Mapping the global mental health research funding system Alexandra Pollitt, Gavin Cochrane, Anne Kirtley, Joachim Krapels, Vincent Larivière, Catherine Lichten, Sarah Parks, Steven Wooding For more information on this publication, visit www.rand.org/t/RR1271 For more information on Project Ecosystem: Mapping the global mental health research funding system, visit www.randeurope.org/mental-health-ecosystem Published by the RAND Corporation, Santa Monica, Calif., and Cambridge, UK © Copyright 2016 RAND Corporation R is a registered trademark. ® RAND Europe is a not-for-profit research organisation that helps improve policy and decisionmaking through research and analysis. RAND’s publications do not necessarily reflect the opinions of its research clients and sponsors. Limited Print and Electronic Distribution Rights This document and trademark(s) contained herein are protected by law. This representation of RAND intellectual property is provided for noncommercial use only. Unauthorized posting of this publication online is prohibited. Permission is given to duplicate this document for personal use only, as long as it is unaltered and complete. Permission is required from RAND to reproduce, or reuse in another form, any of its research documents for commercial use. For information on reprint and linking permissions, please visit www.rand.org/pubs/permissions.html. Support RAND Make a tax-deductible charitable contribution at www.rand.org/giving/contribute www.rand.org www.randeurope.org Preface This study maps the global funding of mental health research between 2009 and 2014. It builds from the bottom up a picture of who the major funders are, what kinds of research they support and how their strategies relate to one another. It also looks to the future, considering some of the areas of focus, challenges and opportunities which may shape the field in the coming few years. We hope that developing a shared understanding of these facets will aid coordination and planning and assist research funders in targeting their scarce resources effectively. This report and the accompanying documents produced as part of the study are available at www.randeurope.org/mental-health-ecosystem. Acknowledgements: We are grateful to the International Alliance of Mental Health Research Funders and in particular the members of the Alliance who kindly supported the study: the Graham Boeckh Foundation, Alberta Innovates – Health Solutions, the Canadian Institutes of Health Research, the UK National Institute for Health Research, the Wellcome Trust, MQ: Transforming Mental Health, and the Movember Foundation. The bibliometric data for the study was provided by the Observatoire des sciences et des tech- nologies (OST). Eddy Nason contributed to the Canadian fieldwork and the team at berResearch contributed useful discussion and suggestions. We would like to thank those who commented on earlier drafts of this report (Ian Boeckh and Danielle Kemmer at the Graham Boeckh Foundation, Cynthia Joyce at MQ and Jonathan Grant at King’s College London). We very much appreciated the helpful and timely comments of our quality assurance reviewers (Salil Gunashekar and Saba Hinrichs). The report was copy-edited by Mark Hughes and designed by Jessica Plumridge and Paul Barrett Book Production. Finally, we are very grateful to all of the organisations who agreed to participate in our deep dive reviews and the researchers who completed surveys as part of the study. For more information about RAND Europe or this document, please contact: Alexandra Pollitt RAND Europe Westbrook Centre Milton Road Cambridge CB4 1YG United Kingdom Tel. +44 (1223) 353 329 apollitt@rand.org Table of Contents Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . iii Table of Contents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Figures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vi Tables . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . viii Headline findings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix Chapter 1 Introduction and background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.1. Previous studies aiming to map research funding . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.2. Our approach, its strengths and its limitations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.3. Structure of this report .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2 2 4 Chapter 2 Mapping the mental health research funding landscape . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.1. 2.2. 2.3. 2.4. 2.5. 2.6. How big is the field of mental health research? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . How many mental health research funders are there? .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Who are they? .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Where are they? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . What are they funding? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . How do funders relate to one another? .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 7 8 10 14 18 21 Chapter 3 What does the future hold? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 3.1. Deep dive profiles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 3.2. Views on the future . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 Chapter 4 What next? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 Annex 1 – Canada . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 Annex 2 – The UK .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 Annex 3 – Funder acronyms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 Figures Study aims and data sources .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Cleaning process of funders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Funders with ten or more acknowledgements .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Number of funders (and respective acknowledgements) by funder type . . . . . . . . . . . . . . . . . . . . Distribution of funders in the government and charity/foundation/non-profit sectors, by numbers of papers on which they are acknowledged . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Average of relative citations by funder sector . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . N umber of government, charity, foundation and non-profit mental health research funders by country . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 2-7 Government funders by country . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 2-8 Charity, foundation and non-profit funders by country . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 2-9 Average relative citations by country of funder . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 2-10 Acknowledgements per funder country by R&D expenditure: (i) all countries. (ii) excluding the United States .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 2-11 Papers in complete data set with ‘Mental Disorder’ MeSH terms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 2-12 Coxcomb plot of papers with acknowledgement data and Mental Disorder MeSH terms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 2-13 Funding acknowledgements by sector for each group of MeSH terms . . . . . . . . . . . . . . . . . . . . . . Figure 2-14 Research level of papers by year . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 2-15 Research level of papers by funder sector . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 2-16 Network of co-acknowledged funders in the entire mental health data set . . . . . . . . . . . . . . . . Figure 2-17 Network of co-acknowledged funders – neurodegenerative and cognition disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 2-18 Network of co-acknowledged funders – depressive, anxiety and personality disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 2-19 Network of co-acknowledged funders – substance use and addictive disorders . . . . . . . . . Figure 2-20 Network of co-acknowledged funders – neurodevelopmental disorders . . . . . . . . . . . . . . . . . . . . Figure 2-21 Network of co-acknowledged funders – schizophrenia, bipolar and other psychotic disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 2-22 Network of co-acknowledged funders – “Adolescent”, “Child”, “infant” and “young adult” categories in MeSH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 2-23 Network of co-acknowledged funders – “Aged” and “middle aged” categories in MeSH .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure A1-1 Breakdown of number of Canadian funders and funding acknowledgements by funder sector . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure A1-2 Average relative citations by funder sector - Canada . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure A1-3 Network of co-acknowledgement of all Canadian funders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure A1-4 Network of co-acknowledged funders on Canadian papers in the entire mental health data set . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure A1-5 Flows of research funding: (i) Canadian funders supporting papers with corresponding authors outside Canada and (ii) papers with Canadian corresponding authors acknowledging non-Canadian funding .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure 1-1 Figure 2-1 Figure 2-2 Figure 2-3 Figure 2-4 Figure 2-5 Figure 2-6 3 8 9 10 12 13 15 15 16 16 17 18 19 19 20 21 24 26 27 28 29 30 31 32 45 46 48 49 50 Figure A2-1 Breakdown of number of UK funders and funding acknowledgement by funder sector . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure A2-2 Average relative citations by funder sector - UK . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure A2-3 Network of co-acknowledgement of all UK funders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure A2-4 Network of co-acknowledged funders on UK papers in the entire mental health data set . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Figure A2-5 Flows of research funding: (i) UK funders supporting papers with corresponding authors outside the UK and (ii) papers with UK corresponding authors acknowledging non-UK funding . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 52 54 55 56 Tables Table 2-1 Table 2-2 Table 3-1 Table A1-1 Table A2-1 Top 30 most frequently acknowledged funders globally .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . T op ten most frequently acknowledged funding countries for each group of MeSH terms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Funders included in deep dive profiles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Top 30 funders in Canada . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Top 30 funders in the UK .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 21 34 46 52 Headline findings 1. The field of mental health research is large (and growing) and diverse – over 220,000 papers were published between 2009 and 2014, supported by over 1,900 funders. 2. Many of the funders identified using our approach would have been unlikely to appear in a top-down analysis of ‘traditional’ mental health research funders: we identified small or relatively new charities and foundations, as well as larger funders whose primary remit does not concern mental health. 3. The US dominates the mental health research field, being both the largest producer of research (36 per cent of publications) and accounting for 31 per cent of government and charity/foundation/non-profit funding organisations. 4. Charities, foundations and non-profits form the most numerous group of mental health research funders (39 per cent of the funders identified), but governments fund the most papers, accounting for over two-thirds of the papers with funding acknowledgements. 5. In the mental health field, papers acknowledging the support of charities, foundations and non-profits tend to have a higher citation impact than those acknowledging other sectors. 6. The highest concentrations of mental health research funders are located in North America, northern and western Europe and China. China is dominated by government funding agencies, while some European countries, in particular Finland and Sweden, have relatively higher numbers of charities and foundations. 7. The mental health papers which focus on a clinical condition cluster into eight groups, with the most common conditions being neurodegenerative and cognition disorders; depressive, anxiety and personality disorders; and substance use and addictive disorders. 8. Funder co-acknowledgement on papers tends to produce national rather than topic-specific clusters, suggesting that despite increasing international collaboration, national boundaries still remain important in mental health research funding. 9. The majority of mental health research funders we looked at in depth do not have an explicit definition for mental health. 10.Funders of mental health research anticipate future or continuing challenges relating to the diversity of the field, difficulty in maintaining funding levels, and the translation of research into practice. 11.Opportunities identified by mental health research funders include increasing collaboration, developing shared definitions, capitalising on government priorities, developing a key role for non-governmental funders and the advance of technology. Chapter 1 Introduction and background Mental illness has a substantial impact on individuals, healthcare systems and society. Recent estimates suggest that mental and substance use disorders comprise 7.4 per cent of the global burden of disease and represent the leading global cause of all non-fatal burden (Whiteford et al., 2013). This burden is increasing, primarily due to demographic change, which is also driving a dramatic increase in neurodegenerative conditions such as dementias and Parkinson’s disease (Murray et al., 2012). When considering in isolation years lived with disability (YLD), mental health and substance abuse disorders represent 21.2 per cent of the global total, with major depression being the leading cause of YLDs in 56 countries (Vos et al., 2015). Aside from the impact of mental illness on individuals, it has been estimated that between 2011 and 2030, mental disorders could cost the global economy US$16 trillion in lost output (Bloom et al. 2011). between 2011 and 2030, mental disorders could cost the global economy US$16 trillion in lost output For many mental health conditions we have a poor understanding of the underlying mechanisms and there remains a lack of effective treatments (Insel & Gogtay 2014). Research is needed to address these challenges. The field of mental health research is broad and fragmented (e.g. Haro et al. 2013; Rutter 2002). It covers a diversity of health conditions, employs a wide array of differ- ent research approaches and is driven by a large and varied population of researchers and funding organisations (as we demonstrate in this report). In a context where important, complex questions remain unaddressed and resources are limited, these characteristics present a significant challenge for efficiently coordinating and conducting research. While a number of national or subfield-specific research mapping exercises have taken place in the past, there has not yet been, to the best of our knowledge, a comprehensive review of the entire mental health research funding ‘ecosystem’ on a global scale. At a time when research is becoming increasingly collaborative and international (e.g. Gazni et al. 2012; Waltman et al. 2011), such an overview will allow funders to better understand the context in which they operate and the complementarity of their portfolios, and will enable researchers to identify opportunities in both their own fields and related areas. This study aims to provide a snapshot of the mental health research funding ecosystem, building from the bottom up a picture of who the major funders are, what kinds of research they support and how their strategies relate to one another. We did this using the funding acknowledgements on journal papers as a starting point and looked at the global landscape, as well as specifically at Canada and the UK (which were of particular interest to the study’s sponsors and are detailed in Annex 1 and Annex 2, respectively). It is interesting to note that although ‘funders’ is a commonly used term, there is considerable diversity in mission and activities. Some funders primarily, or exclusively, award research grants whilst other funders also control institutes and centres; some have a single source of funds and others both raise and dispense money. We have taken a wide definition of funders – basing it on those organisations that appear in the funding acknowledgements 2 Mapping the global mental health research funding system of journal articles – and the sample of funders we have examined in detail reflect that diversity. Alongside our mapping of the global landscape of funders our study also includes a forwardlooking component, highlighting for the major funders globally the areas in which they intend to focus their efforts in the coming years, as well as the opportunities and challenges they expect to shape the field. We hope that by setting out the current landscape and considering the future evolution of the field, those working in mental health research will have a more complete picture of the scale and nature of efforts to address the many unanswered questions which remain. Developing a shared understanding of these facets will aid coordination and planning and assist research funders in targeting their scarce resources effectively. 1.1 Previous studies aiming to map research funding While we believe this study to be the first to examine the global funding landscape for the entire mental health field, previous studies have looked at specific research areas and countries, in mental health as well as in other areas of health and biomedical research. Several of these studies use a ‘top-down’ approach, tracking the activities of key funders in the area of interest (CIHR 2014, Daniels 2012, MBCA 2014, Morgan Jones & Grant 2011, MQ 2015, Singh et al. 2009). Others apply a ‘bottom-up’ approach similar to that used in the present study, where funding acknowledgements from relevant papers are used to identify which funders are active in an area of interest and to characterise aspects of their support (Dawson 1998, Garau et al. 2011, NHS Executive 2001, Shah et al. 2014). These bottom-up studies have focused on mapping National Health Service research in England (NHS Executive 2001), exploring interactions among UK biomedical research funders (Garau et al. 2011 and Shah et al. 2014), and assessing national trends in biomedical research funding in the UK (Dawson 1998). Of particular relevance for mental health research, UK charity MQ carried out an analysis of the research funding landscape for mental health in the UK over the period 2008-2013 (MQ 2015). It focused on the research portfolios of 11 UK funding bodies. Other studies have focused on autism research funding in the United States (Singh et al. 2009, Daniels 2012) and global funding for metastatic breast cancer (Metastatic Breast Cancer Alliance 2014). A framework for categorising Alzheimer’s Disease research has been established, enabling global tracking of funding through the International Alzheimer’s Disease Research Portfolio (IADRP) initiative (Liggins et al. 2014). 1.2 Our approach, its strengths and its limitations Our approach builds on previous studies, taking advantage of increasing data availability and adopting a global perspective in mapping mental health research funding. Four key questions are central to achieving this: • Who are the major mental health research funders? • What do they fund? • How do they relate to one another? • What opportunities and challenges might the future hold? This study aimed to answer these questions using primarily a bottom-up approach, in that we took individual journal papers – the outputs of the research process – as a starting point for defining the mental health field, identifying funders and constructing a data set for the subsequent analyses. However, as the systematic use of this kind of approach in examining the funders of research still remains relatively unexplored, we complement it with data from a number of other sources to validate assumptions and emerging findings. These data sources and how they relate to the study’s key questions are shown in Figure 1-1. Our primary data source was the funding acknowledgements made by researchers on papers published between 2009 and 2014. A survey of researchers was used to explore acknowledgement behaviour and validate the list of funders obtained from the acknowledgement analysis. A telephone survey of the major funders identified in Canada, the UK and globally provided qualitative data on the level and nature of funding, current priorities and collaboration activities. Finally, a set of 32 ‘deep dive’ profiles of funders was compiled, looking in depth at their current practices and future plans. Further detail on the methods for each of these data sources is provided in Appendix A. Introduction and background 3 Figure 1-1 Study aims and data sources (dark shading indicates primary data source; light shading indicates supporting data source) Data source Funding acknowledgements Identifying major funders Researcher survey Funder survey Other bibliometric data1 Funder deep dives Examining what they fund Exploring how they relate to one another Considering future plans Why use bibliometric data? A number of prior studies have explored the research funding landscape using a top-down approach (as mentioned previously), identifying funders and then mapping the areas in which they operate. While this approach allows for reliable and detailed analysis of major funders, it also requires us to know who these funders are from the outset. In this study we chose a bottom-up approach, generating a list of research funders from bibliometric data, in the expectation that this would result in a more complete list of organisations supporting research in the mental health field and allowing the relationships between them and the profile of their funded research to emerge from the data. Using bibliometric data as the initial basis for our analysis was made possible by the increasing availability of systematic information on the funding of papers indexed in the publications database Web of Science. This data on funding is compiled from the acknowledgements made by researchers on journal papers. Scientific publications have long included acknowledgements, whether to express gratitude for funding, expert advice, technical help or other support provided by individuals or organisations. More recently this practice has become more formal with an increasing number of research funders requiring support to be acknowledged in publications. In the past this information has not been analysable at an aggregate level, but in 2008 Thomson Reuters began systematically extracting acknowledgements of research funding, making this data available in a specific field in the Web of Science. This database field allows us to approximate the number of papers attributed to support from different research funders and thus sheds light on the global funding landscape of mental health research. Using bibliometric funding acknowledgements as the initial data source for the study has several important advantages: • It allows us to draw on a single data source for the vast majority of our data, helping ensure consistency. • The Web of Science consistently covers the most visible and important journals across fields, affording a comprehensive overview of the entire mental health research field during our time period. • Unlike in top-down approaches, we can identify funders who, despite having no explicit mission or intention to support mental health research, are nonetheless contributing to the research landscape. • We can identify industry funders, a sector often not included in previous analyses. • Crucially, the funding acknowledgements in the database are linked to a range of other key variables, including topic, country, co-authors and number of citations at the level of individual papers. 1 Other bibliometric data includes information extracted from papers relating to topic, countries of authors, co-authors and number of citations. 4 Mapping the global mental health research funding system While our approach has many advantages, we also recognise that funding acknowledgement data is a relatively new tool for addressing the kinds of questions that form the basis of this study and that our understanding of strengths and flaws in the data is still evolving (e.g. Costas & van Leeuwen 2012). As a result, there remain uncertainties about the extent to which it can provide a reliable basis for this kind of exploration. Therefore, we have taken an inquisitive and sceptical approach towards the data. The study’s methods were selected to address these uncertainties and ensure the validity, accuracy and utility of our findings. The areas of concern (some of which we identified at the outset of the project and others which became apparent throughout), along with the actions taken to address them, are set out in the text box on the right. 1.3 Structure of this report Three components make up the outputs of this study: this report, which provides a broad overview of the global research funding ecosystem; a set of 32 ‘deep dive’ profiles of research funders in Canada, the UK and globally; and a set of six cards looking at particular cross-cutting themes which emerged from the funder profiles (all available at www.randeurope.org/mental-health-ecosystem). The remainder of this report consists of a mapping of the overall mental health research funding ecosystem in Chapter 2 and a summary of funders’ future plans emerging from the deep dives in Chapter 3, before concluding in Chapter 4 with a discussion of how this analysis might be built upon and developed in the coming years. The two annexes provide separate analyses for Canada and the UK, while the supporting appendices detail the methods, definitions of indicators and other additional data. How robust is the data set? What comprises ‘mental health’? Have we selected the right papers? As part of the study we conducted a telephone survey of the most frequently acknowledged funders globally (and separately for Canada and the UK). This revealed that there is no common definition of mental health in use by funders. In the absence of a universally agreed definition, we based our definition on that used in a previous study examining global mental health research outputs, based on journal and paper-level topic classification (see Appendix A and Larivière et al. 2013). The one difference made for the present study was to include substance-related disorders, which it was felt by the study’s advisory committee were an important element of the mental health field. A challenge for studies identifying research that is specific to a particular condition is how to deal with basic research that may, or may not, end up supporting developments in multiple clinical fields – for example, basic neuroscience research could support developments in stroke or neurological conditions as well as in mental health. The aim of this study was to identify research that is clinically relevant to mental health and for that reason we used clinical terms to define the scope of the data set. This means that while we still capture basic research which has been identified as clinically relevant when published (through MeSH terms or publication in a journal classified in psychiatry), we miss other basic research whose clinical relevance was not clear at the time of publication. Are there funders missing from the bibliometric data? To validate the list of research funders obtained from the funding acknowledgement data, we carried out a small-scale survey of researchers selected at random from our paper set (55 responses; for details see Appendix A). None of the survey participants reported receiving funding from organisations which were not already included in our data, and so while we cannot be certain that it includes every single funder, we believe the list to be fairly comprehensive. Introduction and background Are funding acknowledgements found consistently on all papers? As Thomson Reuters only began systematically recording funding acknowledgements part way through 2008, we do not include papers published before 2009 in our analysis. Just under half of the papers in our data set contained funding acknowledgements and, as might be expected for a newly introduced data field, this proportion has increased year on year. We have no reason to believe that the absence of funding acknowledgements on some papers would systematically bias our analysis. Figure A1-1 in Appendix A shows the number of papers with and without funding acknowledgements for each year. Our data set also revealed that the number of acknowledgements per paper has increased over time (see Appendix A). However, a corresponding increase can be seen in the number of authors per paper over this period, with the result that the number of acknowledgements per author has remained constant. This seems a logical observation, given that additional collaborators may bring with them additional funding to a research team. Do researchers acknowledge funding in the way we would expect? A second small-scale survey of researchers carried out as part of this study explored the acknowledgement behaviour of researchers. This revealed that researchers tend to think about their funding as separate pots of money to support specific pieces of research, either exclusively or alongside a more general pool of funding (for example, a longer term fellowship award). In contrast, very few researchers reported pooling their funding and acknowledging all of their funding sources on all publications. This means that at the aggregate level, the funding acknowledgements reported on papers should broadly reflect the overall distribution of research funding. The survey did, however, reveal that we may not fully capture, for example, infrastructure contributions supporting research, as few researchers reported acknowledging facilities and equipment provided by their institution (see Appendix A for further details). For this reason, we remain cautious in drawing 5 conclusions about academic institutions identified as funders in our analysis. Are mentions of industry funders in the funding acknowledgement field qualitatively the same as for other funders? As the funding acknowledgement field in Web of Science is populated by extracting funder names from the acknowledgement sections of papers, we were concerned that mentions of organisations in the pharmaceutical sector may not always reflect funding, but instead relate to declarations of potential conflicts of interest by the authors. To explore this issue further we manually examined a sample of 80 papers with industry funding acknowledgements. This revealed that, in general, papers mentioning more than two industry funders tended to relate to conflict of interest declarations. To account for this in the subsequent analyses, acknowledgements were excluded where the paper had more than two industry funders listed. This led to the removal of 962 papers from our core analysis (as these papers were left with no acknowledgements). Do we capture different variants of the same funder’s name? While some funders ask researchers to acknowledge their support in a standard form, for others there are many variants that exist in the funding acknowledgement field in Web of Science (for example, due to the use of acronyms, inclusion of the funder’s country in the name or simply spelling mistakes). To minimise the effect of this, all variants which were found in ten or more papers were manually examined and attributed to the correct organisation. Manual searches were also carried out across the whole data set to identify additional variants of the funders occurring most frequently. This means that while there is a long ‘tail’ of funder names, some of which may be variants of those in our core analysis set, none of these are acknowledged on more than nine papers and so their exclusion from the totals should not have a major impact on the analysis. Chapter 2 Mapping the mental health research funding landscape Key points 1.The field of mental health research is large (and growing) and diverse – over 220,000 papers were published between 2009 and 2014, supported by over 1,900 funders. 5. In the mental health field, papers acknowledging the support of charities, foundations and nonprofits tend to have a higher citation impact than those acknowledging other sectors. 2. Many of the funders identified using our approach would have been unlikely to appear in a top-down analysis of ‘traditional’ mental health research funders: we identified small or relatively new charities and foundations, as well as larger funders whose primary remit does not concern mental health. 6.The highest concentrations of mental health research funders are located in North America, northern and western Europe and China. China is dominated by government funding agencies, while some European countries, in particular Finland and Sweden, have relatively higher numbers of charities and foundations. 3. The United States dominates the mental health research field, being both the largest producer of research (36 per cent of publications) and accounting for 31 per cent of government and charity/ foundation/non-profit funding organisations. 7. The mental health papers which focus on a clinical condition cluster into eight groups, with the most common conditions being neurodegenerative and cognition disorders; depressive, anxiety and personality disorders; and substance use and addictive disorders. 4.Charities, foundations and non-profits form the most numerous group of mental health research funders (39 per cent of the funders identified), but governments fund the most papers, accounting for over two-thirds of the papers with funding acknowledgements. 2.1 How big is the field of mental health research? In identifying the major funders of mental health research globally we first need to define the field we are considering. In this study we did this on the basis of journal publications, representing the knowledge output of funded research. While this does not allow us to assign a monetary value to the volume of research funded in the mental health field (something discussed further in Chapter 4), it does provide a picture of the volume of knowledge produced, the subfields in which research is taking place and the various actors involved in the mental 8.Funder co-acknowledgement on papers tends to produce national rather than topic-specific clusters, suggesting that despite increasing international collaboration, national boundaries still remain important in mental health research funding. health research funding ecosystem. As in a previous peer-reviewed study mapping mental health publications (Larivière et al. 2013), our selected paper set for this exercise was defined according to a combination of the Medical Subject Headings (MeSH terms)2 assigned to individual papers and the categorisation of the journals in which they appear. A key difference in this study was that while the previous definition explicitly excluded substance-related disorders, a decision was taken 2 MeSH terms are a controlled vocabulary of topic descriptors assigned by the US National Library of Medicine to journal papers. 8 Mapping the global mental health research funding system Figure 2-1 Cleaning process of funders 102,324 56,887 2,179 1,908 32 Number of unique funder names Number of unique funder names (cleaned) Number of unique funder names (cleaned) – with more than 10 acknowledgements Number of unique funder names (cleaned) – with more than 10 acknowledgements with Conflict of Interest declarations removed Deep dive case studies this time in consultation with the study’s advisory group to include such papers, due to the complex interactions between substance use and mental health. The full criteria for the retrieval of papers are set out in Appendix A. Our data set comprised 229,980 papers published during the period 2009-2014. The number of publications increased year on year, from 35,522 in 2009 to 44,348 in 2013,3 continuing the general growth in the field observed in Larivière et al. (2013), albeit with the inclusion of substancerelated disorders in the present study. The share of mental health publications in the total medical publication output increased very slightly during the period our data set covers, from 6.9 per cent to 7.1 per cent. The United States remains the largest producer of mental health research, with 36 per cent of papers having a corresponding author with a US address. The UK (8 per cent), Germany (6 per cent), Canada and Australia (both with 5 per cent) follow. The breakdown of the paper set by corresponding author location is provided in Appendix B. 2.2 How many mental health research funders are there? Our analysis revealed 1,908 funders with ten or more acknowledgements in the data set. Some 85 per cent of the papers with funding acknowledge- 3 This is the most recent year for which complete data is available, since indexing of 2014 publications was only partially complete in spring 2015 when our final data set was extracted. ments in our sample mention one or more of these funders, representing 72 per cent of the total acknowledgements identified. These 1,908 organisations form the core set of funders used in the subsequent analyses. This total was reached through an extensive data cleaning process, summarised in Figure 2-1 above. As noted above, around half of the papers identified (49.5 per cent) contained funding acknowledgements (of course, this does not mean that the other papers did not receive funding; acknowledging support is rarely mandatory/ enforceable). Since in some instances more than one funder was acknowledged, the total number Our analysis revealed 1,908 funders with ten or more acknowledgements in the data set of acknowledgements was 364,324, which corresponded to 102,324 different funder names. Given the expected inconsistencies in the form of funder names (for example, differing use of acronyms or inconsistencies in spelling), the data required substantial manual cleaning, which reduced the number of unique funder names to 56,887.4 Further manual checking of those with acknowledgements in at least ten papers and the removal of conflict of interest declarations produced the final group of 1,908 funders used in our analysis. Selecting funders and then examining what they fund would have been very unlikely to have allowed the identification of this number of organisations. 4 It is also important to note that while some funding acknowledgements were specific to a particular department or initiative within a funding institution others would be very general. For example, one paper may reference a particular NHS hospital whereas another may just reference NHS England. In order to ensure accurate data analysis of the funders, names were aggregated to the highest level where possible. Mapping the mental health research funding landscape 9 Figure 2-2 Funders with ten or more acknowledgements (coloured by country) ALF BBRF University of California US NSF SRC AR UK Alz Assoc. NIMH NSFC MICINN WT Roche Found. Pfizer NRF ARC AstraZeneca FAS RWJF CAPES DHHS DFG Lilly FRQS MRC UK NIH GSK NIDA NHMRC NIA NSERC EU NRC NIHR Janssen MIUR JSPS NHS England NHLBI INSERM MHW Korea MEST FIS FAPESP NICHD CIHRMHLW Japan NIBIB BMBF ESRC UK NINDS NSC Taiwan NWO NIAAA US CDC SMRI SNSF CNPq Brazil US DOD USPHS UK DH VA Academy of Finland KCL NCRR 973 China NCI MEXT Key: USA Taiwan Iceland UK New Zealand Estonia Sweden Ireland Iran Canada Singapore Colombia Netherlands Israel Saudi Arabia Australia India Slovakia China South Africa Croatia France Czech Republic Qatar Germany Poland Venezuela Japan Turkey Nigeria Spain Chile Serbia Finland Hungary Romania Italy Argentina Slovenia Denmark Greece Lebanon Switzerland Malaysia Philippines Belgium Austria Bulgaria South Korea Mexico Pakistan EU Portugal Lithuania Norway Russia Brazil Thailand 10 Mapping the global mental health research funding system 2.3 Who are they? The 1,908 research funders found in our final data set are represented in Figure 2-2. The size of each bubble is proportional to the number of papers on which the funder was acknowledged (although those with fewer than 500 acknowledgements are very similar in size), while the colour indicates the country of the funder to provide an overview of their geographical distribution (position of each funder is not significant in this figure, but the relationships between them are addressed in Section 2.6). A list of funder acronyms can be found in Appendix C. The top 30 most frequently acknowledged funders globally are listed in Table 2-1, while similar national lists for Canada and the UK are provided in Annexes 1 and 2. As expected, the group of top global funders is dominated by government agencies, particularly those in the United States. Charities, foundations and nonprofits are represented in the list by the Brain and Behavior Research Foundation, the Alzheimer’s Association and the Stanley Medical Research Institute, all of which are located in the United States, and the UK’s Wellcome Trust, which is the third highest placed UK funder after the Medical Research Council and National Institute for Health Research. The highest placed non-Anglophone funder on the list is the European Commis- sion, with government agencies of China, Japan, Brazil and a number of western European countries also appearing in the top 30. While a number of caveats are associated with our estimation of the scale of industry funding (for example, in relation to conflict of interest declarations on papers), one pharmaceutical company appears towards the lower end of the top 30, Pfizer. Charities, foundations and non-profits form the most numerous group of funders, but governments fund the most papers Charities, foundations, non-profits and government agencies make up the majority of our set of 1,908 funders. Charities, foundations and nonprofits represent 39 per cent of the total and government bodies 33 per cent, but the latter account for 68 per cent of the funding acknowledgements in our data set (see Figure 2-3). Thus, perhaps unsurprisingly, the typical government funder supports more mental health research than the typical charity, foundation or non-profit. The average number of acknowledgements per government agency is 237, compared with an average of 58 for charities, foundations and non-profits. This is consistent with the dominance of government funders in the list of those most frequently acknowledged. Looking in more detail, however, we can see that the distribution of organisations in terms of the 800 160,000 700 140,000 600 120,000 500 100,000 400 638 300 200 60,000 40,000 389 42,137 100 0 80,000 151,276 743 20,000 105 17,987 Academia Charity/Foundation Government 9,905 Industry 0 Number of acknowledgements Number of funders Figure 2-3 Number of funders (and respective acknowledgements) by funder sector Mapping the mental health research funding landscape 11 Table 2-1 Top 30 most frequently acknowledged funders globally Funder No. of papers Location Sector Proportion of papers 1 US National Institutes of Health (NIH) 16716 USA Government 15% 2 National Institute of Mental Health (NIMH) 10081 USA Government 9% 3 National Institute on Drug Abuse (NIDA) 6231 USA Government 6% 4 National Institute on Aging (NIA) 5266 USA Government 5% 5 Canadian Institutes of Health Research (CIHR) 4701 Canada Government 4% 6 Department of Veterans Affairs (VA) 4387 USA Government 4% 7 National Health and Medical Research Council of Australia (NHMRC) 4033 Australia Government 4% 8 European Commission 4021 EU Government 4% 9 National Natural Science Foundation of China (NSFC) 3836 China Government 3% 10 UK Medical Research Council (MRC UK) 3503 UK Government 3% 11 Brain and Behavior Research Foundation (NARSAD) 3281 USA Charity/ Foundation/ Non-profit 3% 12 Netherlands Organization of Scientific Research (NWO) 3112 Netherlands Government 3% 13 National Institute for Health Research (NIHR) 3062 UK Government 3% 14 National Institute on Alcohol Abuse and Alcoholism (NIAAA) 2887 USA Government 3% 15 Wellcome Trust 2434 UK Charity/ Foundation/ Non-profit 2% 16 German Research Foundation/Deutsche Forschungsgemeinschaft (DFG) 2360 Germany Government 2% 17 National Institute of Health Carlos III (FIS) 2225 Spain Government 2% 18 CNPq Brazil 1994 Brazil Government 2% 19 Federal Ministry of Education and Research (BMBF) 1939 Germany Government 2% 20 National Center for Research Resources (NCRR) 1917 USA Government 2% 21 Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 1909 USA Government 2% 22 Ministry of Education, Culture, Sports, Science and Technology in Japan (MEXT) 1852 Japan Government 2% 23 National Institute of Neurological Disorders and Stroke (NINDS) 1847 USA Government 2% 24 Alzheimer’s Association 1636 USA Charity/ Foundation/ Non-profit 1% 25 Swedish Research Council 1409 Sweden Government 1% 26 Stanley Medical Research Institute (SMRI) 1317 USA Charity/ Foundation/ Non-profit 1% 27 Pfizer 1197 USA Industry 1% 28 Spanish Ministry of Science and Innovation (MICINN) 1151 Spain Government 1% 29 Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) 1132 Brazil Government 1% 30 Department of Health and Human Services (DHHS) 1128 USA Government 1% 12 Mapping the global mental health research funding system Figure 2-4 Distribution of funders in the government and charity/foundation/non-profit sectors, by numbers of papers on which they are acknowledged 400 400 Charities/Foundations 350 350 300 Number of funders Number of funders 300 250 200 150 250 200 150 100 100 50 50 0 Government 20 40 60 80 100 150 200 Funding acknowledgements 500 More 0 20 40 60 80 100 150 200 Funding acknowledgements 500 More volume of research supported is heavily skewed in both sectors (Figure 2-4). While in both government and charity sectors there are large numbers of funders supporting small amounts of mental health research, the government sector has a notably higher number of very large funders. Our data indicates that there are few such large funders in the charity, foundation and non-profit sector. What we cannot judge from this data, however, are the absolute amounts of money involved, something discussed further in Chapter 4. The remaining organisations in our analysis were classified as industry funders or academic institutions.5 While uncertainties around industry funding have been discussed previously, the extent to which academic institutions are providing independent funding for research is also unclear. In many cases, these acknowledgements may represent, for example, the provision of laboratory space, infrastructure or support services by a researcher’s host institution. That is not to suggest that these forms of support are not important, but highlights that they are more difficult to capture in this kind of analysis due to inconsistencies in the way that researchers acknowledge support which may be non-monetary or less-formally attributed to a particular project.6 The share of funding acknowledgements accounted for by each sector has remained fairly constant over the six year time period covered by our data (see Figure B-3 in Appendix B.). 5 In addition to these groups there were a small number of funders 6 Our survey of researchers revealed that only 20 per cent usually that either did not fit into these categories (such as publishers) or were unable to be classified due to a lack of available information. Papers acknowledging charity, foundation or non-profit support have the highest citation impact Measures of citation can be used as an indicator of the scientific impact a particular piece of research has in the academic world. As publication and citation practices vary substantially by discipline (e.g. Moed et al. 1985), we use the indicator ‘average of relative citations’ (ARC), which normalises the number of citations a paper receives according to its age (since older papers have had more time to accumulate citations) and the field in which it is published (see Appendix A for further details). In our data set, the ARC of papers containing funding acknowledgements was substantially acknowledged access to equipment and facilities in journal papers, and only 4 per cent acknowledged estate costs. Mapping the mental health research funding landscape 13 Figure 2-5 Average of relative citations by funder sector (world average = 1.0)7 2.50 2.00 1.91 Field normalised citation 1.63 1.58 1.64 1.48 1.50 1.00 0.93 0.50 0.00 Academia Charity/Foundation Government above the global average (of 1.00) for all sectors (see Figure 2-5), a finding consistent with previous studies demonstrating that papers acknowledging funding tend to be more highly cited than those without such acknowledgements (e.g. Costas & van Leeuwen 2012). In addition to this, however, papers acknowledging support from a charity, foundation or non-profit had a higher citation impact on average than those acknowledging other sectors. This was also true within individual countries (see Annexes 1 and 2 for data on Canada and the UK), suggesting that the higher average citation of papers supported by charities, foundations and non-profits is not due solely to the geographical distribution of funding organisations. There are examples of new funders emerging in the field of mental health One of the primary reasons for using a bottomup approach in this analysis, in contrast to the top-down approach of many previous studies, was to enable us to explore the field of mental health 7 Funder sectors were only assigned to funders with 10 or more acknowledgements Industry Papers with funding Papers without funding acknowledgements acknowledgements research beyond the large and well-known funders. Through the funding acknowledgement data extracted from journal papers we have been able to do this, highlighting some funders who have begun supporting mental health research only recently. We looked at the number of acknowledgements of each funder in each year of the data set and identified those with the greatest differences in frequency between the first part (2009-2012) and second part (2013-2014) of the time period. Some of the funders highlighted by this analysis were organisations which had changed name or restructured during or shortly before the first year of our data set – for example, the Spanish Ministry of the Economy and Competiveness, created in 2011 from the merger of two prior ministries. However, there were also examples of newly established funders. The US National Center for Advancing Translational Sciences (established under the auspices of NIH in 2012) is a notable example here. It was established with the aim of speeding up the delivery of new drugs, diagnostics and medical devices to patients (a challenge highlighted by a number of funders in our deep dive interviews). 14 Mapping the global mental health research funding system the United States is home to 31 per cent of all government, charity, foundation and non-profit mental health research funders in our data set We also identified a range of smaller organisations, primarily in the charity, foundation and non-profit sector, which were either recently established or began new funding programmes related to mental health in the years just prior to our data set. The clearest examples of this were the Swiss Anorexia Nervosa Foundation, which was established in 2007 and appears in our data from 2012, and the William K. Wallace Foundation (US) and Champalimaud Foundation (Portugal), which launched mental health and neuroscience programmes, respectively, in 2007. Being able to identify the emergence of new funders or funding programmes in the data both highlights the value of mapping mental health research funding using a bottom-up approach, and also serves as a useful validation of the sensitivity of our methodology to changes in the ecosystem. 2.4 Where are they? Government, charity, foundation and non-profit funders are clustered in the countries which produce the most mental health research To explore the geographical distribution of mental health research funding agencies we identified the location of each of the funders in our set of 1,908. In instances where funders are international (such as multilateral organisations) the location of the funder’s headquarters is considered to be its home country (with the exception of European Union institution funding, which is not attributed to any one country). For this analysis we use only organ- isations in the government and charity/foundation/non-profit sectors. Industry funders tend to operate in many countries, making it difficult to accurately attribute funding to any one country, while (as discussed previously) the acknowledgement of support from academic institutions in providing non-monetary or less-formal support appears inconsistent. As shown in Figure 2-6 below, the United States is home to 31 per cent of all government, charity, foundation and non-profit mental health research funders in our data set. The UK, Canada, Sweden, China and the Netherlands each have more than 60 funders. In total, government, charity, foundation and non-profit mental health research funders were identified in 55 countries,8 with the majority located in North America, northern and western Europe and China. Perhaps unsurprisingly, the highest concentrations of funding agencies tend to be located in the countries producing the most mental health research. Of the ten countries with the highest volume of mental health publications in our data set, only one (Italy) was not also in the top ten in terms of number of funders. Figure 2-7 and Figure 2-8 show this same data split by sector. They highlight that the predominant funder type varies somewhat by country. While the United States is home to the largest number of funders in both sectors examined here, China is dominated by government funding agencies, while the UK, the United States, Australia, Denmark, Germany and, in particular, Sweden and Finland, have greater numbers of charitable funders. Figure 2-9 shows the average citation impact of funders in each country – that is, the average level of citation of papers acknowledging funders from a given country, when normalized for field and year of publication. Funders in Ireland, EU institutions, the UK, Switzerland, and New Zealand average the highest citation impact, followed by papers funded by institutions in Germany, France, the United States and the Netherlands. Of the countries receiving large numbers of funding acknowledgements, South Korea, Taiwan, Brazil, China and Japan score notably lower than other major research funding and producing countries. 8 58 countries were identified if we include academia Mapping the mental health research funding landscape 15 Figure 2-6 Number of government, charity, foundation and non-profit mental health research funders by country Figure 2-7 Government funders by country 16 Mapping the global mental health research funding system Figure 2-8 Charity, foundation and non-profit funders by country Figure 2-9 Average relative citations by country of funder9 9 For government, charity, foundation and non-profit mental health research funders in countries with over 100 papers Mapping the mental health research funding landscape 17 We also compared the number of acknowledgements per country (of funding organisation) with an indicator of overall spend on research and development. As mentioned previously, we cannot assume a direct link between funding acknowledgements and amounts of funding, but this does provide an indication of which countries may be supporting relatively more or less research in the mental health field compared with other research areas. The R&D expenditure data used is from 2009 or the nearest available year prior to that, given that the time between funding being awarded and a research paper being published has been shown to be around three years on average (e.g. Boyack & Jordan 2011). Figure 2-10 reveals a number of countries with relatively large numbers of acknowledgements in mental health, including the UK, Canada, Figure 2-10 Acknowledgements per funder country by R&D expenditure: (i) all countries. (ii) excluding the United States (Source: UNESCO, 2009 or nearest available prior year) 120,000 Funding acknowledgements 100,000 US 80,000 60,000 40,000 20,000 UK CA 0 DE FR $- $50 CN JP $100 $150 $200 $250 $300 $350 $400 $450 Millions R&D expenditure (US$ current PPP) 25,000 Funding acknowledgements 20,000 UK 15,000 CA 10,000 AU CN NL SE 5,000 FI DK 0 CH BE DE ES BR FR KR IT IN $- $20 JP RU $40 $60 $80 $100 $120 R&D expenditure (US$ current PPP) $140 $160 $180 Millions 18 Mapping the global mental health research funding system Australia and the Netherlands. A second group, including China, Japan, India and Russia has relatively few acknowledgements given the size of their annual R&D expenditure, suggesting that they focus their research resources in other areas. 2.5 What are they funding? Funded topics cluster into eight groups of mental health conditions Medical Subject Headings (MeSH terms) are a defined set of terms applied to journal papers to indicate the type of content. They can be used to understand the topics of the papers in our data set and how these topics relate to one another. We looked at terms within the MeSH subset ‘Mental Disorders’ to explore the various mental health conditions that the research in our data set focuses on. Terms within this subset occur on 69 per cent of all papers (76 per cent of papers with acknowledgments). Since each paper can be assigned a number of terms within the Mental Disorders subset, we could build a network of the co-occurrence of terms. This network showed that within our dataset conditions clustered into eight broad groups, representing terms which tend to occur together on papers. The groups have been labelled with a descriptor that covers the majority of terms in that class (see Appendix D for a full list of terms in each group). Using the entire data set, Figure 2-11 shows the number of papers falling within each of the eight groups. The most common conditions occurring in our data set, together comprising 61 per cent of all papers, are neurodegenerative and cognition disorders; depressive, anxiety and personality disorders; and substance use and addictive disorders. Papers may fall into more than one class if they contain terms from multiple classes. Figure 2-12 takes the same data, but adds an extra dimension by showing the proportion of papers in each group which also include a funding acknowledgement. This varies by the area of mental health the paper relates to, with, for example, 66 per cent of papers on neurodegenerative and cognition disorders acknowledging at least one funding source, in comparison with only 48 per cent of those relating to sleep disorders. Further analysis of the funders acknowledged in each of these groups is set out in Section 2.6, where we look at networks of the funders co-acknowledged on papers within each. Figure 2-11 Papers in complete data set with ‘Mental Disorder’ MeSH terms Sex development disorders Depressive, anxiety and personality disorders Neurodegenerative and cognition disorders Schizophrenia, bipolar and other psychotic disorders Sleep disorders Eating disorders Neurodevelopmental disorders Substance use and addictive disorders Mapping the mental health research funding landscape 19 Figure 2-12 Coxcomb plot of papers with acknowledgement data and Mental Disorder MeSH terms 49.1% 46.4% 46.5% Sex development disorders Depressive, anxiety and personality disorders Neurodegenerative and cognition disorders Schizophrenia, bipolar and other psychotic disorders 44.8% Sleep disorders Eating disorders 34.9% Neurodevelopmental disorders 66.2% Substance use and addictive disorders 48.1% 61.4% Figure 2-13 Funding acknowledgements by sector for each group of MeSH terms Sex development disorders 11% Substance use and addictive disorders 12% Sleep disorders 81% 79% 14% Eating disorders 2% 6% 3% 6% 67% 16% 10% 70% 9% 4% Charity/Foundation 11% Government Depressive anxiety and personality disorders 67% 18% 6% 9% Neurodevelopmental disorders 22% 66% 4% 8% Neurodegenerative and cognition disorders 23% 66% 4% 8% Schizophrenia, bipolar and other psychotic disorders 23% 0% 10% 62% 20% Government funders support the most research in every subfield of mental health, but the involvement of charities and industry varies by area Figure 2-13 shows how the involvement of funders in different sectors varies in each of the eight topic groups. It shows the proportion of funding acknowledgements attributable to each sector in each of the eight groups formed from ‘Mental Disorder’ MeSH terms in our data set. In all eight 30% 40% 50% 7% 60% 70% 80% 90% Industry Academia 8% 100% areas the majority of funding acknowledgements relate to government funders, but in schizophrenia, bipolar and other psychotic disorders, as well as both neurodegenerative and neurodevelopmental conditions, charities, foundations and nonprofits account for more than 20 per cent of the total acknowledgements. Industry funders appear to invest more in sleep disorders and schizophrenia, bipolar and other psychotic disorders than in other areas of mental health. 20 Mapping the global mental health research funding system Figure 2-14 Research level of papers by year 45% 40% 35% % of papers 30% 25% 1 (clinical observation) 20% 3 (clinical investigation) 2 (clinical mix) 4 (basic biomedical) 15% 10% 5% 0% 2009 2010 2011 2012 Industry funders tend to support more applied research The ‘research level’ assigned to a journal provides an indication of the type of research it publishes.10 There are four levels, which form a scale from applied to basic research: (1) clinical observation (e.g. Schizophrenia Bulletin); (2) clinical mix (e.g. Journal of Psychiatric Research); (3) clinical investigation (e.g. Neuropsychopharmacology); and (4) basic biomedical (e.g. Neuroscience). It should be noted that research level is a fairly crude measure, since it is applied at the journal level, rather than to individual papers and not all journals have been classified. However, it is the best approximation available and when used at the aggregate level can provide an overview of how basic or applied a body of research is. In a previous study (Wooding et al. 2013) we noted that over a 20-year time period clinical research has had a larger impact than basic research on patient care in the mental health field. This observation raises questions about how research funders can best balance their portfolios to achieve their intended impacts within appropriate timeframes and highlights the value of exploring the distribution of research types within the field. Figure 2-14 shows that the representation of journals at each research level in our data set has not changed dramatically over time, although the 10 As defined by the Patent Board (formerly CHI Research): Hamilton, K. (2003) Subfield and Level Classification of Journals (CHI Report No. 2012-R). Cherry Hill, NJ: CHI Research 2013 2014 proportion of the most clinically-focused research appears to increase in 2014. While this could be a short term fluctuation or the start of a longer term trend, it is important to bear in mind that the indexing of 2014 papers was incomplete when we extracted our data (and so this variation may be an artefact of differential indexing of journals at each research level). In contrast, we do see a difference in the distribution of research levels according to the sector of the funder acknowledged (Figure 2-15). Industry funding is associated with a greater proportion of the most applied research (level 1) and is acknowledged on a much smaller proportion of papers in basic biomedical (level 4) journals than is the case for funders from other sectors. The US and the UK are consistently the top two funder countries across all subfields of mental health research In all eight areas of mental health research, US funding organisations were most frequently acknowledged in our data set, followed by funders in the UK (Table 2-2). Below these two countries there was more variation, although Canada was third or fourth in each of the six largest areas and Australia was also prominent. Chinese funders were acknowledged proportionally more in neurodegenerative and cognition disorders. Swedish organisations also featured prominently in this area, as well as (along with Spanish funders) on papers relating to eating disorders. Mapping the mental health research funding landscape 21 Figure 2-15 Research level of papers by funder sector 100% 90% 80% 70% 60% 4 (basic biomedical) 50% 3 (clinical investigation) 40% 1 (clinical observation) 2 (clinical mix) 30% 20% 10% 0% Academia Charity/Foundation Government Industry Table 2-2 Top ten most frequently acknowledged funding countries for each group of MeSH terms Neurodegener­ ative and cognition disorders Depressive anxiety and personality disorders Substance use and addictive disorders Neurodevelop­ mental disorders Schizophrenia, bipolar and other psychotic disorders Sleep disorders Eating disorders Sex develop­ ment disorders 1 USA USA USA USA USA USA USA USA 2 UK UK UK UK UK UK UK UK 3 China Netherlands Canada Canada Australia Brazil Spain Japan 4 Canada Canada Australia Australia Canada Canada Sweden Brazil 5 Sweden Australia Netherlands Germany Spain China Germany China 6 Australia Germany Spain Netherlands China Japan Australia EU 7 Spain China China EU Japan Australia Canada Australia 8 Japan Brazil Sweden France Netherlands Germany EU Canada 9 EU Spain Germany Japan Brazil Finland Brazil Germany Germany Sweden Finland China Germany Sweden France Switzerland 10 2.6 How do funders relate to one another? One of the aims of this study was to identify the connections between mental health research funders, whether these arise through formal funding collaborations or due to researchers using funding from two (or more) different organisations to support the same work. To explore these connections, we used papers with multiple funding acknowledgements to link funders. For example, a paper supported by CIHR and the Wellcome Trust would produce a link between these organisations. While we are not aware of previous studies using funding acknowledgement data in this way, network analysis is increasingly being used to evaluate collaborative research and explore the relationships between actors in a network and 22 Mapping the global mental health research funding system information flows between them – numerically or graphically (e.g. Wagner et al. 2005). Networks constructed using funding acknowledgement data indicate simply where two funders are acknowledged on the same paper. As such, this analysis cannot (on its own) differentiate qualitatively between cases of ‘active’ collaboration between funders and instances in which researchers combine funding from two (or more) organisations to support the same work. It can, however, cast light on the extent to which funders’ portfolios overlap or complement one another, highlight where they (knowingly or unknowingly) co-fund research and reveal whether any clusters of funders emerge. To complement this, the profiles of individual funding organisations completed as part of the study detail current collaborative and cooperative activities that each funder actively engages in. In the mental health research field as a whole… A network analysis was conducted to examine the extent of collaboration and co-acknowledgement across our core set of 1,908 funders (Figure 2-16; see Appendix A for methodological details). A larger-scale version of the network is included in the pack which accompanies this overview report. The network analysis aimed to highlight the relationships between funders linked through funding acknowledgements on each paper. Using a ‘network approach’ in exploring this provides a systemic perspective on linkages between funders as it takes into account the dynamics of the system as a whole, as well as the relative position of individual funders in collaborative networks and thus affords greater analytical detail. In the network, each node represents a funder and the connecting lines indicate these funders’ co-acknowledgement on papers (a heavier line indicating a greater number of co-acknowledgements). The size of a node is proportional to the number of acknowledgements that the funder has in the data set. Funders are coloured by modularity class – clusters which emerge from the data and provide an indication of how closely related nodes are in terms of co-acknowledgement. The organisations within each cluster are densely connected to others within the same class and are more sparsely connected to those outside it (see Appendix A for further details). The overall network illustrates the complexity of the research funding ecosystem in mental health. The dominance of US funders is clear, in particular of NIH and its associated institutes. Major government funders in Canada, the UK, China, Australia and the EU can also be seen, surrounded by a large number of smaller government agencies and other funders. Generally, the clusters emerging from the data are geographical, representing either countries or regions. This suggests that despite increasing international collaboration in research (e.g. Gazni et al. 2012; Waltman et al. 2011), national boundaries are still important in funding distribution. Similar networks specifically for Canada and the UK can be found in Annexes 1 and 2. In subfields of mental health… We also developed individual networks for funders acknowledged on papers in each of the topic groups identified in Figure 2-11. These networks give an overview of the funders active in each area and the relationships between them. The five largest topic areas are shown in Figures 2-17 to 2-21. Funders are again coloured according to modularity class. Further details on the construction of the network maps are set out in Appendix A. In neurodegenerative and cognition disorders (Figure 2-17), funders whose portfolios focus on aging and dementia are clearly visible, in particular NIA and a number of charities and foundations focusing on Alzheimer’s and Parkinson’s research. The noticeable presence of some relatively large charity funders is consistent with our earlier observation that this is one of the areas of mental health research in which charities, foundations and non-profits appear to be most active. While US government agencies are still the most prominent funders in this field, there is a wide representation of European funders towards the right of the network, including a notable cluster of UK funders (shown in red) and a similar group of Swedish organisations (in brown). Most other European funders form one cluster (in a lighter green than the United States). For depressive, anxiety and personality disorders (Figure 2-18), the funding landscape divides broadly into two large clusters, one dominated by the United States, but also including some industry funders, and the other consisting mainly of European and Australian funders (again with a Mapping the mental health research funding landscape 23 few pharmaceutical companies). The other organisations acknowledged on significant numbers of papers in this subfield form four national clusters for Canada, Brazil, China and Japan. As one might expect, the funding landscape for substance use and addictive disorders (Figure 2-19) is dominated by NIDA and NIAAA, along with NIH. Most of the major funders in the network are government agencies, an observation consistent with the relatively low involvement of charities, foundations and non-profits seen in Section 2.5. Notable exceptions include the Wellcome Trust and Robert Wood Johnson Foundation. In neurodevelopmental disorders (Figure 2-20) we see a large and closely linked network of US funders. Compared with other research areas (and as expected) NICHD is much more prominent, as are the charitable funders Autism Speaks and the Simons Foundation Autism Research Initiative. EU institutions also appear prominent, a finding consistent with our earlier observation that this is a research area in which they are more heavily involved (see Table 2-2). There are fewer industry funders than found in some other areas (as also illustrated previously) exceptions being Shire and Eli Lilly. The landscape for schizophrenia, bipolar and other psychotic disorders (Figure 2-21) is dominated by a few large US funders – NIMH, NIH, the Brain and Behavior Research Foundation and the Stanley Medical Research Institute. Other major funders tend to be pharmaceutical companies and government agencies in the countries most frequently acknowledged in our data set. Finally, networks were constructed for two population groups of different ages. Figure 2-22 shows funders acknowledged on papers concerned with young people (MeSH terms “Adolescent”, “Child”, “infant” and “young adult”, plus terms making up the levels below them in the hierarchical MeSH structure), a group of particular interest given the early age of onset of many mental health conditions (Kessler et al. 2007). Figure 2-23 shows the corresponding network for older age groups (“Aged” and “middle aged”, plus the terms below them in the MeSH structure). The funding landscape for research relevant to young people (Figure 2-22) shows clear clusters for the United States (in purple), the UK (dark blue) and Canada (red), as well as for Australia, Sweden, China and Brazil (all towards the bottom right of the network). In addition to the government funders frequently acknowledged in a range of areas, charities including the Tourette Syndrome Association, the Simons Foundation Autism Research Institute, Autism Speaks, the MacArthur Foundation (all US), the Colonial Foundation in Australia and the Yrjö Jahnsson Foundation in Finland all feature. The network for older people (Figure 2-23) contains a wide range of organisations, likely reflecting the broad range of topics that the selected MeSH terms are likely to cover. Nevertheless, as found in the network for neurodegenerative conditions, there is a notable cluster of mostly Swedish funders (in pink). NIA is prominent, as might be expected, while a number of Alzheimer’s, Parkinson’s and cancer charities are also visible. 24 Mapping the global mental health research funding system Figure 2-16 Network of co-acknowledged funders in the entire mental health data set (coloured by modularity class). A larger-scale version of this figure has been published alongside this report. Seattle G Clemson Uni Institute on Famil... American Orthopsychiatric Asso... International Society for Chil... Judie and Marshall Polk Resear... Allergan King S China Scholarship Broad GO Sequencing Project Montreal Childrens Hospital Re... International Family Therapy A... Psychological Assessment Reso Inokashira Hospital Research F... Uni of Southern Denmark Argentina Hirosaki Research Institute fo... McGraw Hill Hanyang Uni Cell Science Research Found. J... Spanish Ministry of Public Hea... McLau Promotion and Mutual Aid Corpo... National Center for Geriatrics... Daiichi Sankyo Naito Found. American Society for Clinical ... Strategic Research Program for... Japan Epilepsy Research Found. Brains Japanese Society of Clinical N... NCNP Medical Research Council of Ca... Academic Frontier Project for ... Physicians Academy Queens Uni Niigata Uni China Medical Board of New Yor... Suzuken Memorial Found. Astellas Found. Drummond Found. MS Society of Canada Mental Health Commission of Ca... Random House General Insurance Association ... NEDO, Japan Kanae Science Found. Danone OBI Saul A. Silverman Family Found. Showa Uni SENSHIN Medical Research Found. Mochida Smoking Research Found. of Japan Agencia Nacional de Promocion ... Akdeniz Uni Research Group for Schizophrenia Japan Arteriosclerosis Prevent... RIKEN Health and Labor Sciences Rese... Mitsubishi Tanabe Pharma Corpo... Alberta Health Services Uni of Saskatchewan Mitsui Sumitomo Insurance Welf... Ministry for Food Japanese Research Found. for C... Alberta Childrens Hospital Fou... Templeton Found. In Silico Mind and Life Institute Canadian Diabetes Association/... Lawson Health Research Institute Takeda Science Found. Fetzer Institute Healt Ontario Research Fund Shanghai Key Discipline Program Japan Found. for Neuroscience ... Buddhist Tzu Chi General Hospi... Ontario Institute for Cancer R... Kakenhi NIBIO NCNP Shervert Frazier Rese NeuroDevNet CONICET Auckland Medical Research Found. WPA National Basic Research and De... Alberta Gaming Research Instit... Interstitial Cystitis Associat... Japan Health Sciences Found. Govt. of Canada Royal Society of New Zealand M... Shanghai Key Project of Basic ... JSPS Ritter Found. Uni of Western Ontario Ontario Problem Gambling Resea... Uehara Memorial Found. (Japan) COE Respironics Found. Accident Compensation Corporat... Program for Outstanding Medica... Norlien Found. Chinese Govt. ResMed Found. Health Sciences Found. Uni of Alberta Capital District Health Author... Shanghai Pujiang Talent Program X CREST MOE - Shanghai Key Laboratory ... Whitehall and Packard Found.s Fudan Uni Behrens-Weise-Stiftung Prentiss Found. Zikei Institute of Psychiatry Canadian Cancer Society Resear... Federal Ministry of Health Shanghai Municipal Education C... USAID Uni of Mississipp Juntendo Uni JST International Rett Syndrome Fo... Schizophrenia Society of Ontario Alcohol Advisory Council of Ne... ICES Ministry of Health and the Nat... Toronto Rehabilitation Institu... PSI Found Urban Institute Canadian Health Services and R... Science and Technology Bureau ... William K. Warren Found. of Tu... Ontario Ministry of Research a... Child and Family Research Inst... Beijing Municipality Hunan Provincial Natural Scien... Shanghai Municipal Health Bure... Sichuan Uni FQRNT Saskatchewan Health Research F... Scottish Rite Charitable Found... Hospital for Sick Children Fou... Alkermes Dalhousie Medical Research Fou... China Academy of Chinese Medic... Fonds Quebecois - Societe et l... Manitoba Medical Services Foun... American Psychological Associa... Massachusetts Huntingtons Dise... Shenzhen Bureau of Science PCSIRT Genome Canada Heart&Stroke Fou NSLIJ Research Institute NIH G... State Education Ministry of Ch... National Basic Research Program MEXT MHLW Japan State Key Program of National ... US DOD Ontario Innovations Trust McGill Uni Ontario Neurotrauma Found. Ministere de l'education National Child Health Research... N Jack Brown and Family Alz. Fou... Uni of Texas Shanghai Changning Health Bure... Lebanese Ministry of Public He... Uni of Montreal Canadian Stroke Network Edmond J. Safra Philanthropic ... CAS/SAFEA Shanghai Rising- Star Program Ontario Womens Health Council Neurological Found. of New Zea... CAS Uni of Otago McMaster Uni Vancouver Coastal Health Resea... BC Mental Health and Addiction... Key Program of Medical Develop... Blowitz Ridgeway Found. PAPD, China Janssen Research Found. Spanish Child Psychiatry Assoc... Yunnan Province Govt. Ministry of Social Protection ... Independent Innovation Found. ... Uni of Michigan Fok Ying Tung Found. Pritzker Neuropsychiatric Diso... SSHRC OMHF MEC China Nova Scotia Health Research Fo... New Zealand Lottery Health Board Dalhousie Uni W. Garfield Weston Found. grant USP Health Bureau of Zhejiang Prov... Nellie Ball Research Trust Fund NBRP China Canterbury Medical Research Fo... Essel Found. Psyadon pharmaceuticals Medical Scientific Research Fo... Found. of Shanghai Science and... National Center for Responsibl... California Tobacco-Related Dis... Uni of Utah Shanghai Leading Academic Disc... Yale Uni Shanghai Science & Technology ... APA NAM China Mega-Project for Infecti... NIDDK NICHD SKLID UNICEF Multiple Sclerosis Society of ... Tsinghua-Yue-Yuan Medical Scie... Marriot Found. HHMI Spunk Fund Inc (New York) AIHS INPRFMDIES Guangxi National Natural Scien... Ministry of Health 973 China National R&D Special Fund for ... Emory Uni ASC Commonwealth Research Center o... CANMAT 973 Program Shanghai Science & Technology ... CIHR Ministry of Immigrant Absorpti... Science and Technology Commiss... OMA-MH Uni o Fundamental Research Funds for... 863 project MOST China SAMHSA Peking Uni National Science & Technology ... Canadian Nurses Found. Scientific Research Found. for... Oriented Hundred Talents Progr... USAMR Manitoba Health Research Council Ministry of Health Klingenstein Third Generation ... State Key Laboratory of Cognit... Specialized Research Fund, China Tourette Syndrome Association-... NINR Parkinson Society of Canada FAPESP USA Science and Technology Plannin... MRC National Social Science Found.... Co RRF AbbVie US-Israel Binational Science F... RGC Shenzhen Bureau of Health Qingdao Bureau of Science and ... Duke Uni Science and Technology Coopera... UBC Roswell Park Transdisciplinary... National Infrastructure Progra... China Postdoctoral Science Found Uni of Washington ABMRF 111 Project Wenzhou Science and Technology... Astellas Uni Grants Committee of Hong K... W T Grant Found. Medicine and Health Science Te... Uni of Auckland Organization for Autism Research NAAR Hong Kong Jockey Club Charitie... Hartford Hospital Research Pro... Research Found. of Shanghai He... Jazz Pfizer Foundation John Simon Guggenheim Found. Ministry of Chinese Science an... CONACYT Shanghai Committee of Science ... France Found. KNAW CRC South African Dept. of Health National Insurance Institute o... Actelion NINDS Chinese Ministry of Health Hartford F Israel National Institute for ... Uni of China Uni of Cape Town National Cancer Institute of C... Chinese Scholarship Council Canadian Psychiatric Associati... ADDDF Croucher Found. Shandong Provincial Outstandin... Phil F. Jenkins Research Fund Foundation of Chinese Academy ... Pearson Center for Alcoholism ... NSFC Pacific Alzheimer Research Fou... Hussman Found. Tianjin research program of ap... Medical Science Council NIH The Patrick and Catherine Weld... Stavros S. Niarchos Found. National Research Found. of So... AD Beijing Municipal Science & Te... Inha Uni Research Taiwan Bureau of National Heal... INCT South African Research Chairs ... KOSEF Johnson & Johnson Inc Brazilian Ministry of HealthCa... Korean Research Found. Uni of Hong Kong Israel Academy of Sciences and... Harry and Doris Crossley Found. Dept. of Psychiatry National Institute of Occupati... Ministry of Knowledge Economy ... Katz Family Found. Irving B. Harris Found. NASA Fondazione del Monte di Bologn... National Brain Research Center MOEHRD Taipei City Govt. in Taiwan Korean Centers for Disease Con... National Research Found. FAPESC FAPERJ Asan Institute for Life Sciences Australian-Chinese Academy of ... Catholic Medical Center Resear... UNICEF Fundo de Auxlio aos Docentes ... SNUH NSC Taiwan HRC Universidade do Extremo Sul Ca... Yuli Veterans Hospital Korea Food and Drug Administra... Seaver Found. FA VA Medical Research Center Uni of the Witwatersrand PRONEX, Brazil Instituto Cerebro e Mente-Brazil Yonsei Uni Samsung Medical Center FDA Ministry of Education EGRIS Epilepsy Found. Korea Uni Grant Croatian Ministry of Science FRQS Pusan National Uni Hospital WCU MEST Chang Gung Memorial Hospital i... Ministry of Education National Taiwan Uni Hospital NIDCD Piedmont Region of Italy ABADHS UNIFESP Cure Alzheimers Fund Asklepios-Med (Hungary) McLean Private Donors Psychoph... Found. of Gedeon Richter Kenneth T. and Eileen L. Norri... Novartis Found. Intel Corporati Brain Net Europe Taipei Veterans General Hospit... Inje Uni Uni Medical Center Hamburg-Epp... Academia Sinica Althingi Pfizer RUSK Found. CAPES Korean Healthcare Technology R... Konkuk Uni Research Found. HCPA Shire National Cheng Kung Uni Hospital Found. of Hope NSC FAEPA Fundacion Areces A Lance Armstrong Found. Sa LOreal Kaohsiung Medical Uni Austrian Academy of Science NHRI Taiwan Medice DoH, Taiwan INNT FINEP Kai-Syuan Psychiatric Hospital DFAPEMIG AFIP Roy Otsuka Abbott SCDDSN Mackay Memorial Hospital Borderline Personality Disorde... Ministry of Science Daimler Benz Found. (Germany) Atomic Energy Council of Taiwan Kaohsiung Municipal Hsiao-Kang... APIRE PAHO NRF Fundacion Caja Madrid (Spain) Bruce J. Anderson Found. Philips Cancer Research Center of Exce... WHO BMS FAPERGS Uni of Barcelona Novartis Found. Alfonso Martin Escudero MHW Korea China Medical Uni Fondation Pierre Deniker FIPE Regional Ministry of Innovation UK Epilepsy Research Found. DFID Tel Aviv Un Mutua Madrilena Found. United Arab Emirates Uni Basque Govt. Medical Uni of Vienna Taipei Medical Uni-Wan Fang Ho... Far Eastern Memorial Hospital Tri-service General Hospital F... Cyberonics Inc Mayo Clinic Foundation ISF IG MooDS Uni of Bristol Austrian National Bank Parkinsons Disease Found. EFF Lilly Taipei City Hospital Research American Psychoanalytic Associ... Regione Autonoma della Sardegn... Gottfried und Julia Bangerter-... Greek Ministry of Education Jacobs Found. Switzerland RETICS Conchita Rabago Found. Lundbeck Found. Banco di Sardegna Alfried Krupp von Bohlen und H... DAAD Schwaabe HDF ISO Fundacion Marques de Valdecilla Autonomous Community of Madrid Bristol-Myers Squibb Found. Fundacion Marcelino Botin La Fundacio La Marato de TV3 ISAN Navarra Regional Govt. MICINN FWF Fundacion La Caixa Human Frontiers Science Program FCT Hertie Foundat DFG Uni of Rome Uni of Leeds CIBERER Valeant UCB beyondblue IDIAP jordi Gol IPA Departament de Salut AGAUR CSIC James S McDonnell Found. Plan Nac. Sobre Drogas Mission Interministerielle de ... S Janssen Rockefeller Found. Fundacion Alicia Koplowitz DGPPN Ministry of Cultural Affairs CNPq Brazil SENYFundaci / Fondation SENY COST-Action Xunta de Galicia HEC of Pakistan Ministry of Health of the Gene... Fritz-Thyssen-Stiftung Queensland Health Elite Graduate Network of Bava... UPV-EHU US Fulbright Fellowship Medtronic Junta de Andalucia Swiss National Research Fund WT CAM Merz Fundacion Espanola de Psiquiat... Uni of the Basque Country Rolf-Dierichs-Stiftung BMBF Alexander von Humboldt Researc... Roche GSK Spanish Govt. GdC MEC, Spain Volkswagen Found. (Germany) CIEN Bial Found. MOSHE Poland MINECO Consejeria de Salud de la Junt... Polish Academy of Sciences Kyung-Hee Uni Gulbenkian Found. S-R Found. Social Ministry of the Federal... CIBERNED NHMRC ICREA Found. Dept. of Health of the Govt. o... German National Academic Found. Swiss Federal In SFI AFI EMBO Uni of Essex state Govt. of Bavaria NHS England Gates Cambridge Scholarship Tr... Gobierno de Navarra (Spain) Royal Netherlands Academy of A... ARRS Loterie Romande CIPSM Uni of Iceland BHF UK Andalusian Govt. Hermann and Lilly Schilling Fo... German Max Plan Uni of Birmingham British Medical Association PB Action Medical Research (UK) Charles Uni in Prague FIS Czech Ministry of Education, Y... Conselleria de Sanidad German Ministry of Health Unilever Helse Nord RHF EU Ministry of the Health of the ... MIWFT Uni of London HRB Universitat Munchen Procte Uni of Heidelberg Great Ormond Street Hospital C... OTKA P1 vital Ltd Guys and St Thomas Charitable ... SNSF Found. for Polish Science Health Dept. of the Basque Cou... NSW Health Newcastle Uni Schizophrenia Research Fund Free State of Saxony Else Kroner-Fresenius-Stiftung... Uni Bochum Deutsche Krebshilfe Research F... Agency of the Academy of Scien... Bavarian Ministry of Commerce Uni of Jena ERDF Ludwig Maximilians Uni Swiss Anorexia Nervosa Found. Reina Sofia Found. Uni of Manc Consejeria de Educacion - Junt... Psychiatry Research Trust Arthritis Research Campaign Big Lottery Fund Baily Thomas Charitable Fund Uni of Rostock Medical Uni of Lodz Dutch Medical Research Council European Social Fund Uni of Lubeck Uni of Bonn Stifterverband fur die Deutsch... Royal Society Ministry of Science, Serbia British Council Health Found. Young Investiga NIHR UKs Ministry of Defence Sir Jules Thorn Charitable Trust Estonian Ministry of Education... Motor Neurone Disease Associat... Scottish Mental Health Researc... Isaac Newton Trust Cambridge British Academy Greek Ministry of Development Hungarian Academy of Science Berlin Brandenburgische Akadem... Uni of Aberdeen BBSRC Waterloo Found. German Cancer Aid Nuffield Found. DZNE Alz. Society, UK Uni of Leipzig Landesstiftung Baden-Wurttemberg Nutricia Research Found. Hans und Ilse Breuer Stiftung Hartmann Muller Found. WOS Krakow, Poland ISAO EPSRC Brain Research T Australian National Institute ... Prinses Beatrix Fonds Neuroscience Research Charitab... Uni of Ulm Ferring Pharmaceuticals Inc UK Ministry of Justice Brain Exit Scholarship Leiden Uni Shirley Found. Uni of Nottingham GACR Estonian Science Found. Grant Gatsby Charitable Found. Robert Bosch Found. Uni of Rotterdam Cambridge Overseas Trust redIAPP Age UK Gerencia Regional de Salud de ... Autistica Fondation Leducq Uni of Salamanca Action on Addiction NCCR Hungarian Ministry of Health Dutch Brain Association Ludwig Boltzmann Institute of ... RFBR VWS RIED EPFL NHF World Bank WICN Romanian Ministry for Educatio... Institute of Psychiatry Uni of Southampton WORD Welsh Assembly Govt. RIDE NEURODE SINAPSE ECNP MS Society of Great Britain an... Slovenian Ministry for research Netherlands Brain Found. UK Comic Relief BUPA Found Academy of Medical Sciences (UK) Muscular Dystrophy Campaign Uni of Glasgow TAMOP, Hungary Leverhulme Trust Universities of Tubingen Hirnliga Amsterdam Brain Imaging Platform Research Councils UK Fellowship CIBM Henry Smith Charity & Epilepsy... Czech Science Found. Christian Medical College Mind Science Found. NPSA, UK Hersenstichting La Sapienza Uni Glasgow Centre for Population ... Fondation Jerome Lejeune (Fran... AFM German Federal Ministry for Fa... British Geriatrics Society The Sophia Childrens Hospital ... RIVM NWO Municipality of Rotterdam Dutch Ministry of Defence Greek State Scholarships Found. CVZ Society for Support of Researc... Scottish Funding Council Norwegian Financing mechanism FNRS NeFF European Scientific Advisory B... Stichting tot Steun VCVGZ Center for Translational Molec... Bangor Higher Education Funding Counc... Veneto Region AIRC UK Health Protection Agency EFSD Universite de Strasbourg Sophia Found. for Medical Rese... Uni of Milan WODC Que NPRI Stanley Thomas Johnson Found. Diabetes UK Project Swiss Academy of Medical Scien... UK Centre for Tobacco Control ... Organon Uni of Liege (Belgium) CNCR Dutch National Asthma Found. Dutch Top-Institute Pharma France Erasmus Uni Medical Centre Cardiff Uni DeNDRoN Netherlands Ministry of Educat... Tech NCA AnEUploidy project PHRC Internationaal Parkinson Fonds... Uni of Helsinki Fondat Reta Lila Weston Institute for... Erasmus Medical Centre Progetto Fondazione Roma Dutch Govt. NESDA CNRS Dutch Diabetes Research Found. NISCHR CRC Innovatiefonds Zorgverzekeraars BBMRI -NL Fonds NutsOhra ARC INSERM Carnegie Found. Fonds Leon Fredericq GGZ Rivierdumen Scottish Charity Fonds Psychische Gezondheid Social Sciences Council Regio Alzheimer Nederland grant UPMC VU Amsterdam Stichting VUmc fonds K.U. Leuven Uni OZR Lentis Radboud Uni Nijmegen Medical C... Ghent Uni Hospital ANR NPRI FWO-V Flemish Govt. Stichting Dioraphte Uni of Groningen Netherlands Consortium for Hea... nEUROsyn Jeantet F Association France-Alzheimer VIB FIRB NIVEL Trimbos Institute UNESCO IQ Healthcare Dutch Cancer Society Ipsen Fondazione Cariver GGZ inGeest research Dept. BELSPO Slovak Ministry of Education Global Fund Arkin CHU Montpellier GGZ Friesland SAO-FRMA Slovak Research and Developmen... Universite Claude Bernard Lyon1 La Region Aquitaine Uni of Paris Medical Research Found. Antwerp MRES Uni of Bo IWT program Investissements davenir GGNet Uni of Torino Conseils Regionaux dAquitaine ... Uni of Tur ENGAGE project VSB Fonda NHG Neurosearch Uni Hospital of Strasbourg VEGA IREB FMRE FRC GGZ Drenthe Conseil Regional Aquitaine Eli Lilly Research MGEN AFSSAPS GGZ Mental Health Institute Utrecht Uni Ente Cassa di Risparmio Wyeth Found. GGZ Buitenamstel-Geestgronden Medical Found. Queen Elisabeth Found. Orange Fondation Plan Alzheimer Thomas Riellaerts research fund Psychiatric Association of Tur... La Fondation de France EMGO + Institute for Health an... Fondazione Cassa di Risparmio SBIC Region Ile-de-France Region Rhone-Alpes (France) Region Nord-Pas de Calais (Fra... IMPRT EDF-GDF Institut Pasteur Lille Stichting Johanna KinderFonds FRM Found. College de France Uni of Lille GGZinGeest Uni of Antwerp Dutch Alzheimers Society CIDA Dutch MS Research Found. Associa Dept. of Pharmaceutical Scienc... Maastricht Uni LUMC LECMA Council of Region Burgundy GGZ De Grote Rivieren Association France Parkinson Uni of Padua Brain Found. (The Netherlands) La Fondation pour la Recherche... Conseil General de la Giro Scientific Fund W. Gepts UZ Br... Associazione Ingeest Associazione Amici del Centro ... Altrecht Rivierduinen Dijk en Duin Academic Psychiatric Center AMC Ligue contre le Cancer Prins Clauscentrum Sittard GGZ Eindhoven GGZ Noord Holland Noord Gis - Maladies rares GGZ Midden-Brabant Mondriaan Zorggroep Meerkanten RIAGG Roermond PZ Sancta Maria Sint-Truiden RIAGG Amersfoort PC Ziekeren Sint-Truiden Dimence OPZ Rekem GGZ Noord- Midden Limburg Universitair Centrum Sint-Joze... Maastricht: GGZ Overpelt GGZ Oost-Brabant Mapping the mental health research funding landscape 25 GO Sequencing Project Mashhad Uni of Medical Sciences Robson Family Capital Group Companies Charit... Brain Mapping Support Found. Brain Mapping Medical Research... Tamkin Found. Jennifer Jones-Simon Found. SSHRC The Sidney Kimmel Center for P... Pierson-Lovelace Found. American Sleep Research Societ... North-star Fund King Pharmaceuticals Ahmanson Found. FINECO American Association of Uni Wo... Springer Anclote Found. ughlin Centre Uni of Tennessee Chulalongkorn Uni RTI International MultiHealth Systems Elgart Fund on Brain Aging Canadian Institutes for Advanc... Alliance-Biosecure Found. sway Gordon Fund for Eating Disorders LPFCH Cincinnati Childrens Hospital ... Hastings Center Herald House Case Western Reserve Uni y John Wiley and Sons Uni of New Mexico Israel Anti Drug and Alcohol A... All Childrens Hospital Researc... American Academy of Pediatrics... Brigham & Womens Hospital Endo Pharmaceuticals National Health Research and D... US AID American Medical Association Beatrice Surovell Haskell Fund... Pritzker Consortium e W W Norton Company Minster California Health Care Found. Annie E. Casey Found. New England Research Institutes Brown Uni Lippincott Williams and Wilkins Pennsylvania State Uni MMC Pediatric CJD Leadership Education in Adoles... a Memorial Foundalion Cambridge Uni Press Uni of Buenos Aires Duke Endowment Uni of Arizona RJG Found. Physicians Post-Graduate Press Global Fund Mohegan Sun Casino CME Institute/Physicians Postg... NCCDPHP West Virginia Uni Oxford Uni Press Center for Mental Health Servi... Open Society Institute KZ Baycrest Found. Uni of Arkansas Donaghue Found. Consortiuum of Multiple Sclero... FSCD WSU th Canada Aspect Medical Arizona State Uni Institute for Mental Health Re... Sage Sigma Tau Heinz Found. Kaiser Found. Research Institute Tourettes Action earch Inst... NEDA Shriners Hospitals for Childre... Uni of Nebraska Govt. of Ontario Brigham Young Uni Charles Hood Found. Pharma Neuro Boost National Academy of Neuropsych... Allon US Dept. of Education Klarman Family Found. NDSEG Purdue State of Florida Northwestern Uni NIOSH Adelson Medical Research Found. Uni of Cincinnati . Uni of Calgary Indiana Uni CTSI G. Harold and Leila Y. Mathers... Obsessive Compulsive Found. MICHR OBSSR Oregon Health and Science Uni American Legacy Found. American Psychiatric Publishing National Sleep Found. International OCD Found. Xavier Uni COGEND Commonwealth Fund CEM GENEVA Coordinating Center Neuronetics Inc Betsy and Jonathan Blattmachr ... TRF ASLA NIDRR GENEVA pi Fran and Ray Stark Found. Fund... CCFA Uni of Toronto Thrasher Research Fund Dept. of Education ARCS Found. Harvard Catalyst Atkins Found. FAMRI dation Institute for Research on Gamb... David Judah Fund The Spencer Found. National Institute of Justice Uni of Colorado New York Uni Uni of Iowa Michigan State Uni MOHLTC Sir John Templeton Found. Genentech Uni of Alabama Hogg Found. for Mental Health Peter F. McManus Charitable Tr... AGRE Uni of Manitoba WM Keck Found. John Merck Scholars Fund ATSDR Sidney R. Baer Leonard Levy Found. Sexual Medicine Society of Nor... California HIV/AIDS Research P... Uni of Georgia Office of juvenile Justice and... Bowman Family Found. award Price Found. National Center for Injury Pre... DSRTF VHA Career Development Award undation Guilford Press Greenwall Found. Faculty Childrens Hospital of Philadel... State of Connecticut Childrens Hospital Boston Uni of Minnesota Trichotillomania Learning Centre NHGRI Ontario Graduate Scholarship Breast Cancer Research Found. Mahidol Uni Hilda and Preston Davis Found. Stanford Uni Uni of Miami Blue Cross Blue Shield of Mich... Uni of Florida HNRC CFAR NIH American Nurses Found. Louisiana Board of Regents grant MCHB Highland Street Found. Ohio State Uni Shirley and Jack Goldberg Trust Uni of South Florida The Gerber Found. Clinical Science Research and ... Teva Uni at Buffalo GCRC Abdi Ibrahim Josiah Macy MIND Research Network USUHS National Football League Chari... Univeristy of California Autism Consortium of Boston APF CMS Kane Family Found. Klingenstein Found.s Arkansas Biosciences Institute Cousins Center for Psychoneuro... NIDA Office of AIDS Research CTSA New York Community Trust NSERC Loyola Uni Environmental Protection Agency CFI Doris Duke-Charitable Found. Diana Helis Henry Medical Rese... PHS Belmont Connecticut Mental Health Center Hartwell Found. CIDAR CDPH Carman Trust US Administration on Aging Charles A. Dana and Buster Fou... Uni of Connecticut DOE Clinical Neurosciences Divisio... . IDDRC NIDCR ARRA Philip Morris-USA Kessler Found. Research Center PEPFAR DVBIC Ford Found. David and Lucile Packard Found. Cornell Uni ONDCP MIC State of Michigan CAMH AFTD CTSA Hospira The SCAN Found. NABI Biopharmaceuticals Pittsburgh Found. Joseph Drown Found. Uni of Kentucky Uni of Ottawa Attias Family Found. NKT R&D China DHS CDC NCATS Nancy Kirwan Heart Research Fund NIGMS Uni of Oklahoma Medical College of Wisconsin Forest NHTSA Henry M. Jackson Found. for th... National Institute for Mental ... US NSF Commonwealth of Pennsylvania D... IMHRO UCI ALSAC Uni of Pittsburgh Sidell-Kagan Found. Mount Zion Health Fund Massachusetts General Hospital Pittsburgh Claude D. Pepper Ol... Uni of Louisville of Vermont NIMHD AACAP Sanchez Found.s Arthritis Found. Burroughs Wellcome Fund Uni of Southern California Keck Found. Koret Family Found. Robert Packard Center for ALS ... Bowles Center for Alcohol Stud... RMC Prechter Found. John W. Alden Trust NYCDOHMH Weinberg Found. Uni of South Carolina JPB Medical Found. Fundacion INECO Ischemia Research and Educatio... Rush Uni VCU NIPI NCI Medical Research Service of th... McBean Family Found. DHHS ACISR UNC NCCAM Mount Sinai School of Medicine Research Retirement Found. State of Texas American Cancer Society olumbia Uni NCRR Oklahoma Center for the Advanc... MSFHR NIAID Uni of Houston US Govt. American Diabetic Association MIND Institute Uni of Rochester Jane Botsford Johnson Found. UNAM-DGAPA-PAPIIT Uni of Chicago BSF NEI Johns Hopkins Uni Jewish Community Federation of... UIC Alfred P Sloan Research American Geriatrics Society USEPA Epilepsy Research Found. of Am... Uni of Wisconsin James A. Haley Veterans Hospital Uni of Malaya Litebook Company Ltd Brookdale Found. Uni of Massachusetts Rochester Epidemiology Project Fragile X Found. Hellman Family Found. Larry L Hillblom Found. Boston Uni Vanderbilt Uni Leukemia&Lymphoma Society State of Connecticut ADRC Huntingtons Study Group Peter Emch Family Found. RWJF Ortho McNeil Starr Found. ADRC Muscular Dystrophy Association... University of California Genzyme Irish Govt. Ban-bury Fund Barnes- Jewish Hospital Found. Science Found. Arizona CURE Foundation NIAAA Yerkes Research Center CRCM CTCRI Uni of Missouri Hope Center for Neurological D... USA Banner Alzheimers Found. Harvard Uni Research to Prevent Blindness ... Uni of Kebangsaan Malaysia Uni of Virginia Washington Uni MacArthur Foundation Uni of Kansas New York State Dept. of Health Woodruff Fund Uni of Pennsylvania Johnnie B. Byrd NHLBI Multiple Sclerosis Society AFSP Uni of Maryland Ellison Medical Found. McKnight Research Found. SFARI Hillblom Found. CurePSP Found. Mangurian Found. International Parkinson Found. DNI Norwegian Cancer Society Brain Research Found. NIAMS Irish Life plc CIRM Donald W. Reynolds Found. Uni of Toyama Feinstein Institute for Medica... Baylor College of Medicine Anonymous Medical Found. State of California CART Foundation AHA NLM ONR Helen Bader Found. Cleveland Found. Icelandic Heart Association FONDECYT Atlantic Philanthropies US Social Security Administrat... Autism Speaks USA Trustees of the Blanchette Hoo... Stephen D. Bechtel AFaR Tau Research Consortium Elan ADCS FONDAP Amgen Banner Sun Health Research Ins... Irma T. Hirschl Award ADAA AAQI FIRCA FRAXA Research Found. U.S. Navy Bureau of Medicine a... Berkman Charitable Trust Heinz C Prechter Bipolar Resea... Barrow Neurological Found. John Douglas French Alzheimers... State of Arizona ALS/CVS Therapy Alliance NASA NCC American Parkinson's Disease A... Wallace Research Found. NIBIB BBRF HFSP UGC, India IEDC Biogen Found. for Physical Therapy MOHE, Malaysia Prescott Family Initiative of ... The William and Flora Hewlett ... American Academy of Neurology ... Found. Synapsys NLMFF BrightFocus Found. Commonwealth of Kentucky Resea... Robert and Clarice Smith Fello... JDRF Gilead FONDEF HDRF CSIR, India BHARE Foundation Extendicare Found. Colciencias Arizona Biomedical Research Co... NIMH MES ADRC ion Boehringer Ingelheim Arrillaga Found. Ministry of Health Glenn Found. for Medical Resea... DST, India USDA ICMR Dana Foundation Research Institute of the Norw... Northern California Institute ... Alz Assoc. CHDI Arizona Dept. of Health Services Wyncote Found. American Australian Association Silvio O. Conte Center St. Jude Medical Inc. anofi NIEHS Washington State Uni Robert A. Welch Found. Grant MIFAB Illinois Dept. of Public Healt... Ronald Philip Griffith Fellows... Wake Forest Uni VicHealth CONICYT ANU yal Society Wolfson Merit Aw... Singapore Millennium Found. National Medical Research Coun... March of Dimes USA Cancer Council of Victoria New South Wales Health New York State through Office ... Siemens AHAF Oregon Clinical and Translatio... Skaggs Institute for Chemical ... Queensland Dept. of Health SRI National Palliative Care Resea... MJ Fox Foundation Bill and Melinda Gates Found. Fidelity Found. German Parkinsons Disease Asso... Regional Health Research Found... Autism Research Institute Roskilde County Geelong Region Medical Researc... AZ Fondazione IDEA AFOSR ni Maryland Stem Cell Research Fund Danish National Board of Health NIA Solvay Victorian State Govt. Research Capacity Building Grant Aalborg Psychiatric Hospital Uni of Sydney Aus Govt. Dept. Health Medivation Inc MC National Council for Mental He... Israeli Ministry of Health Bayer Nepean Medical Research Found. Norwegian Ministry of Health a... Baxter Neurosciences Victoria Dainippon-Sumitomo Pharma Uni of Melbourne Monash Uni Defense Science and Technology... Theodore and Vada Stanley Found. Viertel Charitable Found. Victorian Trauma Found. general The Mason Found. Helsefonden Swiss Federal Office of Public... SMRI Community Pharmacy Found. OA Akershus Uni Hospital Beckley Found. Norwegian Directorate of Healt... Robert C. Borwell Endowment Fund USM Kempe Found. A*STAR Aust. Rotary Health EHDN Norwegian Uni of Science and T... Western Norway Regional Health ANZ Mason Foundation Swiss Alzheimers Disease Assoc... APF Danish Research Council Uni of Adelaide FONACIT B Uni Hospital Basel Uni of Wollongong Woods Family Trust Norwegian Found. for Health an... Victorian Health Promotion Fou... and Mental Health Victorian Neurotrauma Initiative KCL Sackler Found. GE-Healthcare Uni of Zurich Macquarie Group Found. New South Wales Dept. of Healt... Hunter Medical Research Instit... Danish Health Insurance Fund Norwegian Parkinson Disease As... HDSA Reckitt Benckiser MNDRI Australia Merck Royal Brisbane and Womens Hosp... Neuroscience Research Australia Innlandet Hospital Trust resea... Colonial Found. ARC Takeda Ministry of Science Technology... Eisai Wyeth Macquarie Uni Foundation of NIH ESRC UK Uni of Bergen ANZ Charitable Trust Ramsay Health Care Australia Flinders Uni Josef and Haldis Andresens Legat Helse Vest RHF PhD grant F FES Uni of Muenster GIF AR UK Fondazione Gaetano e Mafalda L... St. Patricks Uni Hospital Dublin Swedish Dept. of Higher Educat... Ian Potter Found. South-East Norway Health Autho... Norwegian Council for Mental H... FaHCSIA Olga Mayenfisch Found. ASRB Deakin Uni Uni of Queensland RHA Uni of Newcastle Pratt Found. Ludvig og Sara Elsass Found. Norwegian Womens Public Health... Australian Govt. Aachen Uni nstitute of Tec... DVA Wenner-Gren Found. APA UK DH National Heart Found. of Austr... Cancer Council NSW Helen Macpherson Smith Trust J. O. and J. R. Wicking Trust Danish Medical Association Res... Singapore General Hospital Uni of Konstanz Velux Found. Switzerland Alzheimers Australia Dutch Kidney Found. Australian Brewers Found. NRC Centre of Excellence for Alzhe... Rebecca L. Cooper Medical Rese... MRC UK Uni of New South Wales Parkinsons Disease Society UK nck Society APHCRI Healthway Norwegian Institute of Public ... Uni of Tromso Alcohol Education and Rehabili... FKK Biomedical Research Council Liaison Committee Uni Mental Health Research Ins... NSW Institute of Psychiatry Re... South Australian Dept. of Health er and Gamble Pharmaceuti... Helmholtz US Agency for Health Care Poli... Uni College London Augustinus Fonden Centre for Child and Adolescen... Servier CRUK Uni of Oslo CSIRO Austin Hospital Medical Resear... BRACE Danish Medical Research Council Dementia Research Fund of the Central D... Uni of Singapore British Health and Safety Exec... Uni of Cambridge BioMarin RCUK Danish National Psychiatric Re... UWA Uni of Aarhus Scottish Govt. Bernard Wolfe Health Neuroscie... chester McCusker Found. American Epilepsy Society Murdoch Childrens Research Ins... John and Birthe Meyer Found. Egmont Found. Leenaards Found. Switzerland Charles Wolfson Charitable Trust Brain Resource Stanley Center for Psychiatric... Ministry of High Education and... Danish Ministry of the Interio... MIUR National Assembly for Wales ator Award HSE, Ireland SIEF Danish Agency for Science Ivan Nielsens Found. Tryg Fonden Raine Found. for Medical Resea... FAS Worzner Found. National MS-Society iDEA AusAID Health Insurance Found. Dunhill Medical Trust Bank of Sweden Tercentenary Fo... Uni of Copenhagen Research Council of Lithuania Italian PRIN 2007 Komen Breast Cancer Found. Award Aase and Ejnar Danielsens Fund Uni of Western Sydney ERAB EU Jack Brockhoff Foundation Uni of Edinburgh Women and Infants Research Fou... NOVO Nordisk Found. Danish Cancer Society Research... Danish Council for Independent... Trust Dagmar Marshalls Fund Swedish Prison and Probation S... Innovative Medicines Initiative ERC Cancer Council of Queensland Enterprise Ireland Myer Found. Ulleval Uni Hospital Spanish Ministry of Social Aff... Curtin Uni of Technology SRC Uni of Sheffield Norman Collisson Found. Lundbeck Foundation Danish Heart Found. Danish Working Environment Res... Copenhagen Uni Hospital Danish Ministry of Health and ... Uni of Oxford HUBIN Project PSP association Uni of Bologna Knut and Alice Wallenberg Found. Danish Centre for Evaluation a... Copenhagen Council Research Fo... Pears Found. Royal College of Physicians/Du... Uni of Amsterdam Beckett-Found. Uni of Tasmania Novo Nordisk Swedish Society for Medical Re... RAS A.P. Moller Found. Royal Swedish Academy of Scien... IRCSET EM Cymru Telethon Conseil General des Alpes-Mari... International College of OC Sp... Swedish State Support for Clin... Clothworkers Found. d. Mother and Child Found. Wallenberg Found. Linkoping Uni Hospital Manchester Mental Health and S... Stockholm Stress Centre Reta Lila Weston Trust for Med... AHRC UK FRM Italian Ministry of Health Swedish Parkinson Found. Wolfson Trust Uni of Lausanne Soderstrom Konigska Found. Sahlgrenska Academy Shiraz Uni Hjarnfonden Telstra Research Found. Swedish Childrens Cancer Fund Regione Lombardia Uni of Catania Bettencourt-Schueller Found. SIDA National Board of Forensic Med... Alz. Foundation, Sweden SNF ESF ALF Migraine Research Fund y Swedish Childhood Cancer Society Fondazione Cariplo Handlanden Hjalmar Svenssons F... Queensland Uni of Technology Uppsala Uni French Ministry of Education a... Karolinska Inst. Movement Disorder Society Swedish National Board for Hea... Stiftelsen Gamla Tjanarinnor Federazione Italians Giuoco Ca... IRCCS r Uni Istituto Superiore di Sanita Swedish National Institute of ... European Federation of Neurolo... VINNOVA Italian Institute of Technology Bror Gadelius Fund DCRC2 ARSEP, France eensland State Govt. Adlerbertska Research Found. Academy of Finland Swedish Brainpower Swedish Brain Found. Hjalmar Svenssons Found. Thurings Found. Soderberg Found. FONDATION FYSSEN Imperial College London Wilhelm and Martina Lundgren R... Vardal Research Found. Swedish federal Govt. Gun and Bertil Stohnes Stiftelse Swedish Found. for Strategic R... Umea Uni hnology Strategy Board Gran... ECU La Trobe Uni Axel Linders Stiftelse Sjobring Fund Svenska Lakaresallskapet Medical Research Council of so... The Nicol Found. tion FondaMental Sir Charles Gardner Hospital Lund Uni Torsten och Ragnar Soderbergs ... Uni of Cologne Uni of Padova Marta and Nicke Nasvell Found.... Goteborg Medical Society Brain Found. ACT Health NHR AriSLA Fondazione CARIPARO Kuopio Uni Hospital Sigrid Juselius TUBITAK Ake-Wiberg Found. Demensfonden Linnea and Josef Carlsson Found. Sallskapet Bar-navard Uni of Oulu one-Piemonte Ingabritt and Arne Lundberg re... Compagnia di San Paolo Torino ... Monzino Found.s FISM CNR SRA Finnish Found. for Alcohol Stu... Swedish Psychiatry Found. Swedish Medical Society Istanbul Uni Finnish Work Environment Fund Gustav and Victoria Found. Nordic Centre of Excellence in... Skane county councils research... Found. Italian Telethon Found. AFA Insurance Company RNM Biocenter Finland Albert Pahlsson Found. CogState Ltd Loo och Hans Ostermans Found. Bertil Hallstens Forskningssti... CNAMTS Tekes Swedish Royal Bank Tercentenni... Ahlens Found. rona Lindhaga Found. AXA Research Fund Trolle-Wachtmeister Found. for... Uni of Eastern Finland Magnus Bergvall Found. AfAR Crafoord Found. Canberra Hospital Specialists ... Swedish Heart Lung Found. Regional Govt.s of Aquitaine cNEUPRO Finnish Cultural Found. Austin Health Solstickan Found. Jalmari and Rauha Ahokas Found. ordeaux Sapienza Uni of Rome Social Insurance Institution Sweden Royal Physiographic Society Gillbergska Found. EVO grant (Finland) Yrjo Jahnsson Found. rku Polish State Committee for Sci... Gothenburg Dental Society Health Committee, Vastra Gotal... UniGe FORSS KI Found.s Finnish-Swedish Medical Associ... Signe and Ane Gyllenberg Found. Stiftelsen Psykiatriska Forskn... Lars Hierta Memorial Found. Emil Aaltonen Found. Found. Juho Vainio Found. Finnish Medical Found. Research Found. for the Orion ... Stiftelsen Olle Engkvist Byggm... First of May Annual Flower Cam... Ella and Georg Ehrnrooth Found. Regione Toscana Health Authority EuroBiobank Ministry of Social Affairs and... Sven-Jerring Fond Found. Progetto Regione Lombardia City of Kuopio Tehran University of Medical S... Fondazione Mariani Estonian Govt. Regione Piemonte Paivikki and Sakari Sohlberg F... Ing. Cesare Cusan Uni of Ferrara THL, Finland Finnish National Graduate Scho... Jenny and Antti Wihuri Found. ... Finnish Diabetes Research Fund Paulo Found. Finnish Ministry of Education ... Finnish Found. for Pediatric R... Finnish Medical Society Pirkanmaa Hospital District Re... The Helsinki Biomedical Gradua... Tampere Uni ation pour la Recherche ... Uni of Tampere Paavo Nurmi Found. Programma Strategico Finnish Found. for Cardiovascu... Finska LAkaresAllskapet Finnish Dental Society Finnish National Graduate Scho... Finlands Slot Machine Associat... onde Alma and K.A. Snellman Found. e per la Ricerca su... Maire Tapola Found. Finnish Child Psychiatric Rese... Folkhalsan Research Found. Saud Uni p Council ou... KACST Qatar National Research Fund-Q... Arvo and Lea Ylppo Found. Samfundet Folkhalsan in Finland Tampere Tuberculosis Found. Hong Kong Polytechnic Uni 26 Mapping the global mental health research funding system Figure 2-17 Network of co-acknowledged funders – neurodegenerative and cognition disorders (coloured by modularity class) National Key Technologies R&D ... NSFC BBRF ADNI MEST Korea NSERC A*STAR James S McDonnell Foundation US NSF Dana Foundation NIDA ADDDF State of Arizona NRF Korea ARC Pacific Alzheimer Research Fou... 973 China NIBIB US PHS CIHR NHMRC CNRS FRQS MHW Korea DOE NIDCD NIGMS MEXT SFI Larry L Hillblom Foundation HDSA NIAID University of California US DOD John A. Hartford Foundation JSPS CNPq Brazil Lilly VWS Novartis FIS FONDECYT ISAO Alz Assoc. MINECO MICINN ERC Kuopio University Hospital Karolinska Institutet AR UK EU AFI Swedish Alzheimer Association NIHR BBSRC ALF, Sweden Stiftelsen Gamla Tjanarinnor FWO-V Flemish Government GSK CIBERNED Michael J Fox Foundation for P... EPSRC MEC, Spain IUAP, Belgium NRC FAS Sweden BHF UK SRC Gun and Bertil Stohnes Stiftelse Alzheimer Foundation in Sweden ESRC UK DST, India NHS England UK Department of Health Academy of Finland Roche Research Foundation Mayo Alzheimers Disease Resear... CONICET NWO Lundbeck NSC Taiwan FCT Portugal Mayo Clinic Foundation AHA PHRC DFG MRC UK CHDI FAPES CAPES FRM Swedish Brainpower CONACYT Association France-Alzheimer Ministry of Science and Higher... NIA NIMH MHLW Japan NINR NHLBI Eisai MIUR Ricerca Finalizzata and Ricerc... AHAF John Douglas French Alzheimers... ASC Alzheimer Society, UK ADRC VA INSERM NIH Merck Janssen WT NINDS DHHS ANR Canada Research Chair AFaR NCI BMBF Alzheimers Australia NICHD NCRR SNSF Pfizer HDF USA Mapping the mental health research funding landscape 27 Figure 2-18 Network of co-acknowledged funders – depressive, anxiety and personality disorders (coloured by modularity class) MacArthur Foundation FIRCA RWJF NINR US PHS Pfizer Foundation NIDA NIA NINDS Ministry of Health MICINN NIH VA Academy of Finland SNSF GSK MIUR MHW Korea Pfizer NIMH MRC UK NSFC VU Amsterdam, Netherlands NHS England US NSF US DOD NIHR ESRC UK NIAAA DHHS MEXT FIS NCRR EU MHLW Japan US CDC NICHD NCI NRC NHLBI PAHO 973 China CIHR AFSP Lundbeck Novartis FRQS Roche Research Foundation Canada Research Chair SRC OMHF Lilly FAPES SMRI BBRF NCCAM NSC Taiwan BMBF AstraZeneca CNPq Brazil Lundbeck Foundation FAS Sweden NWO NHMRC CAPES DFG WT 28 Mapping the global mental health research funding system Figure 2-19 Network of co-acknowledged funders – substance use and addictive disorders (coloured by modularity class) NCI US CDC NCRR FIRCA RWJF NICHD NIMH MHLW Japan DHHS NIAAA MEXT Academy of Finland Pfizer Cancer Research UK US PHS VA University of California NIAID BBRF NWO ESRC UK NIHR WT MRC UK WHO BMBF GSK EU Australian Govt. CIHR NSC Taiwan NIH ABMRF MSFHR MEC, Spain FAS Sweden CNPq Brazil NHMRC SRC SNSF FIS NSFC ARC DFG MICINN NIDA NIA Mapping the mental health research funding landscape 29 Figure 2-20 Network of co-acknowledged funders – neurodevelopmental disorders (coloured by modularity class) Lilly ESRC UK WT NIHR NSERC CNPq Brazil ARC Shire NSFC CIHR NHS England JSPS NICHD MEXT NIDCD SFARI MHLW Japan MRC UK BMBF US NSF US CDC NIH MICINN NHMRC NWO DFG Autism Speaks NCRR BBRF INSERM FWO-V DHHS ANR VA NSC Taiwan FIS Telethon NAAR Autism Research Institute EU SNSF NIMH NIDA Academy of Finland NIAAA MIUR NIEHS SRC NRC NINDS 30 Mapping the global mental health research funding system Figure 2-21 Network of co-acknowledged funders – schizophrenia, bipolar and other psychotic disorders (coloured by modularity class) Lundbeck NRC Janssen Academy of Finland Lilly BMS NSC Taiwan SRC US PHS VA AstraZeneca Roche Research Foundation BMBF MHW Korea Pfizer MIUR NIMH MICINN EU NCRR NIH Harvard University DHHS NIDA NIA FRQS SRI GSK MEXT NHS England JSPS NWO CNPq Brazil MHLW Japan NHMRC MRC UK PHRC INSERM SNSF CAPES OMHF DFG NIHR CIHR 973 China SMRI NSW Health, Australia NIAAA FIS NSFC Lundbeck Foundation BBRF WT Mapping the mental health research funding landscape 31 Figure 2-22 Network of co-acknowledged funders – “Adolescent”, “Child”, “infant” and “young adult” categories in MeSH (coloured by modularity class) NINDS NIDDK US NSF DHHS NIDCD SFARI SSHRC US CDC Canada Research Chair Harvard University Yrjo Jahnsson Foundation University of California NSERC CIHR OMHF NIAAA AstraZeneca PHRC BMS Lundbeck Autism Speaks Merck ESF NWO GSK NIA NIMH KCL NSFC NHS England National Key Technologies R&D ... Victorian State Government MIUR MEXT ALF, Sweden UK Department of Health Cancer Research UK SMRI 973 China CNPq Brazil NSC Taiwan Telethon Australian Govt. Australian Rotary Health MRC UK DFG ESRC UK FIS ARC FAS Sweden BMBF NIHR WT MHLW Japan NHMRC MHW Korea JSPS Janssen MICINN Fundacion Alicia Koplowitz, Sp... Lilly PAHO HRC WHO Colonial Foundation Pfizer Pfizer Foundation FAPES CAPES MEC, Spain EU US PHS CONACYT Autism Research Institute Roche Research Foundation Karolinska Institutet HRB of Ireland Scottish Govt. FIRCA RWJF NIH VU Amsterdam, Netherlands University of Groningen University of Michigan NIDRR ERC BBRF NCI MacArthur Foundation MSFHR Finland FWO-V SNSF Johns Hopkins University SAMHSA MRC FRQS INSERM NIEHS NIDA VA Tourette Syndrome Association Shire NIAID NINR Academy of Finland NRC NICHD University of Minnesota NCRR AFSP US DOD NHLBI SRC MEST Korea 32 Mapping the global mental health research funding system Figure 2-23 Network of co-acknowledged funders – “Aged” and “middle aged” categories in MeSH (coloured by modularity class) MRC UK BHF UK NWO Academy of Finland University of Helsinki FAS Sweden Cancer Research UK Karolinska Institutet CHDI FWO-V WHO MEXT MICINN Roche Research Foundation ASC Lilly MHLW Japan University of Michigan Pfizer Foundation US PHS FIRCA FAPES NIAMS Johns Hopkins University American Cancer Society HRC AFaR SAMHSA NIDDK NIDCD US NSF Harvard University NIDRR Commonwealth of Pennsylvania D... NICHD NIBIB ADRC NIMHD National Key Technologies R&D ... Forest BBRF Larry L Hillblom Foundation MRC AFSP ARC Australian Rotary Health Australian Govt. JSPS PAHO NINDS NIAAA AstraZeneca ADNI MEST Korea University of New South Wales NIDA CAPES Dana Foundation Merck MEC, Spain Sanofi NHLBI OMHF MIUR Wyeth Janssen Canada Research Chair NIA Pfizer European Social Fund MHW Korea CNPq Brazil NSERC NIH PHRC Ricerca Finalizzata and Ricerc... SMRI Department of Health, Taiwan NRF Korea NSC Taiwan Swedish Brainpower Novartis NHMRC SSHRC FCT Portugal GSK Finnish Cultural Foundation KCL MSFHR EPSRC Mayo Clinic Foundation Lundbeck Foundation INSERM MacArthur Foundation Alz Assoc. Stiftelsen Gamla Tjanarinnor ALF, Sweden BMBF BMS AR UK UK Department of Health DFG SNSF WT CIHR Alzheimer Society, UK Gun and Bertil Stohnes Stiftelse SRC Swedish Alzheimer Association FIS BUPA Foundation UK ISAO VU Amsterdam, Netherlands Lundbeck FRM Scottish Govt. NHS England FRQS ESF Michael J Fox Foundation for P... EU ANR BBSRC NRC VWS NIHR ESRC UK University of Groningen NIMH NINR 973 China US DOD John A. Hartford Foundation RWJF University of California 863 China NIAID NCCAM NSFC DHHS US CDC AHA VA University of Hong Kong NCI NCRR Chapter 3 What does the future hold? Key points 1.Most funders we spoke to expressed a desire to widen existing collaborations and develop new relationships and some discussed particular research areas which they plan to prioritise. 2. Some funders talked about plans to increase their evaluation activities beyond measuring immediate outputs, while none expressed plans to decrease evaluation. 3. Challenges were highlighted in relation to: • Maintaining funding levels, in light of a decline in industry support and pressure on public spending. • Working in a field which is complex and fragmented, both in terms of the stakeholder groups involved and the research areas and approaches employed. • Translating research into practice and effectively scaling up the resulting interventions. 3.1 Overview of deep dives We carried out in-depth reviews of a sample of funders to explore current practices and future plans, in terms of amounts, types, mechanisms and areas of funding (as described in Section 1.2). Our aim in selecting this sample was to cover the major funders globally, as well as in Canada and the UK specifically, while at the same time ensuring diversity in the organisations covered. Our set of 32 profiles comprises organisations of different sizes; from government, charitable and industry sectors; focused on different types of research (basic, applied, translational, health services, etc.); of different ages; and with different ways of working. In addition, all willing members of the International Alliance of Mental Health Research Funders were covered. The organisations 4. Opportunities identified included: • Increasing collaboration, including working with different stakeholder groups and across sectors. • Developing shared definitions and classification systems to promote collaboration and facilitate advocacy. • Capitalising on mental health being a priority area for some governments. • Developing a key role for non-governmental funders in taking a long-term view on priorities and filling gaps in funding. • Using new technologies, such as new research tools and data sharing platforms, to support the researchers they fund and facilitate collaboration and shared working. included are set out in Table 3-1 (asterisks indicate members of the International Alliance of Mental Health Research Funders, as of April 2015). The deep dive profiles were built up from interviews, desk research and analysis of the bibliometric data. We looked at aspects of research funding including areas and mechanisms of funding, collaborations, evaluation practices and strategy development, in each case looking at both current practices and future plans. The full set of funder profiles has been published alongside this report, while the interview protocol used is provided in Appendix A. Six cross-cutting themes emerged from our analysis. The first of these (research areas and definitions) was a topic we planned to explore further with funders from the outset, given the challenges we faced in the first phase of this study in defin- 34 Mapping the global mental health research funding system Table 3-1 Funders included in deep dive profiles Funder Location Sector Research focus 1 AIHS * Canada Government Health general 2 Alz Association US Charity/ Foundation/ Non-profit MH condition 3 BBRF * US Charity/ Foundation/ Non-profit MH general 4 Beyondblue Australia Charity/ Foundation/ Non-profit MH condition 5 BHF UK Charity/ Foundation/ Non-profit Other non-MH area 6 BMBF Germany Government General 7 CIHR * Canada Government Health general 8 CNPq Brazil Brazil Government General 9 ERC EU Government General 10 ESRC UK Government Non-health 11 Fondation FondaMental * France Charity/ Foundation/ Non-profit MH general 12 FRQS * Canada Government Health general 13 GBF * Canada Charity/ Foundation/ Non-profit MH condition 14 Grand Challenges Canada * Canada Government Health general 15 Lundbeck Foundation * Denmark Charity/ Foundation/ Non-profit Health general 16 MHRUK UK Charity/ Foundation/ Non-profit MH general 17 Movember * Australia Charity/ Foundation/ Non-profit Health general 18 MQ * UK Charity/ Foundation/ Non-profit MH general 19 MRC UK Government Health general 20 NHMRC * Australia Government Health general 21 NIDA US Government MH condition 22 NIHR * UK Government Health general 23 NIMH * US Government MH general 24 NSF US Government General 25 OBI Canada Government MH general 26 OMHF * Canada Government MH general 27 Pfizer US Industry Health general 28 Stanley Medical Research Institute US Charity/ Foundation/ Non-profit MH condition 29 VA US Government Health general 30 Wellcome Trust * UK Charity/ Foundation/ Non-profit Health general 31 YAWCRC * Australia Charity/ Foundation/ Non-profit MH general 32 Zon MW Netherlands Government Health general What does the future hold? ing the mental health field. The other five themes emerged from a cross-cutting analysis of the deep dive reviews as the topics which seemed the most pertinent in the field at this time. The six themes are: i. Research areas and definitions As noted above, there is no agreed definition of mental health, although a number of diagnostic or research classification systems exist. This theme looks at funders’ reasons for using (or not using) a particular definition and compares their portfolios of research by topic, as found in our data set. ii. Attitudes to collaboration While conducting research is becoming increasingly collaborative, less is known about collaboration between funders. This theme explores funders’ attitudes to different kinds of collaboration in mental health and considers some of the opportunities and challenges associated with collaborative working in this area. iii. Types of funding Research funders support research through a variety of funding vehicles (grants, fellowships, etc.) and differ in the degree to which they specify research topics and aims. This theme discusses the types of funding provided by funders in our sample and highlights a number of examples of less common practices in the field. iv. Strategy development The funders in our sample vary in how they develop and implement their strategies. This theme considers some of the ways in which strategies differ, including their level of formality, how broad or targeted they are and the stakeholders involved in their development. v. How funding decisions are made Deciding which research applications to support is an important and often resource-intensive task for funders. This theme looks at the decision-making processes used by the funders in our sample, including the kinds of criteria used and the stakeholders involved. vi. Evaluation practices Most research funders carry out some evaluation of the research they fund. This theme summarises the range of approaches employed by funders in our sample, in terms of their reasons for evaluating, the indicators and methods they are using and their future plans in this area. 35 These themes have been written up as a set of six short analyses, each discussing the range of practices observed across our set of 32 funders. They are provided alongside this report to accompany the deep dive profiles (available at www.randeurope. org/mental-health-ecosystem). In the sections that follow we focus on future plans, challenges and opportunities, summarising information collected for the funder deep dives from interviews and document review. 3.2 Views on the future An important part of the deep dive profiles was to explore the future plans of our sample of funding organisations. In doing so we hoped to be able to highlight areas of complementarity and potential collaboration, as well as compare the anticipated challenges and opportunities of organisations of different sizes and in different sectors and countries. The interviews revealed that among many funders, particularly government agencies, there is uncertainty around the level, distribution and research focus of future funding, often due to an obligation to align with potentially-shifting government priorities or a dependency on uncertain funding allocations. Nevertheless, some organisations did highlight areas of focus for future investment. Funders including MQ in the UK and CIHR in Canada mentioned a greater emphasis on youth mental health, something which is already a priority area for some of the other funders in our sample (e.g. the Graham Boeckh Foundation, Young and Well CRC). Given the early age of onset of many mental health conditions, this is consistent with an increasing focus on the prevention of mental illness, as mentioned by others including beyondblue. Another area of growing interest is the use of technology in mental health, both in terms of the potential benefits for research of advances in big data and bioinformatics and in relation to e-health and the development of technology-based treatments. The importance of new technologies is discussed further below. Most funders we spoke to plan to expand current collaborations with other funding organisations and develop new relationships. In some instances, such arrangements were seen as a way to extend an individual organisation’s reach (e.g. OMHF), while in others, and particularly in relation to collaborations with private sector organisa- 36 Mapping the global mental health research funding system tions, they were seen as a valuable way of diversifying the research funding base and potentially facilitating translation of findings to practical application (e.g. AIHS, CNPq, NIDA). Challenges relating to both funding and research translation are discussed further below. The final area in which a number of organisations discussed concrete plans was the expansion of evaluation practices beyond measuring outputs. This was mentioned by a range of government and charitable funders in the United States, Canada, Australia and Europe. An increasing emphasis internationally on demonstrating impacts beyond the generation of knowledge has created a pressing need for both researchers and funders to think beyond traditional academic outputs, but measuring downstream impacts, which often occur over long timescales, across a broad portfolio of funded work is not a straightforward task. The challenges in linking impacts to specific funding are discussed further in Chapter 4. Challenges are anticipated in relation to funding, the diversity of the field and research translation Funding organisations globally are facing challenges in maintaining (sufficient) funding for mental health research, with the largest mental health-specific funder in the world, NIMH, commenting that it has lost more than 20 per cent of its purchasing power in the past ten years. Several organisations mentioned the importance of protecting funding by engaging government and demonstrating the potential benefits of mental health research, while others mentioned the crucial role that other sectors can play. In particular, many highlighted the need for greater private sector funding to offset reduced government support, while also noting that, in contrast to this, the trend has been for investment from the pharmaceutical industry to decline in recent years (e.g. Insel & Gogtay 2013). Limited resources also create the challenge of how best to allocate funding, with some organisations finding it challenging to make decisions on which areas are most likely to produce the greatest benefits and how to balance their portfolios between, for example, research focused on treatment versus prevention, or between pharmacological and psychosocial approaches to therapy. The challenges of allocation and selection are accentuated by the diversity of the mental health field and the complexity of the issues that research is trying to address. Often the precise mechanisms underlying particular conditions are unknown, meaning that the most promising research targets or approaches are unclear. As shown in our analysis in Chapter 2 and in the deep dive profiles, research from many different areas can be relevant to mental health and the funding organisations supporting such work vary in their scale, remit and approach. This fragmentation, along with silos and barriers between different groups of stakeholders, creates challenges in maintaining an awareness of the current state of the field as a whole, in identifying gaps and opportunities and in raising the profile of mental health research generally. Finally, a number of organisations, particularly in Canada and the UK, highlighted difficulties in facilitating the practical application of research findings in improving mental health services. Some commented that insufficient funding is available for research in this area, while it was also mentioned that when successful interventions are identified, it is not easy to scale them up in the mental health care system. Opportunities may exist in increased collaboration, developing shared definitions, capitalising on government priorities, the key role of nongovernmental organisations and advancing technology Most funders contacted in compiling the deep dive profiles expressed a desire (or willingness) to work with other organisations and often this was seen as a way of overcoming the fragmented nature of the mental health field. Suggested forms of collaboration or cooperation include sharing expertise on grant selection processes and peer review, sharing research data or findings and working more closely with other stakeholder groups. A variety of stakeholders were mentioned, including the involvement of patient and family groups and the creation of stronger links among researchers, but also the potential benefits of working with organisations in related sectors. The fact that mental health issues both affect other sectors and are influenced by developments in other sectors suggests that building collaborations with actors in areas such as education and the justice system may be beneficial (e.g. WHO 2013). What does the future hold? It was suggested by some interviewees that collaboration would be aided by developing a clearer, shared classification system and set of definitions. Our deep dive reviews revealed that the majority of funders do not use a working definition of mental health. While some may not need a definition for their own funding activities (for example, if they focus on one particular mental health condition), having a definition may facilitate discussions with other organisations and support the sharing of comparable data. Common definitions might also be a useful tool for advocacy and assist in raising the profile of the mental health field as a whole in a coherent way. International initiatives, such as the International Alliance for Mental Health Research Funders, were considered as valuable tools for sharing progress and ideas internationally, while also potentially having a role in instigating efforts to develop and refine common definitions. Several interviewees commented that mental health is gaining prominence and rising up the policy agenda in their locations (for example, this was mentioned specifically in Australia and Quebec). In these instances, funders emphasised the importance of capitalising on current government priorities to boost investment in mental health research. Similarly, the nationwide BRAIN initiative (Brain Research through Advancing Innovative Neurotechnologies) in the United States was mentioned as an indicator of the prominence of neuroscience in government priorities and an important opportunity for a range of funding organisations to collaborate and raise the profile of mental health research. 37 A particular opportunity was mentioned for charities, foundations and non-profits in the face of pressures on government budgets and a decline in pharmaceutical industry investment in mental health. Free from the constraints of government policy and budget cycles, non-government organisations may be able to ‘fill the gaps’ and take a longer-term view of priorities and initiatives that might take time to become established. One funder also mentioned that opportunities may arise from a growing level of philanthropic support specifically for research in mental health in the United States, commenting that in the past such funding tended to be targeted more towards service delivery. Finally, as previously mentioned, a number of funders highlighted opportunities arising from advances in technology. Such progress has the potential to impact on a number of areas, including new research tools and alternative treatment options, but may also bring particular opportunities for sharing research data and findings and carrying out comparative analysis of large data sets. Several funders mentioned that they now have policies on making available on public platforms the data generated by funded research. In terms of shedding light on the global research funding landscape, new tools have the potential to allow powerful analytical approaches to mapping funding flows and linking funding with the subsequent outputs and impacts of research. This is discussed further in Chapter 4. Chapter 4 What next? Key points 1. This study contributes to elucidating the mental health research funding landscape and advancing our understanding of bottom-up approaches to mapping research systems. 2. Advances in technology and increasing availability of data have allowed, and continue to allow, new and/or more comprehensive approaches to mapping research funding to be developed. This report provides the first global view of the mental health research funding landscape of which we are aware. In doing so, it should help organisations that fund mental health research, by highlighting opportunities for collaboration, as well as exploring the diversity of practice in terms of setting strategy, selecting research to fund and evaluating its impacts. We also looked to the future by investigating the future plans of a sample of key funders. However, this is only a snapshot of mental health research – this chapter considers how to build on this work and discusses the opportunities provided by new technologies in data collection and aggregation. To understand the nature and dynamics of a research field it is necessary to understand the funding flows and the behaviour of the funders within it and to link this to the outputs and impacts from the research that is supported – over the long term the societal benefits it brings, and as a short term measure the knowledge produced and disseminated through publications. In previous studies we have explored the outputs and impacts of mental health research (Larivière et al. 2013; Wooding et al. 2013). This report looks at the ‘other side of the coin’, mapping the funding flows 3. Significant technical, conceptual and cultural challenges remain in improving the accuracy and completeness of data, developing commonly understood definitions in the mental health field to facilitate comparisons and causally linking data on funding flows to the longer term outcomes and impacts produced by research. and investigating funder behaviour. The challenge that remains is to link this information together to show the causal links and identify how particular funding produces particular impacts. Mapping funding flows Mapping the flows of funding in a research system is conceptually simple: it involves cataloguing all the money that is spent on research and identifying what it is used for. What complicates the task is the diversity of research funders, the many different ways research is supported and, in the case of mental health, the nebulous nature of the field. As the availability of data has improved and technology has developed, different approaches have become feasible – and we are currently on the cusp of further change. As described in Chapter 1, a number of previous studies aiming to map research funding have done so by identifying the major research funders in a particular field or locality and manually collating information about their funding portfolios (e.g. CIHR 2014, MQ 2015). This approach has the major advantage of allowing monetary values to be linked to funding awards, topics, institutions and so on. Many funders also categorise their awards according to defined classi- 40 Mapping the global mental health research funding system fication schemes, allowing a detailed analysis of the types and areas of research supported. However, such an approach may not always facilitate a straightforward comparison or aggregation across organisations, due to differences in the classification approaches used. For example, in the mental health field, research might be categorised by condition, therapeutic area, methodological approach, or another research dimension. A topdown approach to defining the research field can also overlook smaller funders and larger funders who may not consider mental health within their primary remit, but nevertheless might support substantial work in mental health (e.g. the British Heart Foundation), in particular interdisciplinary or cross-condition research. Bottom-up approaches to mapping An alternative approach, and the one taken in this study, is to build a map of funding from the bottom up, aiming to find funding relevant to mental health, irrespective of the field or remit of the organisation supporting it. This has become easier in recent years with the systematic recording of funding acknowledgement information in Web of Science. Publications also have the additional advantage of linking information on funding to a range of other data points, including authors, location, topics and citations, and defining the mental health field based on topics of publications ensures that a consistent definition is used across all research funders. We highlighted a number of potential limitations of this approach in Chapter 1, particularly around the inconsistent naming of organisations and, due to the relatively recent introduction of the indicator, the absence of acknowledgement information in a significant number of papers. A further question remains around the extent to which the volume of acknowledgements can be considered a proxy for the amount of money provided: can acknowledgements represent a ‘common currency’? It is, for example, unclear how relative levels of funding compare between a paper with a single funder acknowledged and a paper with a number of different organisations named. Similarly, the number of publications per grant or ‘cost’ per publication may well differ between disciplines or for different types of funding vehicle. Bibliometric data alone is not yet sufficient to provide answers to these questions. While we attempted to address these ques- tions by comparing data for key funders with data provided by berResearch (see below for details on berResearch’s approach), the comparisons were hindered by differences between the definitions of mental health used in our data set and available in the berResearch database. Collation-based approaches to mapping In recent years, the increased use of standardised electronic systems by funders, the increased power of computers and a greater willingness to share data has seen the development of a new approach to mapping research funding, whereby award data from multiple funders is combined. Layers of meta-data are then added to the database, for example research classification systems based on textual analysis of titles, abstracts and keywords, to provide consistent analysis for all funders across the combined data set (berResearch’s Dimensions tool is an example of such an approach11). By collating data at a macro level, independent of any one funder’s constructs, such approaches have the potential to provide comprehensive information across a field on both the structure of funding flows and the amounts of funding involved, but will require the cooperation of funders in providing their data to achieve this. In the future, by incorporating acknowledgement data and hence combining top-down (funder-driven) and bottom-up (publication-driven) approaches, it may also become possible to elucidate more clearly the links between the inputs to and outputs from a research system. Significant technical, conceptual and cultural challenges remain While advances in technology and data availability have provided opportunities for new approaches and tools in mapping research funding, there are still a number of challenges in constructing a comprehensive and reliable picture of the funding landscape. First, while some forms of funding, such as project grants and fellowships, are relatively easy to recognise, other sources of research support are more challenging to identify and quantify. In our data set, the funding acknowledgements referring 11 www.uberresearch.com/dimensions-for-funders/ (as of 17 October 2015) What next? to academic institutions may in part have reflected block funding provided to universities, but this is not something universally recognised in publications and our survey of researchers revealed that few acknowledge support such as estate costs or the provision of equipment. Although this may pose difficulties in assessing the overall scale of funding and the relative contributions of different actors, it does not substantially detract from the utility of such mapping exercises in showing where funders complement and overlap one another, or where opportunities exist for greater cooperation. A more pressing issue may be the common difficulty found across all approaches in establishing where to draw the boundaries around mental health research and how to define areas within it. This clearly presents challenges for an exercise such as this one, which relies on identifying a valid data set on which to base the mapping. Beyond this technical challenge, though, our observation that there is no agreed definition of mental health among research funders underlines that this challenge also exists at a more conceptual level and is reflected in the way that different people and organisations define their objectives, develop their strategies and talk about mental health research. Not every funder needs to use the same set of definitions in their daily operations. Indeed, it is important to acknowledge that no single system is likely to suit all funders and that there are no formal boundaries between fields in an increasingly interdisciplinary research world. However, a common perception of the landscape and robust definitions which can be shared with others would allow funders to compare their own portfolios with those of others, helping them better understand the context in which they are working and the opportunities that exist within it. Finally, looking beyond the inputs and immediate outputs of the research process, there is 41 increasing emphasis internationally on understanding and measuring the downstream impacts of research. While publications can relatively easily be formally attributed to particular grants and hence funders, it is far more difficult to accurately attribute societal impacts in a systematic and comprehensive way. Doing so requires identifying both the impact itself and the pathway by which it was achieved – which may cover a significant period of time, given the length of time it can take for impacts to be produced (e.g. Hanney et al. 2015). Tools such as Researchfish,12 which allows researchers to record a range of different kinds of impacts (in addition to academic outputs) in relation to individual pieces of funding, have the potential, if widely adopted, to catalogue comprehensive and consistent data. However, their utility is dependent on researchers reporting the impacts that have occurred and funders providing suitable training and support. Challenges remain around determining the relative contributions of individual pieces of funding to the achievement of an impact, particularly those arising over longer periods of time. Concluding thought In this study we set out with ambitious aims to comprehensively map the global mental health research funding ecosystem. Although we acknowledge that the approach taken is imperfect and that results should be interpreted with its limitations in mind, we believe that it makes an important contribution to both elucidating the mental health research funding landscape and advancing our understanding of bottom-up approaches to mapping research systems. Driven by a need to better understand the returns generated by specific research funding and advances in the technology, tools and data available to explore the research ecosystem, we hope that this is a step towards further progress in the coming few years. 12 www.researchfish.com (as of 17 October 2015) References Blondel, V. D, Guillaume, J. L, Lambiotte, R, & Lefebvre, E. 2008. Fast unfolding of communities in large networks. Journal of Statistical Mechanics: Theory and Experiment, 2008(10), P10008. Bloom, D. E, Cafiero, E. T, Jané-Llopis, E, Abrahams-Gessel, S, Bloom, L. R, Fathima, S, et al. 2011. The Global Economic Burden of Noncommunicable Diseases. 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Mental health action plan 2013 – 2020. Geneva, Swtizerland: World Health Organization. Wooding, S, Pollitt, A, Castle-Clark, S, Cochrane, G, Diepeveen, S, Guthrie, S, et al. 2013. Mental Health Retrosight: Understanding the returns from research (lessons from schizophrenia): Policy Report Cambridge, UK: RAND Europe. Annex 1 – Canada Our data set includes 10,894 papers with a corresponding author located in Canada. This is 5.7 per cent of the global mental health output in the period 2009–2014. Ninety of our core group of 1,908 funders are Canadian organisations, the breakdown of which by sector is shown in Figure A1-1 below. Canadian funders are acknowledged on 6,077 papers during our time period. As we observe in the data set as a whole and on a similar scale to the global picture, government funders appear to typically fund more mental health research than charities, foundations and non-profits – an average of 270 acknowledgements per government funder, compared with 68 per charity, foundation or non-profit. The ARC of Canadian-funded papers is slightly higher than in the overall data set, a result which is observed across each of the funding sectors (see Figure A1-2 below). The most frequently acknowledged Canadian funders are shown in Table A1-1 below. Figure A1-1 Breakdown of number of Canadian funders and funding acknowledgements by funder sector13 NumberNumber ofNumber funding of funding ofacknowledgements funding acknowledgements acknowledgements Number of funders Number of funders Number of funders 4 4 (4%) (4%) 65 (1%) 65 (1%) 699 699 (6%)(6%) 16 (18%) 16 (18%) Academia Academia Charity/Foundation Charity/Foundation 31 (35%) 31 (35%) Government Government Industry Industry 38 (43%) 38 (43%) 13 Note that one funder acknowledged was a publisher, accounting for 11 acknowledgements 25732573 (22%) (22%) Academia Academia Charity/Foundation Charity/Foundation Government Government Industry Industry 83648364 (71%) (71%) 46 Mapping the global mental health research funding system Figure A1-2 Average relative citations by funder sector – Canada 2.50 1.92 2.00 1.91 1.75 1.65 1.64 1.63 1.64 1.58 1.50 Canada Dataset 1.00 0.50 0.00 Academia Charity/Foundation Government Industry Table A1-1 Top 30 funders in Canada Rank World rank 1 5 2 42 3 Funder Canadian Institutes of Health Research (CIHR) No. of papers Sector Proportion of Canadian papers Proportion of global papers 4701 Government 77.4% 4.2% Fonds de recherche en santé du Québec (FRQS) 838 Government 13.8% 0.7% 47 Natural Sciences and Engineering Research Council of Canada (NSERC) 784 Government 12.9% 0.7% 4 75 Canada Research Chair 446 Government 7.3% 0.4% 5 83 Michael Smith Foundation for Health Research (MSFHR) 391 Charity/ Foundation 6.4% 0.3% 6 93 Ontario Mental Health Foundation (OMHF) 342 Charity/ Foundation 5.6% 0.3% 7 104 Social Sciences and Humanities Research Council (SSHRC) 296 Government 4.9% 0.3% 8 115 Ontario Ministry of Health and Long-Term Care (MOHLTC) 258 Government 4.2% 0.2% 9 121 Alzheimer Society of Canada (ASC) 247 Charity/ Foundation 4.1% 0.2% 10 125 Alberta Innovates Health Solutions (AIHS) 242 Government 4.0% 0.2% Annex 1 – Canada Rank World rank Funder Proportion of Canadian papers Proportion of global papers 11 136 Canada Foundation for Innovation (CFI) 228 Charity/ Foundation 3.8% 0.2% 12 152 Heart and Stroke Foundation, Canada 202 Charity/ Foundation 3.3% 0.2% 13 253 Canadian Psychiatric Association Foundation 119 Charity/ Foundation 2.0% 0.1% 14 254 Manitoba Health Research Council 119 Government 2.0% 0.1% 15 262 University of British Columbia (UBC) 114 Academia 1.9% 0.1% 16 274 University of Toronto 110 Academia 1.8% 0.1% 17 289 Genome Canada 106 Charity/ Foundation 1.7% 0.1% 18 296 Centre for Addiction and Mental Health (CAMH) 104 Academia 1.7% 0.1% 19 365 Pacific Alzheimer Research Foundation Centre 79 Charity/ Foundation 1.3% 0.1% 20 383 Hospital for Sick Children Foundation, Canada 75 Charity/ Foundation 1.2% 0.1% 21 400 Health Canada 70 Government 1.2% 0.1% 22 419 University of Montreal 66 Academia 1.1% 0.1% 23 451 University of Calgary 62 Academia 1.0% 0.1% 24 463 Muscular Dystrophy Association Canada 59 Charity/ Foundation 1.0% 0.1% 25 483 Government of Canada 56 Government 0.9% 0.0% 26 492 Ontario Ministry of Research and Innovation 55 Government 0.9% 0.0% 27 493 Canadian Tobacco Control Research Initiative (CTCRI) 55 Charity/ Foundation 0.9% 0.0% 28 514 Nova Scotia Health Research Foundation 52 Charity/ Foundation 0.9% 0.0% 29 521 Ontario Graduate Scholarship 51 Government 0.8% 0.0% 30 526 Canadian Cancer Society Research Institute 51 Charity/ Foundation 0.8% 0.0% As for the global research landscape, we also developed network maps for Canada showing, firstly, all Canadian funders based on their co-acknowledgement on papers (Figure A1-3) and secondly, the funders acknowledged on papers with a Cana- No. of papers Sector 47 dian address (Figure A1-4). As one would expect, CIHR dominates both networks, with the provincial research funders and other research councils also clearly visible. In Figure A1-4 we can see the relatively large involvement of US funders. 48 Mapping the global mental health research funding system Figure A1-3 Network of co-acknowledgement of all Canadian funders14 Lawson Health Research Institute Drummond Found. CIDA Mental Health Commission of Ca... Uni of Western Ontario Ontario Womens Health Council Canadian Nurses Found. Scottish Rite Charitable Found... Saul A. Silverman Family Found. PSI Foundation CAMH Toronto Rehabilitation Institu... MSFHR Allon Baycrest Found. Vancouver Coastal Health Resea... Health Canada Uni of Saskatchewan Ontario Problem Gambling Resea... Uni of Toronto Ontario Graduate Scholarship ICES BC Mental Health and Addiction... Alberta Gaming Research Instit... OMHF NSERC Ontario Neurotrauma Found. Ontario Institute for Cancer R... Pacific Alzheimer Research Fou... Ontario Ministry of Research a... Litebook Company Ltd MOHLTC Canadian Health Services and R... NeuroDevNet ASC Heart&Stroke Foundation Jack Brown and Family Alz. Fou... Schizophrenia Society of Ontario Valeant CFI Canadian Stroke Network Child and Family Research Inst... Hospital for Sick Children Fou... Canadian Psychiatric Associati... Uni of Montreal National Cancer Institute of C... CANMAT AIHS Canadian Institutes for Advanc... Canadian Diabetes Association/... Genome Canada Norlien Found. CRC Medical Research Council of Ca... Ontario Innovations Trust Uni of Calgary MS Society of Canada Alberta Health Services CIHR Canadian Cancer Society Resear... UBC CTCRI Saskatchewan Health Research F... SSHRC Uni of Alberta Alberta Childrens Hospital Fou... Queens Uni Uni of Ottawa McLaughlin Centre McGill Uni Govt. of Canada FRQS Montreal Childrens Hospital Re... Manitoba Medical Services Foun... Govt. of Ontario Ontario Research Fund McMaster Uni Manitoba Health Research Council Multiple Sclerosis Society of ... Uni of Manitoba Parkinson Society of Canada FQRNT Nova Scotia Health Research Fo... OBI National Health Research and D... Ministere de l'education Fonds Quebecois - Societe et l... Capital District Health Author... MultiHealth Systems 14 Coloured by modularity (see Appendix A for details) Muscular Dystrophy Association... 49 Annex 1 – Canada Figure A1-4 Network of co-acknowledged funders on Canadian papers in the entire mental health data set15 MOHLTC CHDI NINDS NICHD NIAAA NIMH Lundbeck NIDA NIH Lilly WT AFSP Health Canada SSHRC Uni of Toronto PSI Foundation CIHR MSFHR BBRF UBC Heart&Stroke Foundation NIHR CFI AIHS NSERC OMHF Uni of Montreal Autism Speaks ASC NIA 15 Coloured by country Pfizer Janssen Genome Canada Alz Assoc. Canadian Psychiatric Associati... CRC Hospital for Sick Children Fou... SMRI FRQS AZ Key: USA Taiwan Iceland UK New Zealand Estonia Sweden Ireland Iran Canada Singapore Colombia Netherlands Israel Saudi Arabia Australia India Slovakia China South Africa Croatia France Czech Republic Qatar Germany Poland Venezuela Japan Turkey Nigeria Spain Chile Serbia Finland Hungary Romania Italy Argentina Slovenia Denmark Greece Lebanon Switzerland Malaysia Philippines Belgium Austria Bulgaria South Korea Mexico Pakistan EU Portugal Lithuania Norway Russia Brazil Thailand 50 Mapping the global mental health research funding system Finally, we carried out an analysis of the flows of research funding into and out of Canada. In this we use each paper’s funding acknowledgements and corresponding author address as proxies for the source and destination of research funds. In these terms, Canada is a net ‘importer’ making 3,592 funding acknowledgements to overseas funders on papers in our data set. The majority of these acknowledgements relate to US funding organisations. This compares with 1,910 acknowledgements of Canadian funding on papers with a non-Canadian corresponding address. Again, the largest portion of these acknowledgements correspond to papers with a US address. Figure A1-5 Flows of research funding: (i) Canadian funders supporting papers with corresponding authors outside Canada and (ii) papers with Canadian corresponding authors acknowledging non-Canadian funding16 NL 37 AU 173 US 952 FR 99 Number of acknowledgements of Canadian funders on non-Canadian papers ES 27 IL 29 BR 36 DE 68 UK 182 CH 28 SE 14 IT 56 CN 58 JP 53 TW 10 FI 11 IL 13 KR 12 EXPORT DE 73 DK 11 IMPORT IE 15 DK 55 MX 16 Number of funding acknowledgements on Canadian papers NL 22 EU 52 ES 30 16 Numbers represent individual acknowledgements, of which there may be more than one on a paper. Countries with ten or more acknowledgements are presented in the figure. AU 69 BR 58 BE 58 FR 95 UK 257 JP 65 US 2370 SE 43 CN 69 IT 16 CH 114 Annex 2 – The UK Our data set includes 18,138 papers with a corresponding author located in the UK. This is 7.9 per cent of the global mental health output in the period 2009-2014. In our core group of 1,908 funders, 136 are UK organisations, the breakdown of which by sector is shown in Figure A2-1 below. UK funders are acknowledged on 10,257 papers in the data set. As we observe in the data set as a whole, government funders appear to typically fund more mental health research than charities, foundations and non-profits – an average of 341 acknowledgements per government funder, compared with 86 per charity, foundation or non-profit. These averages are substantially higher than the corresponding averages across the whole (global) data set. The ARC of UK-funded papers is substantially higher than we see in the data set as a whole, although this difference is less pronounced for industry-funded research (see Figure A2-2 below). The most frequently acknowledged UK funders are shown in Table A2-1 below. Figure A2-1 Breakdown of number of UK funders and funding acknowledgement by funder sector17 Number of funders Number of funders Number of funders Number ofNumber funding Number of funding ofacknowledgements funding acknowledgements acknowledgements 6 6 (5%) (5%) 1534 1534 (8%) 1542 (8%) 1542 (8%) (8%) 26 (20%) 26 (20%) 31 (23%) 31 (23%) Academia Academia Charity/Foundation Charity/Foundation Government Government Industry Industry 69 (52%) 69 (52%) 17 Note that four funders acknowledged were publishers, accounting for 122 acknowledgements Academia Academia 5914 5914 (30%)(30%) Charity/Foundation Charity/Foundation Government Government 1056310563 (54%)(54%) Industry Industry 52 Mapping the global mental health research funding system Figure A2-2 Average relative citations by funder sector – UK 2.50 2.26 2.02 2.00 1.91 1.86 1.70 1.64 1.63 1.58 1.50 UK Dataset 1.00 0.50 0.00 Academia Charity/Foundation Government Industry Table A2-1 Top 30 funders in the UK Rank World rank Funder No. of papers Sector Proportion of UK papers Proportion of global papers 1 10 UK Medical Research Council (MRC UK) 3503 Government 34.2% 3.1% 2 13 National Institute for Health Research (NIHR) 3062 Government 29.9% 2.7% 3 15 Wellcome Trust 2434 Charity/ Foundation 23.7% 2.2% 4 31 NHS England 1126 Government 11.0% 1.0% 5 49 Economic and Social Research Council (ESRC), UK 751 Government 7.3% 0.7% 6 51 UK Department of Health 700 Government 6.8% 0.6% 7 56 GlaxoSmithKline 653 Industry 6.4% 0.6% 8 60 Kings College London (KCL) 594 Academia 5.8% 0.5% 9 62 AstraZeneca 569 Industry 5.5% 0.5% 10 65 Alzheimers Research UK 528 Charity/ Foundation 5.1% 0.5% 11 92 Biotechnology and Biological Sciences Research Council (BBSRC) 347 Government 3.4% 0.3% Annex 2 – The UK Rank World rank Funder Proportion of UK papers Proportion of global papers 12 106 British Heart Foundation UK 290 Charity/ Foundation 2.8% 0.3% 13 123 Cancer Research UK 244 Charity/ Foundation 2.4% 0.2% 14 128 Scottish Government, Health Department 237 Government 2.3% 0.2% 15 130 Engineering and Physical Sciences Research Council (EPSRC) (UK) 237 Government 2.3% 0.2% 16 139 Alzheimer Society, UK 227 Charity/ Foundation 2.2% 0.2% 17 157 Shire Development, Inc 194 Industry 1.9% 0.2% 18 203 Royal Society 150 Charity/ Foundation 1.5% 0.1% 19 259 Health Foundation 117 Charity/ Foundation 1.1% 0.1% 20 264 Parkinsons Disease Society UK 113 Charity/ Foundation 1.1% 0.1% 21 281 British Academy 109 Academia 1.1% 0.1% 22 290 Multiple Sclerosis Society, UK 105 Charity/ Foundation 1.0% 0.1% 23 294 BUPA Foundation UK 104 Charity/ Foundation 1.0% 0.1% 24 309 University of Bristol 100 Academia 1.0% 0.1% 25 315 Guys and St Thomas Charitable Foundation 98 Charity/ Foundation 1.0% 0.1% 26 343 Sackler Foundation 87 Charity/ Foundation 0.8% 0.1% 27 346 Department for International Development (DFID), UK 86 Government 0.8% 0.1% 28 351 Psychiatry Research Trust, UK 84 Academia 0.8% 0.1% 29 363 University of Edinburgh 80 Academia 0.8% 0.1% 30 366 Stroke Association (UK) 79 Charity/ Foundation 0.8% 0.1% As for the global research landscape, we also developed network maps for the UK showing, firstly, all UK funders based on their co-acknowledgement on papers (Figure A2-3) and secondly, the funders acknowledged on papers with a UK address (Figure A2-4). The MRC, Wellcome Trust and No. of papers Sector 53 NIHR are prominent in both networks, but the network of UK funders also shows the diversity of smaller charities, foundations and non-profits engaged in mental health research. In Figure A2-4 US funders (in red) and other European funding organisations are clearly visible. 54 Mapping the global mental health research funding system Figure A2-3 Network of co-acknowledgement of all UK funders18 Lippincott Williams and Wilkins WORD Fidelity Found. Oxford Uni Press Reta Lila Weston Institute for... National Institute for Mental ... PSP association Motor Neurone Disease Associat... Wolfson Trust Action Medical Research (UK) Gates Cambridge Scholarship Tr... AZ Parkinsons Disease Society UK Gatsby Charitable Found. Uni of Oxford British Medical Association Uni of Leeds DeNDRoN Great Ormond Street Hospital C... Royal College of Physicians/Du... Baily Thomas Charitable Fund UK Epilepsy Research Found. British Council Neuroscience Research Charitab... Psychiatry Research Trust Brain Research Trust Cambridge Overseas Trust Imperial College London Scottish Charity Reta Lila Weston Trust for Med... Shirley Found. Isaac Newton Trust Cambridge McGraw Hill Academy of Medical Sciences (UK) Norman Collisson Found. MS Society of Great Britain an... NHS England Comic Relief Guys and St Thomas Charitable ... Uni of Cambridge NIHR Manchester Mental Health and S... Fragile X Found. Big Lottery Fund International College of OC Sp... Seaver Found. UKs Ministry of Defence Uni of Southampton Dunhill Medical Trust Woods Family Trust Charles Wolfson Charitable Trust Muscular Dystrophy Campaign UK Ministry of Justice Arthritis Research Campaign Tourettes Action Clothworkers Found. Henry Smith Charity & Epilepsy... WT Bernard Wolfe Health Neuroscie... BUPA Found. Pears Found. MRC UK AR UK KCL Schizophrenia Research Fund Uni of Aberdeen Shire CRUK NPSA, UK British Health and Safety Exec... GSK Scottish Mental Health Researc... UK DH Uni of Nottingham Health Found. BHF UK Sackler Found. Alz. Society, UK UK Health Protection Agency Uni of Glasgow Scottish Govt. Age UK Uni of Edinburgh Technology Strategy Board Gran... Nuffield Found. Uni of Sheffield P1 vital Ltd Research Councils UK Fellowship BBSRC Unilever Beckett-Found. AHRC UK Scottish Funding Council Multiple Sclerosis Society ESRC UK Action on Addiction NEURODEM Cymru IPA Royal Society Wolfson Merit Aw... Uni of Birmingham Liaison Committee NPRI Uni of Newcastle VEGA 18 Coloured by modularity W. Garfield Weston Found. grant RCUK Waterloo Found. Uni of Essex Cardiff Uni Uni College London Diabetes UK Project Cambridge Uni Press Higher Education Funding Counc... National Assembly for Wales EPSRC Leverhulme Trust WICN Autistica Uni of Bristol SINAPSE Glasgow Centre for Population ... Reckitt Benckiser BRACE Sir Jules Thorn Charitable Trust Welsh Assembly Govt. UK Centre for Tobacco Control ... British Geriatrics Society Uni of Manchester British Academy Royal Society DFID Carman Trust Bangor Uni Beckley Found. UK Uni of London Annex 2 – The UK 55 Figure A2-4 Network of co-acknowledged funders on UK papers in the entire mental health data set19 BUPA Foundation UK NHLBI NIH BHF UK Stroke Association ESRC UK Academy of Finland NIA NIBIB CIHR Nuffield Foundation, UK AR UK DFG Alz Assoc. University College London ADNI NIMH University of Manchester, UK SNSF Waterloo Foundation British Academy CHDI MRC UK NIHR Parkinsons Disease Society UK Alzheimer Society, UK BMBF Welsh Assembly Government UK Department of Health EU University of Bristol NWO Leverhulme Trust, UK EPSRC Big Lottery Fund, UK Janssen Lundbeck Scottish Govt. NHS England Bial Foundation, Portugal GSK Sackler Foundation University of Nottingham BBRF Cancer Research UK WT NIDA ERC SMRI NHMRC KCL Merck Psychiatry Research Trust, UK SINAPSE BBSRC Lilly Health Foundation Pfizer Guys and St Thomas Charitable Foundation Royal Society Key: 19 Coloured by country USA Taiwan Iceland UK New Zealand Estonia Sweden Ireland Iran Canada Singapore Colombia Netherlands Israel Saudi Arabia Australia India Slovakia China South Africa Croatia France Czech Republic Qatar Germany Poland Venezuela Japan Turkey Nigeria Spain Chile Serbia Finland Hungary Romania Italy Argentina Slovenia Denmark Greece Lebanon Switzerland Malaysia Philippines Belgium Austria Bulgaria South Korea Mexico Pakistan EU Portugal Lithuania Norway Russia Brazil Thailand 56 Mapping the global mental health research funding system Finally, we carried out an analysis of the flows of research funding into and out of the UK. In this we used each paper’s funding acknowledgements and corresponding author address as proxies for the source and destination of research funds. In these terms, the UK is a slight net ‘importer’ making 5,542 funding acknowledgements to overseas funders on papers in our data set. The largest portion of these acknowledgements relate to US funding organisations, although there is also a substantial volume of papers acknowledging EU support. This compares with 5,023 acknowledgements of UK funding on papers with a non-UK corresponding address. Again, the largest portion of these acknowledgements corresponds to papers with a US address. Figure A2-5 Flows of research funding: (i) UK funders supporting papers with corresponding authors outside the UK and (ii) papers with UK corresponding authors acknowledging non-UK funding20 ZA 54 BD 13 TR 11 CH 84 FR 139 NL 273 BR 77 IE 148 AT 28 NZ 19 HR 11 NG 14 IS 16 Number of funding acknowledgements on UK papers ET 11 SI 11 CA 182 KE 14 NZ 20 SE 179 DK 124 CH 227 ES 185 PT 65 SG 22 IT 56 JP 56 BR 56 NO 28 BE 52 US 1725 JP 60 AU 370 CA 257 DK 89 IN 43 IT 145 CN 106 ES 124 TW 85 Number of acknowledgements of UK funders on non-UK papers EU 810 EE 11 KR 105 DE 306 AU 279 TW 12 SG 21 CN 38 NL 137 RU 13 EXPORT IMPORT FI 183 US 2349 NO 89 GR 21 BE 96 SE 122 IL 21 UG 11 20 Numbers represent individual acknowledgements, of which there may be more than one on a paper. Countries with ten or more acknowledgements are presented in the figure HU 11 FR 120 FI 96 IL 16 IE 24 DE 250 Annex 3 – Funder acronyms Acronym Funder name Acronym Funder name 863 China National 863 project of China DFG 973 China National 973 Program of China ADNI Alzheimer’s Disease Neuroimaging Initiative German Research Foundation/Deutsche Forschungsgemeinschaft (Germany) DHHS AFSP American Foundation for Suicide Prevention US Department of Health and Human Services DST, India AHA American Heart Association Department of Science and Technology, New Delhi, India AIHS Alberta Innovates – Health Solutions EPSRC Engineering and Physical Sciences Research Council (UK) Alz Assoc. Alzheimer’s Association ERC European Research Council ANR Agence Nationale de la Recherche (France) ERDF European Regional Development Fund AR UK Alzheimer’s Research UK ESRC UK Economic and Social Research Council, UK ARC Australian Research Council EU European Commission ASC Alzheimer Society of Canada FAPERGS Australian Govt. Australian Government, Department of Health and Ageing Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (Brazil) FAPESP BBRF Brain and Behavior Research Foundation (NARSAD) Fundação de Amparo à Pesquisa do Estado de Sao Paulo (Brazil) FAS Sweden BBSRC Biotechnology and Biological Sciences Research Council (UK) Swedish Council for Working Life and Social Research FCT Portugal BELSPO Belgian Science Policy Office Portuguese Fundação para a Ciencia e a Tecnologia BHF UK British Heart Foundation UK FIRCA BMBF Federal Ministry of Education and Research (Germany) Fogarty International Center of the National Institutes of Health (US) FIS BMS Bristol-Myers-Squibb National Institute of Health Carlos III (Spain) CAPES Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brazil) FRM Fondation pour la Recherche Médicale (France) FRQS CFI Canada Foundation for Innovation Fonds de recherche du Québec – Santé FWO-V CHDI Cure Huntington’s Disease Initiative Foundation, Inc. Fund for Scientific Research Flanders GSK GlaxoSmithKline CIHR Canadian Institutes of Health Research (CIHR) HRB of Ireland Health Research Board of Ireland CNPq Brazil CNPq Brazil HRC New Zealand Health Research Council CNRS Centre national de la recherche scientifique (France) INSERM Institut national de la santé et de la recherche médicale (France) CONACYT Consejo Nacional en Ciencia y Tecnología (Mexico) ISF Israeli Science Foundation CRC Canada Research Chair Janssen Janssen 58 Mapping the global mental health research funding system Acronym Funder name Acronym Funder name JSPS Japan Society for the Promotion of Science NIH US National Institutes of Health NIHR National Institute for Health Research (UK) KCL King’s College London Lilly Eli Lilly and Company NIMH MEC, Spain Ministerio de Educacion y Ciencia (Spain) National Institute of Mental Health (US) NINDS MEST Korea Ministry of Education, Science and Technology of the Republic of Korea National Institute of Neurological Disorders and Stroke (US) NINR National Institute of Nursing Research (US) MEXT Ministry of Education, Culture, Sports, Science and Technology in Japan NOW Netherlands Organization of Scientific Research MHLW Japan Ministry of Health and Welfare, Japan NRC Norwegian Research Council NRF Korea MHW Korea Ministry of Health and Welfare in Korea National Research Foundation of Korea NSC Taiwan MICINN Spanish Ministry of Science and Innovation National Science Council in Taiwan NSERC MIUR Italian Ministry of Education University and Research Natural Sciences and Engineering Research Council of Canada NSFC MOHLTC Ontario Ministry of Health and Long-Term Care National Natural Science Foundation of China OMHF Ontario Mental Health Foundation PAHO Pan American Health Organization PHRC French Ministry of Health RWJF Robert Wood Johnson Foundation MRC UK UK Medical Research Council MSFHR Michael Smith Foundation for Health Research (Canada) NCATS National Center for Advancing Translational Science (US) NCCAM National Center for Complementary and Alternative Medicine (US) SAMHSA Substance Abuse and Mental Health Services Administration NCI National Cancer Institute (US) Scottish Govt. NCRR National Center for Research Resources (US) Scottish Government, Health Department SFARI NHLBI National Heart, Lung, and Blood Institute (US) Simons Foundation Autism Research Initiative SFI Science Foundation Ireland NHMRC National Health and Medical Research Council of Australia SMRI Stanley Medical Research Institute NHS England NHS England NIA National Institute on Aging (US) NIAAA National Institute on Alcohol Abuse and Alcoholism (US) NIAID National Institute of Allergy and Infectious Diseases (US) NIBIB National Institute of Biomedical Imaging and Bioengineering (US) SNSF Swiss National Science Foundation SRC Swedish Research Council SSHRC Social Sciences and Humanities Research Council (Canada) US CDC US Centers for Disease Control and Prevention US DOD US Department of Defense US NSF US National Science Foundation Eunice Kennedy Shriver National Institute of Child Health and Human Development (US) US PHS US Public Health Service USAMRMC US Army Medical Research & Materiel Command NIDA National Institute on Drug Abuse (US) VA Department of Veterans Affairs (US) NIDCD National Institute on Deafness and Other Communication Disorders (US) VU Amsterdam, Netherlands Vrije Universiteit Amsterdam, Netherlands NIDDK National Institute of Diabetes and Digestive and Kidney Diseases (US) VWS Dutch Ministry of Health, Welfare and Sports WHO World Health Organization WT Wellcome Trust NICHD NIEHS National Institute of Environmental Health Sciences (US) NIGMS National Institute of General Medical Sciences (US) RR-1271-GBF