William J. Murphy, Ph.D.

William J. Murphy, Ph.D.
Professor and Acting Chair, Department of Dermatology
Cancer, Dermatology, Hematology Oncology, Pathology - Dermatopathology
Center/Program Affiliation
UC Davis Comprehensive Cancer Center
UC Davis Institute for Regenerative Cures (IRC), 2921 Stockton Blvd. Sacramento, CA 95817
Phone: 916-703-9300
Ph.D., University of Texas, Southwestern Medical School, Dallas, Texas, 1989
B.S., Rutgers University, New Brunswick, New Jersey, 1984
Select Recent Publications
Tietze JK, Wilkins DE, Sckisel GD, Bouchlaka MN, Alderson KL, Weiss JM, et al. Delineation of
antigen-specific and antigen-nonspecific CD8 memory T-cell responses after cytokine-based cancer
immunotherapy. Blood. 2012
Srinivasan M, Flynn R, Price A, Ranger A, Browning JL, Taylor PA, et al. Donor B-cell alloantibody
deposition and germinal center formation are required for the development of murine chronic
GVHD and bronchiolitis obliterans. Blood. 2011
Sun K, Alvarez M, Ames E, Barao I, Chen M, Longo DL, et al. Mouse NK cell-mediated rejection of
bone marrow allografts exhibits patterns consistent with Ly49 subset licensing. Blood. 2011
Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, Murphy WJ, Azuma M,
Anderson AC, Kuchroo VK, Blazar BR. Coexpression of Tim-3 and PD-1 identifies a CD8 T-cell
exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood, 117(17):
4501-10, 2011.
Barao I, Alvarez M, Ames E, Orr MT, Stefanski HE, Blazar BR, Lanier LL, Anderson SK, Redelman
D, Murphy WJ. Mouse Ly49G2 NK cells dominate early responses during both immune
reconstitution and activation independent of MHC. Blood: 4501-10, 2011.
Barao I., M.Alvarez, Redelman D , Weiss JM, Ortaldo JR , Wiltrout RH, and Murphy WJ.
Hydrodynamic Delivery of Human IL-15 cDNA Increases Murine Natural Killer Cell Recovery After
Bone Marrow Transplantation. Biol Blood Marrow Transplant, 2011 under revision.
Coghill JM, Sarantopoulos S, Moran TP, Murphy WJ, Blazar BR, Serody JS. Effector CD4 T cells,
the cytokines they generate, and GVHD: something old and something new. Blood, 117(12): 326876, 2011.
William J. Murphy, Ph.D.
Hu B, He Y, Wu Y, Bao G, Liu H, Welniak LA, Murphy WJ. Activated allogeneic NK cells as
suppressors of alloreactive responses. Biol Blood Marrow Transplant, 16(6): 772-81, 2010.
Orr MT, Murphy WJ, Lanier LL. 'Unlicensed' natural killer cells dominate the response to
cytomegalovirus infection. Nat Immunol, 11(4): 321-7, 2010.
Urbieta M, Barao I, Jones M, Jurecic R, Panoskaltsis-Mortari A, Blazar BR, Murphy WJ, Levy RB.
Hematopoietic progenitor cell regulation by CD4CD25 T cells. Blood, 115(23): 4934-43, 2010.
Weiss JM, Ridnour LA, Back T, Hussain SP, He P, Maciag AE, Keefer LK, Murphy WJ, Harris CC,
Wink DA, Wiltrout RH. Macrophage-dependent nitric oxide expression regulates tumor cell
detachment and metastasis after IL-2/anti-CD40 immunotherapy. J Exp Med, 207(11): 2455-67,
Zhou Q, Munger ME, Highfill SL, Tolar J, Weigel BJ, Riddle M, Sharpe AH, Vallera DA, Azuma M,
Levine BL, June CH, Murphy WJ, Munn DH, Blazar BR. Program death-1 (PD-1) signaling and
regulatory T cells (Tregs) collaborate to resist the function of adoptively transferred cytotoxic T
lymphocytes (CTLs) in advanced acute myeloid leukemia (AML). Blood: 49-63, 2010.
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