LONDON’S GLOBAL UNIVERSITY HCC UK First Annual Conference The Atrium, Royal Free Hospital, Pond Street, London, NW3 2QG Thursday 31 March – Friday 1 April 2016 Programme Organisers Programme Description Professor of Experimental Cancer Medicine and Consultant Medical Oncologist, Department of Oncology, Royal Free Hospital and UCL Cancer Institute The programme is aimed at covering the clinical management, current areas of controversy and the latest in fundamental research in the field of Hepatocellular carcinoma. Tim Meyer James O’Beirne Consultant in Hepatology, Royal Free Hospital Aileen Marshall Consultant in Hepatology, Royal Free Hospital State-of-the-art lectures and ‘live’ multidisciplinary sessions will be included to maximise audience participation. Registration Fee Massimo Pinzani Consultants £120 Conference Coordinator Oncologists, Hepatologists and Gastroenterologists, Non-medical Health Professionals and Basic Scientists interested in liver cancer. Mekala Gunaratnam Endorsement Consultant Hepatologist, Sheila Sherlock Chair in Hepatology, UCL Institute for Liver and Digestive Health, University College London UCL Experimental Cancer Medicine Centre, UCL Cancer Institute Activity and Learning Objectives To understand the latest innovations for the treatment of hepatocellular carcinoma. To understand advances in the molecular biology of hepatocellular carcinoma. To gain insight into the areas of controversy in the management of hepatocellular carcinoma. BASL British Association for the Study of the Liver Trainees/Nurses/Scientists £65 Target Audience This event is endorsed by the European Association for the Study of the Liver (EASL) and the British Association for the Study of the Liver (BASL). Accreditation and Credit Designation HCC UK – First Annual Conference has been approved by the Federation of the Royal Colleges of Physicians of the United Kingdom for 12 category 1 (external) CPD credit(s). Certificate of attendance will be provided to all participants upon request. Day 1 8.30–9.00 Registration 9.00–10.50 Clinical Management and Current Controversies – Chair Tim Meyer 9.00–9.10 9.10–9.30 9.30–9.50 9.50–10.10 10.10–10.30 10.30–10.50 Welcome – Royal Free Hospital Chief Executive David Sloman Transplantation – refining patient selection Aileen Marshall Surgical resection for HCC – selection and outcome Max Malago Transarterial embolization; who, how, when and why? Marcus Peck-Radosavljevic Radioembolisation – who is it good for? Bruno Sangro Role of Specialist Nurse Pam O’Donoghue 10.50–11.10 Morning Coffee 11.10–12.50 Progress with Systemic Therapy – Chair James O’Beirne 11.10–11.30 11.30–11.50 11.50–12.10 12.10–12.30 12.30-12.50 Recent results and trials in progress Tim Meyer Immunotherapy – science Sergio Quezada Immunotherapy – clinical Daniel Palmer Novel approaches – preclinical models Rajiv Jalan Gene therapy for HCC Amit Nathwani 12.50–13.45 Lunch 13.45–15.25 Molecular pathogenesis – Chair Aileen Marshall 13.45–14.05 14.05–14.25 14.25–14.45 14.45–15.05 15.05–15.25 Molecular pathogenesis– implications for therapy Jean-Charles Nault Epigenetics – relevance to HCC Chrissie Thirlwell The role of stem cells in the pathogenesis of HCC Luke Boulter Liver fibrosis in the context of HCC Massimo Pinzani Diagnostic challenges for the pathologist Stefan Hubscher 15.25–15.45 Afternoon Tea 15.45–16.35 Debates – Chair Massimo Pinzani 16.00–15.30 15.30–16.15 16.15–16.25 15.25–16.40 16.40–16.55 16.55–17.10 Surveillance for HCC – In favour James O’Beirne Surveillance for HCC - Against Ian Rowe Audience discussion and voting All Biopsy for HCC – In favour Alberto Quaglia Biopsy Against – Against Helen Reeves Audience discussion and voting All 17.10 Close Day 2 Friday 1 April 2016 8.30–9.00 Arrival 9.00–10.20 Clinical Decision Making – Live Multidisciplinary Meeting – Chair Brian Davidson Pathology TuVinh Luong Radiology Dominic Yu Radioembolization Bruno Sangro Surgery Nigel Heaton / Brian Davidson Oncology Philip Johnson / Deb Sarker Hepatology Graeme Alexander / Helen Reeves 10.20–10.40 Morning Coffee 10.40–12.00 Staging and Molecular Markers – Chair Chrissie Thirlwell 11.00–11.20 11.20–11.40 11.40–12.00 12.20–12.40 Staging and stratification Philip Johnson Prognostic biomarkers Shahid Khan Predictive markers Julien Edeline Novel diagnostics – circulating DNA Tim Forshew Non-coding RNAs as biomarkers in liver cancer Chiara Braconi 12.40–13.30Lunch 13.30–14.30 Epidemiology and Management Challenges - Chair Dinesh Sharma 13.30–13.50 13.50–14.10 14.10–14.30 Epidemiology Michel Coleman Treating viral hepatitis in patients with HCC Doug MacDonald Mixed HCC/CC how should we treat them? Paul Ross 14.30 Close programme Thursday 31 March 2016