Product datasheet
Anti-HLA DM antibody ab113870
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Overview
Product name
Anti-HLA DM antibody
Description
Rabbit polyclonal to HLA DM
Tested applications
WB
Species reactivity
Reacts with: Human
Predicted to work with: Rat
Immunogen
Synthetic peptide corresponding to a region within N terminal amino acids 58-107
(GLSEAYDEDQ LFFFDFSQNT RVPRLPEFAD WAQEQGDAPA ILFDKEFCEW) of Human
HLA DM (NP_006111).
Run BLAST with
Positive control
Run BLAST with
MCF7 cell lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Constituents: 97% PBS, 2% Sucrose
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Applications
Our Abpromise guarantee covers the use of ab113870 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
WB
Abreviews
Notes
Use a concentration of 1 µg/ml. Predicted molecular weight: 29 kDa. Good
results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
Target
Relevance
Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation
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of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B
and HLA-C) and class II (HLA-D). This antibody can be used for HLA typing. HLA DM plays a
critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides
(CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for
acquisition of antigenic peptides.
Cellular localization
Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane;
Single-pass type I membrane protein. Note: Localizes to late endocytic compartment.
Associates with lysosome membranes.
Anti-HLA DM antibody images
Anti-HLA DM antibody (ab113870) at 1 µg/ml
+ MCF7 cell lysate at 10 µg
Predicted band size : 29 kDa
Western blot - HLA DM antibody (ab113870)
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Terms and conditions
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