Prevention & Outcomes
• Riyaz Patel
• BHF Intermediate Fellow (UCL)
• Consultant Cardiologist (Bart’s & UCLH)
• NCCPO/NICOR & Farr Institute
– John Deanfield
– Harry Hemingway
– Aroon Hingorani
Fellowship
• BHF fellowship
– Genetic and non-genetic determinants of risk in patients
with established CHD
9p21
HDL
South Asian Ethnicity
Mortality
%
Mortality rates by
type of CHD
Risk
factors for
first events
=
subsequent
events?
General Populations
(first events)
n=168K,
events=15.5K
Clinical CHD Cohorts
(subsequent events)
n=25K, events=4.5K
Modified from Zaman et al
Patel
et al,2013
JACC 2014
Heart
Data?
Resources
• CALIBER
– Linked dataset, n=2,000,000
www.caliberresearch.org
• GENIUS-CHD
– Global consortium, n=250,000
www.genius-chd.org
• UKB
– Cohort study, n=500,000
www.ukbiobank.ac.uk
Research interests
• CVD risk and prevention
– Genetic & clinical epidemiology
– “Big data” and national registry/linkage studies
– Health informatics & e-health research
– Pragmatic trials & RRCTs
• riyaz.patel@ucl.ac.uk