Product datasheet
Anti-PRG2 antibody [1.B.787] ab14463
Overview
Product name
Anti-PRG2 antibody [1.B.787]
Description
Mouse monoclonal [1.B.787] to PRG2
Specificity
Specific for eosinophil major basic protein(14kD) irrespective of the stages of eosinophil
activation and can be regarded as a pan-eosinophil marker.
Tested applications
IHC-P
Species reactivity
Reacts with: Human
Does not react with: Mouse, Rat, Horse
Immunogen
Full length protein (Human).
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Add glycerol to a final volume of 50% for extra stability and aliquot. Store at 20°C. Avoid freeze / thaw cycle.
Storage buffer
Preservative: None
Constituents: 1mg/ml BSA, PBS, pH 7.2
Purity
Protein A purified
Clonality
Monoclonal
Clone number
1.B.787
Isotype
IgG1
Applications
Our Abpromise guarantee covers the use of ab14463 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
IHC-P
Abreviews
Notes
Use at an assay dependent concentration. Perform enzymatic antigen retrieval
before commencing with IHC staining protocol.
Target
1
Function
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human
basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions.
The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Tissue specificity
High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of
septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium,
endometrium, ovaries, breast, prostate, bone marrow and colon.
Sequence similarities
Contains 1 C-type lectin domain.
Developmental stage
Levels of the proform increase in serum and placenta during pregnancy.
Post-translational
modifications
Nitrated.
Cellular localization
Cytoplasmic vesicle > secretory vesicle. The proform is secreted. The mature protein is found in
the matrix of the eosinophil's large specific granule and Secreted. The proform is secreted.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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Replacement or refund for products not performing as stated on the datasheet
Valid for 12 months from date of delivery
Response to your inquiry within 24 hours
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Terms and conditions
Guarantee only valid for products bought direct from Abcam or one of our authorized distributors
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