Immunology, Infection & Cell Pathology AIMS & OBJECTIVES This IBSc programme focuses on in-depth understanding of the role of the immune system, infectious agents and cellular processes in the pathogenesis of diseases and of how this can be modified by treatment. We seek excellent students who wish to study the mechanisms of infectious and immunological diseases and engage with current issues faced in this area at the leading edge of medicine. We will encourage you to exploit and develop your analytical and critical abilities, to increase your scientific maturity and self-confidence, and help you build an intellectual framework for rapidly assimilating new subject areas and evaluating the claims made in contemporary medical research. The curriculum provides a broad and comprehensive foundation in three compulsory modules on “Immunology in Health and Disease”, “Infectious Agents” and “Cellular Pathology” in term one. These are followed by a choice of two from five optional modules that allow students to extend their study of immunology, infectious diseases and/or neoplastic diseases in term two. The teaching is based on contemporary research-led knowledge at the interface of basic and clinical science and is delivered by research-active experts in each field. Open discussion between lecturers and students is encouraged as a way of addressing important or unresolved scientific questions. The small group tutorials will run through terms one and two to discuss seminal discoveries and provide experience in critical appraisal of research literature. The taught components of this programme are complemented by a substantial laboratory research project based on the student’s interests, which spans four months of the course. This highly popular component has long been the lynchpin of this IBSc. It offers students an invaluable opportunity to experience original scientific research by becoming an integral part of leading UCL biomedical research groups. Frequently, this leads to original research publications, and provides an excellent platform for those with aspirations for careers in clinical academic research. PROGRAMME STRUCTURE Each taught module represents 0.5 course units and the laboratory project represents 1.5 course units. Therefore, students will complete 4 course units, comprising the laboratory project and five taught modules, summarised in the following matrix: Term 1 Compulsory modules INIM3002 Immunology in Health & Disease INIM3003 Infectious Agents INIM3004 Cellular Pathology Term 2 Optional modules (any two) INIM3005 Immunodeficiency & Therapeutics INIM3006 Allergy, Autoimmunity & Transplantation INIM3007 Viruses and Disease INIM3008 Microbial Pathogenesis INIM3009 Neoplasia & it's Treatment INIM3001 Laboratory Based Research Project (Term 1&2) COMPULSORY MODULES INIM3001: LABORATORY BASED RESEARCH PROJECT 1.5 unit Term 1 & 2 (November – April) Dr Richard Milne Assessment: written abstract, oral presentation and end of course oral examination (20%), project write-up (80%) This module aims to give you first-hand experience of original laboratory research under direct supervision of principal investigators at UCL. We assess the aspirations of each student individually to identify their preferences for potential types of project that are relevant to the broad scope of the iBSc. 1 Together with their supervisor, students will then formulate a specific project, design and undertake experiments, and interpret /communicate their work in oral presentations and a written report. This module provides invaluable teaching in scientific methodology, laboratory techniques, critical appraisal of original experimental data, and unique insight into the potential of new discoveries. The skills acquired here provide a competitive platform for students who may wish to pursue a future clinical academic career. INIM3002: IMMUNOLOGY IN HEALTH & DISEASE 0.5 unit Term 1, Block C Dr Brian de Souza Assessment: written essay (20%), unseen written exam (80%) Immunology in Health and Disease provides an overview of the human immune system. Starting at the molecular level (e.g. antigen recognition, antibody diversity), outlining what is known about cellular interactions within the immune system (e.g. cytokines and immunoregulation) and concluding with a consideration of the role of the immune system in host defence, its role in disease, and its possible role in determining ecology and evolution of the species. The module will cover the anatomy and constituents of the immune system and then consider the general principle of how an immune response is generated, beginning with the initial innate immune response to the development of acquired immunity. These concepts will be placed in context: how the immune system fights pathogens, how inappropriate responses can cause disease and how the immune system can be manipulated therapeutically. The module will develop from a basic to a more in depth understanding, with emphasis throughout placed on current developments in this fast moving field. The module includes a series of tutorials which provide students with an opportunity to present and discuss current research papers. INIM3003: INFECTIOUS AGENTS 0.5 unit Term 1, Block A Dr Richard Milne Assessment: journal presentation and reflective commentary (100%) The Infectious Agents module provides state-of-the-art coverage of a selection of current issues in the field of infection. No attempt is made to cover a comprehensive curriculum but, instead, students will learn the language and concepts of the field through specific research-led examples and active discussions. Themed teaching sessions given by experts comprise an introduction to the topic followed by discussion and critique of a recent paper. Papers will be provided in advance and students will be expected to come to sessions prepared to discuss the set paper critically. In some sessions students will be required to lead discussions. The focus throughout the module is on reading and discussing primary literature: full participation in class discussions is essential. The learning objective for this module is the acquisition of a detailed knowledge of the featured topics and a clear sense of the key current issues in the field. Students will also develop their critical analysis skills from reading and discussing the papers for each session. INIM3004: CELLULAR PATHOLOGY 0.5 unit Term 1, Block D Professor Benny Chain Assessment: written essay (20%), unseen written exam (80%) This module provides an overview of the research frontiers of cell biology and cell pathology research. The module is made up of a series of seminars (mostly 2 hours) by experts in selected topics of cell biology. Each lecture aims to provide: 2 1. A brief overview of the topic (but students are expected to be familiar with the basics of each topic as covered in a standard cell biology text book before the course). 2. Details on one or more areas of active research interest, including appropriate description of the experimental technology required 3. Discussion of how changes in the molecular processes in question are linked to disease. Given the scope of molecular cell biology, the module cannot be comprehensive. Nor is it feasible in a single seminar to exhaustively cover even a single topic (for example, the cell cycle). The objectives are to ensure all students have a sufficient basic knowledge of the major processes of the cell, to get a flavour of what are the outstanding questions driving research in the field at present, and how these could be tackled, and to begin to consider the intricate connection between cellular processes and disease. The topics covered have been chosen partly on their importance and partly to reflect the specific research strengths within UCL. The topics which will covered include: The actin cytoskeleton; Protein structure and folding; Cell cycle and cancer; Transcriptional regulation; Cell trafficking; Mitochondria; Signaling; The structure of the chromosome; Cell senescence; Proteolysis; Cell death. OPTIONAL MODULES (A CHOICE OF TWO FROM FIVE MODULES) INIM3005: IMMUNODEFICIENCY & THERAPEUTICS 0.5 unit Term 2, Block B Dr Mahdad Noursadeghi Assessment: written essay (20%), unseen written exam (80%) The immune system comprises components that are involved in recognition of invading pathogens and other noxious agents, microbial killing and tissue homeostasis/repair. Therefore, deficiencies of the immune system can be associated with increased susceptibility to infectious disease or a failure to control inflammation. The study of immunodeficiencies has in fact contributed extensively to our current understanding of normal structure and function in the immune system, and in turn has led innovative approaches to manipulate immune responses for therapeutic purposes. This module seeks to explore the broad repertoire of both genetic (primary immunodeficiency) and environmental (secondary immunodeficiency) causes of impaired immunity, together with the consequences for the patient of such deficiencies and the insights provided into our understanding of the normal immune system. The treatment options that are available for these will be discussed, as well as approaches to immunomodulation including research which aims to transform gene and cell therapies into clinical applications. In this module we aim to give you the framework and examples by which: 1. To understand the molecular basis and medical importance of selected humoral and cellular primary immunodeficiency syndromes. 2. To understand contemporary research approaches to investigate the molecular mechanisms that underlie primary immunodeficiencies, with specific examples from recent discoveries. 3. To understand the range of disorders associated with acquired immunodeficiency syndrome, focussing on ageing, pregnancy, nutritional deficiency, HIV infection and iatrogenic causes such as bone marrow transplantation or immunosuppressive medication. 4. To explore how the study of mechanisms for immunodeficiency provide new insights into normal immunology and opportunities to modulate immune responses for therapeutic applications. 5. To obtain an overview of therapies that target the immune system, including biological agents, T cell or DC therapies and advances in vaccination. INIM3006: ALLERGY, AUTOIMMUNITY & TRANSPLANTATION 0.5 unit Term 2, Block E Organiser: Dr Brian de Souza 3 Assessment: written essay (20%), unseen written exam (80%) This module focuses on disadvantageous immune responses: when the immune system causes disease by mounting undesired responses to allergens, self or transplanted tissues. We will explore the genetics and immune mechanisms underlying these responses and ask why substantial numbers of individuals react in a harmful way to normally ‘harmless’ environmental antigens such as pollens or food. We will consider autoimmunity: the breakdown in the immunological tolerance mechanisms that normally prevent pathogenic responses against our own body constituents. Organ-specific and systemic autoimmune conditions will be covered and the contribution of the various components of the immune system to the destructive process discussed. We will also explore the artificial situation of transplanting an organ or tissue from one individual to another. In addition to looking into the various immunological mechanisms involved in transplant rejection, we will investigate how transplant survival can be further improved and whether the current need for long term immunosuppression after transplantation can be overcome. The module includes a formative ‘Data Interpretation’ assessment based upon your analysis of a research paper. INIM3007: VIRUSES & DISEASE 0.5 unit Term 2, Block C Organiser: Dr Richard Milne Assessment: journal presentation (20%), unseen written exam (80%) What are viruses? How do they replicate? Where do they come from? How do they enter the human population? How do they cause disease? Why do they cause epidemics? Why are some viruses much more dangerous than others? How do we control and prevent infections? This module will address these questions by exploring the remarkable and intimate interaction between virus and host at many levels: molecular, cellular, host organism and population. We will discover how viruses have adapted to optimise survival and replication in the fundamentally hostile environment that their host provides and we will discuss the many effector mechanisms that hosts deploy to prevent viral infection or control it once established. The module is centred on the idea that an understanding of basic virology is essential for understanding viral disease. Drawing on a major strength in experimental and clinical virology at UCL, the module will provide an advanced understanding of the principles of virus replication and structure, insight into the virus-host interaction and a broad knowledge of individual virus infections, their treatment and prevention. INIM3008: MICROBIAL PATHOGENESIS 0.5 unit Term 2, Block A Organiser: Prof Tim McHugh Assessment: oral presentation (10%), library project (10%), unseen written exam (80%) This module focusses on bacterial, fungal and parasitic pathogens that cause human disease. We will consider the role of microbial virulence factors and the host-pathogen interactions that mediate disease and the way that knowledge of these can inform our clinical management strategies. By the end of the module, students will be able to: describe the major bacterial, fungal and parasitic pathogens; describe the molecular mechanisms by which these pathogens invade and cause disease; explain the molecular pathogenesis of examples of acute and chronic infectious diseases including tuberculosis, malaria, meningitis, gastrointestinal and respiratory infections; provide an overview of the techniques for molecular diagnosis of infection and the tools for molecular epidemiology of infection; describe the mechanisms of host immune evasion. INIM3009: NEOPLASIA & ITS TREATMENT 0.5 unit Term 2, Block D Organiser: Dr Clare Bennett Assessment: written essay (20%), unseen written exam (80%) 4 This module explores the processes and molecular mechanisms that underpin neoplastic transformation, tumour invasion and metastasis, with reference to specific haematological and solid tumours. The aim is for the student to build on an assumed core knowledge of cell and molecular biology to understand the natural history of neoplastic disease. There is considerable emphasis on the links between normal growth, development and responsiveness, and neoplastic growth. Site specific aspects of neoplasia (e.g. colon cancer, lung cancer and leukaemia) will be considered. In addition, all these topics will be linked to lectures that explore the mechanisms of current and novel treatment modalities including chemotherapy, biologicals, stem cell transplantation, immunotherapy and gene therapy. The module starts with an overview of current concepts of normal and abnormal growth, cancer stem cells, cell senescence and immortalisation, invasion and metastasis. We then examine cell transformation at a cellular and molecular level and look at DNA damage and repair mechanisms. The properties of the neoplastic cell are examined critically, looking at oncogenes, growth factors and their receptors and there will be a discussion about chromosome abnormalities in cancer. The link between viral infections and human tumours and the biology of oncogenic viruses and their relationship with the immune system will be explored. To put neoplastic disease in its societal context, epidemiological aspects will be covered in a separate session. There will be lectures on stem cells –an increasingly important topic, not only in our understanding of the basic science of neoplasia, but also with important therapeutic implications. Malignant tumours are the second most common form of illness leading to death in this country. Treatments include surgery, radiotherapy, hormones and various forms of cytotoxic chemotherapy. The second part of the module will look at the mechanisms which underlie some of these forms of treatment including the molecular basis of anti-cancer drugs and the use of radiation and its effects. We will cover the basic principles of tumour immunity and the potential of immune mechanisms in the prevention, limitation and evolution of tumours. Physical and chemical oncogenic agents or carcinogens have a more subtle relationship with the immune system, and this will be explored. Lastly, the possibility of manipulating immunogenic tumours to the benefit of the individual or of using immunological weapons to attack malignant tumours will be explored, giving an insight into cancer therapies of the future; and this leads into a discussion of the potential advantages and disadvantages of gene therapy for cancer. TITLES OF PAST LABORATORY BASED RESEARCH PROJECTS ‘Investigating the effects of salt on young and old monocytes’ (Prof Arne Akbar, 2015) 'Engineering T cell help in tumour immunity' (Prof Emma Morris, 2015) ‘What are the signalling mechanisms involved in mast cells of the eye in response to UV light?’ (Prof Virginia Calder, 2015) ‘Use of knock-in epitope tags to study endogenous APOBEC enzyme localisation and binding partners in a model of HPV-driven keratinocyte transformation’ (Dr Tim Fenton, 2015) ‘Expression and functional comparisons between double chain TCR, single chain TCR and Single Chain TCR with additional disulphide bond specific for CMV and EBV’ (Dr Shao-An Xue, 2015) ‘Optimisation of methods to determine the in-vitro oncolytic activity of measles virus’ (Dr Adele Fielding, 2015) ‘Mycobacterial shedding by macrophages’ (Dr Mahdad Noursadeghi, 2015) ‘Targeted genome editing in human primary T cells using CRISPR/Cas9 technology’ (Prof Hans Stauss, 2015) ‘Strain dependent variability in immune responses to BCG’ (Dr Mahdad Noursadeghi, 2015) 5 ‘CAR affinity maturation’ (Dr Martin Pule, 2015) ‘The influence of the PD-1/PD-L1 interaction on human CD4 T cell responses’ (Prof David Sansom, 2015) ‘Investigating human cytomegalovirus antivirals’ (Dr Matthew Reeves, 2015) ‘In vivo tracking of tonic haematopoietic reconstitution’ (Dr Ben Seddon, 2015) ‘The role of Heterochromatin Protein 1 in lytic Cytomegalovirus infection’ (Dr Matthew Reeves, 2015) ‘Evaluation of novel antiviral drugs which interfere with HIV-1-host cofactor interactions in T cells’ (Prof Greg Towers, 2015) ‘The Roll of Eosinophils and Type 2 Innate Lymphoid Cells in Type 1 Diabetes Pathology’ (Prof Lucy Walker, 2015) ‘Characterisation of haemolysis in Clostridium difficile’ (Dr Adam Roberts, 2015) ‘Validation of key genes regulating regression of the canine transmissible venereal tumour (CTVT)’ (Dr Ari Fassati, 2014) ‘Determination of the molecular basis of the TCR dominance’ (Dr Sharyn Thomas, 2014) ‘Migration of Th17 cells and Tregs in autoimmune inflammatory arthritis’ (Prof Michael Ehrenstein, 2014) ‘Investigation on the impact of short chain fatty acids on the function and development of T cells’ (Prof Arne Akbar, 2014) ‘Data analysis of measured serum antibody levels in patients with SLE and Anti-Phospholipid syndrome’ (Prof Anisur Rahman, 2014) ‘iNKT cell signalling in response to endogenous lipid antigens’ (Dr Liz Jury, 2014) ‘Interaction of EGFR inhibition with TH-302 in pancreatic cancer’ (Prof Daniel Hochhauser, 2014) ‘Qualitative and quantitative changes in T cell receptor usage following in vitro antigen stimulation’ (Dr Gabriele Pollara, 2014) ‘The effect of capsular serotype on the inflammatory response to Streptococcus pneumoniae’ (Prof Jeremy Brown, 2014) ‘Drug responses to persister populations of Mycobacterium Tuberculosis’ (Prof Tim McHugh, 2014) ‘Validation of RORC as a target for antiretroviral drug development’ (Dr Ari Fassati, 2014) ‘Investigating the outcome of the interaction between regulatory B cells and plasmacytoid dendritic cells in healthy and in patients with lupus’ (Prof Claudia Mauri, 2014) ‘Primate lentiviral accessory proteins antagonise host innate immune factors’ (Prof Greg Towers, 2014) ‘Effect of blocking p38-MAPK on NK cell effector function’ (Prof Arne Akbar, 2014) ‘The role of cyclophilin A and cyclosporin A in CMV infection’ (Dr Matthew Reeves, 2014) 6 ‘The effect of anti-EGFR antibodies on ROS production and chemotherapy effect’ (Prof Daniel Hochhauser, 2014) ‘Innate immunity in the response to measles virus-mediated oncolysis; dissecting the role of interferons’ (Dr Adele Fielding, 2014) ‘Sub-phenotyping in juvenile dermatomyositis: How does muscle biopsy pathotype correlate with clinical features?’ (Prof Lucy Wedderburn) ‘Generation of EBV-specific single chain TCR for cancer immunotherapy’ (Dr Shao-An Xue, 2014) ‘Complement Activation in IgA Nephropathy’ (Dr Daniel Gale, 2014) ‘The role of the ligand binding in CTLA-4 trafficking and stability’ (Prof David Sansom, 2014) ‘Establishing a Novel Antibody-Mediated Suicide Gene’ (Dr Martin Pule, 2014) ‘The antiviral role of NK cells in hepatitis B virus infection’ (Prof Mala Maini, 2014) ‘Investigating the Properties of TCXCR4 Cells with Reference to Hallmarks of Stemness, Memory, Proliferation and Anti-apoptosis’ (Prof Ronjon Chakraverty, 2014) ‘Priming Th-17 Cells to target tumours through modification of Dendritic Cell signalling’ (Prof Mary Collins, 2013) ‘Investigation of Mobile DNA elements encoding antibiotic resistance in Enterococcus.’ (Dr Adam Roberts, 2013) ‘The synergistic role of pneumolysin, capsule, and lipoproteins in the inflammatory response to Streptococcus pneumoniae' (Prof Jeremy Brown, 2013) ‘An investigation of elevated levels of Tumour Necrosis Factor alpha in patients with Juvenile Idiopathic Arthritis treated with Etanercept’ (Dr John Ioannou, 2013) ‘Pharmacologically tunable Chimeric Antigen Receptors for safer cancer gene therapy’ (Dr Martin Pule, 2013) ‘Regulation of CD80 and CD86 expression in human peripheral blood cells’ (Prof Lucy Walker, 2013) ‘Evaluation of antigen expression by lymphoid stromal subsets’ (Prof Ronjon Chakraverty, 2013) ‘Examining the involvement of the senescence and exhaustion pathways during human ageing’ (Dr Sian Henson, 2013) ‘Varying CD28 costimulation and its impact on T cell metabolic fitness’ (Prof David Sansom, 2013) ‘Comparing the effects of Fetal Calf Serum and Human Serum on the infection of macrophages by HIV’ (Dr Ravi Gupta, 2013) ‘Varying CD28 costimulation and its impact on T cell metabolic fitness’ (Prof David Sansom, 2013) ‘Comparing the effects of Fetal Calf Serum and Human Serum on the infection of macrophages by HIV’ (Dr Ravi Gupta, 2013) ‘Investigating LRBA deficiency in a human myeloid cell line’ (Dr Siobhan Burns, 2013) 7 A SELECTION OF PUBLICATIONS (IBSC STUDENTS IN BOLD) THAT HAVE BEEN ACHIEVED AS A RESULT OF THE IBSC PROGRAMME The Third Signal Cytokine IL-12 Rescues the Anti-Viral Function of Exhausted HBV-Specific CD8 T Cells. Schurich A, Pallett LJ, Lubowiecki M, Singh HD, Gill US, et al. PLoS Pathog (2013) Normalising glycosphingolipid turnover restores function in T cells from patients with SLE G McDonald, S Deepak, L Miguel, C Hall, DA Isenberg, AI Magee, T Butters, EC Jury. Journal of Clinical Investigation (2013) Human MHC class-I restricted high avidity CD4+ T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo. Xue SA, Gao L, Ahmadi M, ghorashian S, Barros RD, Pospori C, Holler A, Wright G, Thomas S, Topp M, Morris EC, Stauss HJ. Oncoimmunology (2013) SLE patients with atherosclerosis are characterised by a distinct invariant Natural Killer T cell phenotype and altered CD1d-mediated lipid antigen presentation. Edward Smith, Sara Croca, Andrew Pitcher, David A Isenberg, Anisur Rahman, Elizabeth C Jury. ARTHRITIS AND RHEUMATISM (2013) Characterization of CD161+ and CD161- regulatory T cells in health and disease (poster) C.L. Duurland, R.F. O’Shaughnessy, G. Chain L.R. Wedderburn Paediatirc Rheumatology European Society, Slovenia (Sept 2013) Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization. McCoy LE, Quigley AF, Strokappe NM, Bulmer-Thomas B, Seaman MS, Mortier D, Rutten L, Chander N, Edwards CJ, Ketteler R, Davis D,Verrips T, Weiss RA.J Exp Med (2012) Tn916-like elements from human, oral, commensal streptococci possess a variety of antibiotic and antiseptic resistance genes. Ciric L, Ellatif M, Sharma P, Patel R, Song X, Mullany P, Roberts AP Int J Antimicrob Agents (2012) Primary Human CD4(+) T Cells Have Diverse Levels of Membrane Lipid Order That Correlate with Their Function. Miguel, L., Owen, D. M., Lim, C., Liebig, C., Evans, J., Magee, A. I., Jury, E. C. J IMMUNOL OGY (2011) PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8(+) T cells Karwacz K, Bricogne C, Macdonald D, Arce F, Bennett CL, Collins MK, Escors D. (2011) EMBO Molecular Medicine (2011) Nitrated nucleosome levels in patients with systemic lupus erythematosus – associations with ethnicity and autoantibody status. Croca S, Pericleous C, Alber K, Yong H, Giles I, Rahman A and Ioannou Y American College of Rheumatology meeting (November 2011) Gyrase B Inhibitor Impairs HIV-1 Replication by Targeting Hsp90 and the Capsid Protein Luciano Vozzolo, Belinda Loh, Paul J. Gane, Maryame Tribak, Lihong Zhou, Ian Anderson, Elisabeth Nyakatura, Richard G. Jenner, David Selwood, and Ariberto Fassati. The Journal of Biological Chemistry (2010) Disease activity and levels of anti-apoA1, anti-HDL and anti-oxLDL in patients with SLE 8 Goulden BS, Turner-Stokes TJ, Pericleous C, Lambrianides A, Bell K, Ioannou Y, Latchman D, Isenberg D, Giles I, Rahman A. British Society of Rheumatology meeting (April 2010) Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation Kevin N. Couper, Tom Barnes, Julius C. R. Hafalla, Valery Combes, Bernhard Ryffel, Thomas Secher, Georges E. Grau, Eleanor M. Riley, J. Brian de Souza. PLoS Pathogens (2010) High expression of the ectonucleotidase CD39 on T cells from the inflamed site identifies two distinct populations, one regulatory and one memory T cell population Moncrieffe, H. Nistala, K., Kamhieh, Y., Eddaoudi, A. and Wedderburn L. R. Journal of Immunology (2010) Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus Elizabeth C. Jury, Fabian Flores-Borja, Hardeep S. Kalsi, Mark Lazarus, David A. Isenberg, Claudia Mauri and Michael R. Ehrenstein. European Journal of Immunology (2010) Blockade of Immunosuppressive Cytokines Restores NK Cell Antiviral Function in Chronic Hepatitis B Virus Infection Dimitra Peppa, Lorenzo Micco, Alia Javaid, Patrick T. F. Kennedy, Anna Schurich, Claire Dunn, Celeste Pallant, Gidon Ellis, Pooja Khanna, Geoffrey Dusheiko, Richard J. Gilson, Mala K. Maini. PLoS Pathogens (2010) Thrombin Binding Predicts the Effects of Sequence Changes in a Human Monoclonal Antiphospholipid Antibody on Its In Vivo Biologic Actions Ian Giles, Charis Pericleous, Xiaowei Liu, Jasmine Ehsanullah, Lindsey Clarke,Paul Brogan, Marvin Newton-West, Robert Swerlick, Anastasia Lambrianides, Pojen Chen, David Latchman, David Isenberg, Silvia Pierangeli and Anisur Rahman. The Journal of Immunology (2009) Expression of vFLIP in a Lentiviral Vaccine Vector Activates NF- B, Matures Dendritic Cells, and Increases CD8_ T-Cell Responses Helen M. Rowe, Luciene Lopes, Najmeeyah Brown, Sofia Efklidou, Timothy Smallie, Sarah Karrar, Paul M. Kaye, and Mary K. Collins Journal of Virology (2009) Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study Jessica J Manson, Alexander Ma, Pauline Rogers, Lesley J Mason, Jo H Berden, Johan van der Vlag, David P D'Cruz, David A Isenberg and Anisur Rahman. Arthritis Research & Therapy (2009) Insertional Gene Activation by Lentiviral and Gammaretroviral Vectors Marieke Bokhoven, Sam L. Stephen, Sean Knight, Evelien F. Gevers, Iain C. Robinson, Yasuhiro Takeuchi, and Mary K. Collins. Journal of Virology (2009) Temporal analysis of early immune responses in patients with acute hepatitis B virus infectionDunn C, Peppa D, Khanna P, Nebbia G, Jones M, Brendish N, Lascar RM, Brown D, Gilson RJ, Tedder RJ, Dusheiko GM, Jacobs M, Klenerman P, Maini MK. Gastroenterology (2009) Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection Abhishek Das, Matthew Hoare, Nathan Davies, A. Ross Lopes, Claire Dunn, Patrick T.F. Kennedy Graeme Alexander, Helene Finney, Alistair Lawson, Fiona J. Plunkett, Antonio Bertoletti, Arne N. Akbar and Mala K. Maini. The Journal of Experimental Medicine (2008) Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell–mediated liver damage Claire Dunn, Maurizia Brunetto, Gary Reynolds, Theodoros Christophides, Patrick T. Kennedy, Pietro Lampertico, Abhishek Das, A. Ross Lopes, Persephone Borrow, Kevin Williams, Elizabeth Humphreys, Simon Aff ord, David H. Adams, Antonio Bertoletti, and Mala K. Maini. The Journal of Experimental Medicine (2007) 9 Arginine Residues Are Important in Determining the Binding of Human Monoclonal Antiphospholipid Antibodies to Clinically Relevant Antigens Ian Giles, Nancy Lambrianides, Nisha Pattni, David Faulkes, David Latchman, Pojen Chen, Silvia Pierangeli, David Isenberg, and Anisur Rahman. The Journal of Immunology (2006) Retroviral Restriction Factors Fv1 and TRIM5_ Act Independently and Can Compete for Incoming Virus before Reverse Transcription Luca D. Passerini, Zuzana Keckesova, and Greg J. Towers. Journal of Virology (2006) Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNF Therapy Michael R. Ehrenstein, Jamie G. Evans, Animesh Singh, Samantha Moore, Gary Warnes, David A. Isenberg and Claudia Mauri. The Journal of Experimental Medicine (2004) Increased Ubiquitination and Reduced Expression of LCK inT Lymphocytes From Patients With Systemic Lupus Erythematosus Elizabeth C. Jury, Panagiotis S. Kabouridis, Amina Abba, Rizgar A. Mageed, and David A. Isenberg Arthritis & Rheumatism (2003) KSHV vFLIP binds to IKK-g to activate IKK Nigel Field, Walter Low, Mark Daniels, Steven Howell, Laurent Daviet, Chris Boshoff and Mary Collins Journal of Cell Science (2003) FURTHER INFORMATION The Integrated BSc in Immunology, Infection and Cell Pathology is run by the Division of Infection and Immunity based at the UCL Cruciform Building, Gower Street. For more information regarding this programme please contact: Ms Biljana Nikolic (Programme Administrator) Email: b.nikolic@ucl.ac.uk Tel: 020 3108 2122 (internal: 52122) Dr Richard Milne (Programme Tutor) Email: r.milne@ucl.ac.uk Tel: 020 7794 0500 (ext: 34203) Further information is available on the division’s website: http://www.ucl.ac.uk/infection-immunity/study/ 10