Jinoh Kim, Ph.D.
Clinical Interests
- We study how various cargo molecules exit the endoplasmic reticulum (ER), the intracellular
compartment where secretory and membrane proteins are synthesized.
- We characterize diseases caused by defects in this ER export step.
- We study how ER export influences human and animal development.
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Research/Academic Interests
Protein secretion is essential for cell survival and proper human development. Most secretory
proteins are synthesized in the endoplasmic reticulum (ER) and are transported to the Golgi
complex before they are released from the cell. Dr. Kim’s laboratory studies how secretory proteins
exit the ER. Dr. Kim's long-term goal is to understand how the ER export process is integrated into
vertebrate development.
Title
Specialty
Division
Clinic
Center/Program Affiliation
Address/Phone
Languages
Education
Associate Professor, Department of Pediatrics
Genomic Medicine, Pediatrics
Genomic Medicine
MIND Institute
UC Davis MIND Institute
UC Davis MIND Institute, 2825 50th St. Sacramento, CA 95817
Korean
Ph.D., University of Connecticut, Storrs, CT, 2000
M.S., Seoul National University, Seoul, 1992
B.S., Seoul National University, Seoul Korea, 1990
Professional Memberships
Honors and Awards
The American Society for Cell Biology
Academic Senate Research Award, 2009
Health Science Research Award, 2008
Select Recent Publications
Yagnik G, Ghuman A, Kim S, Stevens CG, Kimonis V, Stoler J, Sanchez-Lara PA, Bernstein JA,
Naydenov C, Drissi H, Cunningham ML, Kim J, Boyadjiev SA. ALX4 gain-of-function mutations in
nonsyndromic craniosynostosis. Hum Mutat. 2012 Dec;33(12):1626-9.
Jinoh Kim, Ph.D.
Weaver, K.N., M.E.I. Hallek, R.J. Hopkin, K.L. Sund, M. Henrickson, D. del Gaudio, A. Yuksel, G.
O. Acar, M.B. Bober, J. Kim and S.A. Boyadjiev. Keutel syndrome: Report of two nobel MGP
mutations and discussion of clinical overlap with arylsulfatase E deficiency and relapsing
polychondritis. Am. J. Med. Genet. A. 2014 164:1062-1068.
Kim, S.D., G. Yagnik, M. Cunningham, J. Kim, and S.A. Boyadjiev. MAPK/ERK signaling pathway
analysis in primary osteoblasts from patients with non-syndromic sagittal craniosynostosis. Cleft
Palate Craniofac J. 2014 51:115-119.
Thanabalasuriar, A., J. Kim, and S. Gruenheid. The inhibition of COPII trafficking is important for
intestinal epithelial tight junction disruption during enteropathogenic Escherichia coli and
Citrobacter rodentium infection. Microbes Infect. 2013 15:738-744.
Fromme, J.C. and J. Kim. A rapid and quantitative coat protein complex II vesicle formation assay
using luciferase reporters. Anal. Biochem. 2012; 421:482-488.
Kim, S.D., J.L. Liu, T. Roscioli, M.F. Buckley, G. Yagnik, S.A. Boyadjiev, and J. Kim. Leucine-rich
repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1.
FEBS Lett. 2012; 586:1516-1512
Kim, S.D., K.B. Pahuja, M. Ravazzola, J. Yoon, S.A. Boyadjiev, S. Hamamoto, R. Schekman, L. Orci,
and J. Kim. The SEC23-SEC31 interface plays a critical role for export of procollagen from the
endoplasmic reticulum. J. Biol. Chem. 2012; 287:10134-10144
Thanabalasuriar, A., J. Bergeron, A. Gillingham, M. Mimee, J.L. Thomassin, N. Strynadka, J. Kim,
and S. Gruenheid. Sec24 interaction is essential for localization and virulence-associated function
of the bacterial effector protein NleA. Cell. Microbiol. 2012; 14:1206-1218.
Justice CM, Yagnik G, Kim Y, Peter I, Jabs EW, Erazo M, Ye X, Ainehsazan E, Shi L, Cunningham
ML, Kimonis V, Roscioli T, Wall SA, Wilkie AO, Stoler J, Richtsmeier JT, Heuzé Y, Sanchez-Lara
PA, Buckley MF, Druschel CM, Mills JL, Caggana M, Romitti PA, Kay DM, Senders C, Taub PJ,
Klein OD, Boggan J, Zwienenberg-Lee M, Naydenov C, Kim J, Wilson AF, Boyadjiev SA. A
genome-wide association study identifies susceptibility loci for nonsyndromic
Jinoh Kim, Ph.D.
sagittal craniosynostosis near BMP2 and within BBS9. Nat Genet. 2012 Dec;44(12):1360-4.
Zhang, B., C. Zheng, M. Zhu, J. Tao, M. Vasievich, A. Baines, J. Kim, R. Schekman, R.J. Kaufman,
and D. Ginsburg. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver
accumulation of ?1-antitrypsin. Blood 2011; 118:3384-3391.
Boyadjiev S.A., S.D. Kim, A. Hata, C. Haldeman-Englert, E.H. Zackai, C. Naydenov, S. Hamamoto,
R.W. Schekman, and J. Kim. Cranio-Lenticulo-Sutural Dysplasia associated with defects in collagen
secretion. Clin. Genet. 2011; 80:169-176.
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