Report on UCL - French Embassy Science and Technology Workshops on NANOMATERIAS FOR BIOMEDICAL APPLICATIONS Lead by Professor Nguyễn T. K. Thanh (UCL) and Professor Sylvie Colin-Begin (University of Strasbourg, France) 1. Overview We express our sincere gratitude to the French Embassy and UCL for funding the workshop. The was held in University College London, 16 Taviton Street, room 347, on the 9th and 10th of January 2014 The aim of the workshop was to create a forum for leading research scientists between UCLFrance to exchange knowledge and collaborate. It also fostered a new interdisciplinary network of chemists, chemical engineers, physics and clinicians to tackle one of the European Commission Horizon 2020 Societal challenges namely “Human Wellbeing and in Health, demographic change”. The network was very important for an initial step of building a consortium to be prepared for the next phase of funding from EU. 2. Workshop programme Date Thursday 9/1/2014 Talk1 Time Title By 14.00-14.30 Design of inorganic Prof Etienne Duguet, nanoparticles for heat-triggered France drug release. Talk 2 14.30-15.00 Microfluidics and continuous Prof Asterios processing for crystallisation and Gavriilidis, UCL particle synthesis Talk 3 15.00-15.30 15.30-16.00 Cell-scale radiopharmaceutical Dr Marie-Claude dosimetry for molecular Bordage, France radiotherapy Tea/Coffee Talk 4 16.00-16.30 Delivering Peptides to the Brain Talk 5 16.30-17.00 Talk 6 17.00-17.30 Talk 7 17.30-18.00 Prof Ijeoma Uchegbu, UCL Translating cell-released Dr Amanda Brun, microvesicles into a multi-modal France drug delivery system Molecules Materials Medicines: Dr Andreas supramolecular interactions in Schatzlein, UCL cancer therapy Something to be on breast cancer Prof Jayant Vaidya, 1 (to be revised) UCL 18.30- 20.30 Dinner @ Honey & Co. 25a Warren Street, London W1T 5LZ Tel. 0207 388 6175 Date Friday 10/1/2014 Talk 8 9.00-9.30 Noble metal nanoparticles for biosensing via near-field enhancement and signal readout enhancement Dr Lanry Yung, UCL Talk 9 9.30-10.15 Radiolabelling nanomaterials for in vivo biodistribution studies Dr David Kryza , France 10.15-10.45 Tea/Coffee 10.45-11.15 Prostate MRI and clinical usage Dr Shonit Punwani, of multi-parametric whole body UCL imaging 11.15-11.45 Easily Controlled Grafting of 2O3 Nanoparticles: PhysicoChemical Characterization of DNA Organization and Biological Activity Studies New versatile theranostic platforms based on SPIONs and titanate Nanotubes Talk10 Talk 11 Prof Laurence Mott, France Talk12 11.45-12.15 Talk13 12.15-12.45 Dendronized magnetic Prof Sylvie Begin, nanoparticles designed for France targeting, MRI and hyperthermia 13.00-14.00 Lunch Talk14 14.15-14.30 Talk15 14.30-15.00 Ex vivo diagnostic, in vivo imaging and therapeutics using NPs Horizon 2020 on Nano and Healthcare 15.00-15.30 16.00 General Discussion Depart UCL 2 Prof Nadine Milot, France Prof Nguyen TK Thanh, UCL Michael Browne Head of European Research and Innovation at UCL 3. Outcome of the Workshop -The workshop was extremely successful. We were able to exchange results and collaboration. -Prof Sylvie Begin and Prof Thanh were successful in getting the EU COST Action TD1402 (http://www.cost.eu/domains_actions/TDP/Actions/TD1402): Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (RADIOMAG) funded with other European colleagues. -Prof Sylvie Begin and Prof Thanh were met up again after the workshop at a Magnetic Carriers conference in May, where Prof Thanh were introduced to other French colleague Prof. Oliver Sandre, Senior CNRS researcher, Laboratoire de Chimie des Polyméres Organiques (LCPO) (UMR5629) – ENSCPB, University of Bordeaux, Pessac, France. Also Prof Thanh has meet other European colleague Alexandre Pfeifer, they are now working on a Japan Society for the Promotion of Science (JSPS) Core-Core Program and with Prof Thanh is the Network co-ordinator. If the network is successful, French colleagues will be invited to the Network workshop. -Prof Thanh is currently planning in co-ordinating a Horizon 2020 Training Network with colleagues in France. - Prof Sylvie Begin and Prof Thanh are collaborating together in developing a novel contrast agent for magnetic resonance imaging (MRI), where Prof Thanh is visiting Prof Begin lab this September for conducting experiments and later will send her student to Strasbourg. - Prof Sylvie Begin has introduced Prof Thanh to her students, as a consequence a Master student Sara Mahiddine from University of Strasbourg came to Prof Thanh’s lab under Eramus Program. This period is very successful for Sara as she was involved in writing a review with Prof Thanh, and it was published in Chemical Reviews, it has the highest Impact Factor in Chemistry at 45.661 and is also a highly cited journal in the category of Multidisciplinary Chemistry. - Prof Thanh’s recent PhD graduated student Cristina Blanco-Andujar will be working in Prof Sylvie Begin as a postdoc researcher. - Miss Aziliz Hervault who studied with Prof Sylvie Begin at École européenne de chimie, polymères et matériaux at Strasbourg University is now doing PhD with Prof Thanh. -Prof Thanh is now working with Prof Sylvie Begin on an application with collaboration with American colleagues for an NSF grant on Partnerships in International Research and Education-PIRE. -Prof Sylvie Begin and Prof Thanh would like organise a symposium at European Materials Research Society meeting. These are some examples of the immediate outcome from the workshop, as time go on, there will be more interaction and collaboration and success stories. 3 4