B i o MedS i m T h e me s C on fe r en ce Linköping University, Sweden • Bio-mechanics and artificial organs, study of muscular motion. BioMedSim 2005 • Knowledge based systems and knowledge driven data processing for biological and medical applications with emphasis on aids to explicit diagnostic process and diagnosis rule formation. Modeling and Simulation in Biology, • Mathematical modeling in biology, medicine, Medicine and biophysics and biochemistry. • Object Oriented modeling approaches for Biomedical Engineering biological systems. • Mathematical modeling in immunology, neurophysiology, population dynamics and enzyme kinetics. • Mathematical models and simulation studies on cancer and screening infectious diseases. • Mathematical models for drug administration. • Modeling and design of control and assistance devices. • Models, techniques, and simulation tools to seek integrated understanding of living organisms functions. • Regulation of gene expression. • Signal and image processing chains for biological and medical applications with emphasis on diagnosis. Date: 26-27 May 2005 • Systems for educational purposes in subfields of biology and medicine with explicit emphasis on mathematical models, simulation and display tools. Linköping, Sweden • Virtual reality assisted surgery Linköping University, Sweden Invited Speakers David Hill Computer Science and Modeling Laboratory Blaise Pascal University, France Future Challenges for Distributed Computing and Biology : The Case of Grid Computing and Stochastic Distributed Simulation 2 6 M ay 2 0 0 5 09:30-10:00 09:15-10:00 Keynote Speech: David Hill An Optimal System Designing and Simulation for Medical Nanorobots SESSION I : Bio-mechanics and artificial organs, study of muscular motion, simulation studies on screening infectious diseases 10:15-10:45 Simulation of Muscle Force from Muscle-Belly Displacement Using Dynamical Models Ales Belic, Bostjan Simunic, Rihard Karba 10:45-11:15 Asymmetry Of Rhythmic Jejunal Wall Motion And Its Consequences For Fluid Transport Michel Bouchoucha, François Bertrand, François Rocaries 11:15-11:45 Simulating Influenza Outbreaks in Local Communities The purpose of this keynote is to present the new challenges for distributed stochastic simulation in biology. The first part will give a short presentation dealing with the differences between : Grid Computing, Internet Computing, Peer-To-Peer, Cluster Computing, Meta Computing and Parasitic computing. Then the focus will be given to grid computing, which could be considered as distributed computing taken to the next evolutionary stage. We will see what grid computing can do, the concepts of grid computing, the current European status of Grid computing and what will be possible in the near future. We will also state what a grid cannot do. A second part will deal will the distribution of stochastic simulations and the distribution of simulation experiments (whether stochastic or not). The different techniques in use to distribute random numbers will be presented as well as future research directions. Optimization techniques will be exposed and real applications on biology ecological modelling and medical projects will be presented to help understanding the impact of grid computing. Magnus Morin, Henrik Eriksson, Johan Jenvald, Toomas Timpka 11:45-12:15 A Bond Graph Approach To Multi-Physics Lumped Modelling In The Cardiovascular System Jacques LeFèvre, Vanessa Diaz-Zuccarini, Peter Weller 13:15-14:15 Keynote Speech: Peter Vanrolleghem SESSION II : Knowledge based systems and knowledge driven data processing for biological and medical applications, ecological modeling and simulation 14:30-15:00 Evaluation and Comparison of Ecological Models Simulating Nitrogen Processes in Treatment Wetlands, Modeled in Modelica Stina Edelfeldt, Peter Fritzson 15:00-15:30 Noninvasive Automatic Sleep Apnea Classification System Peter Vanrolleghem Department of Applied Mathematics, Biometrics and Process Control Ghent University, Belgium Integration: a Key Word and Challenge in Water Quality Modeling Tarik Al-Ani, Yskandar Hamam, Daniel Novak, Paula Tamara Pozzo Mendoza, Lenka Lhotska 10:15-10:45 A Mathematical Model of the Synchronisation of NAD(P)H Oscillations between Tumour Cells and Neutrophils Thomas Aarup Hansen, Jens Christian Brasen, Lars Folke Olsen 10:45-11:15 From In Vitro Biochemistry to In Vivo Understanding of the Glycolytic Oscillations in Saccharomyces Cerevisiae Gunnar Cedersund, Sune Dano, Preben Sorensen, Mats Jirstrand 11:15-11:45 Biochemical and Metabolic Modeling with Modelica Emma Larsdotter-Nilsson, Peter Fritzson SESSION V : Mathematical modeling in biology, medicine, biophysics and biochemistry 13:15-13:45 Modelling of Signal Transduction and Gene Expression Regulation in Immune System Cells Evgeniya Nedosekina, Elena Ananko, Vitaliy Likhoshvai, Dmitriy Oshchepkov, Nikolay Kolchanov 13:45-14:15 Identification of a Nonlinear Cell Cycle System with Linear Models Martin Fransson, Markus Gerdin, Peter Fritzson 14:15-14:45 Cell differentiation: The genetics of a Stickman Niclas Wadströmer, Robert Forchheimer 15:30-16:00 Open Technical Platform Prototype and Validation Process Model for Patient at Home Medical Monitoring System Alain Lacombe, François Rocaries, Christophe Dietrich, Jean Louis Baldinger, Jerome Boudy 16:00-16:30 Modeling for Simulation and Data Storage of Cellular Pathways: Similarities and Differences Lena Strömbäck, Patrick Lambrix Water is a precious good that is affected by many processes. When looking at river ecosystem health, as increasingly required by EU legislation and public interest, an integrated view on this large scale, complex system is required. Many scientific disciplines must work together and deal with many different types of models and data sets in a variety of ways. The presentation will highlight some of the modelling and simulation tools that support the decision support in this important environmental system. Aso Shojaie SESSION IV : Mathematical modeling in biology, medicine, biophysics and biochemistry 14:45-15:15 Metabolic Model Reduction by Metabolite Pooling on the Basis of Dynamic Phase Planes and Metabolite Correlation Analysis J Maertens, B.M.R Donckels, G. Lequeux, Peter Vanrolleghem SESSION VI : Signal and image processing chains for biological and medical applications with emphasis on diagnosis 2 7 M ay 2 0 0 5 15:30-16:00 SESSION III : Virtual reality assisted surgery From In Vitro Biochemistry to In Vivo Understanding of the Glycolytic Oscillations in Saccharomyces Cerevisiae 08:30-09:00 Computer-Based Surgical Simulation for Medical Education: A Survey Charbel Fares, Yskandar Hamam 09:00-09:30 Collision Detection for Virtual Reality Using Ellipsoidal Fitting Charbel Fares, Yskandar Hamam Cigdem Demir, S. Humayun Gultekin, Bulent Yener 16:00-16:30 Evaluation of 3-D Ultrasound Image Reconstruction Using Monte Carlo Simulated Techniques Antoine Abche, Aldo Maalouf, Elie Karam