NCI Funding Opportunities in Health
Services, Outcomes, and
Comparative Effectiveness Research
Martin L. Brown, Ph.D.
Chief, Health Services and Economics
Applied Research Program
Division of Cancer Control and Population Sciences
http://appliedresearch.cancer.gov/
Academy Health Annual Meeting
Chicago
June 30, 2009
NCI Funding Mechanisms for
Junior and Mid-level Investigators
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K-Awards – NCI Training Awards
R03 – Small Research Grants in Behavioral and
Social Sciences
R21 – Exploratory/Developmental Grants
R01 – Research Projects
 http://deainfo.nci.nih.gov/flash/awards.htm
General Grant Applications Instructions
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http://deainfo.nci.nih.gov/flash/awards.htm
Current Health Services Research
Program Announcements
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Cancer Surveillance Using Health Claims-Based Data System
The Effect of Racial and Ethnic Discrimination /Bias on
Health Care Delivery
Research on the Economics of Diet, Activity, and Energy
Balance
Methodology and Measurement in the Behavioral
and Social Sciences
For more information see:
http://appliedresearch.cancer.gov/funding/pa.html
NCI Funding Mechanisms for Dissemination and
Implementation Research
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R03 – Small Research Grants
 Dissemination and Implementation Research in
Health
 http://grants2.nih.gov/grants/guide/pa-files/PAR06-071.html
R21 – Exploratory/Developmental Grants
 Dissemination and Implementation Research in
Health
 http://grants2.nih.gov/grants/guide/pa-files/PAR06-072.html
R01 – Research Projects
 Dissemination and Implementation Research in
Health
 http://grants1.nih.gov/grants/guide/pa-files/PAR06-039.html
Funding of Comparative
Effectiveness Research
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Under American Recovery and Reinvestment
Act (ARRA), Congress authorized the following
funds for CER:
$300 million to AHRQ
 $400 million to NIH
 $400 million to the Office of the Secretary, DHHS
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These funds must be obligated by September,
30, 2010
Funded projects must ne completed within 2
years.
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Definition of CER
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… the conduct and synthesis of systematic research comparing
different interventions and strategies to prevent, diagnose, treat
and monitor health conditions.
…to inform patients, providers and decision-makers,
responding to their expressed needs, about which interventions
are more effective for which patients under specific
circumstances.
…must assess a comprehensive array of health-related outcomes
for diverse patient populations.
…interventions compared may include medications, procedures,
medical and assistive devices and technologies, behavioral
change strategies, and delivery system interventions.
…necessitates the development, expansion, and use of a variety
of clinical data sources and methods to assess comparative
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effectiveness.
NIH/DHHS Priorities for CER
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Report from Federal Coordinating Council on
CER due to Congress on June 30, 2009.
Report from Institute of Medicine on CER due
to DHSS on June 30, 2009
Prioritization of disease/condition areas and
types of studies
Prioritization of other activities, e.g. data
resources, methods, etc.
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CER Challenge Grants
69 CER-specific topics were included in the NIH Challenge Grant RFA
(March 2009)
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1,700 Applications
Review to be completed by mid-July, 2009
Examples:
05-CA-101* Comparative Effectiveness Research in Cancer Primary
Prevention.
05-CA-102* Comparative Effectiveness Research on Cancer
Screening.
05-CA-104* Comparative Effectiveness Research on Cancer
Treatment.
05-CA-103* Cost-Effectiveness of Patient Navigation.
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NCI CER GO Grants
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Comparative Effectiveness Research in Cancer
Prevention, Screening and Treatment
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30 applications, review to be completed by August 6,
2009
Comparative Effectiveness Research in
Genomic and Personalized Medicine
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30 applications, review to be completed by August 6,
2009
CER GO in Cancer Prevention,
Screening and Treatment
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Health Technology Monitoring and Assessment
Evaluation, Development, Validation and
Integration of Data and Informatics Resources
Development of CE Trials Resources and Operating
Procedures
Development, Evaluation and Validation of
Statistical, Psychometric, Econometric, Informatics
and Modeling Methods
Comparative Effectiveness Studies
Collaboration and Dissemination
For further information on anything
presented today -- including most
appropriate NCI contacts, email ….
Steven Clauser, Ph.D.
Chief, Outcomes Research Branch
Clausers@mail.nih.gov
Martin Brown, Ph.D.
Chief, Health Services & Economics
Branch
Brownm@mail.nih.gov