripartite motif-containing protein 16-like transmembrane protein 60 UNKNOWN glycogen debranching enzyme 60s ribosomal protein l7 ras-interacting protein 1 UNKNOWN small subunit processome component 20 homolog dna-directed rna polymerase i subunit rpa1 traf4-associated factor 1-like breast carcinoma-amplified sequence 3 isoform 1 UNKNOWN 60s ribosomal protein l27 prostaglandin e synthase 3 e3 ubiquitin-protein ligase trim39-like voltage-dependent l-type calcium channel subunit beta-2 UNKNOWN 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.62 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 109 C126R155 C216R131 C127R061 C094R138 C191R074 C244R062 C182R034 C146R145 C103R160 C114R103 C231R152 C187R119 C178R115 C063R087 C228R056 C253R037 C182R095 C041R165 C099R097 C076R087 C007R011 C015R039 C019R136 C002R093 C087R093 C056R017 C057R074 C149R170 C236R112 C056R114 C009R107 C150R076 C260R062 C163R095 C028R168 C091R059 C097R099 C204R085 C207R027 C030R125 C211R028 C209R049 eukaryotic translation initiation factor 3 subunit a-like triadin dapper homolog 1 b-cell cll lymphoma 7 protein family member a neuronal nitric oxide synthase UNKNOWN si:dkeyp- protein UNKNOWN polyamine-modulated factor 1 UNKNOWN butyrate response factor 2 tetratricopeptide repeat protein 4-like u6 snrna-associated sm-like protein lsm1 arachidonate 5-lipoxygenase diencephalon mesencephalon homeobox protein 1-b-like formin-binding protein 4 amp deaminase 1 glyceraldehyde-3-phosphate dehydrogenase sid1 transmembrane family member 2 UNKNOWN UNKNOWN peptidase inhibitor 16 splicing factor 3b subunit 1 cyclin-dependent kinase 4 inhibitor b smoothelin-like protein 2 zinc finger ccch domain-containing protein 18 60s ribosomal protein l36a cytochrome c oxidase subunit vib isoform 1 UNKNOWN heat repeat-containing protein 3 rna-directed dna polymerase from mobile element UNKNOWN mitotic checkpoint serine threonine-protein kinase bub1 beta-taxilin egf-like repeat and discoidin i-like domain-containing UNKNOWN chloride intracellular channel protein 4 UNKNOWN type iv secretion protein rhs hepatocyte growth factor activator-like spermatogenesis-associated protein 20 UNKNOWN 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 110 C031R102 C131R028 C100R066 C167R146 C209R138 C193R099 C124R170 C264R048 C174R060 C190R009 C139R011 C194R064 C144R135 C077R151 C071R089 C180R131 C219R087 C178R116 C168R017 C236R164 C075R111 C113R162 C156R132 C091R163 C130R131 C234R113 C074R029 C016R118 C110R080 C214R103 C185R072 C208R145 C071R044 C080R090 C103R047 C179R074 C201R166 C139R124 C266R039 C121R053 C190R100 C164R145 ras association domain-containing protein 10-like next to brca1 gene 1 protein myomesin-1 isoform 1 cd83 enhancer of rudimentary homolog UNKNOWN e3 ubiquitin-protein ligase sh3rf2-like isoform x1 hyaluronidase-2-like sex comb on midleg-like protein 2-like UNKNOWN cellular tumor antigen p53 UNKNOWN dna-binding protein rfx2-like histone-lysine n-methyltransferase mll3 collagen alpha-1 chain-like nadh dehydrogenase reverse transcriptase-like protein ww domain-binding protein 11 fras1-related extracellular matrix protein 1 UNKNOWN acyl- synthetase family member mitochondrial short coiled-coil protein lish domain and heat repeat-containing protein kiaa1468 UNKNOWN anaphase-promoting complex subunit 2 chromosome-associated kinesin kif4a UNKNOWN a-kinase anchor protein 9-like isoform x3 vcl protein dna-directed rna polymerases and iii subunit rpabc4 adenylosuccinate lyase glutamate-rich wd repeat containing 1 UNKNOWN m-phase phosphoprotein 9 t-cell activation rho gtpase-activating protein gmp reductase 1 solute carrier family facilitated glucose transporter UNKNOWN UNKNOWN kelch repeat and btb domain-containing protein 12 UNKNOWN enhancer of zeste homolog 2 (enx-1) isoform cra_a 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.61 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 111 C228R110 C061R021 C177R095 C204R062 C020R081 C030R158 C188R158 C171R097 C232R031 C131R120 C185R066 C189R138 C012R154 C032R015 C089R082 C243R102 C084R035 C150R052 C071R037 C225R028 C144R046 C265R102 C004R091 C011R035 C023R035 C094R108 C249R008 C055R090 C057R167 C094R011 C005R117 C168R135 C114R045 C154R022 C217R029 C210R102 C238R022 C156R013 C110R162 C264R121 C051R158 C060R030 calcium-transporting atpase sarcoplasmic endoplasmic protein novel protein human titin n-sulphoglucosamine sulphohydrolase precursor troponin slow skeletal muscle-like gamma-interferon-inducible lysosomal thiol reductase transposable element tcb1 transposase lws opsin UNKNOWN calumenin isoform 1 zgc:158564 protein nicotinamide n-methyltransferase inactive serine protease 35 calmodulin-like protein 4 UNKNOWN g-protein coupled receptor 182 UNKNOWN 40s ribosomal protein s10 nadh dehydrogenase transcription factor dp-1 60s ribosomal protein l12 UNKNOWN histone-lysine n-methyltransferase prdm9-like apolipoprotein b-100-like protein adenomatous polyposis coli protein voltage-dependent n-type calcium channel subunit rna-binding protein 38-like golgi ph regulator-like rna-binding protein 45 atp-dependent clp protease proteolytic mitochondrial nadh dehydrogenase pancreatic secretory granule membrane major non-syndromic hearing impairment protein 5 UNKNOWN sorbin and sh3 domain-containing protein 2 isoform 5 histone-arginine methyltransferase carm1-like nuclear transport factor 2 acidic leucine-rich nuclear phosphoprotein 32 family chymotrypsin-like elastase family member 2a-like myoferlin-like isoform x2 glia maturation factor beta 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.60 0.59 0.59 0.59 0.59 112 C066R060 C076R148 C177R131 C265R142 C119R129 C250R108 C142R042 C248R107 C070R111 C085R023 C104R068 C185R035 C217R122 C016R010 C238R091 C187R111 C200R114 C170R069 C038R141 C129R069 C189R165 C042R065 C012R050 C168R019 C173R096 C076R147 C022R010 C174R020 C199R082 C133R159 C005R123 C182R120 C129R030 C040R052 C115R099 C194R123 C051R079 C149R068 C151R105 C131R145 C044R033 C083R154 schwannomin-interacting protein 1 alpha-internexin-like ddb1- and cul4-associated factor 10 sjchgc04011 protein UNKNOWN minor histocompatibility protein ha-1-like adp-ribosylation factor-related protein 1 UNKNOWN h(+) cl(-) exchange transporter 5 camp-regulated phosphoprotein 19 myozenin 1 hydroxyacid-oxoacid mitochondrial ras gtpase-activating-like protein iqgap1-like serine threonine-protein kinase sgk1 acyl- dehydrogenase -like gtp-binding protein sar1b transitional endoplasmic reticulum atpase-like 4-aminobutyrate mitochondrial nadh dehydrogenase transposase UNKNOWN UNKNOWN small glutamine-rich tetratricopeptide repeat-containing krueppel-like factor 11-like pdlim7 protein e3 ubiquitin-protein ligase rnf31-like zinc finger protein 319-like UNKNOWN hypothetical protein M91_01401, partial tgf-beta-activated kinase 1 and map3k7-binding protein sjchgc09650 protein loc734178 protein UNKNOWN amp deaminase 1 sorting and assembly machinery component 50 homolog neutral cholesterol ester hydrolase 1-like late secretory pathway protein avl9 homolog UNKNOWN UNKNOWN ets domain-containing protein elk-3 UNKNOWN transforming growth factor beta regulator 1 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 113 C104R134 C132R054 C073R167 C059R085 C169R059 C144R152 C121R059 C055R083 C108R021 C086R151 C200R037 C155R081 C148R126 C225R096 C079R025 C247R129 C177R125 C136R016 C066R037 C055R170 C126R062 C093R051 C138R066 C076R028 C201R035 C058R057 C006R120 C200R167 C238R078 C120R164 C058R127 C205R127 C104R023 C041R087 C148R098 C161R083 C159R149 C139R168 C108R052 C165R019 C065R041 C158R129 kruppel-like factor 4 uroporphyrinogen decarboxylase UNKNOWN neutrophil cytosolic factor 4 dnaj homolog subfamily c member 25-like UNKNOWN krueppel-like factor 12-like PREDICTED: hypothetical protein LOC557772 UNKNOWN sulfotransferase 6b1 creatine mitochondrial 1b tripartite motif-containing protein 45-like synapsin 2a UNKNOWN p2x purinoceptor 3 nucleoprotein tpr protocadherin-18-like isoform x1 oligosaccharyltransferase complex subunit ostc-like thrombospondin-3 isoform 3 ephrin type-b receptor partial cytochrome c oxidase subunit vib isoform 1 PREDICTED: uncharacterized protein LOC101168094 UNKNOWN UNKNOWN pre-mrna branch site protein p14-like retinoid x beta protein-tyrosine kinase 2-beta isoform 2 alstrom syndrome protein 1 proteoglycan 4 UNKNOWN desmin nadh dehydrogenase subunit 2 protein rrnad1-like calcium-binding protein conserved oligomeric golgi complex subunit partial UNKNOWN tnf receptor-associated factor 4 UNKNOWN microtubule-associated proteins 1a 1b light chain 3a sodium channel subunit beta-1-like oocyte zinc finger protein 6-like PREDICTED: uncharacterized protein LOC101472525 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.59 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 114 C042R086 C085R022 C033R136 C125R021 C172R148 C229R059 C192R149 C095R079 C198R157 C232R021 C148R028 C187R071 C235R036 C258R062 C085R049 C099R162 C133R122 C135R074 C138R118 C254R100 C178R002 C214R141 C017R077 C021R116 C031R065 C114R054 C227R140 C066R027 C086R039 C078R089 C207R167 C061R057 C110R010 C208R049 C159R010 C129R129 C112R060 C129R126 C085R159 C085R103 C155R170 C129R052 cytochrome c oxidase subunit vib isoform 1 cwf19-like protein 2 set and mynd domain-containing protein 5 PREDICTED: uncharacterized protein LOC101485590 tripartite motif-containing protein 16-like probable g-protein coupled receptor 125 UNKNOWN UNKNOWN UNKNOWN zinc finger protein 207 fatty-acid amide hydrolase 2 transferrin receptor protein 1-like ribosomal l1 domain-containing protein 1-like transposase UNKNOWN gastrula zinc finger protein UNKNOWN kelch repeat and btb domain-containing protein 10-like nadph--cytochrome p450 reductase UNKNOWN protein fam53b-like UNKNOWN UNKNOWN forkhead box protein p4 riken cdna 2300009a05 gene ubiquitin-conjugating enzyme e2 g1 dna polymerase subunit gamma- mitochondrial PREDICTED: hypothetical protein LOC560439 loc799552 protein UNKNOWN protein vac14 homolog transmembrane gamma-carboxyglutamic acid protein 4actin-related protein 2 3 complex subunit 2 predicted protein transketolase-like protein 2 tartrate-resistant acid phosphatase type 5 cdk8 protein transposase UNKNOWN UNKNOWN homeobox protein hox-b2a-like ras-related protein rab-11b 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 115 C109R088 C157R028 C125R108 C040R169 C077R044 C102R072 C252R113 C261R094 C138R160 C079R070 C129R093 C063R083 C014R074 C250R124 C144R120 C130R148 C044R116 C145R069 C121R129 C113R106 C099R128 C163R036 C115R025 C046R150 C001R046 C164R107 C257R041 C214R111 C258R042 C262R032 C048R072 C118R080 C220R133 C052R132 C209R093 C043R098 C120R016 C187R009 C171R079 C106R090 C017R024 C239R104 adenylate kinase plexin-d1 protein sec1 family domain-containing protein 2 UNKNOWN selectin e atp-binding cassette sub-family d member 3 isoform 2 platelet-derived growth factor receptor beta lim-domain binding factor 3 dna topoisomerase 2-binding protein 1 uncharacterized protein LOC100191015 dna polymerase subunit gamma-1 UNKNOWN u2 snrnp-associated surp motif-containing protein lymphatic vessel endothelial hyaluronic acid receptor 1 monoacylglycerol lipase abhd6-like cytochrome c oxidase subunit vib isoform 1 mitogen-activated protein kinase 7-like 60s ribosome subunit biogenesis protein nip7 homolog UNKNOWN mitochondrial import receptor subunit tom6 homolog UNKNOWN probable e3 ubiquitin-protein ligase partial heat shock protein beta-1 UNKNOWN cop9 signalosome complex subunit 5 UNKNOWN UNKNOWN UNKNOWN vesicle transport protein sft2a wd repeat-containing protein 44 protein polybromo-1 short transient receptor potential channel 1 transposable element tcb1 transposase tyrosine-protein kinase transmembrane receptor ror2 proline-rich protein 5 liprin-beta-2- partial clathrin coat assembly protein ap180 UNKNOWN high choriolytic enzyme 1 precursor p2y purinoceptor 8 kinesin-like protein kif20b-like 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.58 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 116 C128R064 C178R075 C031R137 C077R149 C212R099 C094R122 C104R137 C029R101 C028R067 C040R084 C133R031 C217R059 C160R024 C214R048 C163R062 C209R137 C084R013 C026R111 C062R112 C017R148 C020R126 C099R114 C229R050 C264R084 C013R153 C078R124 C014R156 C185R140 C135R063 C230R162 C162R016 C158R076 C168R081 C012R120 C157R010 C149R069 C063R169 C198R165 C067R080 C072R011 C146R093 C258R049 39s ribosomal protein mitochondrial-like myosin light chain 4-like inhibitor of growth protein 4 lysine-specific demethylase 4b e3 ubiquitin-protein ligase trim39-like beta-2-glycoprotein 1-like transmembrane protein 120a a chain molecular basis of histone h3k36me3 recognition cell surface protein UNKNOWN heme oxygenase UNKNOWN UNKNOWN pdz domain containing 2-like cytochrome p450 2u1-like UNKNOWN cleavage and polyadenylation specificity factor subunit 7 UNKNOWN phosphatidylinositol- -bisphosphate 3-kinase catalytic vesicle-fusing atpase dual specificity protein kinase ttk beta-soluble nsf attachment protein drebrin 1 protein fam117a-like gdp-man:man c -pp-dol alpha- -mannosyltransferase-like zinc finger and btb domain-containing protein 10 methyltransferase-like protein 16 nitrogen permease regulator 3-like zinc finger protein 135-like cofilin-2 bcl2 adenovirus e1b 19 kda protein-interacting protein 340s ribosomal protein s27 high mobility group protein b1 UNKNOWN protein probable helicase with zinc finger domain dna mismatch repair protein msh2-like UNKNOWN thrombomodulin UNKNOWN UNKNOWN heterogeneous nuclear ribonucleoprotein k 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.57 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 117 C157R130 C052R059 C187R061 C129R050 C076R035 C174R114 C165R015 C002R053 C073R095 C102R085 C112R158 C070R080 C112R149 C094R024 C156R042 C036R151 C074R025 C055R091 C189R154 C246R100 C007R093 C057R027 C156R153 C075R043 C234R061 C016R094 C112R141 C166R128 C094R124 C209R151 C091R122 C157R045 C215R147 C106R023 C142R116 C123R169 C116R036 C164R017 C002R098 C098R125 C173R018 C233R074 UNKNOWN UNKNOWN nadh dehydrogenase cell division cycle protein 27 homolog isoform 1 tho complex subunit 6 homolog UNKNOWN methionine aminopeptidase 1 interferon-induced protein 44-like dnaj homolog subfamily c member 7 isoform 2 UNKNOWN protein serine threonine-protein kinase 38 n-acetylated-alpha-linked acidic dipeptidase 2 tyrosine-protein kinase csk dna-directed rna polymerases and iii subunit rpabc4 UNKNOWN gonadotropin-releasing hormone UNKNOWN triadin microcephalin UNKNOWN UNKNOWN eukaryotic translation initiation factor 4b UNKNOWN 60s acidic ribosomal protein p2 UNKNOWN f-box wd repeat-containing protein 11 isoform 2 methionine aminopeptidase 1 UNKNOWN sarcoplasmic endoplasmic reticulum calcium atpase 1hypothetical protein GLRG_11022 wiskott-aldrich syndrome protein family member 3 cytochrome c oxidase subunit 3 inositol -triphosphate receptor-interacting hepatocyte cell adhesion molecule tripartite motif-containing protein 16-like UNKNOWN UNKNOWN UNKNOWN acylphosphatase-1 isoform x2 phosphoribosyl pyrophosphate synthetase-associated UNKNOWN 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 0.56 118 C232R067 C254R151 C124R018 C160R064 C187R133 C026R046 C010R120 C045R036 C130R012 C123R011 C078R080 C156R106 C175R023 C123R129 C033R068 C128R021 C058R016 C161R120 C176R014 C139R076 C009R071 C128R056 C030R147 C241R010 C228R010 C130R145 C260R058 C169R127 C251R131 C034R076 C073R004 C103R102 C254R095 C070R039 C236R107 C205R170 C217R119 C002R056 C013R158 C007R067 C180R168 C121R146 protein ssuh2 homolog isotocin precursor wd repeat-containing protein 67 PREDICTED: hypothetical protein LOC100697841 methionine synthase reductase UNKNOWN cytochrome b-c1 complex subunit mitochondrial 5-phosphohydroxy-l-lysine phospho-lyase-like cathepsin s precursor p2y purinoceptor 8 dual specificity testis-specific protein kinase 1-like UNKNOWN rna binding protein fox-1 homolog 1-like fish virus induced trim protein integrin-linked kinase-associated serine threonine PREDICTED: uncharacterized protein LOC101467272 stromal cell-derived factor 1 precursor protein fam69b-like obscurin UNKNOWN UNKNOWN UNKNOWN UNKNOWN t-cell surface glycoprotein cd3 zeta chain precursor integrator complex subunit 4 3-oxo-5-alpha-steroid 4-dehydrogenase 2 transmembrane protein 88-like UNKNOWN serine threonine-protein kinase greatwall-like transgelin UNKNOWN epoxide hydrolase 1-like matrix metalloproteinase-23-like probable udp-sugar transporter protein slc35a5 traf-type zinc finger domain-containing protein 1 nebulin-related-anchoring protein telomeric repeat-binding factor 2 UNKNOWN set and mynd domain-containing protein 1-like isoform 2 zinc finger protein 678 transposable element tcb2 transposase cell division cycle 7-related protein kinase 0.56 0.56 0.56 0.56 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 119 C163R131 C219R080 C129R096 C034R031 C024R022 C169R116 C245R046 C246R074 C079R043 C266R145 C199R090 C211R088 C226R167 C116R051 C183R097 C029R088 C152R018 C020R065 C181R072 C197R120 C128R072 C056R009 C181R169 C112R081 C207R092 C131R020 C099R099 C143R125 C061R160 C131R106 C111R089 C122R121 C261R136 C178R102 C019R045 C065R034 C211R135 C071R154 C122R101 C240R120 C059R035 C091R133 myogenin neurofilament light polypeptide poly -specific endoribonuclease-c-like mucosa-associated lymphoid tissue lymphoma endonuclease domain-containing 1 slain motif-containing mucosa-associated lymphoid tissue lymphoma zinc finger protein 51 slam family member 8 UNKNOWN UNKNOWN UNKNOWN zinc finger protein 271-like wd repeat-containing protein 82-like UNKNOWN cd9 antigen zinc finger and scan domain-containing protein 29-like ras-related c3 botulinum toxin substrate 2 filamin a-interacting protein 1-like cg050 protein protein hexim-like protein qn1 homolog protein fam65c e3 ubiquitin-protein ligase rnf130 nuclear transport factor 2 60s ribosomal protein l32 fibronectin-like isoform 2 serine threonine-protein kinase 17a-like UNKNOWN UNKNOWN basement membrane-specific heparan sulfate tyrosyl-dna phosphodiesterase 2-like heat shock factor-binding protein 1 UNKNOWN UNKNOWN UNKNOWN UNKNOWN dna-directed rna polymerases and iii subunit rpabc4 UNKNOWN UNKNOWN UNKNOWN nicotinamide mononucleotide adenylyltransferase 1 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.55 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 120 C131R016 C249R105 C180R119 C019R098 C223R044 C169R012 C188R083 C100R021 C204R114 C192R008 C047R156 C131R110 C164R038 C257R110 C037R146 C053R045 C185R056 C263R100 C103R075 C151R043 C096R164 C123R155 C218R051 C015R089 C007R139 C019R035 C012R009 C165R114 C249R168 C157R006 C175R101 C153R037 C224R013 C031R135 C087R037 C128R018 C168R151 C051R028 C170R071 C244R099 C103R046 C073R120 lissencephaly-1 homolog b protein ubiquitin-conjugating enzyme e2 k fam32a-like non-ltr retrotransposable element UNKNOWN UNKNOWN protein polypeptide n-acetylgalactosaminyltransferase 6 UNKNOWN 28s ribosomal protein mitochondrial-like cold shock domain-containing protein e1 y-box-binding protein 2-a snf-related serine threonine-protein kinase rab gdp dissociation inhibitor beta keratin-associated protein 10-4-like UNKNOWN xin actin-binding repeat-containing protein 1 zinc finger protein 709-like 60s ribosomal protein l6 rna binding motif protein hhip-like protein 1 neutrophil cytosolic factor 1 UNKNOWN chemokine ck-1 f-box wd repeat-containing protein 5 lysm and peptidoglycan-binding domain-containing UNKNOWN ogdh protein solute carrier family 43 member 3-like UNKNOWN alpha cardiac muscle 1 forkhead box protein n3-like bcl-2-like protein 12 cnot1 protein UNKNOWN zinc finger protein 318 mkl myocardin-like protein 1 hyccin UNKNOWN sjchgc03012 protein solute carrier family 12 member 9-like 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 0.54 121 C062R061 C077R043 C167R014 C183R052 C053R106 C038R147 C266R068 C123R085 C063R072 C080R026 C112R143 C219R038 C236R043 C198R124 C008R086 C142R020 C067R137 C256R075 C161R076 C237R170 C089R008 C130R018 C100R058 C163R133 C111R080 C137R035 C030R117 C066R097 C149R067 C173R066 C254R080 C084R051 C023R130 C249R065 C061R022 C063R064 C246R044 C076R098 C129R074 C229R105 C055R093 C120R022 UNKNOWN tgf-beta-activated kinase 1 and map3k7-binding protein PREDICTED: uncharacterized protein LOC101486179 spectrin beta non-erythrocytic 1-like guanine nucleotide exchange factor for rab-3a-like UNKNOWN malcavernin-like protein UNKNOWN gdp-man:man c -pp-dol alpha- -mannosyltransferase-like beta- -galactosyltransferase 2 decorin precursor single-stranded dna-binding protein 2 isoform 1 interferon inducible mx protein leucine-rich repeat-containing protein 16c-like zinc finger protein 135-like UNKNOWN UNKNOWN sarcosine mitochondrial UNKNOWN msx2-interacting protein myosin-binding protein fast-type-like zinc transporter zip9 deoxyribonuclease gamma precursor UNKNOWN tumor necrosis factor ligand superfamily member 13b very long-chain specific acyl- mitochondrial isoform 1 UNKNOWN nicotinamide riboside kinase 2 selenoprotein p muscle-related coiled-coil glucocorticoid-induced transcript 1 protein myomesin 2 collagen-like protein 2 ankyrin repeat and socs box protein 14-like plexin-d1 transposable element tcb1 transposase chromosome transmission fidelity protein 8 homolog UNKNOWN 60s ribosomal protein l22 UNKNOWN semaphorin-7a-like isoform x2 nadh dehydrogenase subunit 1 0.54 0.54 0.54 0.54 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 122 C095R019 C183R073 C048R157 C003R102 C161R016 C121R158 C104R116 C048R140 C240R164 C251R154 C047R128 C191R115 C234R021 C007R142 C076R015 C059R056 C232R104 C257R068 C146R035 C141R102 C104R117 C002R119 C003R091 C061R157 C153R133 C222R023 C057R088 C119R109 C094R045 C121R038 C063R091 C234R074 C233R153 C018R059 C084R029 C162R073 C163R081 C152R011 C191R109 C101R065 C147R057 C064R102 60s ribosomal protein l7 h-2 class ii histocompatibility antigen gamma chain lymphatic vessel endothelial hyaluronic acid receptor 1 zinc finger fyve domain-containing protein 16 nadh-cytochrome b5 reductase 2-like protein lsm12 homolog nascent polypeptide-associated complex subunit alpha cadherin-18-like UNKNOWN protein prune homolog 2-like protein apcdd1-like proteasome activator complex subunit 4 lymphocyte cytosolic protein 2 bone morphogenetic protein 2 UNKNOWN e3 ubiquitin-protein ligase hectd1 UNKNOWN cytochrome c oxidase assembly protein 1 homolog condensin-2 complex subunit g2 UNKNOWN serine arginine-rich splicing factor 4 UNKNOWN UNKNOWN cyclin-dependent kinase 13-like UNKNOWN UNKNOWN deoxyribonuclease gamma serine-protein kinase atm neuroendocrine convertase 2 precursor UNKNOWN homologous-pairing protein 2 homolog UNKNOWN glycylpeptide n-tetradecanoyltransferase 2-like potassium voltage-gated channel subfamily c member 3cadherin-1 isoform 1 UNKNOWN UNKNOWN collagen alpha-1 chain hemoglobin subunit beta-1 mycbp-associated protein alpha cardiac muscle 1 protein memo1 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.53 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 123 C188R033 C131R062 C151R082 C029R028 C073R023 C129R079 C234R078 C260R112 C122R064 C014R031 C131R031 C144R039 C101R113 C255R109 C030R008 C238R023 C118R014 C070R143 C047R124 C126R030 C137R109 C211R073 C213R078 C256R061 C133R021 C189R086 C112R052 C150R029 C006R060 C176R043 C170R126 C098R097 C072R114 C124R054 C074R020 C173R056 C157R055 C021R155 C090R149 C240R162 C039R086 C118R101 zinc finger and scan domain-containing protein 25-like vitamin k epoxide reductase subunit 1-like 1 peroxisomal bifunctional enzyme adenylosuccinate lyase cysteine and glycine-rich protein 3 UNKNOWN transcription factor hes-1 novel protein homeobox protein mox-2 sorting nexin-18 UNKNOWN apoptosis-related protein 3-like UNKNOWN heme-binding protein 2 phosphotriesterase-related protein UNKNOWN t-complex protein 1 subunit theta creb atf bzip transcription factor mesencephalic astrocyte-derived neurotrophic factorserine threonine-protein phosphatase 2a regulatory protein fam193b-like dna-binding partial UNKNOWN UNKNOWN PREDICTED: hypothetical protein LOC565988 zinc finger mym-type protein 1 UNKNOWN UNKNOWN f-box only protein 42 pwwp domain-containing protein mum1-like UNKNOWN wd and tetratricopeptide repeats protein 1 spondin-2-like isoform x1 c-c motif chemokine 25 precursor cub and zona pellucida-like domain-containing protein 1e3 ubiquitin-protein ligase itchy homolog UNKNOWN smoothelin-like protein 2-like UNKNOWN alpha cardiac muscle 1 alpha-actinin-3-like isoform 1 protein-tyrosine kinase 2-beta-like 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.52 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 124 C102R009 C186R010 C060R027 C036R088 C043R036 C185R063 C228R080 C081R054 C092R028 C010R067 C103R092 C160R103 C170R129 C065R036 C164R024 C153R058‡ C013R120 C001R131 C004R077 C116R071 C103R057 C116R024 C128R074 C260R051 C021R029 C079R134 C052R013 C184R133 C069R058 C068R137 C124R049 C164R085 C095R138 C125R152 C208R018 C159R163 C161R062 C132R109 C121R134 C044R160 C129R110 C010R119 UNKNOWN eukaryotic peptide chain release factor subunit 1 xeroderma complementation group a zinc finger protein 654 splicing factor 3b subunit 1 UNKNOWN neuroligin 3b UNKNOWN transmembrane protease serine 9-like UNKNOWN rotatin beta-2-glycoprotein 1-like atp-dependent dna helicase q4 acyl- synthetase family member mitochondrial-like mpv17-like dep domain-containing protein 1a isoform 2 zinc finger protein 703-like UNKNOWN UNKNOWN calcium calmodulin-dependent protein kinase type ii cytochrome c oxidase subunit 4 isoform mitochondrial gonadotropin-releasing hormone perilipin-2 isoform 1 gig2-like protein UNKNOWN UNKNOWN titin isoform n2-a inhibitor of growth protein 4 UNKNOWN UNKNOWN UNKNOWN prolyl endopeptidase-like UNKNOWN UNKNOWN transmembrane protein 111-like chromodomain y-like protein retinoic acid receptor rxr-gamma-b serine threonine-protein kinase plk4-like rab5 gdp gtp exchange factor UNKNOWN dual specificity protein phosphatase 26-like hyaluronidase-2 isoform x1 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.50 125 C127R105 C075R161 C155R129 C108R133 C132R062 C119R170 C174R024 C075R013 C201R124 C183R130 C106R087 C210R025 C264R138 C016R136 C133R064 C161R081 C115R132 C175R061 C092R082 C196R149 C118R159 C128R130 C237R008 C208R108 C003R068 C169R125 C134R047 § C260R032 C206R039 C128R152 C002R051 C089R049 C099R074 C032R088 C113R033 C138R018 C110R134 C128R017 C004R110 C049R164 C133R087 C075R034 actin-related protein 2 3 complex subunit 2 carbohydrate sulfotransferase 14 protein asteroid homolog 1 alpha-ketoglutarate-dependent dioxygenase alkb protein-tyrosine kinase 2-beta isoform 2 deoxyribonuclease lysosomal UNKNOWN rad52 motif-containing protein 1 sumo-activating enzyme subunit 2 UNKNOWN myocilin-like UNKNOWN nucleosome-remodeling factor subunit bptf ctp synthase 1-like spindle assembly abnormal protein 6 homolog atp-binding cassette sub-family b member 9-like nadh dehydrogenase cytochrome c oxidase polypeptide vic-2 40s ribosomal protein s25 UNKNOWN UNKNOWN dystrobrevin beta-like protein casc5 UNKNOWN UNKNOWN nucleoprotein tpr cd8 beta t-cell surface glycoprotein cd5-like UNKNOWN protein-tyrosine sulfotransferase 1-like sestrin-3 isoform 2 gamma-glutamyl hydrolase-like activating transcription factor 7-interacting protein 1 pyruvate kinase protein sgt1 isoform 1 serine threonine-protein phosphatase 2a 55 kda UNKNOWN caspase recruitment domain-containing protein 11-like deleted in lung and esophageal cancer protein 1 UNKNOWN caveolin-3 UNKNOWN 0.50 0.50 0.50 0.50 0.50 0.50 0.50 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 126 C014R093 C025R008 C123R009 C183R063 C155R046 C132R066 C250R023 C066R041 C143R143 C094R169 C207R077 C260R027 C226R069 C143R060 C173R073 C041R043 C093R078 C064R027 C149R077 C029R109 C023R138 C184R049 C083R061 C100R025 C071R116 C224R061 C128R037 C002R129 C141R157 C173R138 C006R012 C030R054 C075R143 C088R062 C138R161 C060R120 C066R111 C098R038 C108R153 C056R162 C060R108 C223R122 UNKNOWN tropomyosin 4 immunoglobulin light chain UNKNOWN arf-gap with sh3 ank repeat and ph domain-containing coiled-coil domain-containing protein 97 probable phospholipid-transporting atpase vd-like 5-aminolevulinate mitochondrial 40s ribosomal protein s2-like myomesin-1 isoform 1 UNKNOWN tetratricopeptide repeat protein 39a-like myosin light chain 2 UNKNOWN gamma-glutamyltransferase 5-like transcription elongation factor spt6 UNKNOWN myogenic factor 5 upf0583 protein c15orf59 homolog myosin heavy chain 60s ribosomal protein l29 translation initiation factor eif-2b subunit delta-like unnamed protein product telomere-associated protein rif1 isoform x2 UNKNOWN clathrin light chain a tyrosine--trna mitochondrial myh9 protein maltase- intestinal cytochrome c oxidase polypeptide mitochondrial UNKNOWN zinc finger protein btb poz domain-containing adapter for cul3-mediated zinc transporter zip11 isoform 1 nadh dehydrogenase 1 beta subcomplex subunit centrosomal protein of 97 kda interferon-induced very large gtpase 1-like chicken-ii-type gonadotropin-releasing hormone complement factor d UNKNOWN cytochrome c oxidase subunit 2 heat shock protein beta-7 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.47 0.46 0.46 0.46 127 C051R058 C171R162 C031R021 C145R100 C152R161 C177R053 C247R088 C244R012 C110R061 C125R129 C089R113 C099R123 C135R026 C106R081 C227R065 C018R118 C228R112 C131R148 C169R138 C127R120 C077R015 C178R159 C237R111 C217R115 C118R138 C012R013 C085R042 C079R135 C153R144 C230R143 C017R035 C088R069 C247R090 C241R022 C226R122 C264R063 C100R002 C221R097 C164R069 C213R107 C093R060 C256R034 cornichon homolog 4 ubiquitin-like modifier-activating enzyme 1-like lumican myosin heavy chain UNKNOWN suprabasin isoform 1 precursor interferon-induced guanylate-binding protein 1 t-box 1 UNKNOWN plastin-1 UNKNOWN phosducin-like protein lysosome-associated membrane glycoprotein 2 UNKNOWN nadh dehydrogenase fermitin family homolog 1 upf0708 protein c6orf162 homolog dpy-30 homolog troponin skeletal muscle retrograde golgi transport protein rgp1 homolog UNKNOWN alpha-aminoadipic semialdehyde dehydrogenase camp-responsive element-binding 2 tyrosinase UNKNOWN cardiac muscle alpha actin 1 nance-horan syndrome histone-lysine n-methyltransferase mll3 twist-related protein 2-like platelet endothelial cell adhesion molecule-like polycomb group protein asxl1 UNKNOWN zinc finger swim domain-containing protein 5 phosphatidylinositol-binding clathrin assembly protein UNKNOWN myosin va matrix-remodeling-associated protein 8-like far upstream element-binding protein 2-like ubiquitin-conjugating enzyme e2 l3 cell division control protein 6 homolog tsc22 domain family protein 3 isoform 1 lim-domain binding factor 3 0.46 0.46 0.46 0.46 0.46 0.46 0.46 0.46 0.46 0.46 0.46 0.46 0.46 0.46 0.46 0.46 0.46 0.46 0.46 0.46 0.46 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 0.45 128 C123R152 C218R084 C030R120 C237R046‡ C094R043 C242R052 C077R054 C135R024 C093R055 C102R168 C008R059 C214R061 C124R109 C250R056 C057R111 C100R097 C169R018 C112R126 C086R148 C007R148 C039R146 C053R041 C148R069 C039R096 C232R083 C038R111 C007R073 C208R163 C135R016 C073R003 C075R016 C062R056 C099R024 C245R120 C165R018 C118R074 C133R095 C009R091 C166R034 C098R120 C142R152 C179R010 UNKNOWN UNKNOWN adhesive plaque matrix protein prostaglandin e synthase 3 diol dehydrogenase-like trimethylguanosine synthase-like transmembrane protein 131-like atp synthase subunit mitochondrial geranylgeranyl transferase type-2 subunit beta vasorin-like spore coat assembly protein adhesive plaque matrix protein UNKNOWN transcriptional regulator atrx cysteine and glycine-rich protein 3 PREDICTED: hypothetical protein LOC557772 UNKNOWN gamma-glutamyltransferase 7 mitogen-activated protein kinase kinase kinase kinase 5 solute carrier family 15 member 2 protein protein vac14 homolog autophagy-related protein 13 isoform 2 myogenin complement c4-1 UNKNOWN UNKNOWN UNKNOWN casp8-associated protein 2 zinc finger protein 52 neurofilament heavy polypeptide-like isoform x2 rna binding protein fox-1 homolog 1-like ap-3 complex subunit delta-1 clip-associating protein 2-like ubiquitin carboxyl-terminal hydrolase 28-like cytoskeleton-associated protein 5 protein nlrc3-like fibulin-1 precursor UNKNOWN acyl- synthetase family member mitochondrial-like UNKNOWN light chain 12 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.44 0.43 0.43 0.43 0.43 0.43 0.43 0.43 129 C084R169 C064R015 C034R158 C194R062 C085R026 C071R076 C213R128 C037R103 C013R125 C199R157 C128R044 C232R118 C082R108 C105R010 C244R017 C203R027 C167R106 C172R117 C088R014 C208R126 C114R088 C107R024 C098R103 C241R059 C121R028 C052R163 C122R054 C020R060 C135R061 C048R082 C120R159 C007R144 C252R059 C252R157 C057R043 C242R149 C179R108 C200R008 C040R096 C079R047 C107R158 C052R071 a2 protein UNKNOWN UNKNOWN mitochondrial nadh-ubiquinone oxidoreductase 75 kda atp-dependent rna helicase dhx8 zz-type zinc finger-containing protein 3 asc-type amino acid transporter 1-like dysferlin-interacting protein 1-like glutathione peroxidase 4a UNKNOWN PREDICTED: uncharacterized protein C1orf112 homolog rna-binding protein fus protein endothelial lipase-like cysteine and glycine-rich protein 3 complement component c1q receptor UNKNOWN calcineurin b homologous protein 2 UNKNOWN UNKNOWN alpha-actinin-2 isoform 2 hypothetical protein BRAFLDRAFT_86387 fibroblast growth factor 1 matrilin-2 precursor membrane spaning protein shc sh2 domain-binding protein 1 serine threonine-protein kinase d3 nck-associated protein 1-like immunoglobulin superfamily member 10 isoform 1 leukotriene b4 receptor dynein heavy chain mhc class i hermansky-pudlak syndrome 3 protein troponin slow skeletal and cardiac muscles disintegrin and metalloproteinase domain-containing axin-2-like c-c motif chemokine 20 precursor parvalbumin-7-like isoform x1 UNKNOWN smad nuclear-interacting protein 1 fibronectin type iii and spry domain-containing protein 2 wiskott-aldrich syndrome protein 0.43 0.43 0.43 0.43 0.43 0.43 0.43 0.43 0.43 0.43 0.43 0.43 0.43 0.43 0.43 0.43 0.43 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 0.42 130 C178R138 C127R060 C008R108 C023R031 C097R152 C004R141 C050R077 C103R023 C139R165 C009R143 C204R163 C137R043 C233R067 C114R022 C001R096 C226R125 C227R164 C071R019 C135R052 C113R119 C160R142 C049R146 C197R155 C128R051 C004R093 C098R094 C007R060 C177R167 C041R018 C017R036 C116R033 C155R032 C046R055 C007R146 C137R001 C169R117 C211R035 C221R048 C243R086 C246R022 C252R013 C122R078 UNKNOWN UNKNOWN cathepsin l mhc class ii alpha partial g protein pathway suppressor 2 UNKNOWN probable e3 ubiquitin-protein ligase herc6-like arachidonate 5-lipoxygenase-activating protein actinin alpha 2 mucin 11a 40s ribosomal protein s6 UNKNOWN protein dpy-30 homolog novel protein vertebrate nebulin tata box-binding protein-associated factor rna isoform cra_a paired amphipathic helix protein sin3a-like t-complex protein 1 subunit theta l _3-like UNKNOWN caveolin-2-like cyclic amp-dependent transcription factor atf-1 UNKNOWN transcription intermediary factor 1-alpha arf-gap with coiled- ank repeat and ph domainUNKNOWN oocyte zinc finger protein 20 UNKNOWN u2 snrnp-associated surp motif-containing protein differentially expressed in fdcp 6 homolog kelch repeat and btb domain-containing protein 12-like suppression of tumorigenicity 5 dapper homolog 1 isoform 2 coatomer subunit alpha UNKNOWN elongator complex protein 4 phosphatase and actin regulator 4 upf0193 protein evg1 isoform 2 UNKNOWN inter-alpha-trypsin inhibitor heavy chain h3-like c14orf159 protein hypothetical protein 0.42 0.42 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.41 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.39 0.39 131 C015R062 C065R038 C125R078 C107R140 C090R130 C136R130 C082R133 C264R127 C260R055 C135R056 C223R078 C217R085 C096R165 C064R028 C126R058 C061R059 C191R135 C003R145 C157R060 C204R112 C221R134 C137R106 C206R009 C194R166 C129R111 C067R162 C005R137 C141R081 C110R127 C047R107 C156R075 C230R159 C229R120 C040R069 C215R093 C260R107 C002R144 C252R090 C131R142 C118R069 C198R110 C128R160 ependymin precursor nadh dehydrogenase subunit 3 svil protein importin-13 son of sevenless homolog 1 telomeric repeat-binding factor 2 UNKNOWN UNKNOWN myosin binding protein cardiac actin-binding rho-activating UNKNOWN UNKNOWN immunoglobulin mu heavy chain dual specificity testis-specific protein kinase 2 UNKNOWN protein kinase c and casein kinase substrate in neurons integrin alpha-iib suppressor of cytokine signaling 5 ataxin-2-like protein UNKNOWN inter-alpha-trypsin inhibitor heavy chain h3-like UNKNOWN UNKNOWN protein nlrc3-like ras association domain-containing protein 10-like cyclic amp-dependent transcription factor atf-4 UNKNOWN protein nlrc3-like transcription initiation factor tfiid subunit 1-like lymphocyte-specific protein tyrosine kinase nadh dehydrogenase subunit 4 secreted phosphoprotein 24 centrosomal protein of 135 kda ubiquitin carboxyl-terminal hydrolase 4 isoform 1 zinc finger mym-type protein 4-like rho gtpase-activating protein 24 myoblast determination protein 2 myoblast determination protein 2 mitochondrial import inner membrane translocase UNKNOWN rrna methyltransferase mitochondrial creatine kinase 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.39 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.37 0.36 0.36 132 C254R062 C003R151 C025R040 C099R030 C102R169 C186R121 C212R169 C118R056 C242R008 C238R137 C193R039 C178R019 C263R059 C077R041 C120R150 C063R031 C107R161 C160R062 C233R135 C147R129 C085R007 C106R167 C144R031 C130R016 C003R058 C224R069 C241R094 C206R142 C052R097 C074R049 C101R089 C200R144 C198R074 C169R047 C116R108 C148R140 C047R125 C052R118 C231R077 C238R102 C016R060 C073R043 inter-alpha-trypsin inhibitor heavy chain h3 cysteine and glycine-rich protein 3 homeobox protein pknox1 pogo transposable element with krab domain-like probable e3 ubiquitin-protein ligase rnf144a-a complement c4-like swi snf-related matrix-associated actin-dependent tyrosine-protein kinase fer- partial UNKNOWN bchain human vinculin head (1-258) in complex with syntaxin-12 UNKNOWN ubiquitin-associated protein 2 yth domain family protein 2-like sh2 domain-containing protein 1a ras gtpase-activating-like protein iqgap3-like cathepsin l mothers against decapentaplegic homolog 1 myosin heavy chain UNKNOWN PREDICTED: hypothetical protein LOC100690503 chromosome 7 open reading frame isoform cra_b 14-3-3 protein eta UNKNOWN msx2-interacting protein tho complex subunit 5 homolog inosine-5 -monophosphate dehydrogenase 2 UNKNOWN copine-8 UNKNOWN thimet oligopeptidase UNKNOWN protein myocilin-like mkl myocardin-like protein 1 e3 ubiquitin-protein ligase synoviolin-like UNKNOWN UNKNOWN structural maintenance of chromosomes protein 4 beta-crystallin b3 adp-ribosylation factor-binding protein gga1-like tetraspanin-3-like isoform 1 0.36 0.36 0.36 0.36 0.36 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.35 0.34 0.34 0.33 0.33 0.33 0.33 0.33 0.32 0.32 0.32 0.32 0.31 0.31 0.31 0.31 0.31 0.30 0.30 0.30 0.30 0.30 0.30 0.29 0.29 0.29 0.29 0.29 0.29 0.28 133 X35 C050R043 C136R001 C132R074 C010R106 C050R154 C193R122 C044R040 C140R061 C138R009 C256R071 C047R111 C147R072 C041R016 C228R108 C094R067 C011R090 C116R075 C103R085 C211R037 C019R022 C113R135 C020R131 C152R152a C115R074 C237R146 C164R166 C176R119 C132R101 C164R059 C133R140 C251R080 C086R103 C139R113 C237R040‡ C211R110‡ C007R074 C211R100 ‡ C059R123 C264R097 ‡ C153R058 C151R040 C235R104 tetraspanin-18 UNKNOWN type-4 ice-structuring protein precursor UNKNOWN UNKNOWN lymphocyte-specific protein tyrosine kinase ubiquitin-associated protein 1-like retinol-binding protein 2-like protein UNKNOWN leucine-rich repeat-containing protein 51 myotilin isoform 1 asph protein acyl- -binding domain-containing protein 6 ttd non-photosensitive 1 protein homolog papain-like cysteine prorease serine threonine-protein kinase pak 2-like tho complex subunit 1 e3 ubiquitin-protein ligase trim21-like circumsporozoite protein f-box only protein 48 regulator of chromosome condensation phosphatidylinositol transfer protein beta isoform ependymin-1 precursor death-inducer obliterator 1 catalase UNKNOWN apolipoprotein a-i precursor replication factor c subunit 3 protein apolipoprotein a-i precursor myosin regulatory light chain atrial isoform myosin light polypeptide 4 transposable element tcb1 transposase PREDICTED: hypothetical protein LOC324610 c4b-binding protein alpha chain precursor zw10 interactor-like tar dna-binding protein 43 sperm-associated antigen 5 magnesium-dependent phosphatase 1 dep domain-containing protein 1a isoform 2 UNKNOWN nadh dehydrogenase subunit 5 0.28 0.28 0.28 0.27 0.27 0.26 0.26 0.26 0.26 0.26 0.25 0.25 0.25 0.25 0.25 0.24 0.24 0.24 0.23 0.23 0.23 0.22 0.20 0.19 0.18 0.17 0.16 0.15 0.11 0.09 0.06 0.04 2.8 2.58 2.12 0.62 0.54 0.53 0.49 0.46 0.45 0.44 134 C018R137‡ C237R046‡ C202R134 heterogeneous nuclear ribonucleoprotein l prostaglandin e synthase 3 protein regulator of cytokinesis 1 0.42 0.36 0.31 * Significantly differentially transcribed genes were annotated in Blast2GO using the BLASTx algorithm and the best -6 BLASTx hit (e-value < 10 ) is presented. § Genes differentially transcribed by juveniles from the enriched vs. unenriched environments in families X22 and X11. ‡ Genes differentially transcribed by juveniles from the enriched vs. unenriched environments in families X35 and X11. a While this gene was initially annotated as ependymin-1, further analyses suggest that contig C152R152 is chimeric 135