New study shows advances in care for women who suffer from recurrent miscarriage
September 12, 2013
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A team of researchers, led by the University of Warwick, have published new data that
could prove vital for advances in care for women who suffer from recurrent miscarriage.
The recurrent loss of pregnancy through miscarriage causes significant distress to
couples, often exacerbated by there being so few treatments available to clinicians.
The search for an effective treatment has been the cause of significant controversy in
the field of medical research, centering on the role of natural killer cells (or NK cells)
and the ability of steroids to prevent miscarriage.
Scientists have been uncertain about how these NK cells could contribute to a
miscarriage and this has raised doubt over their importance in causing pregnancy loss.
Led by Professor Jan Brosens of Warwick Medical School, the team found that elevated
uterine NK cells in the lining of the womb indicate deficient production of steroids.
Deficient steroid production in turn leads to reduced formation of fats and vitamins that
are essential for pregnancy nutrition.
This study, published in The Journal of Clinical Endocrinology & Metabolism, is the first
of its kind to provide an explanation for why high levels of NK cells can cause
miscarriage.
Siobhan Quenby, Professor of Obstetrics at Warwick Medical School, explained, "This
work is really exciting because after years of controversy and doubt we have a crucial
breakthrough. This means, quite simply, that we have excellent scientific justification
for steroid based treatment to prevent miscarriage."
The research was supported by the Biomedical Research Unit in Reproductive Health, a
http://www.news-medical.net/news/20130912/New-study-shows-advances-in-care-for-women-who-suffer-from-recurrent-miscarriage.aspx[12/09/2013 10:17:30]
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New study shows advances in care for women who suffer from recurrent miscarriage
joint initiative between University Hospitals Coventry and Warwickshire NHS Trust and
Warwick Medical School.
Source: University of Warwick
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Posted in: Medical Condition News | Women's Health News
Tags: Endocrinology, Medi-Cal, medical school, Metabolism, Nutrition, Obstetrics, Pregnancy,
Reproductive Health, Steroid, Womb
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