TABLES 2.1. EPA Pesticide Toxicity Classes ........................... 7 2.2. Carcinogenicity Classifications .......................... 11 2.3. Pesticides Used or Potentially Used During ODS/DS .......... 13 3.1. Most Frequent Principal Diagnoses in PGW Registry Personnel, February 1997 .............................. 16 3.2. Symptom Prevalence as Primary and Any Diagnosis ........... 17 3.3. Symptom Prevalence in Subjects with a Primary Diagnosis of Good Health ...................................... 17 3.4. Symptom Prevalence in Subjects Given a Diagnosis Other Than SSID.......................................... 18 3.5. Symptom Prevalence in Subjects Diagnosed with SSID......... 18 3.6. Registry Participation Predictors ......................... 22 3.7. Odds Ratios for CDC-Defined PGW Illnesses in PGWV and Bosnia and Non-Deployed Gulf-Era Veterans ................ 23 4.1. Chemical Identity of Lindane ........................... 26 4.2. Physical and Chemical Properties of Lindane ................ 26 4.3. Formulations of Lindane Available During ODS/DS ........... 27 4.4. Reports of Acute Lindane Toxicity in Humans Following Dermal Application................................... 30 4.5. Reports of Acute Lindane Toxicity in Animals Following Oral Exposure ....................................... 31 4.6. Reports of Acute Lindane Toxicity in Humans Following Oral Exposure ....................................... 32 xiii xiv Pesticides 4.7. Reports of Chronic Lindane Toxicity in Animals Following Oral Exposure ....................................... 34 4.8. Comparison of Exposures to Agricultural Chemicals Resulting in Risk of Non-Hodgkin’s Lymphoma .............. 36 5.1. Chemical Identity of DEET ............................. 39 5.2. Physical and Chemical Properties of DEET .................. 40 5.3. Formulations of DEET Available During ODS/DS ............. 40 5.4. Estimated Exposure to DEET During a Six-Month Mosquito Season ............................................ 43 5.5. In Vivo and In Vitro Dermal Absorption of DEET ............. 45 5.6. Reported Signs and Symptoms of DEET Toxicity ............. 45 5.7. Reported Health Effects in Humans Following the Topical Application of DEET .................................. 47 6.1. Chemical Identity of Permethrin ......................... 54 6.2. Physical and Chemical Properties of Permethrin ............. 54 6.3. Formulations of Permethrin Available During ODS/DS ........ 55 6.4. Chemical Identity of d-Phenothrin ....................... 56 6.5. Physical and Chemical Properties of d-Phenothrin ............ 56 6.6. Formulations of d-Phenothrin Available During ODS/DS ....... 57 6.7. Acute Effects of Permethrin Reported in Animal Studies ........ 60 6.8. Lethal Exposure Levels of Permethrin Reported in Animal Studies ............................................ 60 6.9. Subacute and Chronic Effects of Permethrin in Humans........ 61 6.10. Subacute and Chronic Effects of Permethrin in Animals ........ 63 6.11. Acute Effects of d-Phenothrin in Animals ................... 67 6.12. Chronic Effects of d-Phenothrin in Animals ................. 68 7.1. Chemical Identity of Azamethiphos ....................... 72 7.2. Physical and Chemical Properties of Azamethiphos ........... 72 7.3. Chemical Identity of Chlorpyrifos ........................ 73 7.4. Physical and Chemical Properties of Chlorpyrifos............. 73 7.5. Formulations of Chlorpyrifos Available During ODS/DS ........ 74 Tables xv 7.6. Air and Surface Chlorpyrifos Residues Following Residential Broadcast and Aerosol Applications ....................... 74 7.7. Chemical Identity of Diazinon ........................... 75 7.8. Physical and Chemical Properties of Diazinon ............... 76 7.9. Formulations of Diazinon Available During ODS/DS .......... 76 7.10. Chemical Identity of Dichlorvos ......................... 77 7.11. Physical and Chemical Properties of Dichlorvos .............. 77 7.12. Formulations of Dichlorvos Available During ODS/DS ......... 78 7.13. Chemical Identity of Malathion .......................... 79 7.14. Physical and Chemical Properties of Malathion .............. 80 7.15. Formulations of Malathion Available During ODS/DS ......... 80 7.16. Chemical Identity of Bendiocarb ......................... 82 7.17. Physical and Chemical Properties of Bendiocarb ............. 82 7.18. Chemical Identity of Methomyl .......................... 84 7.19. Physical and Chemical Properties of Methomyl .............. 84 7.20. Chemical Identity of Propoxur ........................... 85 7.21. Physical and Chemical Properties of Propoxur ............... 86 7.22. Formulations of Propoxur Available During ODS/DS .......... 86 7.23. Clinical Manifestations Following Acute Carbamate or OP Poisoning .......................................... 90 7.24. Symptom Rates in Malathion-Exposed Subjects .............. 93 7.25. Symptom Rates and Relative On-Season and Off-Season Risks for Indonesian Farmers Engaged in OP Pesticide Spraying ........................................... 97 7.26. Factors Significantly Linked to Symptom Reporting in Indonesian Farmers Engaged in OP Spraying ................ 98 7.27. Difference Between Peak- and Post-Season Test Score Ratios of Occupationally Exposed and Non-Exposed Israelis ............................................ 98 A.1. Effects in AChE-Inhibitor-Exposed Subjects and Reported by Ill PGWV......................................... 134