Product datasheet
Anti-Keratin 8+18+19 antibody [2A4] ab118855
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Overview
Product name
Anti-Keratin 8+18+19 antibody [2A4]
Description
Mouse monoclonal [2A4] to Keratin 8+18+19
Tested applications
WB, IHC-P, IHC-Fr
Species reactivity
Reacts with: Human
Immunogen
Cytokeratins purified from pig kidney epithelial cells
Positive control
Human Breast tissue
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze /
thaw cycle.
Storage buffer
Preservative: 0.1% Sodium azide
Constituents: 98% PBS, 1% BSA
Clonality
Monoclonal
Clone number
2A4
Isotype
IgG1
Applications
Our Abpromise guarantee covers the use of ab118855 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
Abreviews
Notes
WB
1/1000 - 1/4000. Predicted molecular weight: 54, 48, 44 kDa.
IHC-P
1/100.
IHC-Fr
1/200.
Target
Relevance
Keratin 18 is involved in the uptake of thrombin-antithrombin complexes by hepatic cells By
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similarity. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of
mutated CFTR to the plasma membrane. Together with Keratin 8, is involved in interleukin-6 (IL6)-mediated barrier protection. Keratin 19 is involved in the organization of myofibers. Together
with Keratin 8, helps to link the contractile apparatus to dystrophin at the costameres of striated
muscle.
Cellular localization
Keratin 8: Cytoplasm. Nucleus: nucleoplasm. Nucleus matrix Keratin 18: Cytoplasm: perinuclear
region
Anti-Keratin 8+18+19 antibody [2A4] images
Human Breast: Formalin-Fixed, ParaffinEmbedded (FFPE) using ab118855 at a
dilution of 1/100.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded sections) - Anti-Keratin
8+18+19 antibody [2A4] (ab118855)
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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Replacement or refund for products not performing as stated on the datasheet
Valid for 12 months from date of delivery
Response to your inquiry within 24 hours
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We investigate all quality concerns to ensure our products perform to the highest standards
If the product does not perform as described on this datasheet, we will offer a refund or replacement. For full details of the Abpromise,
please visit http://www.abcam.com/abpromise or contact our technical team.
Terms and conditions
Guarantee only valid for products bought direct from Abcam or one of our authorized distributors
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