Product datasheet
Anti-Neuron navigator 1 antibody ab32209
Overview
Product name
Anti-Neuron navigator 1 antibody
Description
Rabbit polyclonal to Neuron navigator 1
This product is a fast track antibody. It has been affinity purified and shows high
titre values against the immunizing peptide by ELISA.
Read the terms of use »
Specificity
We have tested Rabbit polyclonal to Neuron navigator 1 (ab32209) in Western Blot on adult
mouse heart lysate, we do not detect the full length protein (202 kDa) in this lysate, however we
do detect two fragments corresponding to Neuron navigator 1 (58 kDa and 64 kDa; data not
shown). As Neuron navigator 1 protein is primarily expressed in development, we would
appreciate any testing feedback in more appropriate positive control tissue.
Species reactivity
Predicted to work with: Mouse, Rat, Human
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 1850 to the C-terminus of
Mouse Neuron navigator 1. Read Abcam's proprietary immunogen policy (Peptide available as
ab32208.)
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or 80°C. Avoid freeze / thaw cycle.
Storage buffer
Preservative: 0.016% Sodium Azide
Constituents: 0.8% BSA, 80mM Boric Acid, 60mM Sodium chloride, 20mM Sodium borate, pH
7.4
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Applications
Application notes
This antibody gave a positive result in ELISA against the immunizing peptide (ab32208).
Not yet tested in other applications.
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Target
Relevance
The development of the nervous system (NS) requires the coordinated migration of multiple
waves of neurons and subsequent processes of neurite maturation, both involving selective
guidance mechanisms. In Caenorhabditis elegans, unc-53 codes for a new multidomain protein
involved in the directional migration of a subset of cells. We describe here the first functional
characterization of the mouse homologue, mouse Neuron navigator 1 (mNAV1) expression is
primarily restricted to the CNS during development. mNAV1 is a microtubules associated
protein. The abolition of mNAV1 causes loss of directionality in the leading processes of
pontine-migrating cells, providing evidence for a role of mNAV1 in mediating (Netrin1-induced)
directional migration.
Cellular localization
Cytoplasm › cytoskeleton. Note: Associates with a subset of microtubule plus ends. Enriched in
neuronal growth cone.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Terms and conditions
Guarantee only valid for products bought direct from Abcam or one of our authorized distributors
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