Systems Biology DTC PhD projects, 2010 cohort Project undertaken by Project Title Supervisor 1 Department Supervisor 2 Department The University of Krasimira Tsaneva-Atanasova Bristol Anthony Knight Modeling the kinetics of GPCR pharmacology Graham Ladds WMS Catriona Smith John McCarthy SLS Andrew Blanks WMS Hugo van den Berg Jason Lozier Targeting the eIF4E dorsal site using peptide-mimetics Identification and analysis of genomic changes in the rat uterus associated with progesterone withdrawal and labour Development of digital in vivo footprinting methods for the analysis of differential gene regulation in normal and malignant development Sascha Ott WSB Constanze Bonifer WSB The University of Birmimgham Jessica Hearn Elucidation of biological targets for organometallic anticancer drugs Peter Sadler Chemistry David Wild WSB Manuel Esparza Franco Synthetic engineering of cellular signaling pathways Graham Ladds WMS Mike Chappell Markus Elze Adverse events and responses: modelling and prediction after stem-cell transplants. Jane Hutton Statistics Ulrike Koehl Engineering University of Newcastle upon Tyne Neil Venables Catalysis of dynamic instability by a system of microtubule tip-tracking proteins Robert Cross WMS Till Bretschneider WSB Robert Lockley Modelling the interplay of cell polarity, shape and adhesion dynamics in amoeboid cell motility Till Bretschneider WSB Len Stephens Babraham Institute Samuel Jefferyes Modelling and regulation of shape fluctuations during cell migration Nasir Rajpoot Computer Science Anne Straube WMS Sarah Cosgriff WMS Nasir Rajpoot Computer Science Shona Moore Regulation of cell migration and invasion by the microtubule plus end tracking protein EB2 Anne Straube A comprehensive systems approach to predict functionality of Duffy-Binding-Like (DBL) domains in malarial proteins Hugo van den Berg WSB Richard Plaas LSTM Stuart Nelis Unraveling the role of the ubiquitin proteasome system in plant –pest interactions Ari Sadanandum Durham University Jay Moore WSB Thomas Vigrass Modeling and predicting combinatorial strategies of gene regulation Katherine Denby SLS/WSB Barbel Finkenstadt Statistics Adam Talbot Modeling a gene regulatory switch point that links multiple stress responses Role for ionotropic receptors in the physiological and pathological glial signaling in the brain Vicky Buchanan-Wollaston SLS Jay Moore WSB Yuriy Pankratov SLS Yulia Timofeeva Computer Science Chipo Mashayamombe Peter Hebden