Alaa Afify, M.D.
Clinical Interests
Dr. Afify's subspecialty is cytopathology, including fine-needle aspiration cytology, body fluids and
Pap tests. He is a recognized expert in performing and evaluating fine-needle aspiration biopsies.
Dr. Afify has research interests in hyaluronan and its receptor, CD44. He is researching the role of
CD44 on cancer, including its effects on cell migration, invasion and proliferation. Recently, his lab
is developing immunoliposomes that will target specific cancer cells.
Philosophy of Care:
Dr. Afify's philosophy is that patient care comes first under all circumstances, and never to delay
any work.
Title
Director of Cytopathology
Professor
Specialty
Department
Division
Address/Phone
Cancer, Pathology and Laboratory Medicine, Pathology - Anatomic
Pathology and Laboratory Medicine
Pathology
Pathology Building, 4400 V St. Sacramento, CA 95817
Phone: 916-734-2525
Additional Phone
Education
Physician Referrals: 800-4-UCDAVIS (800-482-3284)
M.D., Alexandria University and School of Medicine, Alexandria, 1981
Internships
Woodhull Medical and Mental Health Center, New York City, New York, 1991-1992
Residency
Brown University School of Medicine, Providence, Rhode Island, 1992-1996
Fellowships
Washington University School of Medicine, St. Louis, Missouri, 1997-1998
Roswell Park Cancer Institute, Buffalo, New York, 1996-1997
Board Certifications
American Board of Pathology, Anatomic and Clinical Pathology, 1997
American Board of Pathology, Cytopathology, 1998
Professional Memberships
American Society of Cytopathology
American Society of Immunohistochemistry
College of American Pathologists
Alaa Afify, M.D.
United States and Canadian Academy of Pathology
Honors and Awards
Select Recent Publications
Best graduating resident of the year, 1996
Afify AM, Tate S, Durbin-Johnson B, Rocke DM, Konia T. Expression of CD44s and CD44v6 in
lung cancer and their correlation with prognostic factors. Int J Biol Markers. 2011 Jan-Mar;26(1):
50-7.
Devaraj S, Tobias P, Kasinath BS, Ramsamooj R, Afify A, Jialal I. Knockout of toll-like receptor-2
attenuates both the proinflammatory state of diabetes and incipient diabetic nephropathy.
Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1796-804. Epub 2011 May 26
Alaa Afify and Lydia Howell. Cervical cancer screening, effective clinician and laboratory
partnership. J of female patient, 2010 35(8):27-29.
Afify A, Purnell P, Nguyen L. Role ofCD44s and CD44v6 on human breast cancer cell adhesion,
migration, and invasion. Exp Mol Pathol, 86(2): 95-100. 2009
Afify A, Yu C, Hejazi N, Howell L. The Diagnostic Utility of Cell Blocks Prepared From Residual
SurePath Pap Material for Detection of Human Papilloma Virus. Appl Immunohistochem Mol
Morphol, 95-100. 2009
Howell LP, Wilton M, Bishop J, Afify A. Living with uncertainty: Equivocal Pap test results and the
evolution of ASC terminology. Diagn Cytopathol. 2009 Oct 23. [Epub ahead ofprint] PMID:
19856423
Singh U, Dasu MR, Yancey PG, Afify A, Devaraj S, Jialal 1.Human C-reactive protein promotes
oxidized low density lipoprotein uptake and matrix metalloproteinase-9 release in Wistar rats. J
Lipid Res, 49(5): 1015-23. 2008
Afify A, McNiel MA, Braggin J, Bailey H, Paulino AF. Expression of CD44s, CD44v6, and
hyaluronan across the spectrum of normal-hyperplasia-carcinoma in breast. Appl
Immunohistochem Mol Morphol, 16(2): 121-7. 2008
Afify AM, Lin-Chang L, Howell L. Correlation of Cytologic Examination with ELISA Assays for
Hyaluronan and Soluble CD44v6 Levels in Evaluation of Effusions. Diagnostic cytopathology, 35:
105-110. 2007
Afify AM, Pang L, Howell L. Diagnostic Utility of CD44 standard, CD44v6, and CD44v3-10
Expression in Adenocarcinomas Presenting in Serous Fluids. Applied Immunohistochemistry &
Molecular Morphology, 15(4): 446-50. 2007
Afify A, Zhou H, Howell L. Diagnostic utility of GLUT-1 expression in adenocarcinomas presenting
in serous fluids. Acta Cytol, 49(6):621-6, 2005.
Alaa Afify, M.D.
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