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Fate of a fertilized egg: Why some embryos
don't implant
By Rachael Rettner / Published February 06, 2014 / LiveScience
Lifestyle
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Some embryos fail to implant in the womb, while others implant
successfully, leading to pregnancy, and a new study sheds light on
why that's the case.
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In the study, researchers found that human embryos typically
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produce a chemical called trypsin, which signals the womb to
prepare its lining for implantation.
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But in embryos with significant genetic abnormalities, this chemical
signal was altered, and it produced a stress response in the womb
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The researchers likened this process to an "entrance exam" set by
the womb an embryo needs to pass this test in order to implant.
http://www.foxnews.com/health/2014/02/06/fate-fertilized-egg-why-some-embryos-dont-implant/[07/02/2014 09:13:36]
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Fate of a fertilized egg: Why some embryos don't implant | Fox News
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But sometimes, the womb may make this exam too difficult or too
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easy, which could lead to the rejection of healthy embryos, or the
implantation of embryos with development problems, the
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researchers said.
The new findings may have implications for fertility treatment
,
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because one of the main reasons fertility treatments like in vitro
fertilization (IVF) fail is that embryos don't implant.
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With future research into the factors that govern implantation, it may
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be possible to identify women at risk for miscarriage
or other
pregnancy complications by taking a sample of her uterus lining,
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said Jan Brosens, a professor at the University of Warwick in the
United Kingdom.
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Certain drugs may also help the uterus set the stage for
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implantation, Brosens said.
"What we're looking at now is how to alter the lining of the womb so
it can set this 'entrance exam' at the right level, and prevent
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implantation failure and miscarriages," Brosens said.
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Human embryos
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are genetically diverse, and some have
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impaired embryos will not implant in the uterus, but often, they
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implant only to undergo miscarriage later.
In the study, the researchers used four-day-old human embryos
that had been created by IVF. Some of the embryos were later
implanted in women, and led to successful pregnancies, while
others were not suitable for implantation because of developmental
impairments. In both cases, the researchers took some of the liquid
in which the embryos were growing, and transferred it to lab dishes
containing cells of the uterus lining to conduct their experiments.
Copyright 2014 LiveScience
, a TechMediaNetwork company. All
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rewritten or redistributed.
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http://www.foxnews.com/health/2014/02/06/fate-fertilized-egg-why-some-embryos-dont-implant/[07/02/2014 09:13:36]