Aquaporins in olfaction
- an EM/LM study
Torgeir Holen, TGIF
June 19th, 2009
An introduction to olfaction
Olfactory epithelium of the nose
and the olfactory bulb
Linda Buck
The olfactory system is ancient and
directly connected to cortex
Linda Buck
The glomerulus - the synaptic unit of
the olfactory system
Linda Buck
Nobel Prize in Medicine 2004
Richard Axel
Linda Buck
... the rat...
The olfaction receptor
Richard Axel, 1993
Whole turbinate in situ... one receptor
(of 1000) per neuron...
Richard Axel, 1993
1000 receptors, 2000 glomeruli, but only
one activated...
Schwob,
2002
Many-to-one.... how?
AQP4 in
olfactory
epithelium
and in the
olfactory
bulb,
Sorbo, Moe &
Holen, 2007
Olfactory epithelium
Linda Buck
Schwob, 2002
Glial cells at the glomerulus
De Saint Jan, 2005
Acknowledgements
• Tom T. Solbu
• Line Strand
• You
• ..........the Heroes!
• ...................Thank you for your attention!