Doctorate in Educational and Child Psychology Tracey Atkins Case Study 1: An Evidence-Based Practice Review Report Theme: Interventions for children with Special Educational Needs Are Working Memory Training programmes effective interventions for young people with ADHD? Summary Working Memory Training (WMT) programmes vary in presentation but all are intended to improve the capacity and efficiency of an individual’s working memory in order to increase cognitive ability and academic attainment (Melby- Lervag & Hulme, 2013). WMT programmes usually comprise consistent practice of short but regular computerised activities that can be carried out in schools or at home for around 30 minutes a day and for up to 10 weeks. For young people with cognitive or behavioural disabilities, WMT has been seen more as a treatment than a teaching tool. The range of international research currently available for WMT in a variety of populations is extensive (Melby-Lervag & Hulme, 2013; Rapport, Orban, Kofler & Freidman, 2013); Chacko, Feirson, Bedard, Marks, Uderman & Chimiklis, 2013). As well as hyperactivity and impulsivity, young people with Attention Deficit Hyperactivity Disorder (ADHD) have been identified as having impairments of executive function with a particular weakness in working memory (Barkley, 1997); Makris, Beiderman, Monuteaux & Seidman, 2009; Willcutt, Doyle, Nigg, Faraone & Pennington, 2005). This systematic review explores whether WMT is an effective intervention for young people with ADHD and whether WMT impacts on working memory functions (as defined by Baddeley, 2000). The WMT programmes selected for this review aimed to develop verbal, visuo-spatial, short-term memory and digit span skills, 1 Doctorate in Educational and Child Psychology Tracey Atkins some of which showed more potential than others. However, critical analysis of methodological issues, differences in WMT programmes and the heterogeneity of ADHD itself, recommends that results must be interpreted with caution. Introduction Working Memory Training Three different working memory training programmes were included in the studies chosen for this review. Each one will be described separately. Cogmed Working Memory Training (CWMT) Cogmed Working Memory Training (www.cogmed.com) is a computerised programme combining software with coaching for children, adolescents and adults. Sessions can be administered on computers at school or at home and used as a tool for teaching or treatment to develop attention skills for people with working memory difficulties, brain injury or learning difficulties. It is intended that participants will be better able to stay focused, ignore distractions, plan next steps, remember instructions, and complete tasks. Cogmed.com suggests that the programme requires qualified trainers to teach users how to administer the product. However, there was no indication in the studies selected for this review that any qualification was utilised. Studies that used ‘Cogmed’ were Chacko, Bedard, Marks, Feirsen, Uderman Chmilkis…& Ramon (2013); Green, Long, Green, Iosif, Dixon, Miller… & Schweitzer (2012) and Holmes, Gathercole, Place, Dunning, Hilton & Elliot (2010). Chacko et al. (2013) administered Cogmed to young people aged between 7 and 11 years old. Sessions lasted around 40 minutes a day for around 25 days. 2 Doctorate in Educational and Child Psychology Tracey Atkins Green et al. (2012) administered CWMT to young people with a mean age of 9.9 years old. Here, 90 tasks were completed in a twenty five day period. Holmes et al. (2010) administered CWMT to young people aged between 8 and 11 years old and spread 20-25 sessions for over a 6–10 week period. CWMT includes the temporary storage and manipulation of 10 verbal and visuo-spatial WM span tasks in both auditory and visual form. The participant chooses any number as specified by the researchers such as 6 out of the 8 tasks or changeable tasks after a period of time. The programme is adapted to the functioning level of the child. If the child answers correctly on consecutive tasks, the level increases accordingly. Placebo groups engage in the same tasks without the responding increase in levels. CWMT programmes used by both Chacko et al. (2013) and Holmes et al. (2010) were conducted at the pupil’s home, whereas, the programme in Green et al. (2012) was conducted at school. CWMT was used here for research purposes but is a commercially available for educational settings or individuals. Individual computer training programme Klingberg, Forssberg & Westerberg (2002) used a computerised training programme with young people aged between 7 and 15 years old. Three working memory tasks per session were presented to the participants. These included tasks on a) visuo-spatial working memory visual stimuli that had to be remembered; b) numbers shown for participant to repeat backwards; and c) letters read aloud then repeated back according to its place in the sequence. Sessions lasted 25 minutes and took place on a daily basis for 5–6 weeks. This study was conducted for research purposes in a children’s hospital. Klingberg et al. (2002) aimed to 3 Doctorate in Educational and Child Psychology Tracey Atkins investigate whether working memory capacity could be increased and the hyperactive motor symptoms of ADHD improved. Braingame Brian Braingame Brian is also a computerised programme aiming to address three aspects of executive function: visuo-spatial working memory; inhibition and ability to switch attention (www.gamingandtraining.nl/beschrijving-braingame-brian/). Braingame Brian is used in the study by Van der Oord, Ponsioen, Geurts, Brink & Prins (2012) for research purposes with young people aged between 8 and 12 years old. Working memory tasks within this programme included activities to target: a) short term memory; b) short term memory, updating and retaining information; c) short term memory and manipulation; d) short term memory and keeping information after a delay and e) short term memory, keeping information after a delay, manipulation and updating. Visual stimuli were provided in 4 x 4 grids where shapes light up randomly and in sequence, after a pause, they had to be repeated. The sequence length is adapted as the participant continues and increased according to correct answers. Participants were provided with computers and the programme was conducted at home under the supervision of parents. Young people were required to complete twenty five sessions of forty minutes each. Psychological Theory Working memory function has significant educational and functional importance in developing young people. Rapport et al. (2013) claim that young people with ADHD are in desperate need of an effective treatment that helps to improve academic and interpersonal outcomes. Working memory training is 4 Doctorate in Educational and Child Psychology Tracey Atkins considered to be hopeful because, for the first time, it addresses the cognitive issues that are now associated with ADHD. Rapport et al. (2013) argue that whilst medication and behaviour management work in the short term, they are not accompanied by gains in academic or learning outcomes (Molina, Hinshaw, Swanson, Arnold, Vitiello, Jenson… & Houck, P. R. (2009), and it is here that research for ADHD needs to concentrate its efforts. Baddeley (2000) describes a model of working memory as one that consists of components that help to store information through inner voice rehearsal (articulatory control system); sound patterns (phonological store) or visual information (visuo-spatial sketchpad). The ‘Episodic Buffer’ binds information together, ready for storage as memories. The ‘Central Executive’ acts as a coordinator for all other components and can store all modalities but has a limited capacity. It is no wonder that deficits in working memory have been associated with difficulties at school including following instructions, prioritising and organising work schedules (Gathercole & Alloway, 2008). By improving working memory, it is hoped that it will play a role in building capacity to perform complex tasks such as learning, comprehension, reasoning and planning (Baddeley, 2007). With 66% of permanently excluded children and 75% of children in PRUs quoted has having special educational needs (DfES, 2008) and that fact that children with ADHD are more than 100 times more likely to be permanently excluded from school than other children (O’Regan, 2009), Educational Psychologists are uniquely placed to draw on the psychological theory of working memory and the effectiveness of evidence-based research to identify and recommend supportive interventions to individuals and schools. Programmes that are easily accessible from school or at home are attractive propositions but it is important for the 5 Doctorate in Educational and Child Psychology Tracey Atkins Educational Psychology profession to know which particular programmes suit which particular profile of individual or group. This paper therefore aims to explore the evidence available for working memory training on a specific age group of young people with ADHD in order to inform EP practice in the future. Rationale To obtain a diagnosis of ADHD, people need to fulfil the criteria of difficulties in attention, hyperactivity and impulsivity, as set out by the Diagnostic Statistical Manual of Mental Disorders (DSM-IV, APA,1994). However, particular difficulties in executive functioning have also been put forward as a description of the condition (Barkley, 1997) as well as impaired prefrontal cortex (Schwietzer, Faber, Grafton, Tune, Hoffman, & Kilts, 2000). Impaired working memory affects social development as well as academic achievement, for example, logical reasoning and problem solving (Klingberg, 2000). The prevalence of young people with ADHD today may amount to between 3% and 9% in the UK alone (NICE, 2008) and the link between improved working memory skills and young people with ADHD has fundamental implications. Difficulties identified in young people with ADHD leads us to the review question of whether working memory training programmes are effective interventions for young people with ADHD? 6 Doctorate in Educational and Child Psychology Tracey Atkins Critical Review of the Evidence Base Literature Search Ideally, as far as resources will allow, studies should be screened by at least two reviewers to minimise errors of judgement, however, on this occasion, these studies were screened and appraised by one reviewer only. Electronic databases PsycINFO; ERIC (ProQuest); and MEDLINE were searched on Sunday, February 2nd and Monday, 3rd February 2014 resulting in the location of 316 articles. Sequential phrases and terms for each of the above databases can be found in Table 1 below. Table 1 Database search terms Sequence Terms 1 Working Memory AND Training AND ADHD 2 Working Memory AND Training AND Attention Deficit Disorder 3 Working Memory AND Intervention AND ADHD 4 Working Memory AND Training AND Attention Deficit Hyperactivity Disorder Inclusion and Exclusion Criteria Studies were included in the review if they met the criteria outlined in Appendix 1. For this systematic review, inclusion and exclusion criteria were narrowed simply to look at whether practice in working memory skills can alter the 7 Doctorate in Educational and Child Psychology Tracey Atkins way working memory functions. Likewise, programmes measuring predominantly “attention” difficulties (such as “Pay Attention!”) were excluded at the title stage. The criteria for participants have been quite stringent so that groups between studies can be matched as closely as possible. For example, as far as information has been available, groups have a similar proportion of those taking medication to those who are not. The diversity of a diagnosis of ADHD and the range of its comorbidities has also meant that research has been chosen where as little of known co-existing behavioural difficulties are included as possible. Comorbidities that may have a perceptible bearing on the results of the training programme are Oppositional Defiance Disorder (ODD), Autistic Spectrum Disorder (ASD) and Conduct Disorder (CD). Research has also been specifically chosen where data on changes in working memory can be extracted separately in order to consider its specific impact. Although peer reviewed research does not guarantee validity, only peer reviewed research was included on the basis that some measure of quality assurance had been implemented. All studies include young people who fit within the school age range where the implications of such training have significant educational importance. There were no restrictions on the date of the studies and studies were also open to international research that could be obtained in English. Subsequent to the initial search, 47 articles were excluded as duplications followed by 187 by title alone. A further 55 articles were excluded by abstract leaving 27 articles to be examined at full text. On closer inspection, it was found that 10 studies that had been included in prior meta-analyses (Rapport, Orban, Kofler, & Friedman,2013 and Melby-Lervag & 8 Doctorate in Educational and Child Psychology Tracey Atkins Hulme, 2013) or systematic reviews (Chacko, Fiersen, Bedard, Marks, Uderman, & Chimiklis, 2013) relating to working memory training, did not fit with the participant profile. These studies were excluded on the grounds that some participants with clinical diagnoses of ADHD were mixed with participants identified with a variety of special needs, some participants were selected through teacher/parent ratings of attention difficulties (Beck, 2010; Dahlin, 2011, 2013;) and some groups were not matched in clinical diagnosis with comparison control groups (Dahlin, 2013). Two promising recent studies were found (Hovik, Saunes, Aarlien, & Egeland, 2013; Egeland, Aarlien, & Saunes, 2013), but were excluded on the basis that participants were diagnosed with Hyperkinetic Disorder. According to the International Classification of Diseases and Related Health Problems criteria (ICD10, World Health Organisation, 1992), Hovik et al. (2013) and Egeland et al. (2013) suggest that a diagnosis of Hyperkinetic Disorder is equivalent to a diagnosis of ADHD but only to ADHD-C (combined type). Whilst supporting the view that there may be overlaps in diagnosis, Tripp, Luk, Schaughency, & Singh (1999) also report that this overlap is imperfect. A diagnosis of ADHD using the DSM-IV criteria identifies a broader range of young people spanning two further subtypes (ADHDInattentive and ADHD-Hyperactive). This would imply, therefore, that the ICD-10 may fail to diagnose young people who do not have the combined symptoms of hyperactivity and inattention. Furthermore, Lahey, Pelham, Loney, & Willcutt (2005) found that although a diagnosis of ADHD was enduring, the severity of symptoms and the identification of an original subtype were changeable over time. For the purposes of obtaining as close a match as possible regarding the effectiveness of an intervention, it would 9 Doctorate in Educational and Child Psychology Tracey Atkins therefore be appropriate to exclude this group as a partial representation of the ADHD population. Of the remaining 17 articles at full text, one was found to be a study protocol; another a Master’s level thesis that was not peer reviewed; three were found to be reviews only; seven were found to investigate either particular conditions within a single working memory training programme (such as a gaming element for motivation) or compare two types of Working Memory Training programme rather than the effectiveness of one. A detailed list of articles excluded according to the inclusion criteria from full text stage onwards is summarised in Appendix 2 and a summary of the five chosen studies can be found in Appendix 3. Critical Review of Studies The critical review will outline how the individual studies in this systematic review were judged in terms of weight of evidence. It will critically consider issues with design, participant selection, intervention, measures and finally, analysis. Three types of published study are identified as randomized groups, pretestposttest designs (Barker, Pistrang, & Elliot, 2002). These studies included Green, et al. (2012); Van der Oord, et al. (2012) and Chacko et al. (2013). Another study is of a similar design (Klingberg et al. 2002) but information on the randomisation of participants is not provided in their study. The 5th study is a nonrandomized onegroup pretest-post-test design (Barker, Pistrang, & Elliot , 2002) by Holmes, et al. (2010). 10 Doctorate in Educational and Child Psychology Tracey Atkins Each study was examined for methodological, comparison group and statistical analysis quality using an adapted version of coding from the APA Task Force on Evidence-Based Interventions in School Psychology (Kratochwill, 2003). Coding protocols can be found in Appendix 4. In order to determine the compatibility and contribution of the chosen studies to the review question, Gough’s (2007) Weight of Evidence Framework was used, a summary of which can be found in table 2 The Weight of Evidence Framework allows studies to be rated in terms of quality of methodology; relevance of methodology; and relevance of evidence to the review question. It needs to be noted, however, that Weight of Evidence scales are subjective and while judgements may indicate a quality study overall, there may still be methodological flaws contained within it (Wright, Brand, Dunn, & Spindler, 2007). As a result, all studies contained within the Weight of Evidence Framework and criteria for this review will be used, regardless of the result of quality, in order for readers to draw their own conclusions (Gough, Oliver, & Thomas, 2012). Table 2 Weight of Evidence Framework (Gough, 2007) Weight of Evidence A Weight of Evidence B Weight of Evidence C Weight of Evidence D Quality of Methodology: Relevance of Methodology: Overall weight of evidence: The accuracy, coherency and transparency of evidence. The appropriateness of the methodology for answering the review question. Relevance of evidence to the review question: The relevance of the focus of the evidence for answering the review question. 11 Overall assessment of the extent to which the study provides evidence to answer the review question Doctorate in Educational and Child Psychology Tracey Atkins An average of these weightings was taken to establish the study’s Overall Weight of Evidence (see Appendix 5). Participants Studies were carried out in different countries. These included the Netherlands (Van der Oord et al. 2012), Sweden (Klingberg et al. 2002), the UK (Holmes et al. 2010) and two in the USA (Chacko et al. 2013; Green et al. 2012). This range of International studies may provide a good representation of results within the mainstream school age range . The mean age of participants ranged from 8 years, 4 months old (Chacko et al. 2013) to 11 years old (Klingberg et al. (2002). As the criteria of this review included children clinically diagnosed with ADHD, preliminary recruitment had to be restricted to institutions where a diagnosis was known, therefore, initial recruitment ranged from community or institute advertisements (Chacko et al. 2013; Green et al. 2012); or outpatient mental health clinics via paediatrician and psychiatrist registers (Van der Oord et al. 2012; Holmes et al. 2010). Klingberg et al. (2002) do not indicate their selection procedure. There are obvious limitations attached to the initial voluntary recruitment of ADHD candidates before randomisation. It may be helpful to view ADHD as a “cluster” group in order to account for the variety of symptoms, subtypes and confounding variables that may affect the results of the study. Potential generalizability may also be limited due to four out of five of the studies failing to provide adequate sample sizes. Based on power analyses using GPower, Green et al. (2012) was the only study that met the required sample size of 22 participants by reporting on 26 participants. Van der Oord et al. (2012) was calculated to require 350 participants while only reporting on 40. Where the effect 12 Doctorate in Educational and Child Psychology Tracey Atkins sizes were available for different dependent variables within one study (Klingberg et al. 2002; Chacko et al. 2013), the median effect size was used to calculate appropriate sample size through G-Power (Rosenthal & Rubin, 1986). This is due to the fact that effect sizes for each of the dependent variables varied greatly. Rosenthal & Rubin (1986) suggest that although this is likely to be a more conservative estimate than using the mean, the mean is only a good representation if the dependent variable effect sizes are virtually equal. Klingberg et al. (2002) required a sample size of 46 while only reporting on 14; and Chacko et al. (2013) required a sample size of 390 while reporting only on 85. Inadequate samples sizes undermine the effect size results and compromise generalizability further. Information on the matching of treatment to control groups was also varied. Klingberg et al. (2002) do not provide details but suggest that there were no significant differences between groups. Lack of information on how the groups differ is reflected in a ‘low’ Weight of Evidence rating for this study. Green et al. (2012), Van der Oord et al. (2012) and Chacko et al. (2013) illustrate group equivalence by providing details on demographic status, gender, age, and ADHD subtype with Van der Oord et al. (2012) and Chacko et al. (2013) also providing equivalence in IQ, and medication use. Further details are provided by Van der Oord et al. (2012) on experience of gaming and Chacko et al. (2013) on percentage of comorbidities and marital status of parents. Methodology The type of working memory intervention varied across the studies. Three studies use “CWMT” (Holmes et al. 2009; Green et al. 2012; Chacko et al. 2013). One study (Klingberg et al. 2002), reported the use of an unnamed specifically 13 Doctorate in Educational and Child Psychology Tracey Atkins designed computerised intervention; and the remaining study used a gaming intervention called “Braingame Brian” (Van der Oord et al. 2012). Although Chacko et al. (2013) intended to measure more generalised outcomes from the training programme, the study was awarded medium for Weight of Evidence within measures category of Weight of Evidence (A) due to the fact that the reliability of the measure was noted, results for working memory changes were able to be specifically extracted, and effect sizes for each were recorded. Van der Oord et al. (2012) received a rating of ‘high as the results and effect size for the working memory element of study were all providedalong with randomization of groups and a control group.. Green et al. (2012) received a medium rating as the working memory element of the study, although explicit in its results, was secondary to the main measurement of on-task behaviour and only measured using the ‘Working Memory Index’ subtest in the Weschler Intelligence Scale for Children (WISC-IV, 2003). Effect sizes for Green et al. (2012) and Klingberg et al. (2002) were calculated for the purposes of this review using Cohen’s d formula (Cohen, 1992). A wait-list control design was used by Van der Oord et al. (2012), this allows for a direct comparison with the same intervention, but there is the possibility of “leakage”, for example, information about the computerised games being disclosed by participants in the treatment group to participants in the wait-list group. The use of placebo groups was used by Green et al. (2012), Klingberg et al. (2002) and Chacko et al. (2013). Although three studies used double-blind placebo conditions (Chacko et al. 2013; Klingberg et al. 2002; Green et al. 2010), the fact that all of them used computerized programmes with adjustability to test the impact on working memory, means that the element of motivation could have contributed to the 14 Doctorate in Educational and Child Psychology Tracey Atkins results. ‘Adjustability’ refers to the automated increase or decrease in level of game difficulty according to the scores obtained in previous games played in the intervention programme. Chacko et al. (2013) found that without adjustability in the games, motivation decreased and participants completed less games. Without the acknowledgment of motivation as a confounding variable, the weight of evidence for the methodological quality of Klingberg et al. (2002) and Green et al. (2010) is limited (see Appendix 5). All randomized controlled designs did not suffer from reported attrition rates at posttest assessment. Klingberg et al. (2002) was rated low for overall weight of evidence. Although the intervention used by Klingberg et al. (2002) was primarily intended to measure the effect of a working memory programme, sample sizes were small and lack of detail on limitations and allocation of participants reduced the opportunity to evaluate the study adequately. Reviews that limit information may be subject to publication bias and should be approached with caution (Wright et al. 2007). Although rated a medium for overall weight of evidence, Holmes et al. (2010) also report a small sample size and the lack of a concurrent control group. Limitations of the nonrandomised one-group pretest-posttest design may include threats to construct validity through potential confounding variables, and expectancy effects, and internal validity such as maturation and endogenous change (Barker, Pistrang, & Elliot, 2012). There is no sign in this study of an attempt to mitigate the effects of such limitations. Measures Klingberg et al. (2002) used a variety of measures for working memory. These included tests for visuo-spatial skills; a forward and backward span board 15 Doctorate in Educational and Child Psychology Tracey Atkins using blocks, and the stroop test. Each of these were scored separately for independent analysis, however, no reliability scores were given for the measures used. Van der Oord et al. (2012) used the Behaviour Rating Inventory of Executive Functioning (BRIEF) and reported test-retest reliability was “good” (p4), however, the “working memory” component was scored separately providing an accessible and appropriate measure of working memory on its own. Unfortunately though, details on the exact breakdown of the “working memory” component are not stated and so can’t be compared to other measures of “working memory”. For the working memory section in the studies reported by Chacko et al. (2013) and Holmes et al. (2010), the Automatic Working Memory Assessment (AWMA) was used. Chacko et al. (2013) measured dot matrix; spatial recall; digit recall and listening recall. Holmes et al. (2010) measured and reported test-retest reliability scores for dot matrix (.85); digit recall (.89); backward digit recall (.86) and Mr X (.84). Green et al. (2012) used the Working Memory Index from the WISC-IV but do not report reliability scores. All studies provided information from which to calculate effect sizes relating directly to working memory performance and as such, specifically relating to the research question for this study. In this respect, weight of evidence ratings of high were awarded to Green et al. (2012) Van der Oord et al. (2012) and Holmes et al. (2010); and medium to Klingberg et al. (2002) and Chacko et al. (2013). Despite the provision of some reliability scores, most of the data to measure impact on working memory alone only included one instrument of measure. The use of more than one instrument of measurement increases measurement validity and reliability. 16 Doctorate in Educational and Child Psychology Tracey Atkins Findings Table 3 (below) shows a summary of the effect sizes and overall quality of the studies included in this review. All studies except (Klingberg et al. 2002) looked at the impact of working memory training programmes on a range of executive functions but it was possible for this systematic review to extract particular information on the changes in working memory function alone. Chacko et al. (2013) obtained an overall weight of evidence” of medium due to the standard of information available for analysis; and recognition of limitations. Effect sizes were supplied showing the most improvement in non-verbal storage using the ‘Dot Matrix’ element of the test (d=1.17), small effect sizes reported were reported for ‘Spatial Recall’ and ‘Digit Recall’ (d=0.29 and 0.28 respectively). Van der Oord et al. (2012) received an overall weight of evidence of high based on the information available and a large effect size ( 2p =0.05). Although the authors report improvements in executive functions in general, they also report that the lack of positive effects of this training programme on working memory and setshifting were unexpected. However, praise for the authors needs to be acknowledged as they critique the use of a parent scale (BRIEF) as potentially biased; and the part parents play in the selection of participants. They also critique the effect parents have as supervisors in the home programme. 17 Doctorate in Educational and Child Psychology Tracey Atkins Table 3 Effect sizes and overall quality ratings Study Green et al. (2012) Klingberg et al. (2002) Outcomes Measures Generalisation to ‘on task’ behaviour in class WM composite of WISC IV Digit span and letter number sequence tests Decrease symptoms of ADHD & increase WM capacity Visuo-spatial task (author’s own design) Stroop test accuracy Span Board task (author’s own design) Time for completion Effect Size Descriptors Large Effect Size Cohen’s d (calculated from given data) d = 1.3 Medium d = 0.59 Medium – Large Large d = 1.11 d = 0.72 Small d = 0.16 Overall Weight of Evidence Medium Low Cohen’s d (calculated from given data) Van der Oord et al. (2012) Increase in cognitive flexibility, inhibition & WM capacity Medium 2p = 0.05 High (Cohen, 1998) Decrease symptoms of ADHD & increase academic achievement Automatic Working Memory Assessment (Alloway, 2007) Impact of WMT on WM Automatic Working Memory Assessment (Alloway, 2007) WASI (Weschler, 1999) (different tests used pre and post to control for re-test effects) Chacko et al. (2013) Holmes et al. (2010) BRIEF (Gioia, Isquith, Guy & Kenworthy, 2000) Dot Matrix Spatial Recall Digit Recall Listening Recall Large Small - Medium Small - Medium Small Verbal STM: Medium Visuo-spatial STM: Large Verbal WM: Medium Visuo-spatial WM: Small - Medium d = 1.17 d = 0.29 d = 0.28 d = 0.07 2p = 0.27 2p = 0.66 2p =0.29 2p .= 0.15 (Ferguson, 2009) 18 Medium Medium Doctorate in Educational and Child Psychology Key: 2 p d Small Medium Large (Cohen, 1998) 0.01 0.06 0.14 (Ferguson, 2009) 0.04 0.25 0.64 (Cohen, 1998, 1992) 0.2 0.5 0.8 SEM was calculated into SDs by the following: SEM x square root of N; Cohen’s d = post-test mean for intervention – post-test mean for control divided by (averaged) SD of both post-test intervention and control (Cohen, 1992). STM = short term memory; WM = Working Memory Green et al. (2012) received an overall weight of evidence of medium. They report statistical significance for working memory improvement through the Working Memory Index (WMI) of the WISC-IV exclusively to the treatment group, however, they were looking for changes in ADHD symptoms such as on-task behaviours and characteristics from the Connors Ratings Scale and draw attention to the limitations of measuring groups, such as ADHD, where there is a wide range of symptoms, subtypes and comorbid disorders. The effect size calculated from the data available was rated as Large (d=1.3). Holmes et al. (2010) received an overall weight of evidence of medium. Authors claim that significant gains in working memory were found from working memory training. Effect sizes show that verbal short-term memory was medium ( 2p =0.27); visuo-spatial short-term memory was large ( 2p =0.66); verbal working memory was medium ( 2p =0.29) and visuo-spatial working memory was small-medium ( 2p =0.15). Credit must be accorded to the authors as they comment on the limitations of a one-group design in that it is not clear whether improvement is due to the training programme or the programme supporting the development of “strategies to compensate for weakness” (p833). 19 Doctorate in Educational and Child Psychology Claims by Klingberg et al’. (2002) that the programme increased working memory capacity was not consistently borne out by the calculation of the effect sizes taken from both the control group and the treatment group. The strongest effect was for stroop test accuracy which was rated as large (d=1.11); followed by span board task which was rated as medium-large (d=0.72); visuo-spatial working memory which was rated as medium (d=0.59) and finally time for stroop test completion which was rated as small (d=0.16). Although the study itself was relevant to the review question and test-retest activities were varied so as to avoid reactivity, information to analyse the effectiveness of the intervention independently, was extremely limited. This information further supported a rating of low for overall weight of evidence. Conclusions and Recommendations Strengths Based on the best available evidence from the studies examined, it appears that working memory training, delivered through a range of computerised programmes, can have a positive effect on working memory function but it is unclear whether this is due to practice effects or the intervention alone. Many studies have commented on the fact that there is generalizability potential but this is yet to be conclusive. Effect sizes where different aspects of working memory data could be isolated showed that stroop test accuracy and span board task (Klingberg et al. 2002) seem to be effective (however, the lack of reliability for these results has already been discussed). A large effect size was also found for visuo-spatial short-term memory by Holmes et al. (2010) who were given an overall weight of evidence rating of medium. Chacko et al. (2013) also found a large effect size for dot matrix tasks and also received a rating of medium foroverall weight of evidence. Finally, Green et al. (2012) found an overall large effect size for his study and 20 Doctorate in Educational and Child Psychology received a rating of medium for overall weight of evidence. This may draw us to the conclusion that there is potential for working memory training to confirm that working memory function is plastic; and that it may be especially useful for developing visuospatial and sequencing skills. Limitations It is difficult to get a true representation of participants with ADHD due to the range and severity of symptoms. Some researchers feel that certain subtypes are separate disorders entirely (Lahey, Pelham, Loney, Lee, & Willcutt2005 and Milich, Balentine, & Lynam, 2001). Non-randomisation (Holmes et al. 2010) and high occurrences of comorbidities (such as ODD), especially compared to the treatment group (Van der Oord et al. 2012), can be subject to regression to the mean and distort results. Lack of a control group can also interfere with representative results (Holmes et al. (2010) and fails to provide convincing evidence for the effects of one particular intervention over another. Limitations such as small sample sizes (Klingberg et al. 2002; Holmes et al. 2010; Van der Oord et al. 2012; Chacko et al. 2013) and studies that use automated adjustments in the treatment condition but none in the placebo condition;, may mean that effects for interventions are overestimated. ‘Adjustability’ in computer interventions (such as CWMT) contains a highly motivating component to the programme (Chacko et al. 2013) the lack of which, for example, in a placebo condition, may be seen to favour the treatment group and boost results. 21 Doctorate in Educational and Child Psychology Recommendations Given the range of findings in the studies included in this systematic review, it is possible to suggest that WMT can help to improve working memory function for some participants (Green et al. 2012) and for some areas of working memory (visuo-spatial and sequencing skills). It is important for Educational Psychologists to inform schools about the fact that research in the area is in one respect, diverse, offering the client an aesthetically attractive intervention with a choice of game to play; but in another respect, the client appears to be rather limited to certain working memory programmes (such as CWMT and Braingame Brian). A greater choice of activities that schools could use to improve working memory may be an area of development for research. Further recommendations highlight the need to address the wide variety of assessment tools used to measure the impact of working memory training and the difficulties with selfreport (Van der Oord et al. 2012). Forthcoming research on working memory training may benefit from the use of a universal scale, such as the AWMA either on its own or alongside other measures; and for researchers to report the reliability data for each measure as a matter of course. The question of motivation must also be taken into account. As computer programmes with adjustability appear to sustain the attention and interest of young people, future research should aim to restrict comparison groups to programmes with a similar advantage. 22 Doctorate in Educational and Child Psychology References Baddeley, A. (2000). The episodic buffer: A new component of working memory? Trends in Cognitive Sciences, 4, 417-423. Baddeley, A. (2007). Working Memory, thought, and action. Oxford University Press Barker, C., Pistrang, N., & Elliot, R. (2012). Research methods in clinical and counselling psychology. London: John Wiley & Sons. Barkley, R. A. (1997). Behavioural inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD. Psychological Bulletin, 121, 65-94. Beck, S. J., Hanson, C. A., Puffenberger, S. S., Benninger, K. L., & Benninger, W. B. (2010). A controlled trial of working memory training for children and adolescents with ADHD. Journal of Clinical Child & Adolescent Psychology, 39(6), 825-836. Braingame Brian (2014). Retrieved from http://www.gamingandtraining.nl/beschrijving-braingame-brian/ Chacko, A., Bedard, A. C., Marks, D. J., Feirsen, N., Uderman, J. Z., Chimiklis, A., Rajwan, E., Cornwell, M., Anderson, L., Zwilling, A., & Ramon, M. (2013). A randomized clinical trial of Cogmed Working Memory Training in school‐age 23 Doctorate in Educational and Child Psychology children with ADHD: a replication in a diverse sample using a control condition. Journal of Child Psychology and Psychiatry. doi:10.1111/jcpp.12146 Chacko, A., Feirsen, A., Marks, D., Uderman., & Chimklis. (2013). Cogmed Working Memory Training for Youth with ADHD: A Closer Examination of Efficacy Utilizing Evidence-Based Criteria. Journal of Clinical Child & Adolescent Psychology, 42(6), 769-783. Cohen, J. (1992). "A power primer". Psychological Bulletin, 112 (1),155–159. doi:10.1037/0033-2909.112.1.155 Cohen, J. (1998). Statistical Power Analysis for Behavioural Sciences (2nd Ed). New York, USA: Lawrence Erlbaum Associates, Publishers. Dahlin, K. I. (2011). Effects of working memory training on reading in children with special needs. Reading and Writing, 24(4), 479-491. Dahlin, K. I. (2013). Working Memory Training and the Effect on Mathematical Achievement in Children with Attention Deficits and Special Needs. Journal of Education & Learning, 2(1). Department for Children, Schools and Families. (2008) Back on track: a strategy for modernizing alternative provision for young people. Command Paper; Cm 7410 30. HM Government (2008) Youth Crime Action Plan 2008. London: Central Office 24 Doctorate in Educational and Child Psychology of Information. Egeland, J., Aarlien, A. K., & Saunes, B. K. (2013). Few effects of far transfer of working memory training in ADHD: a randomized controlled trial. PloS one, 8(10). Ferguson, C. J. (2009). An effect size primer: A guide for clinicians and researchers. Professional Psychology: Research and Practice, 40(5), 532. Gathercole, S. E., & Alloway, T. P. (2008). Working memory and learning: A teacher’s guide. California, USA: Sage Publishing. Green, C. T., Long, D. L., Green, D., Iosif, A. M., Dixon, J. F., Miller, M. R., ... & Schweitzer, J. B. (2012). Will working memory training generalize to improve off-task behavior in children with attention-deficit/hyperactivity disorder?. Neurotherapeutics, 9(3), 639-648. Gough, D. (2007). Weight of Evidence: A Framework for the Appraisal of the Quality and Relevance of Evidence. Research Papers in Education, 22, 213-228. Gough, D., Oliver, S., & Thomas, J. (2012). An Introduction to Systematic Reviews. London, England: Sage Publications Ltd. Holmes, J., Gathercole, S. E., Place, M., Dunning, D L., Hilton, K. A., & Elliott, J. G. 25 Doctorate in Educational and Child Psychology (2010). Working memory deficits can be overcome: Impacts of training and medication on working memory in children with ADHD. Applied Cognitive Psychology, 24(6), 827-836. Hovik, K. T., Saunes, B. K., Aarlien, A. K., & Egeland, J. (2013). RCT of Working Memory Training in ADHD: Long-Term Near-Transfer Effects. PloS one, 8(12). Klingberg, T. (2000). Limitations in information processing in the human brain: Neuroimaging of dual task performance and working memory tasks. Progress in Brain Research, 126, 95-102. Klingberg, T., Forssberg, H., & Westerberg, H. (2002). Training of working memory in children with ADHD. Journal of Clinical and Experimental Neuropsychology, 24(6), 781-79. Klingberg, T. (2010). Training and plasticity of working memory. Trends in CognitiveScience, 14, 177-186. Kratochwill, T.R., & Shernoff, E.S. (2003). Evidence-Based Practice: Promoting Evidence-Based Interventions in School Psychology. School Psychology Quarterly, 18(4), 389-408. Lahey, B. B., Pelham, W. E., Loney, J., Lee, S. S., & Willcutt, E. (2005). Instability of the DSM-IV subtypes of ADHD from preschool through elementary school. Archives of General Psychiatry, 62(8), 896-902. 26 Doctorate in Educational and Child Psychology Lahey, B. B., & Willcutt, E. G. (2010). Predictive validity of a continuous alternative tonominal subtypes of attention-deficit/hyperactivity disorder for DSM–V. Journal of Clinical Child & Adolescent Psychology, 39(6), 761-775. Lee, S. I., Schachar, R. J., Chen, S. X., Ornstein, T. J., Charach, A., Barr, C., & Ickowicz, A. (2008). Predictive validity of DSM‐IV and ICD‐10 criteria for ADHD and hyperkinetic disorder. Journal of child psychology and Psychiatry, 49(1), 70-78. Makris, N., Biederman, J., Valera, E. M., Bush, G., Kaiser, J., Kennedy, D. N., ... & Seidman, L. J. (2007). Cortical thinning of the attention and executive function networks in adults with attention-deficit/hyperactivity disorder. Cerebral Cortex, 17(6), 1364-1375. Melby-Lervåg, M., & Hulme, C. (2013). Is working memory training effective? A meta-analytic review. Developmental Psychology, 49(2), 270. Milich, R., Balentine, A. C., & Lynam, D. R. (2001). ADHD combined type and ADHD predominantly inattentive type are distinct and unrelated disorders. Clinical Psychology: Science and Practice, 8(4), 463-488. 27 Doctorate in Educational and Child Psychology Molina, B. S., Hinshaw, S. P., Swanson, J. M., Arnold, L. E., Vitiello, B., Jensen, P. S., . .. & Houck, P. R. (2009). The MTA at 8 years: prospective follow-up of children treated for combined-type ADHD in a multisite study. Journal of the American Academy of Child & Adolescent Psychiatry, 48(5), 484-500. National Institute for Health and Clinical Excellence. (2008). Attention Deficit Hyperactivity Disorder: Diagnosis and Management of ADHD in Children, Young People and Adults. London, England: NICE Clinical Guidelines, CG72. O’Regan, F. (2009) Persistent disruptive behaviour and exclusion. ADHD in Practice, 1(1): 8–11 Rapport, M. D., Orban, S. A., Kofler, M. J., & Friedman, L. M. (2013). Do programs designed to train working memory, other executive functions, and attention benefit children with ADHD? A meta-analytic review of cognitive, academic, and behavioral outcomes. Clinical psychology review, 33(8), 1237-1252. Schweitzer, J. B., Faber, T. L., Grafton, S. T., Tune, L. E., Hoffman, J. M., & Kilts, C. D. (2000). Alterations in the functional anatomy of working memory in adult attention deficit hyperactivity disorder. American Journal of Psychiatry, 157(2), 278-280. 28 Doctorate in Educational and Child Psychology Tripp, G., Luk, S. L., Schaughency, E. A., & Singh, R. (1999). DSM-IV and ICD-10: A Comparison of the Correlates of ADHD and Hyperkinetic Disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 38(2), 156-164. Tzuriel, D. (2001). Dynamic assessment of young children. (pp. 63-75). New York: Kluwer Academic/Plenum Publishers. Van der Oord, S., Ponsioen, A. J. G. B., Geurts, H. M., Ten Brink, E. L., & Prins, P. J. M. (2012). A pilot study of the efficacy of a computerized executive functioning remediation training with game elements for children with ADHD in an outpatient setting: outcome on parent-and teacher-rated executive functioning and ADHD behaviour. Journal of Attention Disorders, 1-14. doi:10.1177/1087054712453167 Special Educational Needs: Report of the Committee of Enquiry into the Education and Handicapped Children and Young People. (2008). London, England: Her Majesty’s Stationery Office. Retrieved March 2014 from http://www.educationengland.org.uk/documents/warnock/warnock1978.html Willcutt, E. G., Doyle, A. E., Nigg, J. T., Faraone, S. V., & Pennington, B. F. (2005). Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review. Biological psychiatry, 57(11), 1336-1346. 29 Doctorate in Educational and Child Psychology Woolfson, L. M. (2011). Educational Psychology: The Impact of Psychological Research on Education. United Kingdom: Prentice Hall. Wright, R. W., Brand, R. A., Dunn, W., & Spindler, K. P. (2007). How to Write a Systematic Review. Clinical Orthopaedics and Related Research, 455, 23-29. 30 Doctorate in Educational and Child Psychology Appendix 1 Inclusion and exclusion criteria for studies Inclusion Criteria Exclusion Criteria Justification 1. Type of Publication Peer reviewed journal Material not in peer review journal To ensure methodological rigour 2. Language Written in English or translated into English Articles not written in English Translation services were not available 3. Intervention The study must specifically look at training programmes or interventions intended to measure the effectiveness of working memory performance compared to non-working memory training programmes. Studies where the working memory component can be extrapolated from a general Executive Function training programme. Interventions that use the same working memory programme to compare two aspects of working memory; Interventions looking at one particular aspect of Executive Function, such as inhibition or attention alone. To be able to ensure validity and consistency across studies 4. Primary source Must be reporting on primary empirical research evidence Citing secondary data; reviews of previous research. To ensure originality of findings 5. Participants Young people of compulsory school age: 5 – 17yrs; Young people with a primary clinical diagnosis of ADHD or ADD (any subtype). Pre 5 years of age and Post 17 years of age; adults; pre-school; young people not of statutory school age; ratings of attention difficulties by parental or teacher self-report; self-diagnosed ADHD/ADD; ADHD with severe learning difficulties; Young people who are all taking medication; young people with a diagnosis of Hyperkinetic Disorder. To ensure consistency across the population. To be able to examine the implications for learning and education 6. Methodology Designs that include a waitlist; control group; alternative comparison programme; information from which to calculate effect sizes; pre and post measures evaluating outcomes of working memory training. Designs without the following: control groups; alternative comparison programmes; waitlist groups; pre or post measures; non-empirical reviews; Single case designs; interventions focussing on attention. To ensure as far as possible the effects of the intervention alone. 7. Dates Research up to and including 2014 to date. N/A To include the latest research available. 8. Setting Mainstream / special / state schools or home settings for young people aged between 5 and 17 years. Pre-schools; nurseries; universities. To consider the implications for learning and statutory education. 31 Doctorate in Educational and Child Psychology Appendix 2 Excluded Studies Study Exclusion Criteria 1. Gropper, R. J., Gotlieb, H., Kronitz, R., & Tannock, R. (2014). Working Memory Training in College Students with ADHD or LD. Journal of attention disorders, 1087054713516490. Excluded at full text Criteria 5 – Participants at University aged 19 – 52 years old. 2. Johnstone S, J., Roodenrys S., Blackman R., Johnston E., Loveday K., Mantz S., Barratt M. F. (2012) Neurocognitive training for children with and without AD/HD. Attention Deficit and Hyperactivity Disorders. 4(1):11-23. 3. Johnstone S, J., Roodenrys S., Phillips, E., Watt, A. J., Mantz S. (2010) Neurocognitive training for children with and without AD/HD. Attention Deficit and Hyperactivity Disorders. 4(1),11-23. 4. Wass, S. V., Scerif, G., & Johnson, M. H. (2012). Training attentional control and working memory–Is younger, better?. Developmental Review, 32(4), 360-387. 5. Rutledge, K. J., Van den Bos, W., McClure, S. M., Schweitzer, J. B. (2012). Training Cognition in ADHD: Current Findings, Borrowed Concepts, and Future Directions. Neurotherapeutics. Vol 9, 542-558 6. Lineweaver, T. T., Kercood, S., O'Keeffe, N. B., O'Brien, K. M., Massey, E. J., Campbell, S. J., Pierce, J. N. (2012). The effects of distraction and a brief intervention on auditory and visualspatial working memory in college students with attention deficit hyperactivity disorder. Journal of Clinical and Experimental Neuropsychology. Vol.34(8), 791-805. 7. Beck, S. J., Hanson, C. A., Puffenberger, S. S., Benninger, K. L., & Benninger, W. B. (2010). A controlled trial of working memory training for children and adolescents with ADHD. Journal of Clinical Child & Adolescent Psychology, 39(6), 825-836. 8. Dahlin, K. I. (2011). Effects of working memory training on reading in children with special needs. Reading and Writing, 24(4), 479-491. Excluded at full text Criteria 3 – intervention was a combined Working Memory and Impulse Control programme. 9. Roberds, J. A. (2005). The Effect of Interactive MetronomeRTM Training on Response Excluded at full text Criteria 3 – focussed on inhibition only. 32 Excluded at full text Criteria 3 – intervention was a combined Working Memory and Impulse Control programme Excluded at full text Criteria 4 – review of mixed interventions for developing control and working memory. Excluded at full text Criteria 4 – review of mixed interventions for developing control and working memory Excluded at full text Criteria 5 – College students aged 19 – 20 years old. Excluded at full text Criteria 5 – participants were not officially stated to be clinically diagnosed with ADHD. Selection based on rating scales that fitted within DSM-IV criteria. Also known comorbidities. Excluded at full text Criteria 5 – control group 100% diagnosed with ADHD whilst treatment group only 33% ADHD. It was not possible to separate the clinically diagnosed participants in the data. Doctorate in Educational and Child Psychology Inhibition Within ADHD Children. ProQuest. 10. Dahlin, K. I. (2013). Working Memory Training and the Effect on Mathematical Achievement in Children with Attention Deficits and Special Needs. Journal of Education & Learning, 2(1). Excluded at full text Criteria 5 – Out of 57 participants, 17 in treatment group had a prior diagnosis of ADHD and only 3 in the control group. 11. Holmes, J., Gathercole, S. E., & Dunning, D. L. (2009). Adaptive training leads to sustained enhancement of poor working memory in children. Developmental science, 12(4), F9F15. Excluded at full text Criteria 3 – focused on differentiating between adaptive and non-adaptive working memory training therefore, not directly the effect compared to a non-working memory training comparison. Excluded at full text Criteria 5 – 100% participants on medication. Research cannot be matched to results from those who include a mixture or nonmedicated ADHD participants. Excluded at full text Criteria 5 – participants were mixed with small minority diagnosed with ADHD. 12. Hovik, K. T. (2010). Can PC-based training boost working memory in ADHD preadolescents on medication?:a clinical intervention study. 13. Shavelson, R. J., Yuan, K., Alonzo, A. C., Klingberg, T., & Andersson, M. (2008). On the Impact of Computer Cognitive Training on Working Memory and Fluid Intelligence1. Fostering change in institutions, environments, and people: A festschrift in honor of Gavriel Salomon, 35. 14. Steiner, N. J., Sheldrick, R. C., Gotthelf, D., & Perrin, E. C. (2011). Computer-based attention training in the schools for children with attention deficit/hyperactivity disorder: a preliminary trial. Clinical Pediatrics, 50(7), 615-622. 15. Mawjee, K. (2013). ‘Working Memory Training in post-secondary students with AttentionDeficit/Hyperactivity Disorder: Pilot study of the differential effects of training session length’. (Doctoral dissertation, University of Toronto). 16. Gray, S. A., Chaban, P., Martinussen, R., Goldberg, R., Gotlieb, H., Kronitz, R., Hockenberry, M., Tannock, R. (2012). Effects of a computerized working memory training program on working memory, attention, and academics in adolescents with severe LD and comorbid ADHD: a randomized controlled trial. Journal of Child Psychology and Psychiatry, 53(12), 1277-1284. 17. Klingberg, T., Fernell, E., Olesen, P. J., Johnson, M., Gustafsson, P., Dahlström, K., Gillberg, C. J., Forssberg, H., Westerberg, H. (2005). Computerized training of working memory in children with ADHD-a randomized, controlled trial. Journal of the American Academy of Child & Adolescent Psychiatry, 44(2), 177-186. 33 Excluded at full text Criteria 3 – Only ’Attention’ Training. Excluded at full text Criteria 3 – study to measure the effects of the length of a working memory training programme rather than its effects. Criteria 5 – participants were aged 18-25 years old. Excluded at abstract Criteria 5 – participants included those with comorbid ADHD and severe learning difficulties. Excluded at full text Criteria 3 – Study aimed to compare the difficulty level of the same Working Memory programme. Doctorate in Educational and Child Psychology 18. Gibson, B. S., Gondoli, D. M., Johnson, A. C., Steeger, C. M., Dobrzenski, B. A., & Morrissey, R. A. (2011). Component analysis of verbal versus spatial working memory training in adolescents with ADHD: A randomized, controlled trial. Child Neuropsychology, 17(6), 546-563. 19. Gropper, R. J., Gotlieb, H., Kronitz, R., & Tannock, R. (2011). Working Memory Training in College Students With ADHD or LD. Journal of attention disorders, 1087054713516490. 20. Prins, P. J., Dovis, S., Ponsioen, A., Ten Brink, E., & Van der Oord, S. (2011). Does computerized working memory training with game elements enhance motivation and training efficacy in children with ADHD? Cyberpsychology, behavior, and social networking, 14(3), 115-122. Excluded at full text Criteria 3 – Study aimed to compare two aspects of working memory within one working memory programme. Excluded at full text Criteria 5 - College students aged 28 - 30 years old. 21. Ivarsson, M., & Strohmayer, S. (2010). Working memory training improves arithmetic skills and verbal working memory capacity in children with ADHD. 22. Prins, P. J., Brink, E. T., Dovis, S., Ponsioen, A., Geurts, H. M., de Vries, M., & van der Oord, S. (2013). “Braingame Brian”: Toward an Executive Function Training Program with Game Elements for Children with ADHD and Cognitive Control Problems. GAMES FOR HEALTH: Research, Development, and Clinical Applications, 2(1), 44-49. 34 Excluded at full text Criteria 3 – Study aimed to measure the difference in motivation by manipulating one working memory training programme. Effects of gaming elements to the programme were compared to non-gaming elements thereby restricting both groups from accessing the whole programme. Excluded at full text Criteria 1 – Masters Thesis / not a peer reviewed journal. Excluded at full text Criteria 4 - Review Doctorate in Educational and Child Psychology Appendix 3 Summary of Studies Study & Aims Programme Green et al (2012) 90 trials of (COGMED (CWMT) (2006) To explore whether effects of computerized Working Memory Training would generalize to “ontask” behaviour in lessons. www.cogmed.com Design Participants Control Measures Outcome Between subjects Randomized Pretest-postest controlled design. Total no. of participants: 26 Treatment group: 12 Placebo group: 14 Mean age for treatement: 9.9yrs Mean age for placebo: 9.6yrs. Total mean age: 9.7yrs Total boys: 65% Total girls: 35% Placebo (non-adaptive working memory training) Timed sampling every 30 seconds of RAST (Restricted Academic Setting Task) at pre and post measures using academic worksheet l level below functioning level for 15 mins. nd 2 rater scored for reliability. Raters: Blind Inter-rater reliability: >0.95 (with kappa) Results were controlled for the use of medication and medication was not associated with improved performance. Tasks per day for 25 days at home. Mean IQ for treatment: 107.0 Mean IQ for placebo: 105.4 Working Memory Index (WMI) (from WISC IV) assessed change in WM performance. Improvements at post test for treatment group for: “Off task” behaviours: Mean12.3 ±4.6 SE; p=0.01 And “Plays with objects” measured in tallies, mean score 3.4 ±1.5 SE, p=0.04 Treatment group tallies reduced from 9 (pre-test) to 1 (post-test). Treatment group improved on the WMI at pre-test with a difference of 8.4±3.3 SE, p=0.02. CPRS-R (Connors Parent Rating Scale) additional measure Klingberg et al (2002) To investigation into whether a) working memory Computerized training programme for 56 weeks, including each of the following Between subjects Double-Blind Pretest-postest controlled design Diagnosis of ADHD Ages 7 – 15. Treatment group mean age 11.0. Control group mean age 11.4 Treatment 2/7 on 35 Placebo (lower dose) – 10 trials a day and difficulty remained stable with only two Pre and Post testing involved: Visuo-spatial WM task; span board; Stroop Test; Raven’s coloured progressive matrices Test-retest comparisons showed head movements significantly decreased in treatment group compared to control group: Control increase of 6%; treatment decrease of 74% (p=0.00008). Doctorate in Educational and Child Psychology can be improved by training, b) the impact would decrease the symptoms of ADHD. Hypothesising that adaptability would increase WM capacity rather than just lead to faster processing. tasks for 30 trails a day (around 25mins each session) : Visuo spatial task; backwards digit span task; letter span task; reaction time task. Number of stimuli adjusted to increase difficulty. medication; control 2/7 on medication. stimuli to be remembered. (Raven, 1996); Choice reaction time task (Psychology Software Tools, Pittsburg); head movement task (Teicher et al, 1996). Statistically significant improvement in visuo-spatial (p=0006); span board (p=0.001); Raven’s Progressive Matrices (p=001); Stroop test accuracy (p=0.02). No significance for other tasks. Diagnosed with ADHD. Treatment group: 18; wait-list group: 22. Randomised to either group; stratified by gender and medication use. Participants included 29/40: ADHD-C; 7/40: ADHD-In; 4/40: ADHDIm; 16/40: comorb idity with ODD Randomized – wait-list. Pre and post measures included: Parent and teacher questionnaires; Post-test after 6 weeks. And 9 weeks for wait-list group. Followed by ANOVA and chi-square for: Treatment versus waitlist; Treatment conditions pre and post; treatment conditions intervention versus waitlist; intervention within group pre and post follow-up. Using Cohen’s partial Eta Squared. Treatment group showed large effect size reduction in parent rated ADHD symptoms and medium effect sizes for parent rated ODD and inattention symptoms, both (p=<0.08). Authors report large effect size for improvement in EF conditions (total score) compared to wait-list group. Total comparisons between medicated participants and nonmedicated showed only a significant effect for parent rated ODD symptoms (p=<0.05). There was a range of medium to large effects within this group in EF conditions. Authors report large effect sizes within group at followup tests. Study conducted at a Children’s hospital. Van der Oord et al (2012) To measure the effectiveness of an Executive Function Training Programme using gaming elements on cognitive flexibility, response inhibition and WM capacity. Training of 3 Executive Functions: WM; inhibition and cognitive flexibility using “Brainggame Brian” (Prins et al, 2010). 25 sessions of 40 mins each. Difficulty level adjusted. Participants given computers for use at home. Between subjects Randomized Pretest-postest controlled design 36 Doctorate in Educational and Child Psychology Chacko et al (2013) COGMED (CWMT) (2006) www.cogmed.com To replicate a previous studies (Green et al, 2012; Klinberg et al, 2005) and measure the efficacy of a WM programme using a more diverse range of participants with ADHD of WM; ADHD symptoms and academic achievement. 30-45mins, 1 x day for 25 days. Adapted to level of ability as the training progresses. Compliance – through completion of 20/25 sessions, either compliant or non-compliant. Active training time monitored and adjusted accordingly. Between subjects Randomized Pretest-postest controlled design 85 children ranging from between 7-11 years recruited through community advertisements. Mean age for both groups 8.4 years. Treatment Group: 44 Placebo group: 41 Placebo version of CWMT including no adaptation for difficulty level; reduced number of trials per session and alternative games. 53 with ADHD-C; 32 with ADHD-In. 66/85 males evenly distributed between groups. Mean IQ: 104 Both groups matched for characteristics and demographic profiles. Training took place at home. DBD Rating Scale (Pelham et al 1992) used to measure ADHD symptoms. Parents and Teachers on 4 point scale. AWMA (Alloway, 2007) used to measure WM capacity. CWMT improvement index score, baseline compared to top two maximum performance scores). Improvement index score = ≥17. Movement was monitored using actigraphs on ankles and waists. (Reichenbach et al 1992). Impulsivity and inattention measured by A-X Continuous Performance Test (CPT), (Halperin et al. 1991). Academic achievement measured by WRAT4-PMV (Roid & Ledbetter, 2006) Assessors blind to treatment randomization. 37 Intent-To-Treat approach to compare treatment effects. Compliance: Treatment: 35/44 met compliance standard; Placebo: 31/41 met compliance standard. Notable difference in time spent training between treatment and placebo (p=<0.0001) Treatment mean39.1mins compared to Placebo mean 26 mins, lower than minimum recommended: 30 mins. ADHD symptoms: No significant main effect for diminution of symptoms from teacher ratings; no significant main effects between groups for parent ratings. Significant differences for Working Memory were reported as follows: between treatment conditions for non –verbal storaage/ dot matrix tasks (d=1.17),(p=<0.00009) and verbal storage/digital recall (d=0.28), (p=<0.0050); but no significant effects for verbal or nonverbal storage, manipulation and processing (complex working memory function). No significant effects were found for assessments on attention and impulse control. Doctorate in Educational and Child Psychology There was a significant effect of time for both but not on separate aspects of academic achievement. Holmes et al (2010) COGMED (2006) (CWMT) www.cogmed.com To compare the impacts of specific WM training and drug treatments on Working Memory in children with ADHD. Computer training school-based intervention. With medication pretest measured without medication. Programme Administered by TA. Non-randomized one group pretest-posttest design. 25 children aged between 8-11 years (mean 9.9 years); with a diagnosis of ADHD; recruited through psychiatrists and paediatricians; Medication alone. AWMA was used to assess verbal STM; visuo-spatial STM; verbal WM; visuospatial WM. Standard and composite scores were taken. Medication is able to improve working memory function but not to the extent of medication and working memory training. Medication showed significant interaction between visuo-spatial elements of WM only. Working Memory Training led to significant effects in more WM components : visuo-spatial STM; verbal WM and visuo-spatial WM. 20-25 sessions over 6-10 weeks Key: WM – Working Memory; statistical significance: p=<0.05; ADHD-C = Combined subtype; ADHD-In = Inattentive subtype; ADHD-Im = Impulsive subtype; ODD = Oppositional Defiance Disorder; EF = Executive Function; CWMT = COGMED Working Memory Training; DBD = Disruptive Behaviour Disorders Rating Scale; AWMA = Automatic Working Memory Assessment; WRAT4-PMV = Wide Range Achievement Test Progress Monitoring Version; STM = short term memory; TA = Teaching Assistant; 38 Doctorate in Educational and Child Psychology Appendix 4 Coding Protocol University College London, Educational Psychology, Literature Review Coding Protocol adapted from Task Force on Evidence-Based Interventions in School Psychology, American Psychology Association, Kratochwill (2003). Name of Coder: Date: 21.2.14 Full Study Reference in proper format: Holmes, J., Gathercole, S. E., Place, M., Dunning, D L., Hilton, K. A. & Elliott, J. G. (2010). Working memory deficits can be overcome: Impacts of training and medication on working memory in children with ADHD. Applied Cognitive Psychology. Vol.24(6), Sep 2010, pp. 827-836. Intervention Name: Working Memory Training Study ID Number: 1 Type of Publication: Book/Monograph Journal Article Book Chapter Other (specify): 1.General Characteristics A. General Design Characteristics A1. Random assignment designs (if random assignment design, select one of the following) Completely randomized design Randomized block design (between participants, e.g., matched classrooms) Randomized block design (within participants) Randomized hierarchical design (nested treatments A2. Nonrandomized designs (if non-random assignment design, select one of the following) Nonrandomized design Nonrandomized block design (between participants) Nonrandomized block design (within participants) Nonrandomized hierarchical design Optional coding for Quasi-experimental designs This was a non-randomised one group pretest-posttest design. A3. Overall confidence of judgment on how participants were assigned (select on of the following) Very low (little basis) Low (guess) Moderate (weak inference) 39 Doctorate in Educational and Child Psychology High (strong inference) Very high (explicitly stated) N/A Unknown/unable to code B Participants Total size of sample (start of study): 25 Intervention group sample size:_______ Control group sample size:________ C. Type of Program Universal prevention program Selective prevention program Targeted prevention program Intervention/Treatment Unknown D. Stage of Program Model/demonstration programs Early stage programs Established/institutionalized programs Unknown E. Concurrent or Historical Intervention Exposure Current exposure Prior exposure Unknown Section 2 Key Features for Coding Studies and Rating Level of Evidence/Support A Measurement (Estimating the quality of the measures used to establish effects) (Rating Scale: 3= Strong Evidence, 2=Promising Evidence, 1=Weak Evidence, 0=No Evidence) A1 The use of the outcome measures produce reliable scores for the majority of the primary outcomes (see following table for a detailed breakdown on the outcomes) Yes No Unknown/unable to code A2 Multi-method (at least two assessment methods used) Yes No N/A Unknown/unable to code 40 Doctorate in Educational and Child Psychology AWMA and WASI used to compare conditions (with medication and without medication and training) A3 Multi-source (at least two sources used self-reports, teachers etc.) Yes No N/A Unknown/unable to code A4 Validity of measures reported (well-known or standardized or norm-referenced are considered good, consider any cultural considerations) Yes validated with specific target group In part, validated for general population only No Unknown/unable to code Overall Rating of Measurement: 3 2 1 0 B Comparison Group B1 Type of Comparison group Typical intervention Attention placebo Intervention element placebo Alternative intervention Pharmacotherapy No intervention Wait list/delayed intervention Minimal contact Unable to identify type of comparison Same group tested at pretest in two conditions (with medication and without medication). B2 Overall rating of judgment of type of comparison group Very low Low Moderate High Very high Unable to identify comparison group B3 Counterbalancing of change agent (participants who receive intervention from a single therapist/teacher etc were counter-balanced across intervention) By change agent Statistical (analyse includes a test for intervention) Other Not reported/None B4 Group equivalence established Random assignment Posthoc matched set 41 Doctorate in Educational and Child Psychology Statistical matching Post hoc test for group equivalence Adjusted scores due to one or more covariates. B5 Equivalent mortality Low attrition (less than 20 % for post) Low attrition (less than 30% for follow-up) Intent to intervene analysis carried out? Findings_____________ Overall Level of Evidence : 2 3= Strong Evidence / 2=Promising Evidence / 1=Weak Evidence / 0=No Evidence C Appropriate Statistical Analysis Analysis 1 : WMT found to significantly improve all aspects of WM measured, compared to only Visuo-spatial on medication alone. Appropriate unit of analysis Familywise/expermenter wise error rate controlled when applicable Sufficiently large N Expectations for a medium effect size for correlational analysis estimated that sample size was under powered. No - Minimum of 46 participants based on a median effect size of 0.66 Overall Rating of Analysis: 3 2 1 0 42 Doctorate in Educational and Child Psychology Coding Protocol University College London, Educational Psychology, Literature Review Coding Protocol adapted from Task Force on Evidence-Based Interventions in School Psychology, American Psychology Association, Kratochwill (2003). Name of Coder: Date: 21.2.14 Full Study Reference in proper format: Chacko, A., Bedard, A. C., Marks, D. J., Feirsen, N., Uderman, J. Z., Chimiklis, A., Rajwan, E., Cornwell, M., Anderson, L., Zwilling, A., & Ramon, M. (2013). A randomized clinical trial of Cogmed Working Memory Training in school‐age children with ADHD: a replication in a diverse sample using a control condition. Journal of Child Psychology and Psychiatry, doi: 10.1111/jcpp.12146. Intervention Name: Study ID Number: Cogmed Working Memory Training 2 Type of Publication: Book/Monograph Journal Article Book Chapter Other (specify): 1.General Characteristics A. General Design Characteristics A1. Random assignment designs (if random assignment design, select one of the following) Completely randomized design Randomized block design (between participants, e.g., matched classrooms) Randomized block design (within participants) Randomized hierarchical design (nested treatments A2. Nonrandomized designs (if non-random assignment design, select one of the following) Nonrandomized design Nonrandomized block design (between participants) Nonrandomized block design (within participants) Nonrandomized hierarchical design Optional coding for Quasi-experimental designs A3. Overall confidence of judgment on how participants were assigned (select on of the following) Very low (little basis) Low (guess) Moderate (weak inference) High (strong inference) Very high (explicitly stated) N/A 43 Doctorate in Educational and Child Psychology Unknown/unable to code B Participants Total size of sample (start of study): 85 Intervention group sample size: 44 Control group sample size: 41 C. Type of Program Universal prevention program Selective prevention program Targeted prevention program Intervention/Treatment Unknown D. Stage of Program Model/demonstration programs Early stage programs Established/institutionalized programs Unknown E. Concurrent or Historical Intervention Exposure Current exposure Prior exposure Unknown However, 25 on medication but details of dose, individual effect are not known. Section 2 Key Features for Coding Studies and Rating Level of Evidence/Support A Measurement (Estimating the quality of the measures used to establish effects) (Rating Scale: 3= Strong Evidence, 2=Promising Evidence, 1=Weak Evidence, 0=No Evidence) A1 The use of the outcome measures produce reliable scores for the majority of the primary outcomes (see following table for a detailed breakdown on the outcomes) Yes No Unknown/unable to code A2 Multi-method (at least two assessment methods used) Yes No N/A Unknown/unable to code However, for Working Memory alone, only on method used. 44 Doctorate in Educational and Child Psychology A3 Multi-source (at least two sources used self-reports, teachers etc.) Yes No N/A Unknown/unable to code As mentioned above, in general at least two sources used but not for Working Memory measures. A4 Validity of measures reported (well-known or standardized or norm-referenced are considered good, consider any cultural considerations) Yes validated with specific target group In part, validated for general population only No Unknown/unable to code Overall Rating of Measurement: 3 2 1 0 Due to the fact that Working Memory measures were being examined in the review only. B Comparison Group B1 Type of Comparison group Typical intervention Attention placebo Intervention element placebo Alternative intervention Pharmacotherapy No intervention Wait list/delayed intervention Minimal contact Unable to identify type of comparison B2 Overall rating of judgment of type of comparison group Very low Low Moderate High Very high Unable to identify comparison group B3 Counterbalancing of change agent (participants who receive intervention from a single therapist/teacher etc were counter-balanced across intervention) By change agent Statistical (analyse includes a test for intervention) Other Not reported/None Time on the training programme was adapted to even out and compare between groups. B4 Group equivalence established 45 Doctorate in Educational and Child Psychology Random assignment Posthoc matched set Statistical matching Post hoc test for group equivalence B5 Equivalent mortality Low attrition (less than 20 % for post) Low attrition (less than 30% for follow-up) Intent to intervene analysis carried out? Findings_____________ Overall Level of Evidence : 3 3= Strong Evidence 2=Promising Evidence 1=Weak Evidence 0=No Evidence C Appropriate Statistical Analysis Analysis 1 - Working Memory was measured using AWMA (Alloway, 2007) Appropriate unit of analysis Familywise/expermenter wise error rate controlled when applicable Sufficiently large N No - Minimum of 390 participants based on a median effect size of 0.285 Overall Rating of Analysis: 3 2 1 0 46 Doctorate in Educational and Child Psychology Coding Protocol University College London, Educational Psychology, Literature Review Coding Protocol adapted from Task Force on Evidence-Based Interventions in School Psychology, American Psychology Association, Kratochwill (2003). Name of Coder: Date: 21.2.14 Full Study Reference in proper format: Van der Oord, S., Ponsioen, A. J. G. B., Geurts, H. M., Ten Brink, E. L., & Prins, P. J. M. (2012). A pilot study of the efficacy of a computerized executive functioning remediation training with game elements for children with ADHD in an outpatient setting: outcome on parent-and teacher-rated executive functioning and ADHD behavior. Journal of attention disorders, xx(x) 1-14, doi: 10.1177/1087054712453167. Intervention Name: “Braingame Brian” Study ID Number: 3 Type of Publication: Book/Monograph Journal Article Book Chapter Other (specify): 1.General Characteristics A. General Design Characteristics A1. Random assignment designs (if random assignment design, select one of the following) Completely randomized design Randomized block design (between participants, e.g., matched classrooms) Randomized block design (within participants) Randomized hierarchical design (nested treatments A2. Nonrandomized designs (if non-random assignment design, select one of the following) Nonrandomized design Nonrandomized block design (between participants) Nonrandomized block design (within participants) Nonrandomized hierarchical design Optional coding for Quasi-experimental designs A3. Overall confidence of judgment on how participants were assigned (select on of the following) Very low (little basis) Low (guess) Moderate (weak inference) High (strong inference) Very high (explicitly stated) N/A 47 Doctorate in Educational and Child Psychology Unknown/unable to code B Participants Total size of sample (start of study): 43 Intervention group sample size: 21 Control group sample size: 22 C. Type of Program Universal prevention program Selective prevention program Targeted prevention program Intervention/Treatment Unknown D. Stage of Program Model/demonstration programs Early stage programs Established/institutionalized programs Unknown E. Concurrent or Historical Intervention Exposure Current exposure Prior exposure Unknown Section 2 Key Features for Coding Studies and Rating Level of Evidence/Support A Measurement (Estimating the quality of the measures used to establish effects) (Rating Scale: 3= Strong Evidence, 2=Promising Evidence, 1=Weak Evidence, 0=No Evidence) A1 The use of the outcome measures produce reliable scores for the majority of the primary outcomes (see following table for a detailed breakdown on the outcomes) Yes No Unknown/unable to code A2 Multi-method (at least two assessment methods used) Yes No N/A Unknown/unable to code However, not for Working Memory alone. 48 Doctorate in Educational and Child Psychology A3 Multi-source (at least two sources used self-reports, teachers etc.) Yes No N/A Unknown/unable to code However, not for Working Memory alone. A4 Validity of measures reported (well-known or standardized or norm-referenced are considered good, consider any cultural considerations) Yes validated with specific target group In part, validated for general population only No Unknown/unable to code Overall Rating of Measurement: 3 2 1 0 Due to measures for Working Memory alone only using one element of BRIEF. B Comparison Group B1 Type of Comparison group Typical intervention Attention placebo Intervention element placebo Alternative intervention Pharmacotherapy No intervention Wait list/delayed intervention Minimal contact Unable to identify type of comparison B2 Overall rating of judgment of type of comparison group Very low Low Moderate High Very high Unable to identify comparison group B3 Counterbalancing of change agent (participants who receive intervention from a single therapist/teacher etc were counter-balanced across intervention) By change agent Statistical (analyse includes a test for intervention) Other Not reported/None Where items were missing in analysis, item was replaced by the mean of the other items in the subscale, if more than one item missing, the subscale was not used. 49 Doctorate in Educational and Child Psychology B4 Group equivalence established Random assignment Posthoc matched set Statistical matching Post hoc test for group equivalence B5 Equivalent mortality Low attrition (less than 20 % for post) Low attrition (less than 30% for follow-up) Intent to intervene analysis carried out? Findings_____________ Report states that missing items in analysis were replaced by the mean of other items in the subscale and that if more than one item missing, subscale was not used. Report also indicated that those who did not complete 20/25 sessions were not used. This implies that there may be some attrition bias (Wright et al, 2007). Overall Level of Evidence 2 3= Strong Evidence 2=Promising Evidence 1=Weak Evidence 0=No Evidence C Appropriate Statistical Analysis Analysis 1 - ANOVA Appropriate unit of analysis Familywise/expermenter wise error rate controlled when applicable Sufficiently large N Expectations of a medium effect size due to some confounding variables, indicating that 43 participants may be under powered. Analysis 2__________________________________________________________________ __________ Appropriate unit of analysis Familywise/expermenter wise error rate controlled when applicable Sufficiently large N Analysis 3__________________________________________________________________ __________ Appropriate unit of analysis Familywise/expermenter wise error rate controlled when applicable Sufficiently large N No - Minimum of 350 participants based on a median effect size of 0.05 Overall Rating of Analysis: 3 2 1 0 50 Doctorate in Educational and Child Psychology Coding Protocol University College London, Educational Psychology, Literature Review Coding Protocol adapted from Task Force on Evidence-Based Interventions in School Psychology, American Psychology Association, Kratochwill (2003). Name of Coder: Date: 21.2.14 Full Study Reference in proper format: Klingberg, T., Forssberg, H., & Westerberg, H. (2002). Training of working memory in children with ADHD. Journal of clinical and experimental neuropsychology, 24(6), 781-791. Intervention Name: Study ID Number: Computerized Working Memory Training Programme 4 Type of Publication: Book/Monograph Journal Article Book Chapter Other (specify): 1.General Characteristics A. General Design Characteristics A1. Random assignment designs (if random assignment design, select one of the following) Completely randomized design Randomized block design (between participants, e.g., matched classrooms) Randomized block design (within participants) Randomized hierarchical design (nested treatments Although not specifically stated except that the design was a “double-blind, placebo, controlled design” and that there were no significant differences between groups. A2. Nonrandomized designs (if non-random assignment design, select one of the following) Nonrandomized design Nonrandomized block design (between participants) Nonrandomized block design (within participants) Nonrandomized hierarchical design Optional coding for Quasi-experimental designs A3. Overall confidence of judgment on how participants were assigned (select on of the following) Very low (little basis) Low (guess) Moderate (weak inference) High (strong inference) 51 Doctorate in Educational and Child Psychology Very high (explicitly stated) N/A Unknown/unable to code B Participants Total size of sample (start of study): 14 Intervention group sample size: 7 Control group sample size: 7 C. Type of Program Universal prevention program Selective prevention program Targeted prevention program Intervention/Treatment Unknown D. Stage of Program Model/demonstration programs Early stage programs Established/institutionalized programs Unknown E. Concurrent or Historical Intervention Exposure Current exposure Prior exposure Unknown Section 2 Key Features for Coding Studies and Rating Level of Evidence/Support A Measurement (Estimating the quality of the measures used to establish effects) (Rating Scale: 3= Strong Evidence, 2=Promising Evidence, 1=Weak Evidence, 0=No Evidence) A1 The use of the outcome measures produce reliable scores for the majority of the primary outcomes (see following table for a detailed breakdown on the outcomes) Yes No Unknown/unable to code A2 Multi-method (at least two assessment methods used) Yes No N/A Unknown/unable to code A3 Multi-source (at least two sources used self-reports, teachers etc.) 52 Doctorate in Educational and Child Psychology Yes No N/A Unknown/unable to code A4 Validity of measures reported (well-known or standardized or norm-referenced are considered good, consider any cultural considerations) Yes validated with specific target group In part, validated for general population only No Unknown/unable to code Overall Rating of Measurement: 3 2 1 0 B Comparison Group B1 Type of Comparison group Typical intervention Attention placebo Intervention element placebo Alternative intervention Pharmacotherapy No intervention Wait list/delayed intervention Minimal contact Unable to identify type of comparison B2 Overall rating of judgment of type of comparison group Very low Low Moderate High Very high Unable to identify comparison group Not enough information to be able to judge. Despite reporting no difference between group, method of measurement is not indicated. B3 Counterbalancing of change agent (participants who receive intervention from a single therapist/teacher etc were counter-balanced across intervention) By change agent Statistical (analyse includes a test for intervention) Other Not reported/None B4 Group equivalence established Random assignment Posthoc matched set Statistical matching Post hoc test for group equivalence 53 Doctorate in Educational and Child Psychology B5 Equivalent mortality Low attrition (less than 20 % for post) Low attrition (less than 30% for follow-up) Intent to intervene analysis carried out? Findings_____________ Overall Level of Evidence - 1 3= Strong Evidence 2=Promising Evidence 1=Weak Evidence 0=No Evidence C Appropriate Statistical Analysis Analysis 1 Correlational Analysis Appropriate unit of analysis Familywise/expermenter wise error rate controlled when applicable Sufficiently large N Expectation for effect size is medium (64) indicating that sample size is greatly under powered. No - Minimum of 38 participants based on a median effect size of 0.95 Overall Rating of Analysis: 3 2 1 0 54 Doctorate in Educational and Child Psychology Coding Protocol University College London, Educational Psychology, Literature Review Coding Protocol adapted from Task Force on Evidence-Based Interventions in School Psychology, American Psychology Association, Kratochwill (2003). Name of Coder: Date: 21.2.14 Full Study Reference in proper format: Green, C. T., Long, D. L., Green, D., Iosif, A. M., Dixon, J. F., Miller, M. R., Fassbender, C., & Schweitzer, J. B. (2012). Will working memory training generalize to improve off-task behavior in children with attention-deficit/hyperactivity disorder? Neurotherapeutics, 9(3), 639-648. Intervention Name: Cogmed Working Memory Training (CWMT) Study ID Number: 5 Type of Publication: Book/Monograph Journal Article Book Chapter Other (specify): 1.General Characteristics A. General Design Characteristics A1. Random assignment designs (if random assignment design, select one of the following) Completely randomized design Randomized block design (between participants, e.g., matched classrooms) Randomized block design (within participants) Randomized hierarchical design (nested treatments A2. Nonrandomized designs (if non-random assignment design, select one of the following) Nonrandomized design Nonrandomized block design (between participants) Nonrandomized block design (within participants) Nonrandomized hierarchical design Optional coding for Quasi-experimental designs A3. Overall confidence of judgment on how participants were assigned (select on of the following) Very low (little basis) Low (guess) Moderate (weak inference) High (strong inference) Very high (explicitly stated) N/A Unknown/unable to code 55 Doctorate in Educational and Child Psychology B Participants Total size of sample (start of study): 26 Intervention group sample size: 12 Control group sample size: 14 C. Type of Program Universal prevention program Selective prevention program Targeted prevention program Intervention/Treatment Unknown D. Stage of Program Model/demonstration programs Early stage programs Established/institutionalized programs Unknown E. Concurrent or Historical Intervention Exposure Current exposure Prior exposure Unknown Section 2 Key Features for Coding Studies and Rating Level of Evidence/Support A Measurement (Estimating the quality of the measures used to establish effects) (Rating Scale: 3= Strong Evidence, 2=Promising Evidence, 1=Weak Evidence, 0=No Evidence) A1 The use of the outcome measures produce reliable scores for the majority of the primary outcomes (see following table for a detailed breakdown on the outcomes) Yes No Unknown/unable to code A2 Multi-method (at least two assessment methods used) Yes No N/A Unknown/unable to code A3 Multi-source (at least two sources used self-reports, teachers etc.) Yes No N/A 56 Doctorate in Educational and Child Psychology Unknown/unable to code A4 Validity of measures reported (well-known or standardized or norm-referenced are considered good, consider any cultural considerations) Yes validated with specific target group In part, validated for general population only No Unknown/unable to code Overall Rating of Measurement: 3 2 1 0 B Comparison Group B1 Type of Comparison group Typical intervention Attention placebo Intervention element placebo Alternative intervention Pharmacotherapy No intervention Wait list/delayed intervention Minimal contact Unable to identify type of comparison B2 Overall rating of judgment of type of comparison group Very low Low Moderate High Very high Unable to identify comparison group B3 Counterbalancing of change agent (participants who receive intervention from a single therapist/teacher etc were counter-balanced across intervention) By change agent Statistical (analyse includes a test for intervention) Other Not reported/None B4 Group equivalence established Random assignment Posthoc matched set Statistical matching Post hoc test for group equivalence B5 Equivalent mortality Low attrition (less than 20 % for post) Low attrition (less than 30% for follow-up) Intent to intervene analysis carried out? Findings_____________ Overall Level of Evidence - 2 57 Doctorate in Educational and Child Psychology 3= Strong Evidence 2=Promising Evidence 1=Weak Evidence 0=No Evidence C Appropriate Statistical Analysis Analysis 1 - Generalised Linear Model = RAST Appropriate unit of analysis Familywise/expermenter wise error rate controlled when applicable Sufficiently large N Analysis 2 - WISC for WMI (Working Memory Index) Appropriate unit of analysis Familywise/expermenter wise error rate controlled when applicable Sufficiently large N Analysis 3 - Connors Rating Scale Appropriate unit of analysis Familywise/expermenter wise error rate controlled when applicable Sufficiently large N Yes - Minimum of 22 participants needed based on an effect size of 1.3 Overall Rating of Analysis: 3 2 1 0 58 Doctorate in Educational and Child Psychology Appendix 5 Weighting of Studies A: Methodological Quality The Kratochwill (2003) coding protocol was used to weight designs; studies were weighted on measures; comparison groups and analysis. 1. Measures Weighting High Medium Low Description Used 2 measures which have reliability of .85 or above (reported in text). Data collected using multiple methods and multiple sources. Validity is reported. Used measures that produce reliable scores of .70 for the population under study Data collected using either multiple methods AND/OR from multiple sources. A case for validity does not need to be presented. Uses measures that produce reliable scores of 0.50 for the population under study 2. Comparison Group Weighting High Medium Low Description Uses at least 1 type of ‘active’ comparison group Initial group equivalency is reported Evidence of counterbalancing Equal mortality rate between the intervention and comparison group (of under 20% attrition) Uses at least a ‘no intervention group’ comparison group. Equivalent mortality with low attrition (under 20%). If equivalent mortality is not demonstrated, conducted an intent-to-intervene analysis. Uses a comparison group. Demonstrated 1 of the following: 1. Counterbalancing of change agents, 2. Group equivalency, 3. Equivalent mortality with low attrition (under 20%). If equivalent mortality is not demonstrated, conducted an intent-to-intervene analysis. 59 Doctorate in Educational and Child Psychology 3. Analysis Weighting High Medium Low Description 1. Conducted an appropriate statistical analysis 2. Corrected for family wise / experimenter error (if appropriate) 3. Used a sufficiently large sample size 4. Provided enough information for the effect size to be calculated Demonstrated two of the following: 1. Conducted an appropriate statistical analysis 2. Corrected for family wise / experimenter error (if appropriate) 3. Used a sufficiently large sample size 4. Provided enough information for the effect size to be calculated Demonstrated one of the following: 1. Conducted an appropriate statistical analysis 3. Used a sufficiently large sample size 4. Provided enough information for the effect size to be calculated Overall Methodological Quality The following scores were assigned to calculate the overall methodological quality of studies: High weightings = 3 Medium weightings = 2 Low weightings = 1 Studies which did not meet criteria = 0 Scores were then averaged. Overall Methodological Quality Average Scores High Medium Low At least 2.5 Between 1.5 and 2.4 Less than 1.4 60 Doctorate in Educational and Child Psychology Studies Measures Comparison Group Analysis Green, T. C., Long, D. L., Green, D., Iosit, A., Dixon, F. J., Miller, M. R., Fassbender, C & Schweitzer. (2012). Medium Score = 2 Medium Score = 2 Medium Score = 2 Medium 2 Medium Score = 2 Low Score = 1 Low Score = 1 Low 1.33 Van der Oord, S., Poinsioen, A. J. G. B., Guerts, H. M., Ten Brink, E. L. & Prins, P. J. M. (2012). Medium Score = 2 Medium Score = 2 Medium Score = 2 Medium 2 Chacko, A., Bedard, A. C., Marks, D. J., Feirsen, N., Uderman, J. Z., Chimiklis, A., …& Ramon, M. (2013). Medium Score = 2 High Score = 3 Medium Score = 2 Medium 2.33 Holmes, J., Gathercole, S. E., Place, M., Dunning, D. L., Hilton, K. A. & Elliot, J. G. (2010) Medium Score = 2 Medium Score = 2 Medium Score = 2 Medium 2 Klingberg, T., Forssberg, H. & Westerberg, H. (2002) Overall Quality of Methodology (B) Relevance of Methodology This weighting reviews the appropriateness of the evidence for answering the review question. Weighting High Medium Low Description Uses random assignment of participants. Uses an active comparison group. Takes pre and post measures for both the intervention and control group. Uses a comparison group. Takes pre and post measures for both the intervention and control group. Takes pre and post measures. 61 Doctorate in Educational and Child Psychology (C) Relevance of Evidence to Review Question This weighting is a review-specific judgement about the relevance of the focus of the evidence for the review question. Weighting High Medium Low Description Uses Working Memory Training exclusively Measures working memory improvement pre and post intervention Complies with special population (ADHD) Medication use is acknowledged and controlled for. Uses Working Memory Training exclusively. Some measures of working memory improvement pre and post intervention are available. Complies with special population (ADHD). Some measures of working memory improvement pre and post intervention are available. Complies with special population (ADHD). Working Memory Training is included as an intervention with other interventions. (D) Overall Weight of Evidence This is an overall assessment of the extent to which the study contributes evidence to answer the review question. It is calculated by assigning the following scores: High weightings = 3 Medium weightings = 2 Low weightings = 1 Studies which did not meet criteria = 0 The scores were then averaged and the following weighting of evidence was awarded for each score: High weighting = More than 2.5 Medium weighting = Between 1.5 and 2.4 Low weighting = Less than 1.4 62 Doctorate in Educational and Child Psychology Studies Green, T. C., Long, D. L., Green, D., Iosit, A., Dixon, F. J., Miller, M. R., Fassbender, C & Schweitzer. (2012). Klingberg, T., Forssberg, H. & Westerberg, H. (2002) Van der Oord, S., Poinsioen, A. J. G. B., Guerts, H. M., Ten Brink, E. L. & Prins, P. J. M. (2012). Chacko, A., Bedard, A. C., Marks, D. J., Feirsen, N., Uderman, J. Z., Chimiklis, A.,… & Ramon, M. (2013). Holmes, J., Gathercole, S. E., Place, M., Dunning, D. L., Hilton, K. A. & Elliot, J. G. (2010) (A) Quality of Methodology (B) Relevance of Methodology (C) Relevance of evidence to the review question (D) Overall Weight of Evidence Medium Score = 2 High Score = 3 High Score = 3 Medium 2.33 Low Score = 1 Low Score = 1 Medium Score = 2 Low 1.37 Medium Score = 2 High Score = 3 High Score = 3 High 2.66 Medium Score = 2 High Score = 3 Medium Score = 2 Medium 2.33 Medium Score = 2 Medium Score = 2 High Score = 3 Medium 2.33 63