William J. Murphy, Ph.D. Title Specialty Professor and Acting Chair, Department of Dermatology Cancer, Dermatology, Hematology Oncology, Pathology - Dermatopathology Department Dermatology Division Dermatology Center/Program Affiliation Address/Phone UC Davis Comprehensive Cancer Center UC Davis Institute for Regenerative Cures (IRC), 2921 Stockton Blvd. Sacramento, CA 95817 Phone: 916-703-9300 Education Ph.D., University of Texas, Southwestern Medical School, Dallas, Texas, 1989 B.S., Rutgers University, New Brunswick, New Jersey, 1984 Select Recent Publications Tietze JK, Wilkins DE, Sckisel GD, Bouchlaka MN, Alderson KL, Weiss JM, et al. Delineation of antigen-specific and antigen-nonspecific CD8 memory T-cell responses after cytokine-based cancer immunotherapy. Blood. 2012 Srinivasan M, Flynn R, Price A, Ranger A, Browning JL, Taylor PA, et al. Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. Blood. 2011 Sun K, Alvarez M, Ames E, Barao I, Chen M, Longo DL, et al. Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing. Blood. 2011 Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M, Anderson AC, Kuchroo VK, Blazar BR. Coexpression of Tim-3 and PD-1 identifies a CD8 T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood, 117(17): 4501-10, 2011. Barao I, Alvarez M, Ames E, Orr MT, Stefanski HE, Blazar BR, Lanier LL, Anderson SK, Redelman D, Murphy WJ. Mouse Ly49G2 NK cells dominate early responses during both immune reconstitution and activation independent of MHC. Blood: 4501-10, 2011. Barao I., M.Alvarez, Redelman D , Weiss JM, Ortaldo JR , Wiltrout RH, and Murphy WJ. Hydrodynamic Delivery of Human IL-15 cDNA Increases Murine Natural Killer Cell Recovery After Bone Marrow Transplantation. Biol Blood Marrow Transplant, 2011 under revision. Coghill JM, Sarantopoulos S, Moran TP, Murphy WJ, Blazar BR, Serody JS. Effector CD4 T cells, the cytokines they generate, and GVHD: something old and something new. Blood, 117(12): 326876, 2011. William J. Murphy, Ph.D. Hu B, He Y, Wu Y, Bao G, Liu H, Welniak LA, Murphy WJ. Activated allogeneic NK cells as suppressors of alloreactive responses. Biol Blood Marrow Transplant, 16(6): 772-81, 2010. Orr MT, Murphy WJ, Lanier LL. 'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection. Nat Immunol, 11(4): 321-7, 2010. Urbieta M, Barao I, Jones M, Jurecic R, Panoskaltsis-Mortari A, Blazar BR, Murphy WJ, Levy RB. Hematopoietic progenitor cell regulation by CD4CD25 T cells. Blood, 115(23): 4934-43, 2010. Weiss JM, Ridnour LA, Back T, Hussain SP, He P, Maciag AE, Keefer LK, Murphy WJ, Harris CC, Wink DA, Wiltrout RH. Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy. J Exp Med, 207(11): 2455-67, 2010. Zhou Q, Munger ME, Highfill SL, Tolar J, Weigel BJ, Riddle M, Sharpe AH, Vallera DA, Azuma M, Levine BL, June CH, Murphy WJ, Munn DH, Blazar BR. Program death-1 (PD-1) signaling and regulatory T cells (Tregs) collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes (CTLs) in advanced acute myeloid leukemia (AML). Blood: 49-63, 2010. © 2016 UC Regents