THEDAEDALUSFUNDFORINNOVATION OVERVIEW&2016APPLICATIONPROCESS OBJECTIVES Toacceleratepromisingresearchprojectstowardstranslationbyachievingoneormoreofthefollowingvalue-creation inflectionpoints: 1. Licensingthetechnologytoanestablishedcompany; 2. Securinganindustrialpartnerandfundingforcontinuedresearchintheframeworkofaresearchalliancewith industry;or 3. Formationofastart-upcompany. PROJECTTYPES Ø DaedalusFundforInnovationawardsaredesignedtosupportinnovativeresearchactivitiessuchasthoseaimedat extendingpreliminaryobservations,establishingproof-of-concept,performingpreliminarydrugscreens,scaling-up atechnologyorprocess,andgenerating(orstrengthening)intellectualpropertypositions. Ø Iffeasible,projectsmaybestructuredsuchthatasmallportionofthebudgetedactivitiesmay,withsufficiently strongjustification,beoutsourcedtoanexternalorganizationsuchasaCRO. PROGRAMELIGIBILITY Ø PrincipalInvestigatorswitharesearchportfolioandlaboratoryspacewhosefull-timeemployerisWeillCornell Medicine.InvestigatorswhomayhaveafacultyappointmenttoWeillCornellMedicinebutwhoarenotfull-time employeesofWCMarenoteligible. Ø NoPImaysubmitmorethanoneproposaltothisRFP. Ø Yourproposal/applicationtotheDaedalusFundmustbeapprovedandsignedoffbytheheadofyourlaband/or yourdepartmentchairman. FUNDINGANDBUDGETING Ø Awardsmaybemadeofupto$100,000perproject. Ø FundingwillnotbesubjecttoWCMIDCR. PROJECTDURATION Ø Projectsshouldbedesignedandstructuredsoastolastbetween6-12months TERMSANDCONDITIONSOFTHEAWARD Ø ThePIwillcommithis/hertimeandeffort,asappropriate,toleadandoverseetheproject Ø Allintellectualproperty,includingbackgroundpatents,ifany,andanyinventionsmadeinthecourseofperforming thefundedproject,mustbeassignedtoCornell Ø BudgetitemswillnotincludePIsalaryorcapitalequipment Ø Ifindustryfundingisobtainedfortheprojectwithintheawardyear,Daedalusfundingmustbereturned. Ø Afinalreportwillbeduewithinthirty(30)daysofcompletionoftheproject Ø Inadditiontothefinalreport,PIsmaybeaskedtoupdatetheDaedalusScientificAdvisoryCommittee(seeProject CriteriaandAssessmentbelow)onprogressduringscheduledmeetingsviaashortPowerPointpresentation APPLICATIONFORMAT AllsubmissionsmustbeinMicrosoftWord(.docordocx)orAdobeAcrobat(.pdf)format.Pre-andfullproposalsshould besubmittedbye-mailtoDaedalusFund@med.cornell.edu.Thesubjectlineshouldread“DaedalusFundforInnovation Proposal.” Continuedonfollowingpage. APPLICATIONPROCESSSCHEDULE Ø Requests-for-Proposalswillbeissuedonceayear,inFebruary. Ø 2-pageproposalswithpreliminarybudgetsaredueonMonday,March21. § Pre-proposalswillbesubjecttoapreliminaryreviewprocessandasubsetofapplicantswillbeinformedof decisionsandinvitedtosubmitfullproposalsbyFriday,April22. Ø FullProposalswithDetailedbudgetswillbedueonMonday,May23 Ø FinalistswillbeaskedtoparticipateinameetingwiththeScientificAdvisoryCommitteeinJune(dateTBD)aspart oftheevaluationprocess. Ø AwardswillbeannouncedandgrantedonThursday,June30. PROJECTASSESSMENTANDSELECTIONCRITERIA Ø ProjectswillbeselectedbyaScientificAdvisoryCommitteeappointedbytheDeancomprisingentrepreneurs, venturecapitalists,industryleadersandWCMfaculty Ø Theselectioncriteriawillemphasizethefollowingsuccessfactors,allofwhichshouldbeaddressedinthebodyof thepre-proposal: • unmetmedicalneed. • highlevelofscientificrigorandvalidity. • highlevelofinnovationandnovelty. • commercialpotentialandmarketopportunity. • thepossibilityofgeneratingnewintellectualpropertyand/orstrengtheningpre-existingintellectualproperty positions. • probabilityofachievingprojectobjectiveswiththeallottedfunding. • probabilityofovercomingtechnicalobstaclestoachieveprojectobjectives. • cleardelineationofafeasibleR&Droadmap,includingmilestones(i.e.,valuesteps),detailinghowDaedalus fundingwillhaveanimpactandleadtoasignificantvalue-creationinflectionpoint. Deadlines RequestforProposalsissued Deadlineforsubmissionofpre-proposals Decisionsannounced/Fullproposalssolicited Monday,May23 Deadlineforsubmissionoffullproposals June(DateTBD) FinalistsmeetwithScientificAdvisory Committee Awardsannounced Thursday,June30 Thursday,February18 Monday,March21 Friday,April22 The Daedalus Fund for Innovation 2016 Pre-Proposal Application Cover Page PLEASE RETURN THE COMPLETED FULL PROPOSAL NO LATER THAN Monday, March 21 TO: BIOPHARMA ALLIANCES AND RESEARCH COLLABORATIONS Olin Hall, Box 15, New York, NY 10021 or email to DaedalusFund@med.cornell.edu Investigator Data and Contact Information Name: Title: Department: Phone: Room #: E-mail: Project Summary Project Title: Project Duration (Number of Months): Total Funding Requested: Abstract Briefly describe the proposed project's goals, methodology, potential for success, and potential for commercial development. Signature of Investigator Signature of Departmental Chairman THEDAEDALUSFUNDFORINNOVATION FORMATFORPRE-PROPOSALS Projectpre-proposalsshouldbenomorethan2pageslong,excludingthecoverpage. Emphasisshouldbeondefiningwhatthenextvalue-creationinflectionpointis,andarticulatinghowitwillbeachieved bywayofatechnicalplanwithwell-definedmilestones,andacorrespondingbudget. PAGE1:COVERPAGE InvestigatorDataandContactInformation(tobeprovidedforeachPrincipalInvestigator) Ø Name Ø Title Ø Department,Division,Centerand/orLaboratory Ø RoomNumber Ø TelephoneNumber Ø EmailAddress ProjectSummary Ø TitleofProposal Ø RequestedPeriodofPerformance Ø TotalFundingRequested Abstract PAGES2–3:PROJECTPROPOSAL Thepre-proposalshouldaddressandcontainthefollowing: AbstractorProjectSynopsis BackgroundandSignificance Ø Backgroundandproblemstatement:Whatistheproblemthatyouareaddressingandwhy? Ø Brieflydescriberecentresearchdirectlyrelevanttotheproblem,includingothersinthefield,andinparticular,your ownpriorwork,ifany. Ø Whatisknownandwhatisnovelintheapproach? Ø Highlighttherisksandpotentialbenefitsoftheproject ResearchPlan Ø Summarizetheexperimentsyouwillperformtosolvetheproblem(i.e.,toadvancethetechnologytothenextvaluecreationinflectionpoint) i) Whataretheshortandlonger-termgoalsoftheresearch? ii) Whatcanbeaccomplishedduringthefundingperiodrequested? iii) Whataretheanticipatedchallenges? KeyPersonnelandCollaborators Ø Listofindividuals/collaborators/organizationsrequiredtocompletetheproject. continuedonfollowingpage. Funding Ø Totalamountrequested Ø OtherSourcesofSupport(identifyallprior,currentand/orpendingsourcesofsupporttoyourlabrelatedtothe proposedresearchproject). IntellectualProperty Ø Provideabriefdescriptionofanyinventionsyouhavealreadymaderelatedtotheproposedresearch. Ø ProvideabriefstatementaboutthecurrentIPstatusoftheinvention. Ø Describehowtheproposedresearchwilladdvaluetoandenhancetheinvention’spatentabilityand/orcommercial potentialand/orimportance. APPENDIX Relevantpublications/manuscripts(pleaselimittothe5mostrecentandsalient) AcopyofyourNIHBiosketch The Daedalus Fund for Innovation 2016 Full Proposal Application Cover Page PLEASE RETURN THE COMPLETED FULL PROPOSAL NO LATER THAN Monday, May 23 TO: BIOPHARMA ALLIANCES AND RESEARCH COLLABORATIONS Olin Hall, Box 15, New York, NY 10021 or email to DaedalusFund@med.cornell.edu Investigator Data and Contact Information Name: Title: Department: Room #: Phone: E-mail: Project Information Project Title: Project Duration (Number of Months): Total Funding Requested: Signature of Investigator Signature of Departmental Chairman THEDAEDALUSFUNDFORINNOVATION FORMATFORFULLPROPOSALS Fullprojectproposalsshouldbenomorethan10pageslong,excludingthecoverpage. Theemphasisshouldbeondefiningwhatthenextvalue-creationinflectionpointis,andarticulatinghowitwillbe achievedbywayofatechnicalplanwithwell-definedmilestonesandacorrespondingbudget. COVERPAGE:PINAMEANDDEPARTMENT,PROJECTTITLE,TOTALBUDGETREQUEST SECTION1:PROJECTSUMMARYORABSTRACT A. Describetheneed,problemoropportunity,andsignificanceofthetechnology. B. Describethepotentialbenefitsoftheproposedprojectwithrespecttoadvancingthetechnology. C. Statemajorresearchobjectivesoftheproject. SECTION2:DETAILEDPROJECTDESCRIPTION I.ResearchPlanandObjectives A. Provideabriefintroductiontotheareaofinvestigation. B. Describeyourspecificresearchobjectivesandsummarizetheexperimentsyouwillperformtoachieveeach. C. Estimatethecostandtimerequiredforcompletionofeachobjective. D. Describetheanticipatedresultswherepossible. E. ProvideaworkperformancescheduleorGanttchart. F. Proposekeytechnicalmilestonesfortheproject. II.RelatedResearchandResearchSupport Describesignificantrecentresearchrelatedtothisproposal,includingyourownworkandothersinthefield. SECTION3:INTELLECTUALPROPERTY A. Provideabriefdescriptionofanyinventionsyouhavealreadymaderelatedtotheproposedresearch. B. ProvideastatementaboutthecurrentIPstatusoftheinvention. C. Describehowtheproposedresearchwilladdvaluetoandenhancetheinvention’spatentabilityand/orcommercial potentialand/orimportance. SECTION4:DETAILEDBUDGET Theresearchprojectmaybestructuredsuchthatsome,orevenalargeportionoftheapproved,budgetedactivitieswill beoutsourcedtooneormoreapprovedentities(e.g.,contractresearchlaboratories/organizations,engineering/design firms). SECTION5:KEYPERSONNEL&COLLABORATORS APPENDIX–MANUSCRIPTS/PUBLICATIONS(pleaselimitto5mostrecentandsalient)