Product datasheet
Anti-SH3TC2 antibody ab111197
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Overview
Product name
Anti-SH3TC2 antibody
Description
Rabbit polyclonal to SH3TC2
Specificity
ab111197 detects endogenous levels of total SH3TC2 protein.
Tested applications
IHC-P
Species reactivity
Reacts with: Human
Immunogen
Synthetic peptide derived from an internal region of Human SH3TC2.
Positive control
Human brain tissue.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 0.88% Sodium chloride, 49.1% PBS
Note: PBS (without Mg2+ and Ca2+)
Purity
Immunogen affinity purified
Purification notes
ab111197 was affinity-purified from rabbit antiserum by affinity-chromatography using epitopespecific immunogen.
Clonality
Polyclonal
Isotype
IgG
Applications
Our Abpromise guarantee covers the use of ab111197 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
IHC-P
Abreviews
Notes
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6
before commencing with IHC staining protocol.
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Target
Tissue specificity
Strongly expressed in brain and spinal cord. Expressed at equal level in spinal cord and sciatic
nerve. Weakly expressed in striated muscle.
Involvement in disease
Defects in SH3TC2 are the cause of Charcot-Marie-Tooth disease type 4C (CMT4C)
[MIM:601596]. CMT4C is a recessive form of Charcot-Marie-Tooth disease, the most common
inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified
in two main groups on the basis of electrophysiologic properties and histopathology: primary
peripheral demyelinating neuropathy and primary peripheral axonal neuropathy. Demyelinating
CMT neuropathies are characterized by severely reduced nerve conduction velocities (less than
38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve
biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes,
and hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-MarieTooth disease are designated CMT4. CMT4C is characterized by onset in childhood, earlyonset scoliosis and a distinct Schwann cell pathology.
Defects in SH3TC2 are the cause of mononeuropathy of the median nerve mild (MNMN)
[MIM:613353]. A disease characterized by median nerve mononeuropathy at the wrist. The
clinical presentation ranges from a mild phenotype, consistent with carpal tunnel syndrome, to a
severe median nerve mononeuropathy at the wrist associated with evidence of a more
widespread axonal polyneuropathy. The latter phenotype is similar to that of patients with
hereditary neuropathy with liability to pressure palsies.
Sequence similarities
Contains 1 SH3 domain.
Contains 8 TPR repeats.
Anti-SH3TC2 antibody images
ab111197 at 1/50 dilution staining SH3TC2 in
paraffin-embedded Human Brain tissue by
Immunohistochemistry. The image on the right
is treated with the synthesized peptide.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded sections) - SH3TC2 antibody
(ab111197)
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