Product datasheet
Recombinant Human ARMS2 protein ab174457
1 Image
Overview
Product name
Recombinant Human ARMS2 protein
Protein length
Full length protein
Description
Nature
Recombinant
Source
E. coli
Amino Acid Sequence
Accession
P0C7Q2
Species
Human
Sequence
MGSSHHHHHHSSGLVPRGSHMGSMLRLYPGPMVTEAEGKGGPEMASLSSS
VVPVSFISTLRESVLDPGVGGEGASDKQRSKLSLSHSMIPAAKIHTELCL
PAFFSPAGTQRRFQQPQHHLTLSIIHTAAR
Molecular weight
14 kDa including tags
Amino acids
1 to 107
Tags
His tag N-Terminus
Additional sequence information
NCBI Accession No.: NP_001093137
Specifications
Our Abpromise guarantee covers the use of ab174457 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Applications
SDS-PAGE
Purity
> 85 % by SDS-PAGE.
Form
Liquid
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or 80°C. Avoid freeze / thaw cycle.
Information available upon request.
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General Info
Relevance
ARMS2 is thought to play a role in diseases in the elderly. Mutations in this gene have been
associated with age-related macular degeneration (ARMD). ARMD is the most common cause
of irreversible vision loss. In most patients, the disease is manifest as ophthalmoscopically
visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal
pigment epithelium and within an elastin containing structure known as Bruch's membrane.
ARMD is likely to be a mechanistically heterogeneous group of disorders, and the specific
disease mechanisms that underlie the vast majority of cases are currently unknown. However,
studies have suggested that both genetic and environmental factors may be implicated.
Cellular localization
Cytoplasmic
Recombinant Human ARMS2 protein images
15% SDS-PAGE analysis of ab174457 (3
µg)
SDS-PAGE - (ab174457)
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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Replacement or refund for products not performing as stated on the datasheet
Valid for 12 months from date of delivery
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Terms and conditions
Guarantee only valid for products bought direct from Abcam or one of our authorized distributors
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