H F-XC A N GE H F-XC A N GE N y bu to k lic c u-tr a c k Pharmaceutical Manufacturing Sustainability More Green More Competitive More Successful Common Sense Sustainability David March Process Capital Productivity Specialist Copyright © 2009 Rockwell Automation, Inc. All rights reserved. .d o o .c m C m w o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to .d o Sustainability is evolution by another name. Definition: “Sustain”: To keep in existence. To maintain. To persist. sounds like “survival” to me. Therefore, Sustainability from an evolutionary perspective has 2 components: 1. Use of Resources 2. Adaptability Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 2 m w o Hurray For Darwin: Our Agenda Principals lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to lic k .d o Definition: “Sustain”: To keep in existence. To maintain. To persist. sounds like “survival” to me. Therefore, Sustainability is really just evolution. Fitness based on: Efficient Use of Resources Adaptability Agenda 1. Resource Efficiency: The Atom Economy 1. 2. 3. 4. 2. Process Resources: Process Efficiency Support Resources: The Production Eco-System Dealing with Waste: Capital Efficiency Adaptability and Agility: Success in the Marketplace 1. 2. Time to Market: Exploiting eco-niches Time to Adapt: Responding to change Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 3 m w o .c C m Agenda: o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to .d o The Atom Economy is the most direct and effective measure of process efficiency. It compares the number of atoms going into a process to the number of atoms of good product coming out of the process. It counts all the atoms! Raw materials Energy (yes energy atoms… fuel) Yield Waste LCA (Life Cycle Analysis) It does not look at it from a cost perspective but a “mass” perspective. Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 4 m w o The Atom Economy: A Definition lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to .d o In The Long Run: Both the economics and the sustainability of a process will be determined by its Atom Economy The species that uses resources most efficiently will survive (be sustained) Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 5 m w o From the Evolutionary Perspective lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to .d o • Pharmaceutical manufacturing is the least efficient of all chemical industries in terms of Atom Economy (kg waste / kg product) – Pharma Average Ratio is 200 to 1 (waste generated to product) some products as high as 800 X – BioPharma is worse. Typical waste to product ratios between 3,000 to 10,000 to 1 • Pharmaceuticals reported 530 Million Tons of Waste to EPA. • Of the 170 chemicals reported to the EPA for Pharmaceuticals, the top 20 solvents represent 90% of the mass of waste generated. • Compare with a Refinery: 97.3% Efficient Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 6 m w o Pharmaceutical Process Efficiency lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to • Pharmaceutical Plant Site Waste is 80% Solvent • Pharmaceuticals reported 530 Million Tons of Waste to EPA. • Solvents Represent: – – – • lic k .d o 75-80% of energy usage 75-80% of the environmental impact 80-90% of the mass balance Most solvents are not recovered because of their thermal value (similar to coal). Incinerated for power at plant, or sold to others for incineration. – – – – – Natural Gas: Coal THF MEK Ethanol 54.3 MJ/kg 30.3 MJ/kg ( 48% of US Energy Generation) 32.2 MJ/kg ( 40% lower than Natural Gas) 34.0 MJ/kg 30.0 MJ/kg Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 7 m w o .c C m Where is the inefficiency? SOLVENTS o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to Item Recovered Energy .d o Hazardous Waste Disposal Virgin IDA Used 728,000 gallons / year 728,000 gallons / year Price of Virgin Solvent $ 2.50 per gallon $ 2.50 per gallon Sell Price of Waste $ 0.42 per gallon - $ 0.52 per gallon Solvent Recovery % 92% 92% Labor Operating Costs $ 55,500 per year $ 55,500 per year Energy and Consumables $ 39,800 $ 39,800 Initial Investment $ 3,080,000 $ 3,080,000 Savings Per Year $ 1,393,000 $ 4,498,000 ROI / Payback (months) 22% and 27 month payback 80% and 8 month payback Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 8 m w o Example Ethanol Recovery from IDA lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to .d o Pharmaceutical Manufacturers, especially Generics, could be significantly impacted by a carbon tax: because of the very high mass leverage (inverse atom economy): Almost 90% of the mass balance ends up as Carbon Dioxide. Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 9 m w o HOLD ON… .Things are going to change lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to lic k A plant boundary view distorts the impact of incineration vs recovery. As a result most THF is incinerated rather than recovered. (higher energy than coal) Incineration creates energy and generates waste (carbon dioxide) Distillation uses energy which creates waste (carbon dioxide and unrecoverable bottom stills) Incineration: 0.573 kg waste/kg THF Recovery 0.368 kg waste/kg THF Solvent Heat Released MJ/kg Carbon content kgC/kg solvent Ethyl Acetate 12.1 0.64 Ethanol 13.85 0.52 Methanol 9.99 0.37 Toluene 23.15 0.91 THF 17.99 0.67 Acetic Acid 5.87 0.40 Hexane 23.66 0.84 Ether 17.89 0.65 IPA 15.70 0.60 Copyright © 2009 Rockwell Automation, Inc. All rights reserved. .d o 10 m A Life Cycle Analysis: THF w o .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to .d o Broaden our perspective from plant boundary to entire life cycle. When we recover a solvent, emissions are being avoided because there is no need to produce that kilogram of solvent. We need to consider not only the production of THF itself, but all the intermediaries required throughout the process, all the way back to the original fossil extractive source. We must consider the entire Chemical Tree. Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 11 m w o Life Cycle Analysis of THF lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to Copyright © 2009 Rockwell Automation, Inc. All rights reserved. .d o 12 m w o Chemical Tree (LCA) THF lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to .d o The Difference in Carbon Dioxide generation between recovery and incineration at the plant boundary is only 0.205 kg/kg solvent (0.5730.368) However, 78 kg of carbon dioxide was generated in producing the 1 kg of THF. This is a 380 times difference. (78 kg / 0.205 kg) Considering a 200 to 1 Atom Economy leverage ratio, the impact of a carbon tax will have a 15,600 to 1 leverage impact (78 * 200) Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 13 m w o THF Life Cycle and Carbon Dioxide lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to lic k .d o Modules ModulesInstalled Installedon onSite Site Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 14 m Case Study w o .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to .d o This is all fine, good and interesting but doesn’t apply to me because we use an aqueous process. Our solvents are all buffers. Sure aqueous buffers are inexpensive and easily neutralized and disposed of… ..BUT it is wasteful and does have an environmental impact. Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 15 m w o SO WHAT? I’m a big molecule Bio Person lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to • • • • lic k .d o Energy required to create the purified water (12-18 megohm) Energy required to treat the waste water discharge. Energy Required to create buffer components (acids, ionic compounds) Carbon Dioxide generated in buffer component process. ** These maybe minor in comparison to organic solvents, but they represent waste and environmental stress. Let’s look at the sustainability costs and implications of aqueous buffers. Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 16 m w o .c C m Sustainability Issues of Aqueous Solvents o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to Item Unit Energy .d o Carbon Dioxide High Purity Water Liters 0.32 KWh/L 0.42 lbs/L Waste Water Liters 0.001 KWh/L 0.001 lbs/L Acid / Bases Kg 1.042 KWh/Kg 1.41 lbs/Kg Ionic Buffers Kg 0.843 KWh/Kg 1.22 lbs/Kg Transportation Kg/Mile NA 0.0376 lbs/Kg-mile Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 17 m w o Life Cycle Analysis of Aqueous Buffers lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to • • • • • • • lic k .d o Avg Solvent Usage 40 liters/min Avg Lines 4 Yearly Solvent Consumption: 4,800,000 liters KWh consumed: 1,630,000 KWH Electricity Cost: $ 146,480 ( at $0.09 KWH) Carbon Dioxide Generation: 2,275 Tons Carbon Tax: $ 63,706 (at current $ 28 per ton) • Estimated Capital Investment: $ 250,000 • IRR (5 years): 79% • Payback period: 1.25 years Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 18 m w o .c C m Solvent Sustainability: Avg BioPharma Plant o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to lic k Estimated Yearly Savings: $ 570,000 .d o Total Solvent: 80 Liters Total Time: 20 min. Peak Area: (ZBTR): 2.0 min. Potential Recoverable: 91% ROI: 254% Desired Fraction Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 19 m Example: w o .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to lic k .d o Column Control System Detector Flow Switch Manifold Sol. 1 Sol. 2 Sol. 3 Sol. 4 Waste Copyright © 2009 Rockwell Automation, Inc. All rights reserved. Product 20 m Gradient Solvent Recovery w o .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y k lic .d o Besides the atoms required in the process, production relies on a unique support ecosystem. If the eco-system is threatened, then the species is threatened (niche) CIP / SIP / WFI / Clean Rooms The FDA is constantly threatening the pharma-manufacturing eco-system. Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 21 m w o Eco-System Resources to bu .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to k lic .d o The Case For Single Use and Disposables Technology Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 22 o .c m C m w o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k POUNDS CARBON / BATCH SIP CIP Transporting Plastic Pumping Water & Wastewater Steel Fab. Amortized per Batch Polymerizing Plastic per Batch Extruding Plastic WFI Still Cleanroom Energy Incinerating Plastic TOTAL Single Use % 0.0 0.0% 30.5 0.2% 148.5 0.8% 3.7 0.0% 2,970.7 16.6% 799.3 4.5% 499.6 2.8% 7,308.7 40.8% 132.1 0.7% 6,029.3 33.6% 17,922.4 Stainless % 388.5 1.0% 1,988.0 4.9% 0.0 0.0% 28.7 0.1% 7,723.8 19.2% 0.0 0.0% 0.0 0.0% 29,828.8 74.3% 204.1 0.5% 0.0 0.0% 40,161.9 N y bu to k lic w .d o Diff. 388.5 1,957.5 -148.5 25.0 4,753.1 -799.3 -499.6 22,520.1 72.0 -6,029.3 22,239.5 Courtesy Leveen & Monge, ISPE Tampa Conference, 02 March, 2009 55% reduction in carbon footprint Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 23 m Environmental Advantages of FlexFactory: Carbon Footprint o .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to k lic Biomanufacturing Revolution 1,000L Bioreactor 1982 1,000L Bioreactor 1994 .d o Xcellerex 2000L Single Use Bioreactor TODAY Water consumption is reduced by nearly 85% Total carbon footprint reduced by approximately 55%. . Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 24 o .c m C m w o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k POUNDS CARBON / BATCH SIP CIP Transporting Plastic Pumping Water & Wastewater Steel Fab. Amortized per Batch Polymerizing Plastic per Batch Extruding Plastic WFI Still Cleanroom Energy Incinerating Plastic TOTAL Single Use % 0.0 0.0% 30.5 0.2% 148.5 0.8% 3.7 0.0% 2,970.7 16.6% 799.3 4.5% 499.6 2.8% 7,308.7 40.8% 132.1 0.7% 6,029.3 33.6% 17,922.4 Stainless % 388.5 1.0% 1,988.0 4.9% 0.0 0.0% 28.7 0.1% 7,723.8 19.2% 0.0 0.0% 0.0 0.0% 29,828.8 74.3% 204.1 0.5% 0.0 0.0% 40,161.9 N y bu to k lic w .d o Diff. 388.5 1,957.5 -148.5 25.0 4,753.1 -799.3 -499.6 22,520.1 72.0 -6,029.3 22,239.5 Courtesy Leveen & Monge, ISPE Tampa Conference, 02 March, 2009 We still generate a lot of waste: Chromatography resins Filtration All must be decontaminated Single use bags and disposed of. Gowning Spent Media Biomass Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 25 m Environmental Advantages of Single Use: Carbon Footprint o .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to k lic w Recovering Hydrogen and Energy from Pharmaceutical Waste Syngas Polishing System Waste Feed System Steam/CO2 System Scrubber System .d o Waste Syngas Preheater Scrubbed Syngas P T T Carbon Bed T FM Demister Mat HEPA Filter P Steam In T Medwaste Feed Screw P Spray Tower T Steam/CO2 Reformer T T Steam In T Screw-Conveying Kiln CO2 T Chiller T P Double Gate Lockhopper T Product Syngas Vane Vacuum Pump T O2 Variable-speed Motor-drive Pump Caustic Sterilzed Solids Receiver Payback about 3 years. Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 26 o .c m C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to k lic Steam Reforming-Hydrogen and Syngas Generator Copyright © 2009 Rockwell Automation, Inc. All rights reserved. .d o 27 m w o .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y k lic .d o New biopharma plants are too expensive and capital is tied up too long unproductively. Solutions: 1. Single Use Disposables 2. Controlled Environment Modules Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 28 m w o Capital Efficiency to bu .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to k lic Biomanufacturing Revolution 1,000L Bioreactor 1982 1,000L Bioreactor 1994 .d o Xcellerex 2000L Single Use Bioreactor TODAY Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 29 o .c m C m w o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu Copyright © 2009 Rockwell Automation, Inc. All rights reserved. lic .d o 30 m w o Individual Unit Operation Clean Modules k to .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y k lic .d o People are the biggest source of contamination. Keep them out of unit ops. Gowning dramatically reduced Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 31 m w o Working with Controlled Environment Modules to bu .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N lic k to bu y Plant Footprint: Conventional vs. Xcellerex FlexFactory .d o for 4 x 2000L lines, cell vial to purified API bulk MEDIA LOCKERS/ GOWNING U.S.P. BUFFER EQUIP. PREP U.S.P. LABS LOCKERS/ GOWNING FlexFactory™ PROCESSING SUITE C.I.P./ S.I.P. OFFICES D.S.P. CLEAN UTILITIES WASH LABS D.S.P. WAREHOUSE PLANT UTILITIES OFFICES WAREHOUSE PLANT UTILITIES Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 32 m w o .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to lic k .d o • • • • Capital Cost Reduced by 65% Major investment delayed until product is ready. Water consumption is reduced by nearly 85% Gowning Costs decrease by 40%; Modular CEM architecture enables independent operation of each unit process. Operators can move freely up and down lines or across lines, without extra gowning and degowning. • Increase in Sq Ft Efficiency---A single FlexFactory line can produce multiple drugs — at the same time! • Total carbon footprint reduced by approximately 55%. • Final COGS reduced by 30% or more. Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 33 m w o .c C m Operating Benefits o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to .d o The ability to effectively change and to quickly take advantage of new opportunities. For Pharma this means: Time to Market & Flexible Manufacturing Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 34 m w o Adaptability and Agility lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to From 3-5 Years .d o To 12-18 Months Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 35 m w o Time to Market is Everything lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE N y k lic w .d o *Pharma Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 36 m Modularization* –Past 20 Years o .c to bu c u-tr a c k C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to Copyright © 2009 Rockwell Automation, Inc. All rights reserved. .d o 37 m w o What was built… process room lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to Copyright © 2009 Rockwell Automation, Inc. All rights reserved. .d o 38 m MCC Room w o Interlock lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to Copyright © 2009 Rockwell Automation, Inc. All rights reserved. .d o 39 m w o What was designed… Cut-away Section lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to Copyright © 2009 Rockwell Automation, Inc. All rights reserved. .d o 40 m w o Modular Process Solutions lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to Copyright © 2009 Rockwell Automation, Inc. All rights reserved. .d o 41 m w o What was built… on the high seas lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to Copyright © 2009 Rockwell Automation, Inc. All rights reserved. .d o 42 m w o 5:30 PM Friday Night lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to Copyright © 2009 Rockwell Automation, Inc. All rights reserved. .d o 43 m w o Modules Lifted on to Pad lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to Copyright © 2009 Rockwell Automation, Inc. All rights reserved. .d o 44 m w o 8:00 AM Monday lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to k lic .d o Flexibility and Adaptability Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 45 o .c m C m w o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE N y k .d o m o .c to bu w o c u-tr a c k C m C lic k Standard Unit Ops, Single Use Technology and Modular Construction Provides Improved Flexibility w w .d o w w w lic to bu y N O W ! PD O W ! PD c u-tr a c k Seed reactor (Wave System20 shown) N-1 reactor (Xcellerex XDR-200 shown) Chromatography Production reactor (Xcellerex XDR-2000 shown) 0.2u Filtration (BioFlash , GEAKTA-Ready) (Sartorius Sartopore shown) Disposable centrifuge Depth filtration (Centritech Cell I shown) (Millipore POD shown) Ultra-diafiltration (GE Hollow Fiber shown) Virus Filtration Buffer/Media Prep Buffer/Process Storage (Pall DV20 shown) (Xcellerex XDM-500 shown) (Hyclone Labtainer shown) Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 46 .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to .d o • Survival of the Fittest: – Most Efficient Use of Resources • Solvent Usage • Single Use Technology – Ability To Adapt • Time to Market • Standard Unit Ops Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 47 m w o Sustainability Recap lic k .c C m o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c H F-XC A N GE H F-XC A N GE c u-tr a c k N y bu to k lic .d o Thank You And Good Luck For more information please contact: David March 704-559-5348 damarch@ra.rockwell.com Copyright © 2009 Rockwell Automation, Inc. All rights reserved. 48 o .c m C m w o .d o w w w w w C lic k to bu y N O W ! PD O W ! PD c u-tr a c k .c