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Federal Laboratory Construction at Kansas State University
Threats to U.S. Bio/Agro Security: Natural and Deliberate!
3
4
Bio/Agro Security Threats are Diverse: U.S. is Unprepared
Examples of NBAF Disease Threats to Animals ± People
5
6
Winning the NBAF Nationwide Site‐Selection Competition
Winning the NBAF Nationwide Site‐Selection Competition
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8
Bio/Agro Security Enterprise
Safeguarding Food Worldwide
Bio/Agro Security Enterprise
Historical Context and Scope
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10
Bio/Agro Security Enterprise
Historical Context and Scope
Bio/Agro Security Enterprise
Historical Context and Scope
11
12
Bio/Agro Security Enterprise
Historical Context and Scope
Unique‐in‐the‐World — Livestock/Crops/Food — BSL‐3/3Ag Facility
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14
Unique‐in‐the‐World — Livestock/Crops/Food — BSL‐3/3Ag Facility
Unique‐in‐the‐World — Livestock/Crops/Food — BSL‐3/3Ag Facility
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Unique‐in‐the‐World — Livestock/Crops/Food — BSL‐3/3Ag Facility
Unique‐in‐the‐World — Livestock/Crops/Food — BSL‐3/3Ag Facility
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Unique‐in‐the‐World — Livestock/Crops/Food — BSL‐3/3Ag Facility
Unique‐in‐the‐World — Livestock/Crops/Food — BSL‐3/3Ag Facility
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Unique-in-the-World — Livestock/Crops/Food — BSL-3/3Ag Facility
| BIOSECURITY RESEARCH INSTITUTE
Status
Principal
Investigator
Infectious Disease/
Disease Pathogen
BRI
R&D
Area
Select Agent
(CDC or USDA)
Registration
Transfer
(or Permit)
Approval
A/E
Pending
NA
A/E
Approved
NA
E
Approved
Approved
A/E/I
Approved
NA
A/E/P
NA
Approved
A/E/P
NA
Approved
A/P
NA
NA
A/P
NA
Approved
A
NA
NA
Approval Process
Projects Pending
Rift Valley Fever
Submitted
06/2015
Wilson: USDA
Richt: K-State
Start Date
Pending
K-State
(NBAF Disease Project)
Start Date
Pending
Stack
Raythayibacter toxicus
K-State
Lab R&D
Start Date
Pending
Wilson: USDA
Richt: K-State
(NBAF Disease Project)
Start Date
Pending
Ganta
Ehrlichia ruminantium
K-State
Lab R&D and in Livestock
Start Date
Pending
Richt
Vesicular Stomatitis Virus
K-State
Richt
(NBAF Disease Project)
In White Tailed Deer
African Swine Fever
Lab R&D and in Livestock
Rift Valley Fever
Vector-Borne Transmission
VSV-based Ebola
Vaccine Trial in Pigs
Japanese Encephalitis
Start Date
06/2016
Vanlandingham
Start Date
05/2016
Vanlandingham
Zika Virus
K-State
Lab R&D and in Mice
Ganta
Rickettsiae rickettsia
K-State
Vaccine Trial in Dogs
Start Date
05/2016
K-State
PPQ
(NBAF Disease Project)
Lab R&D and in Pigs
Projects Updated 05/05/2016: Personnel Approved to Work with Select Agents in the BRI  100
Unique-in-the-World — Livestock/Crops/Food — BSL-3/3Ag Facility
21
| BIOSECURITY RESEARCH INSTITUTE
Project
Started
Principal
Investigator
Infectious Disease/
Disease Pathogen
BRI
R&D
Area
Select Agent
(CDC or USDA)
Registration
Transfer
(or Permit)
Approval
P
NA
Approved
P/E
NA
Approved
A/E
Approved
A/E/P
NA
NA
A/E/P/I
NA
NA
A/E/P/I
NA
NA
A/E
NA
Approved
A/E
Approved
Approved
A/E/P
NA
Approved
A/E
1st U.S. BSL-3Ag
Livestock RVF R&D
NA
A/P
NA
NA
F
NA
Approved
A/E
1st Non-Federal
Livestock CSF R&D
NA
A/E
Approved
NA
Projects Ongoing
Valent
Wheat Blast
K-State
Lab R&D
01/2012
Wilson/Drolet
Exotic Bluetongue
USDA
Lab R&D
05/2012
Richt
Highly Pathogenic Avian
Influenza (HPAI)
11/2009
07/2012
08/2012
09/2012
03/2013
04/2013
K-State
Higgs
K-State
Yellow Fever
Lab R&D and in Mosquitoes
Higgs
Chikungunya Virus
K-State
Lab R&D and in Mice
Shi
Chinese Porcine Reproductive
& Respiratory Syndrome Virus
K-State
Wilson: USDA
Richt/Ma: K-State
06/2014
Wilson: USDA
Richt: K-State
04/2015
05/2015
06/2015
02/2016
03/2016
Vanlandingham
Rift Valley Fever
(NBAF Disease Project)
Storage, Lab & Small Animal R&D
Schmallenberg Virus
Lab R&D and in sheep and cattle
Rift Valley Fever
(NBAF Disease Project)
In Sheep and Cattle
Japanese Encephalitis
(NBAF Disease Project)
Phebus
K-State
Shiga Toxin-producing
Escherichia coli (STEC)
Shi
Classical Swine Fever
Shi
Food Processing Scale R&D
(NBAF Disease Project)
Synthetic Virus: Lab R&D & in Pigs
Classical Swine Fever
(NBAF Disease Project)
Rowland
Classical Swine Fever
K-State
Rowland
African Swine Fever
K-State
Approved
Lab R&D and in Livestock
(NBAF Disease Project)
Phebus
Approved
Lab R&D and in Mice
K-State
K-State
Domestic &
Foreign Strains
(PRRS) Lab R&D and in Pigs
K-State
K-State
Approved
Lab R&D
Higgs
Wilson/McVey: USDA
Richt: K-State
04/2015
Western Equine
Encephalitis Virus
K-State
05/2013
06/2014
Lab R&D and in Pigs & Chickens
PPQ
1st Non-Federal Lab
A/E
Lab R&D and in Livestock
(NBAF Disease Project)
NA
11/15/2013
11/15/2013
Australia
ASF Strains
09/30/15
NA
Approved
1st Non-Federal Lab
A/E
Lab R&D and in Livestock
Foodborne Pathogens
Commercial Scale Sausage
Processing Study
Approved
F
Approved
Projects Updated 05/05/2016: Personnel Approved to Work with Select Agents in the BRI  100
22
Unique-in-the-World — Livestock/Crops/Food — BSL-3/3Ag Facility
| BIOSECURITY RESEARCH INSTITUTE
Project
Ended
Principal
Investigator
Infectious Disease/
Disease Pathogen
BRI
R&D
Area
Select Agent
(CDC or USDA)
Registration
Transfer
(or Permit)
Approval
A
NA
Approved
A
NA
Approved
P
Approved
Approved
A/E
NA
Approved
F
NA
Approved
P
Approved
Approved
A/E
N/A
NA
A/E
NA
Approved
F
NA
Approved
A
NA
Approved
A
NA
Approved
A
NA
NA
A
NA
Approved
F
NA
Approved
F/P
Approved
Approved
P
Approved
Approved
F
NA
Approved
Projects Completed
11/2008
04/2010
10/2011
11/2011
Hesse/Rowland
K-State
Porcine Reproductive and
Respiratory Syndrome (PRRS)
& Porcine Circovirus in Pigs
Richt
Pandemic H1N1
K-State
In Pigs
Rajagopalan
Anthrax; Glanders;
Vaccinia Ankara (MVA)
NanoScale Corp.
Wilson: USDA
Richt: K-State
Lab Inactivation Studies
Rift Valley Fever MP12
(NBAF-Related Project)
Vaccine Strain in Sheep & Cattle
2,000 lb. Hamburger Grinds
11/2011
Phebus
K-State
With Shiga Toxin-producing
Strains of E. coli
08/2011
Oberst
Plague; Brucellosis;
Anthrax; Tularemia
06/2012
06/2012
K-State
Food Threat Detection Studies
K-State
Barmah Forest Virus/
Ross River Virus
McVey
Rift Valley Fever MP12
Higgs
USDA
Lab R&D
(NBAF-Related Project)
Vaccine Strain in Mice
2,000 lb. Hamburger Grinds
08/2012
Phebus
K-State
With the Anthrax Sterne
(Vaccine) Strain
10/2012
Ma/Richt
Swine Influenza
K-State
In Pigs
05/2013
Ma/Richt
H7N9 Influenza
K-State
Lab R&D and in Pigs
09/2013
Hesse
Porcine Epidemic Diarrhea
Virus (PEDv)
K-State
In Pigs
02/2014
Ma/Richt
Swine Influenza
K-State
In Mice
04/2014
Phebus
04/2014
04/2015
01/2016
K-State
Anthrax
Sterne (Vaccine) Strain
Food Threat Modeling Studies
Phebus
Plague; Anthrax; Tularemia
K-State
Food Threat Modeling Studies
White
Rice Bacterial Blight
K-State
Long-Term Storage
Phebus
K-State
Foodborne Pathogens
School Lunch Safety Study with
Hospitality Management
PPQ
Projects Updated 05/05/2016: Personnel Approved to Work with Select Agents in the BRI  100
Bio/Agro Security Enterprise — BASE — NBAF‐Related Upgrades
23
24
Bio/Agro Security Enterprise — BASE — 1st First Responder … Reliably
Bio/Agro Security Enterprise — BASE — 1st First Responder … Repeatedly
25
26
Bio/Agro Security Enterprise — BASE — Public‐Sector Collaborators
Bio/Agro Security Enterprise — BASE — Private‐Sector Collaborators
27
28
Bio/Agro Security Enterprise — BASE — Technology Acceleration
Bio/Agro Security Central, U.S.A.
Government  Industry  University
29
NBAF
in Kansas
Hits the Mission Bull’s-eye!