New Heart Care System based on UT-Heart for Tailor-made Medicine

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ITU Workshop on
“E-health services in low-resource settings: Requirements
and ITU role”
(Tokyo, Japan, 4-5 February 2013)
New Heart Care System based on
UT-Heart for Tailor-made Medicine
Prof. Toshiaki Hisada, Ph.D. in Eng. Univ. of Tokyo
Prof. Seiryou Sugiura, Ph.D. in MD. Univ. of Tokyo
Yoshimasa Kadooka, Ph.D. in Sci. Fujitsu Ltd.
•Collaborative research with Hisada Lab. of the University of Tokyo
•Supported by Japan Science and Technology Agency
Tokyo, Japan, 4-5 February 2013
Results of computational simulation by using
UT-Heart
Copyright 2013 FUJITSU LIMITED
1
What we are aiming at.
P-V loop
mechanics
Tension
Multi-physics
X-bridge
Glucose
Biochemistr
y
glycolysi
s
ATP
lactate
Na+ Ca++
Channels
Electrical
activity
K+
Molecular
function/structure
10-9m
Action potential
ECG
Cell
10-2m
Orga
n
100m
Human body
Multi-scale
Integration
Understanding
of knowledge
of human body
Discovery
Copyright 2013 FUJITSU LIMITED
2
Construction of numerical model based on
CT-images
CT-scan images
Imbedding to
the torso
model
Copyright 2013 FUJITSU LIMITED
3
Pumping Principle of the Heart as a Blood
Pump
Sinoatrial node
Electrophysiology
100µm
Pressure
volume
Excitation-Contraction Coupling
Organ
Myocardium
Cell
Copyright 2013
4
FUJITSU
Fiber direction
Fiber orientation
Atrium
Ventricles
endo
mid
epi
5 2013
Copyright
5
FUJITSU
Tetrahedral FEM model for mechanics
Voxel model for EP analysis
Torso
structure
Excitation
propagation
664,334 elements
2,561,750 DOF
19,088,161 nodes
Heart
fluid
Deformation
30,819,249 nodes
(Total 49,425,860 nodes )
435,227 elements
1,668,669 DOF
(total
~4.2 million DOF)
Copyright 2013 FUJITSU LIMITED
6
Measurement of Electrocardiogram(ECG)
Comparison of ECG measurement between heart
simulator and human heart
Cardiac Pumping
Potential Distribution on
torso surface
Cardiac Excitation
Lead II ECG
Copyright 2013 FUJITSU LIMITED
7
Planning of Surgery for Dilative
Cardiomyopathy
Surgery Planning of “Batista” by Heart Simulator
Contractile force: 100%
Plan A
Aneurysm
Necrotic myocardium
Contractile force: 30%
Before surgery
Plan B
?
Quantitative Prediction (QP) of
Pressure - Volume
QP of Stress – Strain
Copyright 2013 FUJITSU LIMITED
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New Medical System to realize Tailormade Medicine in the Cloud
Heart Simulator
Patient data
Cardiac Excitation Propagation
Micro Numerical Cell
Ion channel model in Cell
Fluid and Structure Interaction
Surgery planning,
Prediction of effect
Blood pressure, electrocardiogram,
and blood test
Interactive Visualization
System
Echo
Valves
Relational model for
Excitation and Contraction
Diagnostic support
Micro Model
Coronary Circulation
CT・MRI
Peta-scale Computer
Prediction of
administering effect
Medical information integration data base
Electrical Care Card
Taylor-made Medical Treatment
by Heart Simulator
Treatment for Intractable disease
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Copyright 2013 FUJITSU LIMITED
Standardization for patient data
The data format for simulation results should be
standardize.
Unification of storage method for patient data
Conservation of relational information between
modality data and simulation result
Example: Data specification
Data
Type
Modality
Data
Simulation
Results
Format
・DICOM
・MFER
?
・Patient ID
・Simulation Date
・Organ name, bone, etc.
・Physical quantities: velocity, force, ..etc
・Type of Element
・No. of time steps
・Simulation scheme Tetra
FEM, FDM, FVM, etc
Hexa
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Copyright 2013 FUJITSU LIMITED
Conclusions and Recommedation
We have developed a heart simulator
“UT-Heart” which will contribute for a
tailor-made medical treatment.
Various kinds of computer simulations
will be adopted for medical treatment
in the near future.
We recommend to develop a
standardized format for simulation
results (3D/4D image data) same as
DICOM format for Modality data.
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