DRAFT PROGRAMME Division of Medicine Research Retreat Friday, 24th April 2015 Marriott Hotel Regents Park, 128 King Henry’s Road, NW3 3ST REGISTRATION FROM 08.30 hrs. MORNING SESSIONS SESSION 1 Chairs: Liz Jury and Markella Ponticos 09.20 Welcome 09.30 Professor Raymond MacAllister Director Division of Medicine UCL Professor Michael Hausser 09.50 Dorota Rowczenio 10.05 Madhur Motwani 10.20 Jimstan Periselneris Molecular basis for late onset of the autoinflammatory diseases cryopyrinassociated periodic syndrome (CAPS) and TNF receptor associated periodic syndrome (TRAPS) Exudate suction blister: A novel in vivo model of acute inflammation and resolution in humans Pneumolysin deficient Streptococcus pneumoniae cause more inflammatory cytokine release than wild type bacteria 10.35 – 11.20 Coffee break and poster session SESSION 2 Chairs: Blandine Poulet and Kiran Nistala 11.20 Professor Rachel Batterham Modulating Gut Hormones to Treat Obesity and Cure Type 2 Diabetes - Fact of Fantasy? 11.40 Kristine Oleinika 11.55 James Irving 12.10 Natalia Becares Salles Invariant natural killer T cell role in the CD1d mediated induction of regulatory B cells Stability and structural change during the ordered aggregation of α1antitrypsin Effects of LXRα phosphorylation on the regulation of lipid metabolism and liver fibrosis 12.25 – 13.30 Lunch and posters All-optical interrogation of neural circuits AFTERNOON SESSIONS SESSION 3 Chairs: Adam Giangreco and Jenny Rohn 13.30 Professor Claudia Mauri The ups and down or moving animal house : an unexpected link between gut microbiota and arthritis 13.50 Tanvi Agrawal 14.05 Imran Haq 14.20 Sofia Lourenco HER2 determines thymus epithelial progenitor cell homeostasis and age associated T cell mediated immunity A novel homozygous α1-antitrypsin mutation, A336P (PiBaghdad), which results in moderate plasma deficiency but a functionally null individual Mesenchymal Stem Cells antigen presenting to naïve T cells : potential for a novel cancer immunotherapy? 14.35 - 15.00 Tea/Coffee break and posters SESSION 4 Chairs: Andrew Plumb and Alan Holmes 15.00 Professor Sir Mark Pepys Drug Discovery and development from academia to pharma 15.20 Simon Walker-Samuel 15.35 Balaji Ganeshan 15.50 Tammy Kalber Imaging tumour microstructure and fluid dynamics with MRI High-Risk Breast Cancer Phenotype Identified by Quantitative Radiomic Analysis of Positron Emission Tomography – Computed Tomography with Histopathological Correlation and Survival Risk Generation of Multi-Modal Imaging Mesenchymal Stem Cells 16.05 – 17.00 Drinks reception