Product datasheet Anti-ARMS2 antibody [EPR12924] ab179440 1 Image Overview Product name Anti-ARMS2 antibody [EPR12924] Description Rabbit monoclonal [EPR12924] to ARMS2 Tested applications WB Species reactivity Reacts with: Mouse, Rat Predicted to work with: Human Immunogen Recombinant fragment within Human ARMS2. The exact sequence is proprietary. Database link: P0C7Q2 Positive control Mouse and Rat eyeball lysates. General notes This product is a recombinant rabbit monoclonal antibody. Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487. Properties Form Liquid Storage instructions Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Storage buffer pH: 7.20 Preservative: 0.01% Sodium azide Constituents: 50% Glycerol, 49% PBS, 0.05% BSA Purity Tissue culture supernatant Clonality Monoclonal Clone number EPR12924 Isotype IgG Applications Our Abpromise guarantee covers the use of ab179440 in the following tested applications. The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user. 1 Application Abreviews WB Application notes Notes 1/1000 - 1/10000. Predicted molecular weight: 11 kDa. Is unsuitable for ICC/IF,IHC or IP. Target Relevance ARMS2 is thought to play a role in diseases in the elderly. Mutations in this gene have been associated with age-related macular degeneration (ARMD). ARMD is the most common cause of irreversible vision loss. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin containing structure known as Bruch's membrane. ARMD is likely to be a mechanistically heterogeneous group of disorders, and the specific disease mechanisms that underlie the vast majority of cases are currently unknown. However, studies have suggested that both genetic and environmental factors may be implicated. Cellular localization Cytoplasmic Anti-ARMS2 antibody [EPR12924] images All lanes : Anti-ARMS2 antibody [EPR12924] (ab179440) at 1/1000 dilution Lane 1 : Mouse eyeball lysate Lane 2 : Rat eyeball lysate Lysates/proteins at 10 µg per lane. Predicted band size : 11 kDa Western blot - Anti-ARMS2 [EPR12924] antibody (ab179440) Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE" Our Abpromise to you: Quality guaranteed and expert technical support Replacement or refund for products not performing as stated on the datasheet Valid for 12 months from date of delivery Response to your inquiry within 24 hours We provide support in Chinese, English, French, German, Japanese and Spanish Extensive multi-media technical resources to help you We investigate all quality concerns to ensure our products perform to the highest standards If the product does not perform as described on this datasheet, we will offer a refund or replacement. For full details of the Abpromise, please visit http://www.abcam.com/abpromise or contact our technical team. Terms and conditions 2 Guarantee only valid for products bought direct from Abcam or one of our authorized distributors 3