UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET SUCROSE SOLUTION Table of Contents Ref. No. MSDS /PD/22_01 Valid for: 2 years from approval Page 1. Chemical Product 2. Composition and Information on Ingredients 3. Hazards Identification 4. First Aid Measures 5. Fire and Explosion Data 6. Accidental Release Measures 7. Handling and Storage 8. Exposure Controls/ Personal Protection 9. Physical and Chemical Properties 10. Stability and Reactivity Data 11. Toxicological Information 12. Ecological Information 13. Disposal Considerations 14. References 15. Appendices 16. Revision History Page 1 of 9 2 2 2 3 4 5 5 6 7 7 8 8 8 9 9 9 UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET SUCROSE SOLUTION 1. Ref. No. MSDS /PD/22_01 Valid for: 2 years from approval Chemical Product Product Name: Sucrose Chemical name: Sucrose Synonyms: beta-D-Fructofuranosyl-alpha-Dglucopyranoside Chemical Formula: C12H22O11 2. Composition and Information on Ingredients Composition: sucrose 100% by weight Toxicological Data on Ingredients: N/A 3. Hazards Identification Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), eye contact (irritant), ingestion and inhalation. Potential Chronic Health Effects: A4 (Not classifiable for human or animal) MUTAGENIC EFFECTS: N/A TERATOGENIC EFFECTS: N/A DEVELOPMENTAL TOXICITY: Repeated or prolonged exposure is not known to aggravate medical condition. CARCINOGENIC EFFECTS: Page 2 of 9 UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET SUCROSE SOLUTION 4. Ref. No. MSDS /PD/22_01 Valid for: 2 years from approval First Aid Measures General measures: N/A Skin contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious skin contact: N/A Eye contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs. Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Serious indigestion: N/A Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious inhalation: N/A Page 3 of 9 UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET SUCROSE SOLUTION 5. Ref. No. MSDS /PD/22_01 Valid for: 2 years from approval Fire and Explosion Data Flammability of the Product: May be combustible at high temperature Auto-Ignition Temperature: N/A Flash points: CLOSED CUP: Higher than 93.3°C (200°F) Flammable limits: N/A Products of Combustion: These products are carbon oxides (CO, CO2) Fire Hazards in Presence of Various Substances: Slightly flammable to flammable in presence of heat Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: N/A Risks of explosion of the product in presence of static discharge: N/A Fire fighting media and Instructions: SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks on Fire Hazards: N/A Special Remarks on Explosion Hazards: N/A Page 4 of 9 UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET SUCROSE SOLUTION 6. Ref. No. MSDS /PD/22_01 Valid for: 2 years from approval Accidental Release Measures NB: Wear appropriate protective equipment/clothing including gloves before removing any spills. Small spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large spill: Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Be careful that the product is not present at a concentration level above the threshold limit value (TLV). Check TLV on the MSDS and with local authorities. 7. Handling and Storage Precautions: Keep locked up and away from incompatibles such as oxidizing agents, acids, and heat or other sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest and do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the container or the label. Storage: Keep container tightly closed, in a cool, well-ventilated area. Do not store above 23°C (73.4°F). Page 5 of 9 UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET SUCROSE SOLUTION Ref. No. MSDS /PD/22_01 Valid for: 2 years from approval 8. Exposure Controls/Personal Protection Airborne Exposure Limits: TWA: 15 (mg/m3) from OSHA (PEL) [United States] Inhalation Total. TWA: 10 (mg/m3) from ACGIH (TLV) [United States] [1999] Inhalation Total. TWA: 10 (mg/m3) from NIOSH Inhalation Total. TWA: 5 (mg/m3) from NIOSH Inhalation Respirable. TWA: 5 (mg/m3) from OSHA (PEL) [United States] Inhalation Respirable. Consult local authorities for acceptable exposure limits. Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal Protection: Safety glasses, lab coat, gloves, vapour and dust respirator, making sure to use an approved/certified respirator or equivalent. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Page 6 of 9 UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET SUCROSE SOLUTION 9. Ref. No. MSDS /PD/22_01 Valid for: 2 years from approval Physical and Chemical Properties Physical state and appearance: White crystalline solid Odour: Characteristic carmel to odourless Taste: Sweet Molecular Weight: 342.3 g/mole pH (1% solution/water): N/A Boiling Point: N/A Melting Point: 186°C (366.8°F) Critical Temperature: N/A Specific Gravity (Water = 1): 1.587 Vapour Pressure (mmHg): N/A Vapour Density: N/A Volatility: N/A Odour Threshold: N/A Water/Oil Distribution Coefficient: The product is more soluble in water; log(oil/water) = -3.7 Ionicity (in Water): N/A Dispersion Properties: See solubility in water, methanol Solubility: Easily soluble in cold water. Partially soluble in methanol. Insoluble in diethyl ether. 10. Stability and Reactivity Data Stability: The product is stable Corrosivity: N/A Instability temperature: N/A Conditions of Instability: Excess heat, incompatible materials Incompatibles: Reactive with oxidizing agents, acids (ex: sulfuric acid, nitric acid) Polymerization: Will not occur Page 7 of 9 UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET SUCROSE SOLUTION 11. Ref. No. MSDS /PD/22_01 Valid for: 2 years from approval Toxicological Information Toxicity to animals: Acute oral toxicity (LD50): 29700 mg/kg [Rat] Effects on humans: Acute potential health effects: Skin: May cause skin irritation. Low hazard for usual industrial handling. Eyes: Dust may cause mechanical irritation. Inhalation: Excessive inhalation may cause minor respiratory irritation. Ingestion: Ingestion of large amounts may cause gastrointestinal (digestive) tract irritation. Expected to be a low ingestion hazard. Chronic potential health effects: CARCINOGENIC EFFECTS: A4 (Not classifiable for human or animal.) MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast TERATOGENIC EFFECTS: No adverse reproductive affects have been found in humans. However at extremely high oral doses of 683,000 mg/kg given to rats during pregnancy showed some effects on newborn (growth, developmental anomalies of central nervous system). Passes through the placental barrier in human. DEVELOPMENTAL TOXICITY: N/A Other information: Slightly hazardous in case of skin contact (irritant), ingestion and inhalation. 12. Ecological Information Ecotoxicity: N/A 13. Disposal Considerations Waste Disposal: Waste must be disposed of in accordance with local environmental control regulations. Page 8 of 9 UNIVERSITY OF MALTA FACULTY OF MEDICINE & SURGERY PHARMACY DEPARTMENT MATERIAL SAFETY DATA SHEET SUCROSE SOLUTION 14. Ref. No. MSDS /PD/22_01 Valid for: 2 years from approval References Sciencelab.com. Material Safety Data Sheet; Sucrose solution, MSDS [Online] 2005 [cited 2012 Nov 6]. Available from: URL: http://www.sciencelab.com/msds.php?msdsId=9927285 Wardsci.com. Material Safety Data Sheet; Sucrose solution, MSDS [Online] 2012 [cited 2012 Nov 6]. Available from: URL: http://wardsci.com/images/pdf/msds/Sucrose_Solution_20Pct_729.00.pdf Teknova.com. Material Safety Data Sheet; Sucrose solution, MSDS [Online] 2012 [cited 2012 Nov 6]. Available from: URL: http://www.teknova.com/v/vspfiles/files/MSDS/S0020.pdf 15. Appendices N/A 16. Revision History Version Number Amendments/ Reasons for change 01 Initial Release Page 9 of 9