Trauma
KADOORIE CENTRE
FOR CRITICAL CARE
RESEARCH AND
Research & Development
EDUCATION
V O L U M E
OUR RESEARCH
THEMES
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I S S U E
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S E P T E M B E R
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Kadoorie Centre Grand Opening
Effectiveness of
treatments
Rehabilitation
Patient / Staff
experience
INSIDE
THIS
ISSUE:
Kadoorie Centre 1
Opening
MaTOMS
2
WOLLF
2
AIM
2
FAB
3
OVIVA
3
Forthcoming
Meetings
3
Contact Details
4
On 12th July 2013 Sir Michael
and Lady Betty Kadoorie
officially opened the new
extension above the front
entrance to the hospital and
unveiled a plaque
commemorating the event
(pictured above with Professor
Keith Willett).
Sir Michael and Lady Betty
Kadoorie very kindly
supported phase one of the
Kadoorie centre, opened in
July 2003. The research teams
of Professor Keith Willett, Dr
Duncan Young, Dr Peter
Watkinson and Professor Sallie
Lamb have since been so
successful that a further major
donation from Sir Michael has
supported the development of
phase two.
The expansion has created
office space for a further 21
staff, a meeting room and staff
room and remodelled the
reception area. The building
has many eco-friendly features
which includes solar panels
that create electricity for the
hospital.
The Kadoorie Centre is a place
for collaborative research and
development in critical care,
traumatic injury and
rehabilitation. The staff (both
NHS and Oxford University),
work with patients and clinical
colleagues to ensure good quality
research is developed that will
improve patient care.
Current activities include the
clinical effectiveness of: different
forms of monitoring acutely ill
patients, limb supports following
injury, wound dressings, exercise
regimens, different forms of
ventilation (support for
breathing), drugs that promote
fracture healing; and studies that
assess recovery from major
injuries/illness over time.
For further details of on-going
research, go to the Kadoorie
website at www.ouh.nhs.uk/
Kadoorie.
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MaTOMs
MaTOMS is a feasibility study
looking at the acceptability of
collecting outcome measures in
major trauma patients. The
study aims to gather outcome
data from adults and children,
on discharge, at 6 months and
at 1 year.
Since the study opened in April
2013 we have found
recruitment slower than
anticipated. Contributing
factors have been the
complexity of the patients’
injuries and their adjustment to
them, the many competing
research studies for this
particular group and we are
keen that potential participants are
not burdened with numerous
research studies.
To date we have recruited 26
participants. Our target is to
recruit 100 participants (90 adults
and 10 children).
For further details contact:
Susanna Symonds
WOLLF: Update
WOLLF is a randomised
controlled trial of standard wound
management versus negative
pressure wound therapy in the
treatment of adult patients with an
open fracture of the lower limb.
The primary outcome measure is
the disability rating index one year
post injury (Null Hypothesis—no
difference between the two
groups). A qualitative sub study
will also assess patient experience
of having an open fracture, being
enrolled in the study, giving or
declining consent for the trial and
the acceptability of the trial
procedures.
The trial is funded by HTA and
sponsored by the University of
Warwick and University Hospitals
Coventry and Warwickshire NHS
Trust.
Professor Matthew Costa is the
Chief Investigator.
WOLLF has been open to
recruitment since April 2012 and is
a multi-centre trial at 13 sites thus far
(aiming for 20 sites).
Recruitment will continue until
March 2016 with a 1 year follow up
period. Up until the end of August 75
participants have been recruited.
The study has been running well in
Oxford after opening to recruitment
in October 2012. We have
consented 15 participants to date.
For further details contact: Louise
Spoors
AIM: Update
The trauma team at the John
Radcliffe Hospital are:
1.
Top (joint) recruiting
AIM site with 42 recruits!
2.
Lead on highest number
recruits in one month (6)
3.
Are ahead of site
recruitment target of 1
per month, with 42
patients recruited across
38 months (see graph
below)
Fantastic achievement, well
done to all the trauma teams!
The AIM Trial is taking place in
20 sites across the UK and will
continue recruiting until later
this year. At the end of August
all-site recruitment was ahead of
target, 495/464. End of study
target is 525, 30 to go! Six
month follow up appointments
continue into 2014.
Our gratitude to all who have
contributed.
Please continue to screen
and recruit for these final few
months. Thank you!
If you would like to know more,
please contact the AIM Trial
Office: Tel: 01865 740328 or
aim.trial@ndorms.ox.ac.uk
Lesley Morgan, AIM Trial
Manager
VOLUME
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ISSUE
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FAB (Fractures and Bisphosphonates)
This is a double-blind,
randomised controlled trial to
determine if alendronic acid
affects fracture healing of men
and women aged 50 and over
who have suffered distal radial
fracture (Primary Objective).
Although bisphosphonates are
widely used in the treatment of
osteoporosis currently there is
no consensus regarding what
should be done with
bisphosphonate therapy following
an acute fracture. It remains
unclear whether early treatment
might be advantageous or
deleterious to fracture healing and
clinical outcome.
Patients aged 50 and over who have
fractured their wrist and are not on
bisphosphonate therapy will be
invited to take part in the study.
Participants do not have to be
osteoporotic to enter the study; the
primary question is based on
fracture healing whilst taking
bisphosphonates and as such it is
not necessary to know the bone
density of participants.
Secondary Objectives: upper
limb function, the effect of
alendronic acid on the prevalence of
Chronic Regional Pain Syndrome,
difference in pain, active range of
movement, grip strength and
assessment of whether the bones have
healed.
Recruitment opened in Oxford in June
2013. We have recruited 7 participants
so far, with the aim of recruiting 50 in
total at this site. The study is open
across the UK at 9 sites in total, with
recruitment currently (end August
2013) at 192 of the 500 target.
For further details contact: Vivienne
OVIVA
OVIVA is an open label
randomized study of intravenous
versus oral antibiotic therapy for
serious bone and joint infections
requiring prolonged antibiotic
treatment. It began as a
preliminary single-centre study
in June 2010 in Oxford and has
now gone multi-centre.
The OVIVA team are excited to
see five other sites already
recruiting patients into the
study. These include:
Guys and St Thomas Hospital
Royal Free
Royal National Orthopaedic
Hospital Stanmore
Royal Liverpool University
Hospital
Birmingham Heartlands
The primary endpoint of the
study is to determine whether
oral antibiotics are no worse
than intravenous antibiotics for
serious bone and joint infection.
This is judged by the numbers
meeting a primary endpoint for
definitive treatment failure
during 1 year follow up.
The study is funded by the NIHR
HTA programme and the
Biomedical Research Centre.
For further details contact:
Louise Spoors
Forthcoming Meetings
Injuries and Emergencies
Speciality Group (IESG) is
part of the Thames Valley
Comprehensive Local Research
Network (TVCLRN).
Chairman: Mr Andrew
MacAndrew.
Next meeting:
Friday 20th September at 1.30pm
(lunch at 12.30pm) at Milton
Keynes Hospital
Trauma Orthopaedic
Research Collaboration
(TORC): This is a national
meeting attended by a mixture
of Trauma, Ortho-geriatric and
Bone & Metabolic Health
specialists and multidisciplinary
staff.
Chairman: Tim Chesser
Next Meetings:
December 6th 11-2 at Oxford
TVCLRN Research Nurse
Meeting
This is an informal meeting for
research support staff working
within NHS research. The aim of
the meeting is to offer peer
support and share information
and training through regular
meetings
Next Meeting: To be announced:
Rosemary Rue Building (Teaching
room A), Old Campus Road,
Oxford. Contact Louise
Spoors for details.
Trauma User Group (TUG):
This is a joint meeting between
clinical and research staff, and
service users who have an interest
in helping to shape existing and
future research studies. New
members are always welcome.
Light refreshments will be served.
Next Meeting:
Tuesday 8th October 2013 from 6
-8pm at the Kadoorie Centre,
Level 3, John Radcliffe Hospital.
If you are interested in
becoming a member or for
more information please
contact Vivienne Fairclough
or Susanna Symonds
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VOLUME
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Kadoorie Centre
for Critical Care Research and Education
Level 3
vivienne.fairclough@ouh.nhs.uk
John Radcliffe Hospital
lynn.hutchings@ndorms.ox.ac.uk
Oxford
david.keene@ndorms.ox.ac.uk
OX3 9DU
s.lamb@warwick.ac.uk
Contact: Chris Bouse
sally.lambert@ouh.nhs.uk
Phone: 01865 223101
debbie.langstaff@ouh.nhs.uk
Fax:
01865 223103
lesley.morgan@ndorms.ox.ac.uk
01865 223102
emma.roberts@ndorms.ox.ac.uk
louise.spoors@ouh.nhs.uk
Email addresses
susanna.symonds@ouh.nhs.uk
linda.andrews@ouh.nhs.uk
josephalsousou@doctors.org.uk
www.ouh.nhs.uk/kadoorie/
chris.bouse@ouh.nhs.uk
liz.tutton@ouh.nhs.uk
keith.willett@ndorms.ox.ac.uk
julie.wright@ouh.nhs.uk
Selected Recent References
Keene D, James G, Lamb SE,
Walton J, Gray B, Coleman D,
Handley R, Handa A, Willett K.
Factors associated with mobility
outcomes in older people postankle fracture: An observational
cohort study focussing on peripheral
vessel function. Injury. 2013 Jul;44
(7):987-93. doi: 10.1016/
j.injury.2012.08.042. Epub 2012 Sep
27.
Alsousou J, Ali A, Willett K,
Harrison P. The role of platelet-
rich plasma in tissue regeneration.
Platelets. 2013;24(3):173-82. doi:
10.3109/09537104.2012.684730. Epub
2012 May 30. PMID: 22647081
Young D, Lamb SE, Shah S,
MacKenzie I, Tunnicliffe W, Lall R,
Rowan K, Cuthbertson BH;
OSCAR Study Group. HighFrequency Oscillation for Acute
Respiratory Distress Syndrome. N Engl
J Med. 2013 Feb 28;368(9):806-13. doi:
10.1056/NEJMoa1215716. Epub 2013
Jan 22. PMID: 23339638
Lamb SE, Gates S, Williams
MA, Williamson EM, Mt-Isa S,
Withers EJ, Castelnuovo E,
Smith J, Ashby D, Cooke MW,
Petrou S, Underwood MR
Emergency department treatments
and physiotherapy for acute
whiplash: A pragmatic, two-step,
randomised controlled trial The
Lancet. 2013; 9866(381): 546-556
Useful Links
The Comprehensive Clinical Research Network: www.crncc.nihr.ac.uk/about_us/ccrn
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences:
www.ndorms.ox.ac.uk
Injury Minimization Programme for Schools (I.M.P.S.): www.impsweb.co.uk
University of Oxford: www.ox.ac.uk