Selected Journal Articles Year 2 (2012-2013)
2013
Multi-cycle recovery of lactoferrin and lactoperoxidase from crude whey using fimbriated highcapacity magnetic cation exchangers and a novel ‘rotor-stator’ high-gradient magnetic
separator
Brown, G.N., Müller, C., Theodosiou, E., Franzreb, M., & Thomas, O.R.T. (2013) Biotechnol Bioeng,
110(6), 1714 –1725. doi: 10.1002/bit.24842.
Patient and public preferences for health states associated with AMD
Butt, T., Dunbar, H. M., Morris, S., Orr, S., & Rubin, G. S. (2013) Optom Vis Sci, 90(8), 855-60.
doi:10.1097/OPX.0b013e3182962318.
Innovation in biopharmaceutical manufacture
Davidson, A., Farid, S.S. (2013) Bioprocess Int. 11(9) (in press)
Continuous protein purification using functionalized magnetic nanoparticles and aqueous
micellar two-phase systems
Fischer, I., Gärtner, Hsu, C-C., Müller, C., Overton, T.W., Thomas, O.R.T., & Franzreb, M. (2013) J
Chromatogr A, 1305, 7-16. doi: 10.1016/j.chroma.2013.06.011
Chromatography modelling to describe protein adsorption at bead level
Gerontas, S., Shapiro, M.S., Bracewell, D.G. (2013) J Chromatogr A, 1284, 44-52. doi:
10.1016/j.chroma.2013.01.102
FpFs as IgG mimetics
Khalili, H., Godwin, A., Choi, J. W., Lever, R., Khaw, P. T., & Brocchini, S. (2013). Bioconj Chem. doi:
10.1021/bc400246z [Epub ahead of print]
Identifying analytics for high throughput bioprocess development studies
Konstantinidis S., Kong S., & Titchener-Hooker N. (2013). Biotechnol Bioeng, 110 (7), 1924–1935, doi:
10.1002/bit.24850
An ultra scale-down characterization of low shear stress primary recovery stages to enhance
selectivity of fusion protein recovery from its molecular variants
Lau E.C., Kong S., McNulty S., Entwisle C., Mcilgorm A., Dalton K.A., Hoare M. (2013). Biotechnol
Bioeng, 110 (7), 1973–1983. doi: 10.1002/bit.24865
Designing cost-effective biopharmaceutical facilities using mixed-integer optimization
Liu, S., Simaria, A.S., Farid, S. S., & Papageorgiou, L. (2013). Biotechnol Prog. doi: 10.1002/btpr.1795
[Epub ahead of print]
Mixed integer optimisation of antibody purification processes
Liu, S., Simaria, A.S., Farid, S.S. and Papageorgiou, L.G. (2013) Computer Aided Chemical
Engineering, 32: 157–162. doi 10.1016/B978-0-444-63234-0.50027-0
Multiobjective optimisation of production, distribution and capacity planning of global supply
chains in the process industry
Liu, S., & Papageorgiou, L. G. (2013). OMEGA International Journal of Management Science, 41, 369382. doi:10.1016/j.omega.2012.03.007
Selected Journal Articles Year 2 (2012-2013)
Preparation and characterisation of amphotericin B-copolymer complex for the treatment of
leishmaniasis
Mohamed-Ahmed, A. H. A., Les, K. A., Brocchini, S., & Croft, S. L. (2013). Polym Chem, 4 (3), 584-591.
doi:10.1039/c2py20425h
Noncovalent complexation of amphotericin-B with Poly (α-glutamic acid)
Mohamed-Ahmed, A. H., Les, K. A., Seifert, K., Croft, S. L., & Brocchini, S. (2013). Mol Pharm, 10 (3),
940-950. doi:10.1021/mp300339p
Anti-leishmanial activity, uptake and biodistribution of an amphotericin B - poly(α-glutamic acid)
complex
Mohamed-Ahmed, A. H., Seifert, K., Yardley, V., Burrell-Saward, H., Brocchini, S., & Croft, S. L. (2013).
Antimicrob Agents Chemother. doi:10.1128/AAC.02343-12
Integrated system for temperature-controlled FPLC comprising improved copolymer modified
beaded agarose adsorbents and a travelling cooling zone reactor (TCZR) arrangement
Müller, T.K.H., Cao, P., Ewert, S., Wohlgemuth, J., Liu, H., Willett, T.C., Theodosiou, E., Thomas,
O.R.T. & Franzreb, M. (2013) J Chromatogr A, 1285, 97-109. doi: 10.1016/j.chroma.2013.02.025.
In situ modification of chromatography adsorbents using cold atmospheric pressure plasmas
Olszewski, P., Willett, T.C., Theodosiou, E., Thomas, O.R.T., & Walsh, J. L. (2013) Appl Phys Lett, 102,
202104-1 – 20104-5. doi: 10.1063/1.4807931.
Characterisation of ilomastat for prolonged ocular drug release
Parkinson, G., Gaisford, S., Ru, Q., Lockwood, A., Khalili, A., Brocchini, S., & Sheridan, R. (2013).
AAPS PharmSciTech, 13 (4), 1063-1072. doi:10.1208/s12249-012-9832-1
A case-study investigating physico-chemical characteristics that control the function of a
liposomal adjuvant
Perrie, Y., Kastner, E., Kaur, R., & Wilkinson, A. (2013). Vaccines & Immunotherapeutics, 9, 1374 –
1381. doi:10.4161/hv.24694
Optimising the design and operation of semi-continuous affinity chromatography for clinical
and commercial manufacture
Pollock, J., Bolton, G., Coffman, J., Ho, S. V., Bracewell, D. G., & Farid, S. S. (2013). J Chromatogr A,
1284, 17-27. doi:10.1016/j.chroma.2013.01.082
Fed-batch and perfusion culture processes: economic, environmental, and operational
feasibility under uncertainty
Pollock, J., Ho, S. V., & Farid, S. S. (2013). Biotechnol Bioeng, 110 (1), 206-219. doi:10.1002/bit.24608
The solution structure of rabbit IgG accounts for its interactions with the Fc receptor and
complement C1q and its conformational stability
Rayner, L. E., Kadkhodayi-Kholghi, N., Heenan, R. K., Gor, J., Dalby, P. A., & Perkins, S. J. (2013). J
Mol Biol, 425 (3), 506-523. doi:10.1016/j.jmb.2012.11.019
Optically induced thermal gradients for protein characterization in nanolitre-scale samples in
microfluidic devices
Sagar, D. M., Aoudjane, S., Gaudet, M., Aeppli, G., & Dalby, P. A. (2013). Sci Rep, 3, 1-6.
doi:10.1038/srep02130
Selected Journal Articles Year 2 (2012-2013)
Allogeneic cell therapy bioprocess economics and optimization: single-use cell expansion
technologies
Simaria, A.S., Hassan, S., Varadaraju, H., Rowley, J, Warren, K., Vanek, P., & Farid, S. S. (2013).
Biotechnol Bioeng. doi:10.1002/bit.25008 [Epub ahead of print]
Cost-effectiveness of single-use technologies for commercial cell therapy manufacture
Simaria, A.S., Hassan, S., & Farid, S.S. (2013). American Pharmaceutical Review, 16, 40-45.
Integration of stochastic simulation with multivariate analysis: short-term facility fit prediction
Stonier, A., Pain, D., Westlake, A., Hutchinson, N., Thornhill, N. F., & Farid, S. S. (2013). Biotechnol
Prog, 29 (2), 368-377. doi:10.1002/btpr.1678
Systematic review of drug administration costs and implications for biopharmaceutical
manufacturing
Tetteh E & Morris S. (2013) Appl Hlth Econ Hlth Policy.doiI: 10.1007/s40258-013-0045-x [Epub ahead
of print]
Measuring current and future cost of skin cancer in England
Vallejo-Torres L., Morris S., Kinge J.M., Poirier V., & Verne J (2013) J Public Hlth. doi:
10.1093/pubmed/fdt032 [Epub ahead of print]
Income-related inequity in healthcare utilisation among individuals with cardiovascular disease
in England-accounting for vertical inequity
Vallejo-Torres, L., & Morris, S. (2013). Health Econ, 22 (5), 533-553. doi:10.1002/hec.2821
Prediction of biopharmaceutical facility fit issues using decision tree analysis
Yang Y., Farid S.S., Thornhill N.F. (2013) Comp Aided Chem Eng, 32, 61-66. doi: 10.1016/B978-0-44463234-0.50011-7
Mathematical programming formulations for non-smooth and non-convex electricity dispatch
problems
Yang, L., Fraga, E. S., & Papageorgiou, L. G. (2013). Electric Power Systems Res, 95, 302-308.
doi.org/10.1016/j.epsr.2012.09.015
2012
A spatially-explicit, multi-period milp modelling framework for the optimal design of a hybrid
biofuel supply chain
Akgul, O., Shah, N., & Papageorgiou, L. G. (2012) Comp Aided Chem Eng, 31.
Efficient discovery of chromatography equipment sizing strategies for antibody purification
processes using evolutionary computing
Allmendinger, R., Simaria, A. S., & Farid, S. S. (2012). Lecture Notes in Computer Science, 7492, 468477. doi:10.1007/978-3-642-32964-7_47
A mathematical programming approach to community structure detection in complex networks
Bennett, L., Liu, S., Papageorgiou, L. G., & Tsoka, S. (2012). Comp Aided Chem Eng, 31, 1387 –
1391.
Selected Journal Articles Year 2 (2012-2013)
Comparative binding of disulfide-bridged PEG-Fabs
Brocchini, S., Khalili, H., Godwin, A., Choi, J. W., & Lever, R. (2012). Bioconjug Chem. 23(11), 2262-77.
doi: 10.1021/bc300372r
Automated methods for accurate determination of the critical velocity of packed bed
chromatography
Chang, Y., Gerontas, S., & Titchener-Hooker, N.J. (2012) Biotechnol Prog, 28(3), 740-5.
doi:10.1002/btpr.1544
Site-specific PEGylation at histidine tags
Cong, Y., Pawlisz, E., Bryant, P., Balan, S., Laurine, E., Tommasi, R., Singh, R., Dubey, S., Peciak, K.,
Bird, M., Sivasankar, A., Swierkosz, J., Muroni, M., Heidelberger, S., Farys, M., Khayrzad, F., Edwards,
J., Badescu, G., Hodgson, I., Heise, C., Somavarapu, S., Liddell, J., Powell, K., Zloh, M., Choi, J.-W.,
Godwin, A., & Brocchini, S. (2012) Bioconjug Chem, 23 (2), 248–263. doi:10.1021/bc200530x
Evaluating and visualising the cost-effectiveness and robustness of biopharmaceutical
manufacturing strategies
Farid, S.S. (2012) in Subramanian, G. (ed.) Biopharmaceutical Production Technology, Wiley VCH, Ch
22, 717-742. doi:10.1002/9783527653096.ch22
Use of design of experiment and microscale down strategies in formulation and cycle
development for lyophilization
Grant, Y., Dalby, P. A., & Matejtschuk, P. (2012). American Pharmaceutical Review, 15 (2)
Freeze drying formulation using microscale and design of experiment approaches: a case study
using granulocyte colony-stimulating factor
Grant, Y., Matejtschuk, P., Bird, C., Wadhwa, M., & Dalby, P.A.(2012) Biotech Lett, 34 (4), 641– 648.
doi:10.1007/s10529-011-0822-2
Target fishing and docking studies of the novel derivatives of aryl-aminopyridines with potential
anticancer activity
Erić, S., Ke, S., Barata T., Solmajer, T., Antić Stanković, J., Juranić, Z., Savić, V., & Zloh, M. (2012)
Bioorg Med Chem, 20(17), 5220-8. doi:10.1016/j.bmc.2012.06.051
Strategic assay selection for analytics in high throughput process development: case studies
for downstream processing of monoclonal antibodies
Konstantinidis, S., Kong, S., Chhatre, S., Velayudhan, A., Heldin, E., & Titchener-Hooker, N.J. (2012).
Biotechnol J, 7 (10), 1256-1268. doi: 10.1002/biot.201100476
The hybrid experimental simplex algorithm – An alternative method for ‘sweet spot’
identification in early bioprocess development: Case studies in ion exchange chromatography
Konstantinidis, S., Chhatre, S., Velayudhan, A., Heldin, E., & Titchener-Hooker, N. (2012) Anal Chim
Acta, 743C, 19-32. doi:10.1016/ j.aca.2012.06.039
Investigating the use of column inserts to achieve better chromatographic bed support
Lan, T., Gerontas, S., Smith, G. R., Langdon, J., Ward, J. M., & Titchener-Hooker, N. J. (2012).
Biotechnol Prog, 28 (5), 1285-1291. doi:10.1002/btpr.1597
A model predictive control approach for multi-echelon supply chain management with price
elasticity of demand
Selected Journal Articles Year 2 (2012-2013)
Liu, S., Shah, N., & Papageorgiou, L. G. (2012). AIChE Journal, 58, 369-382
A mathematical programming approach for optimal design of distributed energy systems at the
neighbourhood level
Mehleri, E. D., Sarimveis, H., Markatos, N. C., & Papageorgiou, L. G. (2012). Energy, 42, 96-104.
On behalf of the EUROACTION Study Group. Cost-effectiveness of a European preventive
cardiology programme in primary care: a Markov modelling approach
Mistry H., Morris S. Dyer M., Kotseva K., Wood D., Buxton M. (2012) BMJ Open, 2, e001029. doi:
10.1136/bmjopen-2012-001029
Utilisation of key descriptors from protein sequence data to aid bioprocess route selection
O'Malley, C. J., Montague, G. A., Martin, E. B., Liddell, J. M., Kara, B., & Titchener-Hooker, N. J.
(2012). Food Bioprod Proc 90(4) 755-761, doi:10.1016/j.fbp.2012.01.005
A generic hierarchical screening method for the analysis of microscale refolds using an
automated robotic platform
Ordidge, G. C., Mannall, G., Liddell, J., Dalby, P. A., & Micheletti, M. (2012). Biotechnol Prog, 28 (2),
435-444. doi:10.1002/btpr.1502
Characterisation of Ilomastat for Prolonged Ocular Drug Release
Parkinson G, Gaisford S, Ru Q, Lockwood A, Khalili A, Sheridan R, Khaw PT, Brocchini S, Fadda HM.
AAPS PharmSciTech 2012,13(4):1063-72. doi:10.1002/btpr.1597
Rational substrate and enzyme engineering of transketolase for aromatics
Payongsri, P., Steadman, D., Strafford, J., MacMurray, A., Hailes, H. C., & Dalby, P. A. (2012). Org
Biomol Chem, 10 (45), 9021-9029. doi:10.1039/c2ob25751c
Computer-aided design and evaluation of batch and continuous multi-mode biopharmaceutical
manufacturing processes
Pollock, J., Ho, S. V., & Farid, S. S. (2012). Comp Aided Chem Eng, 30, 487-491. doi: 10.1016/B978-0444-59519-5.50098-8
Optimal synthesis of chromatographic trains for downstream protein processing
Polykarpou, E. M., Dalby, P. A., & Papageorgiou, L. G. (2012). Biotechnol Prog, 27(6) 1653-1660.
doi:10.1002/btpr.670
A novel efficient optimisation system for purification process synthesis
Polykarpou, E. M., Dalby, P. A., & Papageorgiou, L. G. (2012). Biochem Eng J, 67, 186-193.
doi:10.1016/j.bej.2012.06.012
Production planning of batch and semi-continuous bioprocesses across multiple
biopharmaceutical facilities
Siganporia, C., Ghosh, S., Daszkowski, T., Papageorgiou, L. G., & Farid, S. (2012). Comp Aided Chem
Eng, 30, 377 – 381. doi:10.1016/B978-0-444-59519-5.50076-9
A multi-level metaheuristic algorithm to optimise antibody purification processes at the
bioprocess-business interface
Selected Journal Articles Year 2 (2012-2013)
Simaria, AS, Turner, R, & Farid, S. S. (2012). Biochem Eng J, 69, 144-154.
doi:10.1016/j.bej.2012.08.013
Decisional tool to assess current and future process robustness in an antibody purification
facility
Stonier, A., Simaria, A. S., Smith, M., & Farid, S. S. (2012). Biotechnol Prog, 28 (4), 1019-1028.
doi:10.1002/btpr.1569
Directed evolution to re-adapt a co-evolved network within an enzyme
Strafford, J., Payongsri, P., Hibbert, E. G., Morris, P., Batth, S. S., Steadman, D., Dalby, P. A. (2012). J
Biotechnol, 157 (1), 237-245. doi:10.1016/j.jbiotec.2011.11.017