Product datasheet
Anti-LY75 antibody [PN-15] (Biotin) ab79458
1 References
Overview
Product name
Anti-LY75 antibody [PN-15] (Biotin)
Description
Mouse monoclonal [PN-15] to LY75 (Biotin)
Conjugation
Biotin
Specificity
ab79458 shows no significant cross-reactivity with other carbohydrate determinants, such as the
Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group
antigens.
Tested applications
WB, IHC-P
Species reactivity
Reacts with: Rat, Human
Immunogen
Microsomal fraction of human renal cortical tissue homogenate
Positive control
Normal kidney. Renal cell carcinoma tissue.
General notes
ab79458 may be a useful reagent in the investigations of carcinomas of proximal nephrogenic
differentiation especially those showing tubular differentiation.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze /
thaw cycle.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: 0.2% BSA, 10mM PBS, pH 7.4
Purity
Protein G purified
Primary antibody notes
ab79458 may be a useful reagent in the investigations of carcinomas of proximal nephrogenic
differentiation especially those showing tubular differentiation.
Clonality
Monoclonal
Clone number
PN-15
Isotype
IgG1
Light chain type
kappa
Applications
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Our Abpromise guarantee covers the use of ab79458 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
Abreviews
Notes
WB
Use at an assay dependent concentration. Predicted molecular weight: 198 kDa.
IHC-P
Use a concentration of 2 - 4 µg/ml.
Use for 30 min at RT. Staining of formalin-fixed tissues requires digestion with
Protease XXV at 1mg/ml PBS for 10 minutes at 37°C.
Target
Function
Acts as an endocytic receptor to direct captured antigens from the extracellular space to a
specialized antigen-processing compartment (By similarity). Causes reduced proliferation of Blymphocytes.
Tissue specificity
Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and
B lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma
cells called Hodgkin and Reed-Sternberg (HRS) cells.
Sequence similarities
Contains 10 C-type lectin domains.
Contains 1 fibronectin type-II domain.
Contains 1 ricin B-type lectin domain.
Post-translational
modifications
N-glycosylated.
Cellular localization
Membrane.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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