Department of Chemistry
Investigating the catalytic potential of a unique aromatic nitration enzyme
Professor Greg Challis (Warwick) and Dr Luke Humphreys
(GlaxoSmithKline)
Project Description:
A PhD studentship funded jointly by BBSRC and GlaxoSmithKline is available from October
2014 to explore the catalytic potential of a unique cytochrome P450 enzyme recently
discovered by the Challis group (Nat. Chem. Biol. 2012, 8, 814-816). This enzyme catalyses
regiospecific nitration of the indole of L-tryptophan, the first committed step in the
biosynthesis of the thaxtomin phytotoxins in plant pathogenic Streptomyces bacteria.
The studentship is open to UK/EU nationals only due to funding restrictions.
Fees etc: will provide stipend plus fees for 3.5 years.
Entry Requirements:
Honours degree (at least II.1 or equivalent) in Chemistry.
How to apply:
Details of how to apply are available at http://www.go.warwick.ac.uk/chem-phd
Before applying, please make informal inquiries to Professor Greg Challis
(G.L.Challis@warwick.ac.uk). Informal enquiries should include a CV and personal
statement.
Deadline for applications is April 30, 2014