Product datasheet
Anti-FK506 antibody [FK1] ab8316
Overview
Product name
Anti-FK506 antibody [FK1]
Description
Mouse monoclonal [FK1] to FK506
Specificity
Recognizes conjugated and non-conjugated FK-506 with apparent dissociation constant Kd=109M.
Tested applications
ELISA
General notes
FK506 antigen is a novel macrolide with similar but more potent immunosuppressant activity
than cyclosporine. FK506 is used for primary or rescue immunosuppression in patients after
solid organ transplantation. Clinically relevant FK506 side effects are nephrotoxicity,
neurotoxicity, diabetes mellitus and hypertension. Most of these side effects are more closely
related to FK 506 blood levels than dosage; therefore therapeutic drug monitoring (TDM) of
FK506 levels is a prerequisite for therapy. Whole blood is the matrix of choice for FK506 TDM.
The whole blood target level range aimed for in clinical practice is between 3.0 and 20.0 ng/ml
and depends on the patient’s liver function, the type of organ transplanted and the time after
transplantation.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
PBS with 0.1% sodium azide, pH 7.4
Purity
Purified IgM
Purification notes
Purified by euglobulin precipitation and dialysis. Purity is tested by electrophoresis.
Primary antibody notes
FK506 antigen is a novel macrolide with similar but more potent immunosuppressant activity
than cyclosporine. FK506 is used for primary or rescue immunosuppression in patients after
solid organ transplantation. Clinically relevant FK506 side effects are nephrotoxicity,
neurotoxicity, diabetes mellitus and hypertension. Most of these side effects are more closely
related to FK 506 blood levels than dosage; therefore therapeutic drug monitoring (TDM) of
FK506 levels is a prerequisite for therapy. Whole blood is the matrix of choice for FK506 TDM.
The whole blood target level range aimed for in clinical practice is between 3.0 and 20.0 ng/ml
and depends on the patient’s liver function, the type of organ transplanted and the time after
transplantation.
Clonality
Monoclonal
Clone number
FK1
1
Myeloma
Sp2/0
Isotype
IgM
Light chain type
unknown
Applications
Our Abpromise guarantee covers the use of ab8316 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
Abreviews
ELISA
Notes
Use at an assay dependent concentration.
Target
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Terms and conditions
Guarantee only valid for products bought direct from Abcam or one of our authorized distributors
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