Gender & Health Call for Papers Advances in Gender-Based Health Services Research Chair: Rosaly Correa-de-Araujo, Agency for Healthcare Research and Quality Sunday, June 25 • 10:30 am – 12:00 pm ●Gender Differences in the Relationship between Neighborhood Socioeconomic Characteristics and Allostatic Load Chloe Bird, Ph.D., Brian Finch, Ph.D., D. Phuong Do, MPhil, Jose Escarce, MD, Ph.D., Nicole Lurie, MSPH, Teresa Seeman, Ph.D. Presented By: Chloe Bird, Ph.D., Sociologist, Health, RAND, 1776 Main Street, Santa Monica, CA 90407-2138; Tel: (310) 393-0411 x6260; Fax: (310) 260-8159; Email: chloe@rand.org Research Objective: Few studies examine whether potential biological pathways through which neighborhoods affect health differ by gender. We examined the extent to which neighborhood characteristics are related to men’s and women’s biological markers of stress, based on a summary index of allostatic load (AL), adjusting for individual characteristics. Study Design: Using 3-level hierarchical linear regression, we analyzed National Health and Nutritional Examination Survey III (NHANES) interview and laboratory data, merged with data on sociodemographic characteristics of their residential census tract. AL was measured as a summary score (range 09) based on clinical cut points for 9 indicators from 3 systems: metabolic (total cholesterol, HDL cholesterol, glycosylated hemoglobin, waist/hip ratio), cardiac (systolic and diastolic blood pressure, radial heart rate) and inflammatory (c-reactive protein, serum albumin). Population Studied: Our analyses included 14,320 adults from 83 counties and 1805 census tracts, who completed surveys and medical exams, were not missing on key components of the outcome measures, and for whom residential census tract could be geocoded. The sample was 47% male; 43% white, 27% black, 26% Hispanic, 4% other. Subjects ranged in age from 19.5 to 90 (mean = 48); 53% were employed and 58% had at least a high school education. The mean family income/poverty ratio was 2.41. Principal Findings: Across all models, individual level socioeconomic controls including Hispanic ethnicity (p < .001), lower family income (p < .03), lower education (p < .05), lack of employment (p < .005), age (p < .001) were independently associated with higher AL. Adjusting for individual level characteristics, living in a census tract with a higher percentage of households in poverty was associated with a higher AL for women but not men (coeff. for women = .351, p = .01 versus -.007 for men, p = .965). In separate analyses, higher median income (in 10k units) was associated with lower AL for women but not men (coeff. for women = -.042, p .001 vs. -.015 for men, p = .302), and percentage of adults in the tract with less than high school education was associated with higher AL for women but not men (coeff. for women = .389, p < .001, vs. .221 for men, p = .056). In contrast, for men but not women living in a census tract with a higher percentage of blacks was associated with higher AL (coeff. for men = .185, p = .027, vs. .075 for women, p = .296). Conclusions: Gender differences in neighborhood income, education, and racial composition effects on allostatic load suggest that neighborhoods themselves may influence both individual and population health differently for men and women. Implications for Policy, Delivery, or Practice: By assessing potential pathways through which health—and gender differences in health may be generated, this study contributes to a larger effort aimed at developing an understanding of whether changing neighborhood features, such as neighborhood quality could improve health and reduce health disparities. The mechanisms through which these effects are produced need to be explored. Primary Funding Source: NIEHS ●Gender Differences in the Intergenerational Connections Between Child Maltreatment and Intimate Partner Violence Xiangming Fang, Ph.D., Phaedra S. Corso, Ph.D. Presented By: Xiangming Fang, Ph.D., Health Economist, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, 4770 Buford Highway, MS K60, Atlanta, GA 30341; Tel: (770)488-1572; Fax: (770)488-1011; Email: xfang@cdc.gov Research Objective: Intimate partner violence (IPV) is a national problem affecting millions of adults each year in the United States. Previous research on how child maltreatment victimization affects future IPV perpetration or victimization has had some limitations, including inadequate controlling for confounding factors, unrepresentative samplings, and lack of adequate investigation of gender differences in the connections between child maltreatment and adult IPV. Furthermore, little is known about whether youth violence (YV) perpetration mediates the effect of child maltreatment on IPV perpetration, or whether youth violence victimization mediates the effect of child maltreatment on IPV victimization. In this study, we use a longitudinal and nationally representative sample to examine the effects of three forms of child maltreatment (neglect, physical abuse, and sexual abuse) and YV perpetration/victimization on IPV perpetration/victimization, and the role that gender plays in the developmental relationships. Study Design: Data describing self-reported YV behaviors from Wave I of the National Longitudinal Study of Adolescent Health (Add Health) study (1994 – 1995) were matched with self-reported IPV perpetration and victimization within young adult sexual relationships and retrospective reports of child maltreatment during Wave III (2001 – 2002) of the Add Health study. Hierarchical Logistic Regression models were used to analyze the developmental relationship between child maltreatment and adult IPV perpetration/victimization. Population Studied: This study included 10,320 participants (5,724 women and 4,596 men) aged 18 to 26 who reported being involved in at least one sexual relationship in the two years preceding Wave III of the Add Health survey. Principal Findings: Controlling for demographic and socioeconomic variables, childhood physical abuse is a significant predictor of future IPV perpetration for females, but not for males. Childhood neglect is significantly predictive of IPV perpetration for both females and males. Childhood sexual abuse is not significantly associated with IPV perpetration for females; however, for males, it is the most significant predictor of IPV perpetration. YV perpetration is a significant predictor of IPV perpetration for both males and females. For females, YV perpetration partly mediates the effect of both childhood physical abuse and neglect on IPV perpetration. For males, YV perpetration only mediates the effect of childhood neglect on IPV perpetration. Findings on the effects of child maltreatment and YV victimization on IPV victimization will also be discussed. Conclusions: In general, victims of child maltreatment are more likely to be the perpetrators or victims of IPV. However, gender differences exist for the developmental relationship between child maltreatment and IPV perpetration/victimization. YV victimization does not mediate the effect of any form of child maltreatment on IPV victimization for either males or females. YV perpetration partly mediates the effect of both childhood physical abuse and neglect on IPV perpetration for females, but only mediates the effect of childhood neglect on IPV perpetration for males. Implications for Policy, Delivery, or Practice: IPV prevention should begin as early as childhood. When designing the optimal time and settings of IPV prevention programs, it is important to take into account the gender differences in the developmental relationship between child maltreatment and adult IPV perpetration/victimization. Primary Funding Source: CDC ●Barriers to Colorectal Cancer Screening and to Screening Decision-Making by Gender Greta Friedemann-Sanchez, Ph.D., MA, Joan M. Griffin, Ph.D., Melissa R. Partin, Ph.D. Presented By: Greta Friedemann-Sanchez, Ph.D.. MA, Core Investigator, Center for Chronic Disease Outcomes Research,CCDOR, VA Medical Center, One Veterans Drive, Minneapolis, MN 55417; Tel: 612-467-4376; Fax: 612-727-5699; Email: Greta.Friedemann-Sanchez@med.va.gov Research Objective: Four screening modalities have been found to be efficacious at reducing colorectal (CRC) mortality: Fecal Occult Blood Test, sigmoidoscopy, Double Contrast Barium Enema, and colonoscopy. National data suggest that women are less likely to be screened for CRC than men. Predictors of this gendered difference have not been studied. The objective of this qualitative research study was to examine mode-specific gender differences in colorectal cancer screening barriers and preferences. Study Design: Six focus groups were conducted with male and four with female veterans to elicit information about barriers and facilitators to four screening modes. The groups were stratified by screening status (screened/unscreened). Six to eight individuals participated per group. A semi-structured interview guide was developed to assess perceptions, attitudes, beliefs and preferences about of CRC screening options. Discussions were recorded, transcribed, coded and analyzed according to the conceptual domains present in the interview guide. In addition, analysis incorporated domains that arose during the discussions. Population Studied: Female and male veterans between the ages of 50 and 75, who received care at the Minneapolis VA Medical Center’s primary care clinic in the past two years. Principal Findings: Previous studies on CRC screening preferences have found that patient’s prefer colonoscopy and FOBT at nearly equal rates. Our findings indicate similar screening mode preferences (both females and males preferred colonoscopy) and attitudes about the relative importance of colorectal versus reproductive cancer screening (both perceived screening for reproductive cancers as higher priority), but notable differences in barriers to screening completion and information preferences regarding endoscopic procedures. For instance, women who had a prior endoscopic procedure viewed the required preparation as a major barrier to screening, but men did not. Women and men also expressed significantly different fears (affective versus physical fears about the procedure, respectively) and information preferences regarding endoscopic procedures. Finally, women perceived CRC as a male disease thus feeling less vulnerable to CRC. Conclusions: Men and women have similar preferences for screening mode options but express different barriers to screening completion. Content of mode-specific information needs varies by gender. Tailoring by gender the type of knowledge may facilitate mode choice in a shared decision context, and it may be warranted given the gendered barriers by mode and reasoning behind the preferred mode. Providing specific information addressing type of discomfort (physical and affective) may also affect individual’s mode preference. Subtle differences in languages may make significant differences in the decision-making process and ultimately in patient’s preferences. Implications for Policy, Delivery, or Practice: Tailoring educational materials to gender specific barriers and information needs may be warranted and may improve screening among female veterans. Primary Funding Source: VA ●Hysterectomy and Risk of Cardiovascular Disease: The Atherosclerosis Risk in Communities (ARIC) Study Wanda Nicholson, M.D., M.P.H., Keiko Asao, M.P.H., Josef Coresh, M.D., Ph.D., Frederick Brancati, M.D., M.H.S., Neil R. Powe, M.D., M.P.H., M.B.A. Presented By: Wanda Nicholson, M.D., M.P.H., Gynecology and Obstetrics and Population and Family Health Sciences, Johns Hopkins Schools of Medicine and Public Health, 600 North Wolfe Street, Phipps 247, Baltimore, MD 21287; Email: wnichol@jhmi.edu Research Objective: Cardiovascular disease (CVD), including coronary heart disease and stroke, are leading causes of death among U.S. women. Hysterectomy is one of the most common surgical procedures performed in women with approximately 600,000 procedures per year in the U.S. Prior studies have suggested that hysterectomy may be associated with CVD through a decrease in prostaglandin levels and vascular contractility. Because of the extensive use of hysterectomy in the management of gynecological conditions, our objectives were to estimate the magnitude of association between hysterectomy status and CVD and to determine whether hysterectomy is predictive of future CVD. Study Design: Population-based, prospective cohort analysis from the Atherosclerosis Risk in Communities (ARIC) Study. The ARIC Study, designed as a longitudinal study of atherosclerosis, is a community-based, bi-racial cohort of men and women recruited between 1987 and 1989 with 9 years of follow-up. The predictor variable, hysterectomy status, was categorized as follows: no hysterectomy /no oophorectomy; hysterectomy alone or with unilateral oophorectomy(USO); and hysterectomy with bilateral oophorectomy (BSO)]. The outcomes were incident coronary heart disease (CHD) and incident stroke defined using standard methods. Incident rates for CHD and stroke were estimated across hysterectomy categories. CVD risk factors were compared across hysterectomy categories. Hysterectomy and risk of CVD was estimated for 512 incident CHD cases and 259 incident stroke cases with Cox proportional hazard regression models, adjusting for socio-demographics, known CVD risk factors and menopausal status at baseline. Population Studied: 7,399 White and African-American women, aged 45-64 years at baseline. Principal Findings: Women with any type of hysterectomy were of lower socioeconomic status and were more likely to have hypertension or diabetes, higher triglyceride levels, and lower physical activity compared to women with no hysterectomy/no oophorectomy (all P < 0.05). Incidence rates (IR) per 1,000 person-years for CHD were highest among women with hysterectomy/BSO (IR 5.8; 95% Confidence Interval (CI) 4.8, 7.1) and hysterectomy alone/USO (IR 5.3; 95% CI 4.4, 6.4) and lowest among women with no hysterectomy/no oophorectomy (IR 5.0; 95% CI 4.5, 5.6). Hystererectomy alone/USO (Hazard ratio (HR) 1.02; 95% CI 0.81, 1.31) and hysterectomy/BSO (HR 1.16; 95% CI 0.93, 1.46) were not statistically significantly associated with the risk of CHD. Incidence rates for stroke were highest among women with hysterectomy/BSO (IR 3.4; 95% CI 2.6, 4.4) and hysterectomy alone/USO (IR 2.7; 95% CI 2.1, 3.6) and lowest among women with no hysterectomy (IR 2.3; 95% CI 1.9, 2.7). In adjusted analysis, hysterectomy/BSO was associated with a 48% increased risk of stroke. After adjustment for covariates, the association was markedly attenuated and no longer significant (HR 1.25; 95% CI 0.86, 1.80). Conclusions: While women with hysterectomy alone/USO or hysterectomy/BSO have a worse CVD risk profile compared to women without hysterectomy, hysterectomy status is not predictive of CHD or stroke. Implications for Policy, Delivery, or Practice: The extent of CVD risk factors among women undergoing hysterectomy suggests that clinicians providing gynecological care might incorporate interventions to reduce CVD risk factors into their clinical practice. Further research might focus on clinical pathways common to both hysterectomy and CVD. Primary Funding Source: National Institute of Diabetes and Digestive and Kidney Diseases ●Effect of Depression and Comorbid Pain on Retirement: Gender Differences Haijun Tian, Ph.D Candidate Presented By: Haijun Tian, Ph.D Candidate, Doctoral Fellow, Pardee RAND Graduate School, RAND Corporation, 1776 Main Street, Santa Monica, CA 90407; Tel: 310-699-7988; Fax: 310-260-8151; Email: tian@rand.org Research Objective: To analyze the effect of depression and comorbid pain on the transition from employment to full retirement among older adult workers, and compare differential effects between male and female workers. Study Design: Using The Health and Retirement Survey (HRS), a longitudinal national representative survey of individuals born between 1931-1941—observations from 19942002, the study conducted multivariate ulogistic regression analysis with random effects, controlling for sociodemographics, chronic health conditions, insurance status, and job characteristics. The outcome is full retirement and primary explanatory variables are: depression only (based on short-form CESD), pain only (self-report of pain), and depression with comorbid pain. Population Studied: Longitudinal data were used from Wave 2 to wave 6 of the Health and Retirement Survey, a nationally representative sample of older workers with average age of 60. Principal Findings: Depression and pain status has differential impacts on retirement for women workers and men workers. Depression with pain predicts the early retirement for women, but not for men. Older women workers with depression and pain are more likely to be fully retired in two years (OR =1.42, p=0.03) compared to neither condition. Although the estimated odds ratio (OR) of retirement for older adult workers with depression and pain is higher than those with either condition alone, they are not statistically different. The effect of pain dominates the effect of depression for men workers. Men with pain only are more likely to be fully retired compared those with neither condition (OR = 1.25, p=0.03). Though men with depression and pain also reported higher odds ratio of retirement, they are not statistically significant. Conclusions: (1)Depression and pain status has differential impacts on retirement for women workers and men workers. (2)Depression and comorbid pain predict retirement, but depression alone may not.The social consequences of depression might be overestimated due to the compounding effect of comorbid pain. Implications for Policy, Delivery, or Practice: (1) Retirement costs of depression and pain are probably high for older women since early retirement usually implies a decrease in an individual’s earnings and possible loss of insurance (if individuals are still not qualified for Medicare or do not have retiree insurance). Therefore older American women with depression and pain deserve special policy considerations. (2) The depressed older women with comorbid pain may benefit from treatment practices and guidelines that address the duality of these conditions throughout the process of care. Primary Funding Source: No Funding Call for Papers Towards Improved Maternal Health: Policies, Practices & Programs Chair: Kristen Kjerulff, Penn State College of Medicine Sunday, June 25 • 3:45 pm – 5:15 pm ●Variation in the Accucacy of Recorded Maternal Events in Birth Certificates and Hospital Discharge Data between Physicians and Certified Nurse-Midwives Heather Bradford, CNM, ARNP, MSN, Mona Lydon-Rochelle, Ph.D., CNM Presented By: Heather Bradford, CNM, ARNP, MSN, Certified Nurse-Midwive, , Center for Women's Health at Evergreen, 930 1st Street South, Kirkland, WA 98033; Tel: 425785-2637; Fax: 425-952-0191; Email: hbradford@comcast.net Research Objective: Certified nurse-midwives (CNMs) attended nearly 10 percent of U.S. in-hospital vaginal births in 2004, representing a dramatic rise over a two decade period. CNM professional groups espouse the view that women delivered by CNMs are more likely than those delivered by physicians to be socioeconomically disadvantaged and from racial groups at high risk of adverse perinatal outcomes, are less likely to receive medical interventions and procedures, and yet have lower rates of preterm delivery and low birth weight infants. Data from live-birth certificates and hospital discharge summaries are relied upon heavily for national surveillance and research on childbirth. Despite the great importance of these data sources, the variation in accuracy by birth attendant in reporting this information has not been evaluated. The study objective was to compare the accuracy of recorded maternal medical conditions, pregnancy complications, intrapartum and postpartum events in birth certificate and hospital discharge data between physicians and certified nurse-midwives. Study Design: We conducted a population-based validation study of 19 nonfederal short-stay hospitals in Washington State. Using the medical record as our gold standard, we estimated the true-positive rates (TPRs) for maternal events between CNMs and physicians based on the birth certificate factors, hospital discharge data, and birth certificate and hospital discharge data combined. Population Studied: The study sampling frame consisted of the 26,363 women who had live births at these 19 hospitals during 2000. We restricted the analyses to the 10 hospitals that had CNM-attended births, and to women with vaginal births. For this analysis, 220 women had a CNM-attended birth, and 2479 women had a physician-attended birth. Principal Findings: The accuracy of reporting of maternal medical conditions and pregnancy complications was consistent between birth attendants except for pregnancyinduced hypertension, where CNM accuracy was greater in the birth certificate record, with a TPR of 73.3% versus 37.2%. CNMs had substantially higher TPRs than did physicians for several intrapartum and postpartum recorded birth certificate data, including premature rupture of membranes (56.0% vs. 26.1%), augmentation of labor (50.7% vs. 30.5%), and induction of labor (67.7% vs. 44.7%). CNM reporting was more accurate when examining birth certificate or hospital discharge data combined for augmentation of labor (TPR of 50.7% vs. 30.5%). No significant variation in reporting accuracy was found for hospital discharge data. Conclusions: We found that birth certificate and hospital discharge data combined had substantially higher TPRs than did birth certificate data alone for labor induction, cephalopelvic disproportion, prolonged rupture of membranes, gestational diabetes, and pregnancy-induced hypertension; however, CNMs had consistently higher TPRs relative to physicians. Our findings highlight discrepancies between type of birth attendant, which suggests that researchers conducting perinatal epidemiological studies should not rely only on birth certificate data when assessing maternal events. More studies need to be conducted which evaluate reporting accuracy among birth attendants. Future research should compare the accuracy of MD and CNM birth certificate and hospital discharge recorded data in a largepopulation based study. Implications for Policy, Delivery, or Practice: Given that CNMS deliver 10% (n=327,000) of all U.S. vaginal births each year, our findings have important implications for public health policy, clinical practice, and individual decision-making among women. If national priorities are to be established and effective interventions that improve maternal and infant health are to be practiced, the assessment of factors related to CNM and MD care using administrative data sources must be based on both accurate and comparable data. Primary Funding Source: No Funding ●Preconceptional Health and Health Care Use in the Central Pennsylvania Women’s Health Study (CePAWHS): Implications for Preconceptional Health Care Marianne Hillemeier, Ph.D., MPH, Carol S. Weisman, Ph.D., Gary A. Chase, Ph.D., Cynthia H. Chuang, MD, Sara A. Baker, MSW Presented By: Marianne Hillemeier, Ph.D., MPH, Assistant Professor, Health Policy and Administration, The Pennsylvania State University, 116 Henderson, University Park, PA 16802; Tel: 814-863-0873; Fax: 814-863-2905; Email: mmh18@psu.edu Research Objective: To analyze how the health status of preconceptional women (including women who have never been pregnant and those who have had a pregnancy) is associated with health care use, including services related to pregnancy. Study Design: Population-based random digit dial telephone survey. The thirty-minute survey included questions on health status, health risks, pregnancy history, health care access and use, and sociodemographics. Health-related variables were selected based on an integrated perinatal health framework identifying indicators of women’s health at multiple life stages. Health measures included chronic conditions, infections, mental health, health behaviors, and psychosocial stress. Health care use measures included having a regular physical examination in the past year, seeing an obstetriciangynecologist in the past two years, and talking to a health care professional in the past year about planning for pregnancy. Population Studied: 2,002 women ages 18-45 residing in a 28-county region in predominantly rural Central Pennsylvania. A subset of 1,335 women with reproductive capacity (excluding women with hysterectomies, tubal ligations, or other cause of infertility) is analyzed. Principal Findings: In factor analyses, health status and health risk variables clustered in five factors (accounting for 44% of total variance): cardiovascular risks (hypertension, high cholesterol, diabetes, obesity); biopsychosocial components of stress; substance use (tobacco, drugs, alcohol); safety and hygiene (intimate partner violence and douching); and healthy behaviors (regular physical activity, fruit and vegetable consumption). Scale scores created from these factors varied significantly by sociodemographics, reproductive life stage (preconceptional versus interconceptional), and health insurance status. Multiple logistic regression analyses for the three health care use outcomes show that cardiovascular risks and healthy behaviors increase the likelihood of receiving a regular exam, and cardiovascular risks decrease the likelihood of seeing an obstetrician-gynecologist. Age, reproductive stage, and health insurance (currently having insurance and continuity of insurance in the past year) also predicted utilization. Conclusions: The health care needs of preconceptional women are diverse and vary by sociodemographic variables. Among health status indicators, only cardiovascular risks and healthy behaviors are associated with health care use, controlling for sociodemographics and health insurance. No health variables predicted receiving counseling on pregnancy planning. Implications for Policy, Delivery, or Practice: Recent attention to reducing adverse pregnancy outcomes by improving women’s preconceptional health care (e.g., CDC Select Panel on Preconception Care) requires information on the health care needs of women who may become pregnant and on their health care use patterns. Preconceptional women with specific health care needs may not be receiving appropriate health care. Primary Funding Source: Pennsylvania Department of Health ●Major Depression Among Mothers: Diagnosis, Treatment and Disparities Sandraluz Lara-Cinisomo, Ph.D., Narayan Sastry, Ph.D. Presented By: Sandraluz Lara-Cinisomo, Ph.D., Associate Behavioral Scientist, RAND Corp., 201 N. Craig Street, Suite 202, Pittsburgh, PA 15213; Tel: 412-683-2300 x4459; Email: slara@rand.org Research Objective: In this paper, we use data from the Los Angeles Family and Neighborhood Survey (L.A.FANS) to examine disparities in diagnosis and treatment in major depression among mothers by race/ethnicity and immigration status as well as other key covariates. In addition to providing large samples of groups of interest, L.A.FANS uses an instrument that screens for a major depressive episode during the 12-month period preceding the interview. Study Design: L.A.FANS collected extensive information on the household socioeconomic status, health status including mental health, health insurance, health care utilization, and many other topics. The response rate among mothers selected for the survey was 89 percent from the 2,306, which yielded a sample of 2,052 respondents. Of the mothers who completed the survey, just over 91 percent had all of the necessary data for the analysis conducted in this study (N = 1873). L.A.FANS assessed depressive symptoms and major depression using the Comprehensive International Diagnostic Interview short form (CIDI-SF) (Kessler, Andrews, Mroczek, Ustun, & Wittchen, 1998). Population Studied: Five racial and ethnic groups are represented in the data. The largest group was Hispanic mothers (62 percent) followed by non-Hispanic whites (21 percent); there were equal proportions of non-Hispanic black and Asian and Pacific Islanders (8 percent each). Native Americans were the smallest group, making up 1 percent of the total sample. All mothers resided in Los Angeles County, CA. Principal Findings: The results indicate that 15 percent of all mothers in our sample met the classification for major depression. Racial and ethnic disparities were statistically significant, as determined by a chi-square test. White and Hispanic mothers had very similar levels of depression, while black mothers had substantially higher levels (24 percent) and Asian and Pacific Islander mothers had substantially lower levels (7 percent). Of the 285 mothers who met the criteria for depression, close to 70% had not been diagnosed with depression by a medical professional or treated for depression using psychotherapy. Among the remaining 85 mothers, 44% were diagnosed and treated, 56% were diagnosed and untreated, and 11% were undiagnosed and taking antidepressants for some other medical concern. Results show that after controlling to family characteristics (e.g., marital status), unmarried mothers were significantly (ß= .095; p < .05) more likely to be depressed compared to married mothers. Unmarried mothers were also significantly less likely to be diagnosed or treated for depression. Undocumented mothers were significantly less likely to be classified as having major depression compared to documented immigrant mothers. Conclusions: Results from this study highlight the prevalence in depression that exists among mothers. In addition, this study shows that the majority of mothers with major depression are not being diagnosed or treatment. Implications for Policy, Delivery, or Practice: Given the potentially debilitating effects of depression on an individual and the effects it can have on her children, efforts must be made toward increasing diagnosis and treatment of depression among mothers primarily among unmarried mothers who tend to have fewer support systems to buffer the potentially deleterious effects of depression. Further investigation is necessary to identify factors that protect undocumented immigrant women from major depression. Primary Funding Source: National Institute of Child Health and Human Development ●The Effect of Medicaid Family Planning Expansions on Unplanned Births Richard Lindrooth, Ph.D., Jeffrey S. McCullough, Ph.D. Presented By: Richard Lindrooth, Ph.D., Associate Professor, Center for Health Economic and Policy Studies, Medical University of South Carolina, 151B Rutledge Ave P.O. Box 250961, Charleston, SC 29425; Tel: 8437922192; Fax: 8437921358; Email: lindrorc@musc.edu Research Objective: To measure the effect of Medicaid family planning expansions on unplanned births and assess the medical cost offsets of the expansions in selected states. Study Design: We conduct a retrospective pre-post differencein-difference analysis using data from all 50 states plus the District of Columbia in 1990-2001. States that did not expand coverage are used as a control for states that did expand coverage. The model allows for the policy effect to vary with both eligibility criteria and duration since program implementation. Sub-analyses of three states (California, New Mexico, and South Carolina) that expanded coverage are conducted to assess the net economic impact of these programs. This impact is measured as the difference between Medicaid-expansion programmatic costs and the reduction in maternity and child health expenditures associated with the expansion. Multivariate regression is used to control for socio-economic characteristics. Population Studied: All births in all 50 states plus the District of Columbia in 1990-2001 from the 2003 National Vital Statistics Reports. We control for changes in demographics used data from the Department of Census. State-level changes in eligibility criteria for Medicaid coverage of family planning services is the intervention. Principal Findings: Medicaid family planning expansions significantly reduce unplanned births, particularly for women aged 25 through 39. Postpartum expansions reduce births primarily for women aged 25-34 whereas income expansions primarily affect women aged 30-39. The cost of both postpartum and income-based eligibility expansions are offset by lower delivery related costs. Conclusions: Both postpartum and income-based expansions lead to significantly lower unplanned pregnancies. Incomebased expansions may be more efficacious than postpartum expansions. The cost of the expansions is offset by reduced Medicaid expenditures on births. Implications for Policy, Delivery, or Practice: The cost of Medicaid family planning expansions is offset by health care cost savings due to fewer unplanned births. Thus a policy of increased access to family planning services will be beneficial from an economic perspective. Primary Funding Source: Berlex, Inc ●Twelve Weeks After Birth: Women, Work and Health Patricia McGovern, Ph.D., M.P.H., Dwenda Gjerdingen, M.D., MS, Bryan Dowd, Ph.D., Rada Dagher, M.P.H., Laurie Ukestad, MS, David McCaffrey, BA Presented By: Patricia McGovern, Ph.D., MPH, Associate Professor, Division of Environmental Health Sciences, University of MN, School of Public Health, Mayo BLDG., MMC 807,420 Delaware St. SE, Mpls, MN 55455; Tel: 612-6257429; Fax: 612626-4837; Email: pmcg@umn.edu Research Objective: Mothers of infants are one of the fastest growing segments of the American labor force, yet relatively little is known about the association of work characteristics on women’s recovery from childbirth. This study will identify the psychosocial work factors associated with women’s postpartum health 12 weeks after delivery. Study Design: We employ a model of health and workforce participation and a prospective cohort design to estimate a production function for maternal health. Women were recruited while hospitalized for childbirth and interviewed at enrollment, 6 and 12 weeks postpartum. Two-Stage Least Squares was used to estimate the effects of personal and employment characteristics on maternal health at twelve weeks after childbirth. Health outcomes were measured with the SF-12 for general mental and physical health and a list of 28 symptoms commonly experienced during the postpartum period. Population Studied: The population included women ages 18 and older residing in the Twin Cities, Minnesota and admitted to the hospital for childbirth in 2001. Sample selection criteria included: having had a live, singleton birth at a study hospital, speaking English, and being employed. Principal Findings: At twelve weeks postpartum, 661 women (81% of enrollees) were employed and interviewed. On average women were 30 years old; 86% were Caucasian, 88% were married, 47% were primipara, 48% had professional (vs. 14% service and 38% clerical) jobs and 50% had returned to work. On average, women slept 6.8 (SD: 1.2) hours per night, being awakened twice. Women reported an average of four postpartum symptoms (SD: 3.1), most frequently fatigue (43%), headaches (42%), back or neck pain (38%) and sexual symptoms (37%). On the SF-12, postpartum women scored slightly, but significantly higher than national norms with mean PCS scores of 55.7 (SD: 5.2) vs. 52.7 (SD: 9.1) for physical health and mean MCS scores of 50.4 (SD: 7.3) vs. 47.2 (SD: 12.1) for mental health Multivariate analyses revealed that fewer postpartum symptoms were associated with better preconception health, no prenatal mood problems, not breastfeeding, more perceived control, more social support and fewer job-related psychological demands. Better mental health was associated with no prenatal mood problems, more perceived control, more social support and less job stress. Better physical health was associated with better preconception health for all women and higher levels of coworker support for working women. Conclusions: These mothers continue to experience several childbirth-related symptoms at twelve weeks after delivery indicating a need for rest and recovery beyond the traditional postpartum period of four to six weeks. Health care providers should consider evaluating women on expected symptoms, functional limitations, fatigue and appropriate length of family and medical leave in association with return to work. Women may need assistance to identify modifiable factors that could decrease job stress and increase control over work and home including social support from family and coworkers. Implications for Policy, Delivery, or Practice: Women experiencing poorer postpartum health may need medical certification for intermittent leave (which provides for a parttime gradual return to work) rather than straight-time leave from work under the federal Family and Medical Leave Act. Primary Funding Source: National Institute for Occupational Safety & Health Related Posters Gender & Health Poster Session A Sunday, June 25 • 2:00 pm – 3:30 pm ●Direct Costs of Medical Care for Treating Hepatitis C Patients in a Veterans Affairs Medical Center. Titilope Adeniyi, BA, Yvonne Jonk, Ph.D., Eric Dieperink, M.D., Astrid Knott Johnson, Ph.D., Samuel Ho, M.D. Presented By: Titilope Adeniyi, BA, Health Science Specialist, Hepatitis C Resource Center, Minneapolis VA Medical Center, One Veterans Drive #111D2, Minneapolis, MN 55417; Tel: (612) 467-4733; Email: Titilope.Adeniyi@med.va.gov Research Objective: Of the four strains of Hepatitis C, genotype 1 is the most prevalent and difficult to treat. Genotype 1 requires 48 weeks of therapy while genotypes 2-4 (non-genotype 1) require 24 weeks of therapy. Irrespective of genotype, prior to 2001, combination therapies consisted of interferon alfa 2B and ribavirin (IR). During 2001 interferon alfa 2B was replaced with peginterferon creating a new combination-therapy (PR). Thus, patients were transitioning from interferon alfa 2B to peginterferon and received all three antiviral medications during the course of their treatment (IPR). The purpose of this study is to identify the utilization and total direct cost of medical care, including outpatient and pharmaceutical care services associated with treatment and follow-up of Hepatitis C (HCV) patients. Our secondary objective is to determine the cost per patient with a sustained viralogic response (SVR). Study Design: This study takes the intent-to-treat perspective. Outpatient utilization and pharmacy data were extracted from VA administrative databases. Cost data for outpatient care were extracted from the Health Economics Resource Center’s outpatient average cost database. Cost data for the prescriptions medication were derived from the Veterans Health Information Systems and Technology Architecture database. All costs are reported in 2003 dollars. Population Studied: 99 patients with a positive HCV enzymelinked immunoassay (EIA) test conducted at the Minneapolis VA Medical Center in calendar years 2000 – 2001 and subsequently treated with pharmacotherapy were included in the study. Principal Findings: Genotype 1 patients treated with IR (n=28), IPR (n=19), and PR (n=24) therapy, received 438.4, 796.5, and 223.5 days of antiviral medication treatment at a cost of $9,322 and $17,987 and $11,256 respectively. Nongenotype 1 patients treated with IR (n=20), IPR (n=5), and PR (n=3) therapy received an average of 226.8, 690.4 and 141.7 days of antiviral medication treatment at a cost of $7,621, $13,665 and $9,568 respectively. Genotype 1 patients treated with IR, IPR, and PR therapy and followed for a year and a half to determine cure rates averaged 16.3, 19.2, and 6.4 Hepatitis C related clinic visits at a cost of $1,787, $1,998 and $669 respectively. Non-genotype 1 patients treated with IR, IPR, and PR averaged 12.3, 9.0 and 5.3 Hepatitis C related clinic visits at a cost of $1,309, $941 and $534 respectively. The overall cost per SVR rate for the entire cohort is $33,128 (n=38). Genotype 1 patients had an overall cost per SVR rate of $44,407 (n=22). Genotype 1 IR, IPR, and PR patients had a cost per cure rate of $38,882 (n=8), $47,463 (n=8), and $47,700 (n=6) respectively. Non-genotype 1 patients had an overall cost per SVR rate of $17,620 (n=16). Non-genotype 1 IR, IPR, and PR patients had a cost per SVR rate of $13,737 (n=13), $24,343 (n=3), and ‘NA’ (n=0) respectively. Conclusions: Largely due to treatment patterns, the cost of treating genotype 1 patients is more substantial than the cost of treating non-genotype 1 patients. As treatment efficacy (%SVR) improves, the Cost per SVR decreases. Implications for Policy, Delivery, or Practice: These data represent real-world costs for hepatitis-C related care that would provide more accurate cost-benefit or cost-effectiveness analyses. Primary Funding Source: Hepatitis C Resource Center ●Increasing Chlamydia trachomatis (Ct) Screening of Young, Sexually Active Women Enrolled in Commercial Health Plans Adam Atherly, Ph.D., Sarah Blake, MA Presented By: Adam Atherly, Ph.D., Associate Professor, Health Policy and Management, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322; Tel: 404-727-1175; Fax: 404-7279198; Email: adam.atherly@emory.edu Research Objective: To identify best practices among commercial health plans to increase low Chlamydia trachomatis (Ct) screening rates among young, sexually active women. The Ct bacterium is the most frequently reported infectious disease in the United States, with total annual spending estimated to be over 2 billion dollars and an estimated 4 million new cases diagnosed each year. However, approximately 75% of women infected with Ct are asymptomatic and do not realize they are infected. Left untreated, Ct may lead to ectopic pregnancy, infertility, pelvic inflammatory disease and an increased susceptibility to human immunodeficiency virus. Routine testing is the most effective method available to identify women infected with Ct, however many women at risk for Ct are not routinely screened with only 16% of females aged 12-19 enrolled in a managed care organization had been tested for Ct during a 2 year period. NCQA reports that although the Ct screening increased by 2 percentage points in 2002, the top-performing plans still only screened 38.5 percent of sexually active women ages 16 to 26. Study Design: We used plan level NCQA quality data to identify commercial health plans. The health plans were then contacted, and qualitative interviews were conducted to identify health plan activities that lead to high Ct screening rates by providers. Population Studied: Plans were selected which were either high performing (in the top quarter of all plans) or had demonstrated an increase in Ct screening rates of at least 3 percentage points over the last 2-3 years. Interviews were restricted to plans reporting Ct screening rates to NCQA for at least 3 years, plans with enrollment of at least 1,000 commercially insured women age 15-26 years, and plans that were not staff model managed care plans. Principal Findings: Health plans demonstrated two unique sets of issues in improving the Ct screening rates. First, providers within the health plans are often unaware of the extent of Ct in commercial health plans and they often view Ct as a problem restricted to lower income, Medicaid populations. Second, health plans have problems in receiving accurate data on Ct screening rates. Most health plans indicated that if Ct screening became a HEDIS accreditation criteria, it would become more important to achieve high screening rates. Conclusions: There are several potential avenues that have been used by successful health plans to improve provider screening rates. Provider education, including “Chlamydia tool kits,” newsletters, continuing education programs, and feedback have proven successful in modifying provider behavior. Also, improved data and data collection capabilities can provider a more accurate picture of the true Ct screening rates. Implications for Policy, Delivery, or Practice: Although Ct screening rates are currently low, there are a number of possible approaches available to commercial health plans to increase Ct rates. Policy implications point to important needed improvements in women’s health and communicable disease control in privately insured populations. Primary Funding Source: AHRQ ●Social and Demographic Factors Associated with Antenatal Care Use in East Timor Domin Chan, M.H.S., Ph.C., Marcia Weaver, Ph.D., Susan Thompson, M.P.H., MaryAnne Mercer, Dr.P.H. Presented By: Domin Chan, M.H.S., Ph.C., Doctoral Candidate, Health Services, University of Washington, 6728 11th Ave NW, Seattle, WA 98117; Tel: 206-277-4159; Fax: 206764-2935; Email: dominc@u.washington.edu Research Objective: This study examines the relationship between individual factors, social factors, and antenatal care use in Timor Leste. Infant mortality in East Timor (Timor Leste) is high (70-95 per 1000 live births). Most women live in rural areas where access to health facilities is poor. Antenatal care is important to improving infant health outcomes and reducing infant mortality. Study Design: Data was taken from the first Timor Leste Demographic and General Health Survey 2003. Multivariate logistic regression was used to assess factors associated with antenatal care use and adequacy. Adequate antenatal care use, defined by the Timor Leste Ministry of Health, is at least one visit in the first and second trimesters, and at least two visits in the third trimester. Population Studied: A sample of women who had a live birth in the five years preceding the survey (N=3391) were asked about antenatal care use, frequency, and timing for the most recent birth. Principal Findings: In Timor Leste, 36.3% women had an antenatal care visit for their most recent birth and about 19.5 % had the recommended adequate use of four or more antenatal care visits. Higher education of women was significantly associated with antenatal care use and adequacy. Higher self-estimated socioeconomic status (SES) was related to antenatal care use (OR=2.4 for top 10% SES, p<0.001) but not antenatal care adequacy. Longer time to the closest health provider (10 minutes) was related to lower likelihood of antenatal care use. Electricity, which is present mainly in urban areas, was also associated with antenatal care use (OR=2.5, p<0.001) and adequacy (OR=1.7, p=0.001). Women whose most recent birth was her sixth or more were less likely to have adequate antenatal care (OR=0.65, p=0.44). The role of women in household decision-making and its relationship with antenatal care use and adequacy was more complex. Women having joint control with their husbands over social visits and medical care services were associated with adequate antenatal care use (OR= 1.7, p=0.037 and OR=1.5, p=0.038 respectively). Women who had joint control of their health care decision-making with their husbands were more likely to have adequate antenatal care use (OR=1.53, p=0.037). However, women having joint decision-making on large household purchases was associated with 32% lower odds of any antenatal care use (OR=0.67, p=0.016) and 54% lower odds of adequate antenatal care use (OR=0.46, p<0.001) than women whose husbands controlled large purchase decisions. Conclusions: Women’s education and higher socioeconomic status were positively associated with antenatal care use. Longer time or distance to the closest health provider was associated with less antenatal care use. Women who had joint control with their husbands of their social visits, health care services and health care decision-making were more likely to have adequate antenatal care use. Implications for Policy, Delivery, or Practice: Efforts to improve antenatal care use in Timor Leste might focus on enhancing women’s education and on improving access through such means as, transportation and basic infrastructure or outreach services such as mobile clinics. Poor women and those of very high parity need to be targeted for services. Primary Funding Source: No Funding ●An Exploration of the Relationship Among Gender, Comorbidities, and Pain Sheila Franco Presented By: Sheila Franco, CDC/NCHS, 3311 Toledo Road Room 6221, Hyattsville, MD 20782; Tel: 301-458-4331; Fax: 301458-4038; Email: boe5@cdc.gov Research Objective: Pain costs the nation directly in the costs to treat it, and indirectly in lower work productivity, lost work days, and job-related disability. For individuals with pain, it affects their quality of life and physical and mental functioning. In recent decades, the medical community has increasingly recognized the importance of treating and controlling pain. In general, women report more pain than men. This analysis examines differences in selected measures of reported pain by gender. In addition, it investigates whether women and men with similar comorbid conditions are as likely to report pain. Study Design: Two nationally representative surveys from the National Center for Health Statistics are used to examine pain—The National Health and Nutrition Examination Survey (NHANES) and the National Health Interview Survey (NHIS). NHANES collects data from physical exams and information on family characteristics during interviews. NHIS obtains data on illnesses, injuries, chronic conditions, and other health topics through household interviews. Different durations and types of pain are examined. Bivariate and multivariate analyses using SAS and SUDAAN are conducted. Population Studied: The analysis is limited to adults age 20 and older. Principal Findings: Results from the NHANES reveal that one-quarter of adults report experiencing pain in the past month that lasted more than 24 hours. Those reporting pain are more likely to report comorbid conditions including heart disease, thyroid conditions, stroke, and arthritis than those not reporting pain. Women report more pain—migraines, low back pain, neck pain, pain lasting more than 24 hours, and joint pain within the past year—than men, even after controlling for age and race/ethnicity. Women with heart disease are more likely to report pain than men with heart disease. Almost one-third of NHIS adult respondents report that they experienced joint pain in the past month. Women are twice as likely as men to report they had a severe headache or migraine in the past three months. Both women and men with pain are more likely to report comorbid conditions, including heart disease and arthritis. However, women with heart disease, diabetes, and obesity are more likely than men with these conditions to report pain. In contrast, women and men with arthritis and depression symptoms are equally likely to report most measures of pain. Conclusions: Experiencing pain is associated with increased reporting of comorbid conditions including heart disease and arthritis. Examining men and women with several common conditions reveals that women with heart disease, diabetes, and obesity are more likely to report pain than men with these conditions. Implications for Policy, Delivery, or Practice: Both men and women with pain report more comorbid conditions than those without pain. This may reflect poorer general health, different perceptions of pain or reporting of pain, or differential treatment of those with pain and comorbid conditions. Practitioners should be aware of differences in pain prevalence, as well as the complex relationships among pain, comorbid conditions, and gender, when evaluating patients with pain. Primary Funding Source: No Funding ●Differential Diffusion of new HIV Technologies in the U.S.: HAART as an Examplar Allen Fremont, M.D., Ph.D., David Eisenman, M.D., MSHS, Laura Bogart, Ph.D., Chloe Bird, Ph.D., Rebecca Collins, Ph.D., Daniela Golinelli, Ph.D., William Cunningham, M.D., M.P.H. Presented By: Allen Fremont, M.D., Ph.D., Natural Scientist, Health, RAND, 1776 Main Street, PO Box 2138, Santa Monica, CA 90407-2139; Tel: 310 393 0411 x7569; Email: fremont@rand.org Research Objective: We sought to examine whether diffusion of new HIV technologies is slower for women in the U.S., the source of any such disparities, and whether disparities narrow over time as technologies become more established. In investigating these issues, we considered diffusion of highly active antiretroviral therapy (HAART)in the late 1990s as a key example of an emerging technology for treating patients with HIV. Study Design: Prospective cohort study comparing rates of HAART use at 3 points in time among HIV infected individuals receiving medical care, stratified by gender/risk group (i.e., women, heterosexual men, and gay/bisexual men) and race (i.e., white, black, Latino, other). Population Studied: We examined data from 3 waves of a national probability sample of 1,421 HIV-infected adults in HIV care who were enrolled in the HIV Cost and Services Utilization Study (HCSUS) from January 1996 to December 1998. Principal Findings: There were significant differences among the three groups at every time-point. At the first two study waves, women and heterosexual men had lower use of HAART compared to gay/bisexual men. By late 1998, women were still the least likely of the three groups to receive HAART, although the gap had narrowed, and all groups had increased rates of utilization. At the final observation, 48.9% of women were receiving HAART compared to 58.1% of gay/bisexual men and 57.3% of heterosexual men (p < 0.01). Thus, the disparity decreased from approximately 100% greater HAART utilization by gay/bisexual men compared with women, to only 17%. Gender disparities in 1998 were only partially explained by women’s lower income and educational levels. Conclusions: Our findings suggest that differential diffusion can lead to gender disparities in HIV care. The diffusion of HAART between 1996 and late 1998 decreased, but did not eliminate, gender disparities favoring gay/bisexual men. Our results are consistent with diffusion theory, which posits that the diffusion of innovations happens slowest for vulnerable populations compared to more privileged groups, as newer technologies are most rapidly adopted by or provided to individuals with greater advantage. Implications for Policy, Delivery, or Practice: Policies that reduce the impact of income and education inequalities on health care may help to narrow gender disparities for new HIV technologies, but other factors may also disadvantage women. Primary Funding Source: NICHD ●Teenage Pregnancy and School Dropouts in Texas: Effect on Earnings Percy Galimbertti, M.D., M.S., Ph.D. Presented By: Percy Galimbertti, M.D., M.S., Ph.D., Research Scientist, Health Science Center, Rural and Community Health Institute, Texas A&M University, 301 Tarrow, 7th Floor, College Station, TX 77840; Tel: (979) 458-7249; Fax: (979) 458-7213; Email: galimbertti@tamhsc.edu Research Objective: Prior studies have identified negative social, psychological, and economic consequences of teenage pregnancy and school dropout event. Most of the studies on income have compared the performance of high school graduates to school dropouts. Our study investigates the effects of the dropout event because of teenage pregnancy on yearly earnings, as compared to other female dropouts who left school because of other reasons. The study also performs a descriptive analysis of the characteristics of the sample, grouped by the reasons for leaving school. Study Design: The study analyzes data from the Texas Education Agency that was incorporated into the Texas Schools Microdata Panel of the Green Center for the Study of Science and Society of the University of Texas at Dallas. The sample is composed by five cohorts of female dropouts from Texas public schools (1994 to 1998). Their yearly earnings have been constructed using data from the Texas Workforce Commission reports from 2000 to 2002. The evaluation of the impact of the dropout event due to teenage pregnancy on income uses statistical regression analyses (Ordinary Least Squares and the Heckman Selection model). Among the control variables, we included demographics, economic indicator, immigrant status, individual ability measured by the Texas Assessment of Academic Skills, and a set of different “types” of dropouts according to their reason for leaving school. Population Studied: We studied a cohort comprised of all female students who dropped out from Texas public schools between 1994 and 1998. The total number of female dropouts during that period was 62,791. However, we selected only the individuals with a recorded reason for leaving school, and those who were at most 19 years old when they left school. The final sample was comprised of 38,550 female students. Principal Findings: The regression statistical analyses show a consistent and significant negative effect (at alpha level = 0.01) of dropping out of school because of teenage pregnancy on yearly earnings, when compared to female dropouts who left school because of other reasons. Other things being equal, female students who left school because of teenage pregnancy had lower income that students who dropped out of school because of other reasons (2,800 dollars or 20% lower in a two-year period). Conclusions: In addition to the health risks associated with early motherhood and the social and psychological consequences of teenage pregnancy, female students who leave school due to teenage pregnancy have lower income levels, compared to other female school dropouts. The income disparity found in our study must be added to the already large negative effect of dropping out of school (for any reason) on earnings, when compared to other women who did not drop out of school. Implications for Policy, Delivery, or Practice: Interdisciplinary efforts are required in order to decrease the incidence of teenage pregnancy, a topic that has important social, economic, and health implications (physical and psychological). Preventive programs should include efforts to increase health literacy and awareness on this topic. Social programs should include support for young mothers in the labor market. Primary Funding Source: No Funding ●Perinatal Depression: A Systematic Review of Prevalence and Incidence Norma Gavin, Ph.D., Bradley N. Gaynes, M.D., M.P.H., Kathleen N. Lohr, Ph.D., Samantha Meltzer-Brody, M.D., M.P.H., Gerald Gartlehner, M.D., M.P.H., Tammeka Swinson, BA Presented By: Norma Gavin, Ph.D., Senior Research Economist, , RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709-2194; Tel: (919) 541-6432; Fax: (919) 990-8454; Email: gavin@rti.org Research Objective: Estimates of the prevalence of perinatal depression vary widely—from 5% to more than 25% of pregnant women and new mothers. To estimate disease burden more accurately and thereby better target and prioritize health care expenditures, we need more precise estimates of the condition’s prevalence and incidence. We systematically reviewed evidence on the prevalence and incidence of perinatal depression to determine whether adequate evidence currently exists to define a more precise estimate. Study Design: We searched MEDLINE, CINAHL, PsycINFO, and Sociofile, conducted hand searches, and consulted experts to identify English-language articles published from 1980 through March 2004 on the prevalence or incidence of perinatal depression. We included prospective cross-sectional, cohort, and case-control studies that used a structured clinical interview to assess women for major depression or minor depression during pregnancy or the first year postpartum. We excluded studies that relied solely on self-report screens and studies that did not distinguish women with major or minor depression from those with bipolar disorder, primary psychotic disorders, or maternity blues. We combined all estimates with the same diagnosis, estimate type, and time period using meta-analytic techniques and analyzed associations between the prevalence of depression and study characteristics in a series of meta-regressions. Population Studied: Pregnant women and new mothers up to 12 months after delivery and nonchildbearing women of similar age in developed countries. Principal Findings: Of the 109 articles reviewed, the 28 meeting our inclusion criteria provided 88 estimates of the point prevalence, 29 estimates of the period prevalence, 33 estimates of the incidence of perinatal depression. Only 3 studies included a comparison group. The studies were generally too small for reliable subgroup analyses. For major and minor depression together, the combined point prevalence estimates from meta-analyses ranged from 6.5% to 12.9% at different trimesters of pregnancy and months in the first postpartum year, and the combined period prevalence shows that as many as 19.2% of women have a depressive episode during the first 3 months postpartum. For major depression alone, the combined point prevalence estimates ranged from 1.0% to 5.6%, and the combined period prevalence was 7.1% during the first 3 months postpartum. Most episodes have onset following delivery. We found no significant differences between the combined estimates and the prevalence of depression among nonchildbearing women of similar age. However, all estimates have wide 95% confidence intervals, showing significant uncertainty in their true levels. The following study characteristics significantly influenced the prevalence of perinatal depression: the risk status of women at study entry, their socioeconomic status, the interview methods, and the diagnostic criteria used to identify cases. Conclusions: To better delineate periods of peak prevalence and incidence for perinatal depression and identify high risk subpopulations, we need studies with larger and more representative samples. Implications for Policy, Delivery, or Practice: Many women experience depression during the perinatal period, with potentially devastating consequences for them, their infants, and other family members. It behooves us to take opportunities provided through regular prenatal and postpartum physician contacts to screen for depression. Primary Funding Source: AHRQ ●How Accurate are Perinatal Depression Screens? A Systematic Review of the Evidence Bradley N. Gaynes, M.D., M.P.H., Norma Gavin, Ph.D., Samantha Meltzer-Brody, M.D., M.P.H., Gerald Gartlehner, M.D., M.P.H., William C. Miller, M.D., Ph.D., Kathleen Lohr, Ph.D. Presented By: Bradley N. Gaynes, M.D., M.P.H., Associate Professor of Psychiatry, Psychiatry, University of North Carolina School of Medicine, CB # 7160, Chapel Hill, NC 27599-7160; Tel: 919-966-8028; Fax: 919-843-4370; Email: bgaynes@med.unc.edu Research Objective: Pre-natal and postpartum visits provide opportunities for depression screening. Although many screening instruments have been developed or modified to detect major and minor depression in pregnant and newly delivered women, the evidence on their screening accuracy relative to a reference standard has yet to be systematically reviewed and assessed. Accordingly, we reviewed the evidence on perinatal depression screening accuracy. Study Design: We searched MEDLINE, CINAHL, PsycINFO, Sociofile, and the Cochrane Library (1980 through March 2004); performed bibliographic hand searches; and consulted experts. We selected studies that were published in English, provided original data allowing calculation of sensitivity and specificity, and confirmed depression using a reference standard. For each instrument and associated cutoff, we calculated sensitivity and specificity. When three or more studies used a specific cutoff, we estimated a pooled sensitivity and specificity using meta-analytic methods. Population Studied: Pregnant women and mothers up to one year after delivery. Studies could be conducted in any clinical setting but had to be from a developed country to increase the likelihood of being generalizable to the US population. We excluded studies that exclusively addressed bipolar disorder, a primary psychotic disorder, or maternity blues and those that included women with known depressive disorders at the outset (for whom a screen would not provide new information). We focus here on English-language instruments, given their greater relevance to our population of interest. Principal Findings: Of ninety-six articles reviewed, ten studies met inclusion criteria. In general, studies were of fair to good quality, although external validity was only poor to fair. Specifically, the study populations were nearly entirely white, so the accuracy of these screeners in other populations is unclear. A major limitation in the available evidence is the very small number of depressed patients involved, a fact that results in substantial imprecision in the point estimate of sensitivity and prevented us from determining an ideal cutoff point. For pregnant women, one study involving few depressed patients provided limited information. For postpartum women with major depression, specificity for all screeners was relatively high, but sensitivities varied considerably. The Edinburgh Postnatal Depression Scale and the Postpartum Depression Screening Scale appeared more sensitive (estimates from 0.75 to 1.0) than the Beck Depression Inventory (estimates from 0.32 to 0.68), but wide confidence intervals overlapped substantially. For postpartum women with major or minor depression, tools performed less accurately. Conclusions: Available evidence, although limited, indicates that perinatal depression screens are feasible and perform similarly to those used in primary care. Further research requires larger numbers of depressed patients and the use of more representative populations. Implications for Policy, Delivery, or Practice: Screening instruments with reasonable test characteristics appear feasible to use in a perinatal population with a depression prevalence between 5% and 10%. Since using these tools likely carries low risk and each has reasonable specificity (and, thus, a reasonable positive predictive value), maximizing sensitivity can guide tool selection. The standard cutoffs of 13 for the EPDS and 81 for the PDSS appear to be acceptable thresholds. Primary Funding Source: AHRQ, National Institute of Mental Health ●Predictors of Breast Cancer Fatalism Among Women in Mississippi Allyson Hall, Ph.D., Amal Khoury, Ph.D., Ellen Lopez, Ph.D. Presented By: Allyson Hall, Ph.D., Research Assoc Prof, Health Services Research, Management, and Policy, University of Florida, PO Box 100195, Gainesville, FL 32608; Tel: 352 273 5129; Fax: 352 273 5061; Email: ahall@phhp.ufl.edu Research Objective: Cancer fatalism, ‘the belief that cancer is death sentence’, has been shown to be a deterrent to cancer screening participation. The aim of this study was to examine predictors of breast cancer fatalism including: sociodemographic characteristics, personal and vicarious experiences with cancer, perceptions of the health care system, and knowledge about breast cancer. Study Design: This cross-sectional study examined data from a 2003 statewide survey of women (40+ years) residing in Mississippi. Survey questions were developed from an extensive literature review, and from information gathered during six focus groups conducted with women in the state. The outcome variable, ‘breast cancer fatalism’ was based on survey respondents’ level of agreement with the statement ‘breast cancer is a death sentence’. Women were classified as either having a fatalistic attitude (i.e. agreed or strongly agreed with the statement) or as not having a fatalistic attitude (i.e. disagreed or strongly disagreed with the statement). Bivariate analyses compared the characteristics of women who reported a fatalistic attitude to those who did not report a fatalistic attitude. Logistic regression examined the association between fatalism and the explanatory variables. Population Studied: The survey sample included 1,050 women. Women with a previous breast cancer diagnosis, and those who responded ‘don’t know’ to the fatalism statement were excluded from the analysis, resulting in a sample size of 958. The mean age was 59 years. Half of the women had a high-school diploma or less, about 1/3 reported a family history of breast cancer, and almost 1/3 were classified as holding fatalistic attitudes towards breast cancer. Principal Findings: Analyses revealed that women who were older, less educated, African American, and had a family history of breast cancer were more likely to hold a fatalistic attitude towards the disease. However, other characteristics such as household income, marital status, and perceived health status were not significantly associated with a fatalistic belief. Women who rated their overall quality of care negatively, and indicated that they believed that ‘doctors hide information from people of their race’ were also likely to report a fatalistic attitude, as were women who thought that ‘breast cancer cannot be cured if found early’ and that ‘treatment can be worse than the disease’. Conclusions: Although several socioeconomic characteristics were found to be related to a fatalistic attitude, a woman’s perception of their health care experiences and their attitudes about breast cancer were also important. In sum, women who had mistrust of the health care system and held negative attitudes about breast cancer treatment were more likely to be fatalistic. Implications for Policy, Delivery, or Practice: Findings from this study support the development of targeted communitybased educational programs tailored predominately toward African American women. The purpose of such educational programs would be to enhance knowledge and positive attitudes about breast cancer prevention and treatment. In addition, hospitals and other health care providers are encouraged to work towards improving overall perceptions of the delivery system. Primary Funding Source: Susan G. Koman Breast Cancer Foundation ●Demographic, Health Status, Health Insurance and Health Care Utilization Trends for Medicare Beneficiaries by Veteran Status: 1992-2002 Yvonne Jonk, Ph.D., Andrea Cutting, MA, Heidi O'Connor, MS, Tamara Schult, MS, Dowd, Bryan, Ph.D., Feldman, Roger, Ph.D. Presented By: Yvonne Jonk, Ph.D., Health Economist, Center for Chronic Disease Outcomes Research, Minneapolis VA Medical Center, One Veterans Drive 1110, Minneapolis, MN 55417; Tel: (612) 467-3882; Fax: (612) 725-2118; Email: yvonne.jonk@med.va.gov Research Objective: Analyze trends in the demographic characteristics, health status, health insurance, and health care utilization of veteran and non-veteran Medicare beneficiaries over the past decade. Given the Veterans Health Administration (VHA’s) administrative changes and expansions in eligibility guidelines in the mid-90’s, trends in veterans’ use of VHA health care services are also analyzed. Study Design: An observational study utilizing longitudinal cohort survey data. The Medicare Current Beneficiary Survey identifies veterans and serves as the primary data source in analyzing health care utilization. The data set provides comprehensive information on health and socioeconomic status, health insurance, and utilization of health care services. Population Studied: A nationally representative sample of 11,471 veteran and 38,732 non-veteran Medicare beneficiaries in 1992-2002. Principal Findings: Over the past decade, veterans consistently comprised over a quarter of Medicare beneficiaries. While the vast majority of veterans were white males over the age of 65, approximately three-quarters of nonveteran Medicare beneficiaries were female. In the early 90’s a higher percentage of veterans were in the 65-74 year age range than non-veterans with these age differences diminishing over time. While veterans were less likely to be black and less likely to be of Hispanic ethnicity, the percent Hispanic has been steadily increasing over time for both veteran and non-veteran groups. Although both groups have become better educated over time, a higher percentage of veterans have attended college, were more likely to be working, more likely to be married, and earned higher incomes than non-veterans. Although health status measures remained fairly consistent over time for both groups, a higher percentage of veterans reported no problems with Activities of Daily Living (ADLs) and Independent ADLs than non-veterans. Veterans were more likely to live in the community versus an institutional facility than non-veterans. Interestingly, the percent of veterans reporting a service connected disability declined from 14.6% in 1992 to a low of 10.4% in 2001. While the majority of veterans and non-veterans were enrolled in both Medicare A and B, the percent enrolled in Medicare HMOs has been steadily increasing from 6-7% in 1992 to almost 20% in 2000. Veterans were 6-7 times less likely to be enrolled in Medicaid than non-veterans. An increasing reliance on Medicaid was realized for both groups. Veterans’ use of VHA services increased from 10% in 1992 to 24% in 2002. While use of VHA inpatient services has held steady, all veteran Medicare beneficiaries increased their use of VHA outpatient and prescription drug services in the late 90’s. Conclusions: The veteran Medicare population appears to be less racially and ethnically diverse than non-veterans, in better health, and less reliant on Medicaid. This trend was accompanied by veterans’ increasing reliance on the VHA as an important source of coverage for outpatient and prescription drug services. Implications for Policy, Delivery, or Practice: The additional impact of an aging veteran population, the growth of the Medicare eligible veteran population, and their reliance on VHA coverage for outpatient and prescription drugs will continue to challenge VHA’s budget in the coming years. Primary Funding Source: VA ●Qualitative Research to Identify Women’s Preferences and Inform Design: Creating a New Model Smoking Cessation Program for Women Veterans Judith Katzburg, Ph.D., M.P.H., RN, Melissa Farmer, Ph.D., Ines Poza, Ph.D., Scott E. Sherman, M.D., M.P.H. Presented By: Judith Katzburg, Ph.D., M.P.H., RN, Health Services Researcher, Center for the Study of Healthcare Provider Behavior, VA Greater Los Angeles Healthcare System, 16111 Plummer St., Sepulveda, CA 91343; Tel: 818-891-7711 x5443; Fax: 818-895-5838; Email: jkatzbur@ucla.edu Research Objective: There is a high prevalence of smoking (30%) for both men and women using Veterans Health Administration services (VA); current VA tobacco control efforts appear to be less effective for women than for men. There is little available literature regarding tailoring a smoking cessation program to better meet women’s needs. Our intermediate goal was to develop a consumer-driven approach in the design of a new program. The long term goal was to develop and implement a new model smoking cessation program for women, taking into consideration women’s needs and preferences. Study Design: We conducted a series of concept development focus groups with female smokers to identify potential new smoking cessation interventions. A professional moderator led the sessions, which were audiotaped. Transcripts were reviewed by two researchers. They independently classified themes within the Ideal Program domain, based on an initial line-by-line reading using standardized techniques to examine for repetitions, similarities and differences, within and across groups, as described by Ryan & Bernard, 2003. Population Studied: Women who attended the Women’s Health Program at one of two VA sites were recruited by phone. A total of 310 women were contacted, and 45 reported being current smokers; 23 women smokers participated in one of four focus groups (group size – 5-7). Principal Findings: Within the domain Ideal Program, two key themes were generated from the focus group discussions: Support and Choice/Control. First, the women wanted support. Types of support included emotional support and education or information. Emotional support, both to quit and to prevent relapse, was discussed across all groups. Peer (other smokers) and professional support were important sources of support. Formats for providing support included individual and group models. In addition to support, the women also wanted choices and control in a smoking cessation program suggesting the need for an individualized program. The heterogeneity of women’s preferences further supported the need for an individualized program. Conclusions: The focus groups generated important hypotheses regarding the necessary components of a smoking-cessation program for women veterans. The results of these focus groups were presented to an expert panel which then designed a new smoking cessation program for women, predicated on the expressed desires of women in conjunction with current evidence-based research. It is hoped that this new menu-driven program (which offers numerous choices as to type, source, and format of the intervention as well as for sources for support) will better meet women veteran’s needs. The implementation and evaluation of a successful program will, in part, substantiate the hypotheses generated by the focus groups. Implications for Policy, Delivery, or Practice: The use of qualitative methods, to inform development of a new smoking cessation intervention designed to best meet women veteran’s needs, proved informative. Variations in preferences regarding support as well as an expressed desire for choice/control were suggestive of the need to create an individualized program. The use of focus groups to inform program design may serve as a model for creating new smoking cessation interventions for other minority or vulnerable populations. Primary Funding Source: No Funding ●Developing a Survey Item for a Health Plan Performance Measure for Osteoporosis Testing in Older Women Heather LaBelle, MA, Min Gayles, M.P.H., Lok Wong, MHS, Alix Love, M.P.H., Claudia Squire, M.P.H. Presented By: Heather LaBelle, MA, Health Care Analyst, Quality Measurement, NCQA, 2000 L Street NW, Washington, DC 20036; Tel: 202-955-3563; Fax: 202-955-3599; Email: labelle@ncqa.org Research Objective: To develop a quality of care measure for health plans to improve prevention of osteoporosis and increase appropriate treatment of osteoporosis in older women based on USPSTF guideline recommendations that women over 65 should receive routine screening for osteoporosis. Study Design: A clinical expert panel was convened to develop measurement specifications and survey questions based on existing guidelines. Cognitive testing was conducted to develop and test the survey question. Two rounds of concept testing were conducted to identify appropriate terms for the survey question. An additional two rounds of cognitive interviews were conducted to test the respondents’ question comprehension, recall, and decision processes to identify whether they had a bone density test to check for osteoporosis. Population Studied: In 2005, a total of 20 female Medicare beneficiaries 65 years and older who had not participated in a health study in the last 6 months were recruited into the study from North Carolina, representing a diverse selection of education, race, age, and osteoporosis screening and testing status. The study sample also included respondents who had a visit to a doctor and a fall or problem with balance or walking during the past year. Principal Findings: Two rounds of concept testing identified terms for osteoporosis that resonated with respondents including osteoporosis and brittle bones. The interviews also elicited that bone density test was the best term to describe osteoporosis testing. The terms selected by respondents were used to develop the survey question assessed in the two rounds of cognitive interviews. Based on the interviews, examples of where the test may be administered to differentiate this test from an x-ray were added to further clarify the question. The final question developed was: “Have you ever had a bone density test to check for osteoporosis, sometimes thought of as “brittle bones”? This test may have been done to your back, hip, wrist, heel or finger.” Conclusions: The question was well understood by older women and resonated in the population. The study validated the new survey question for a HEDIS performance measure that will assess if women at risk for osteoporosis have received a bone density test for routine screening and appropriate management. The HEDIS measure Osteoporosis Testing in Older Women will be implemented in 2006 and the survey question will be included in the Medicare Health Outcomes Survey. Implications for Policy, Delivery, or Practice: This measure will improve osteoporosis prevention and management in older women. The prevalence of osteoporosis is high among older women, placing them at higher risk for falls and osteoporotic-fractures, including debilitating hip fractures. Health plans can develop quality improvement interventions to educate patients and providers on osteoporosis. Appropriate and timely identification and management of osteoporosis will improve the quality of life of seniors. Primary Funding Source: CMS ●Talk to her: Health Care Counseling for Women in the Clinical Setting Alina Salganicoff, Ph.D., Usha Ranji, MS Presented By: Alina Salganicoff, Ph.D., Vice President, Women's Health Policy, Kaiser Family Foundation, 2400 Sand Hill Road, Menlo Park, CA 94025; Tel: 650-854-9400; Fax: 650854-4800; Email: alinas@kff.org Research Objective: To assess the extent to which women and their physicians discuss issues of primary prevention in the clinical setting. Study Design: A nationally representative telephone survey of 2,766 women ages 18 and older, in English/Spanish, was conducted on a range of health care issues such as health status, insurance, health utilization, and provider relationships. African American, Latina, and low-income women were over sampled. Population Studied: Women ages 18 and older, residing in the continental U.S. Principal Findings: While over half of adult women cite health care providers as their primary source of health information (53%), a sizable share of women report that they have not discussed several important prevention topics with a provider in the prior three years. While counseling rates were highest for diet, exercise, and nutrition (55%) and calcium and bone loss (43%), just one-third (33%) of women report discussing smoking, 29% mental health issues, and 20% alcohol or drug use with their health care provider in the past 3 years. Having a usual source of care was associated with significantly higher counseling rates. With regard to sexual health, less than one-third of reproductive age (18 to 44) women report having discussed sexual history with a provider (31%), and rates were lower for discussions about sexually transmitted diseases (28%), emergency contraception (14%), and domestic or dating violence (12%). Lower-income women and women of color were found to have higher screening rates on sexual health issues than white women. There were few differences between women who had identified that they also had an OB/GYN provider. Conclusions: Despite growing attention to the important role of early intervention and healthy behaviors in health promotion and disease prevention, a sizable share of women do not get needed counseling when they see the doctor. Provider information and counseling on health risks remains an important tool for health promotion, but needs to be improved to reach more women. Implications for Policy, Delivery, or Practice: It is increasingly becoming accepted that health care screening and counseling is part of a high quality health care experience. Despite the growing acceptance of the importance of counseling, many women are not given the information and screening that is recommended during a health care visit. With growing attention to the health care consumer’s role in maintaining their health and well-being, there is still much that needs to be done to assure that the educational opportunity in the health visit is not lost. Despite the fact that women still rely heavily on health care providers as their primary source of health care information, physicians often do not have time to offer counseling and education and are not reimbursed for the time it takes to provide these high-touch services. Furthermore, many providers may not have received the necessary training to provide counseling in these areas, particularly in the area of mental illness, sexual health, and physical abuse. Given the potential payoff in terms of healthy behaviors and prevention, this is an area that needs further attention in the clinical setting. Primary Funding Source: Foundation ●Mammography Jeremiah Schuur, M.D., Akash Shah, BS, Howard Forman, M.D., M.B.A., Cary Gross, M.D. Presented By: Jeremiah Schuur, M.D., Robert Wood Johnson Clinical Scholar, Internal Medicine, VA Medical Center, West Haven, CT & Yale University, School of Medicine, IE-61 SHM, PO Box 208088, New Haven, CT 06520-8088; Tel: 203-7375357; Fax: 203-785-3461; Email: jeremiah.schuur@yale.edu Research Objective: Women insured by Medicaid utilize mammography less frequently than women with Medicare. It is unknown if practice-level variables are a root-cause of this finding. We examined the impact of insurance type and reimbursement rates on successful scheduling of a prompt appointment for a diagnostic mammogram. Study Design: Randomized crossover experiment of mammography facilities in 11 states. To assess variation in Medicaid reimbursement we calculated a state-level Medicaid to Medicare Reimbursement Ratio (MMRR) for unilateral diagnostic mammography (CPT code 76090). We chose five states with high MMRR (mean=1.03 of Medicare; NY, NE, OK, AR and VA); five states with low MMRR (mean=0.31; MO, NJ, NH, UT and CO); and Connecticut (mid-MMRR=0.51). We chose one or two Hospital Referral Regions (HRR) per state, as defined in the Dartmouth Atlas of Healthcare, and called each facility within selected HRRs and all facilities in Connecticut. Four trained research assistants called mammography facilities as standardized patients (SPs). The SP was a 50 year old woman who recently moved to the area and needed a diagnostic mammogram to assess a recent “abnormal mammogram.” The SP stated her insurance prior to scheduling an appointment and negotiated the third next available appointment. Each facility was called twice, separated by at least one week. Insurance (Medicaid vs. Medicare) was randomized between calls. Our primary outcomes were (1) acceptance of Medicaid and/or Medicare (defined as scheduling an appointment with the SP) and (2) the wait time from call to appointment. We defined “timely” appointments as those scheduled within 20 business days. Our analysis included all facilities that performed diagnostic mammograms and where both calls were completed. We used McNemar’s test to compare the proportion of scheduled appointments by insurance type and paired T-tests to compare wait times by insurance type and MMRR. Population Studied: We called 520 mammography facilities in 11 states. Principal Findings: There was no association between Medicaid reimbursement and access to diagnostic mammography. 90% of facilities performed diagnostic mammography. We completed calls to 97.7% of eligible facilities. Overall, 381 of 432 (88.2%) facilities accepted Medicaid while 417 of 432 (96.5%) facilities accepted Medicare (p<.0001). There was no significant difference in the proportion of “timely” appointments between Medicaid and Medicare (93.6% vs. 92.8%; p=0.51). There was no significant difference between mean wait times comparing Medicaid (9.8, median=7.5) with Medicare (9.9, median=8.0; p=0.82). Insurance acceptance, timeliness and difference in wait times did not differ when stratified by MMRR (high vs. low). Conclusions: Women with Medicaid insurance do not experience significant delays in scheduling diagnostic mammograms compared to similar women with Medicare. Fewer facilities accept Medicaid than Medicare, but this is of questionable clinical significance as more than 85% accept Medicaid and timeliness didn’t differ between insurance types. Medicaid reimbursement level does not significantly impact any of our three measures of access to diagnostic mammography. Implications for Policy, Delivery, or Practice: Action to improve mammography access should focus on outreach, awareness and case management with at-risk patients and communities rather than on increasing Medicaid reimbursement for mammography providers. Primary Funding Source: Internal Funds ●Trends in Breast and Cervical Cancer Screening Rates, 1999 – 2003 Sarah Shih, M.P.H., Russell Mardon, Ph.D., Richard Dixon, M.D., FACP, Steve Coughlin, Ph.D., Mona Saraiya, M.D., M.P.H., Florence Tangka, Ph.D. Presented By: Sarah Shih, M.P.H., Senior Healthcare Analyst, Research and Analysis, National Committee for Quality Assurance, 401 Hunter Ave., City Island, NY 10464; Tel: 718885-2544; Fax: 202-955-3599; Email: shih@ncqa.org Research Objective: To evaluate the trends and regional performance of cervical and breast cancer screening as reported by the Health Plan Employer Data and Information Set (HEDIS®). Study Design: Few national data sources exist to track the quality of health care. Data collected using HEDIS specifications were used to follow the national and regional trends of cervical and breast cancer screening. Rates were calculated for commercial and Medicaid managed care organizations (MCOs) and stratified by census regions as well as for selected health plan and member characteristics. Population Studied: Commercial and Medicaid MCOs reporting HEDIS to the National Committee for Quality Assurance (NCQA) from 2000 to 2004 (services provided in calendar years 1999 to 2003). Approximately 87.5% of the commercially insured and 38.7% of the Medicaid insured are represented in the data reported in this study. Principal Findings: Overall rates of screening have increased slightly for breast and cervical cancer. The national average for cervical cancer screening rates in commercial MCOs, increased by 7.8 percentage points from 74.7%. The increase in the breast cancer screening rate was only about half a percentage point (75.4% to 75.9%). Improvement in screening rates for Medicaid MCOs was greater, with 5.7 point increase from 49.6% for breast cancer and 10 point increase from 51.5% for cervical cancer. Regional trends exhibit continued increases in each region for both screening rates. However, the gap between the highest and lowest performing regions still remains. For example, the difference in regional averages for cervical cancer screening rates in Medicaid MCOs between New England and South Central is over 20 percentage points, despite a 13 point improvement in the South Central region from 43.7% in 1999. A similar performance pattern is observed in commercial MCOs though the gap (8.8 pts) is smaller between the same regions. We further explored other explanations for the differences in performance rates, including MCO characteristics. Few characteristics were associated with plan performance, although plans that have consistently reported HEDIS data for more than one year have higher rates for all the preventive service indicators. Conclusions: Although rates have increased for breast and cervical cancer screening between 1999 and 2003, there is room for improvement, especially for cervical cancer screening and for regions that still lag behind the national average for both cancer screenings. HEDIS provides an additional data source to track trends in preventive services as similar observations regarding national trends in screening rates have been observed with data sources compiled by the National Centers for Health Statistics. However, more detailed information is needed by race/ethnicity and age groups in order to better target improvement activities. Implications for Policy, Delivery, or Practice: Health People 2010 targets for breast and cervical cancer screening rates are achievable as 75% of the commercial MCOs have met the 70% screening rate goal and about 10% of the Medicaid MCOs have done so also. However, for cervical cancer screening, only a handful of MCOs have met the 90% screening rate goal. As early detection and treatment is the most effective method for reducing deaths from breast and cervical cancer, additional information is needed to better understand what contributes to the variation in screening rates. Primary Funding Source: CDC, Through a grant from Office of Women's Health ●Gender and Safety – Diagnosis-specific Analyses of Claims Vibeke Sparring, MSc, Pia Maria Jonsson, M.D., Ph.D. Presented By: Vibeke Sparring, MSc, Ph.D. student, Medical Management Centre, Karolinska Institutet, Berzelius vag 3, Stockholm, 17177; Tel: +46852486324; Fax: +46852483600; Email: vibeke.sparring@ki.se Research Objective: The aim of the study is to identify and analyse general trends and specific problems in the management of men and women with coronary heart disease, diabetes mellitus, primary hip arthrosis and cataract based on information from the database of the Patient Insurance Fund. Specific aims of the study is: - to describe gender-specific trends in the occurrence of reported adverse events and the severity of consequent injury, - to analyse the distribution of these events on different healthcare regions, levels of care, types of healthcare organisations, personnel categories and medical specialties, - to compare the occurrence of different types of adverse events and the severity of consequent injury between men and women with the four diagnoses, - to identify specific risk situations and safety problems related to the management of men and women with the four diagnoses. Study Design: The cases registered with one of the four diagnoses were selected. All the registered cases during the corresponding periods constituted comparison groups. As a first step, the data has been analysed by looking for gender disparities in general. The second step is to analyse the material on the basis of the specific aims mentioned above. Population Studied: The Swedish Patient Insurance operates on a “no fault” principle and gives economic compensation to patients who have got physical or mental injury as a consequence of medical treatment. Compensation is granted regardless of medical responsibility or malpractice. Excluded from compensation are complications that are regarded as a part of “normal” risk-taking in medical care. Since the start in the 1970’s, more than 100,000 claims have been filed and more than 40 percent of the claims have given rise to compensation. Data about these cases are available in a numerical database, including both information about the involved healthcare provider and the patient. Since the mid 1990’s, also the cases not compensated by the insurance have been included in the database. Principal Findings: Preliminary results show that out of the 20,299 claims registered 1997-2003 (10,072,471 discharges), women accounted for 60.8% of the claims and men for 39.2%. For patients with the primary diagnosis ischemic heart disease the total number of claims where 610 (535,887 discharges), 32.8% were women and 67.2% men. Claims from patients with diabetes mellitus totalled a number of 61 (118,190 discharges), 36.1% women and 63.9% men. Hip arthrosis had 753 claims (136,561 discharges) whereof women accounted for 66.3% and men for 33.7%. Cataract surgery (19,136 discharges) led to 99 complaints. Women accounted for 60.6% of these claims and men for 39.4%. In general, women have a 3% higher payrate than men. Conclusions: The study shows that diagnosis-specific analyses could be a way of approaching this database. Disparities are generally found when combining gender and age. Having looked at IF gender disparities exists, the second phase will focuse on WHY? Implications for Policy, Delivery, or Practice: The results of the study can serve as a starting point for future genderspecific analyses of the social and economic consequences of safety problems. Primary Funding Source: No Funding ●Sustained Reduction in Neonatal Intensive Care Unit Admission Rates in a Medicaid Managed Care Program Using a Prenatal Care Program with a Strong Social Outreach Emphasis Joseph Stankaitis, M.D., M.P.H., Howard R. Brill, Ph.D., Darlene M. Walker, RN, MS, FNP, Deborah Peartree, BSN, MS, Mardy Sandler, MSW Presented By: Joseph Stankaitis, M.D., M.P.H., Chief Medical Officer, , Monroe Plan for Medical Care, 2700 Elmwood Avenue, Rochester, NY 14618; Tel: (585) 256-8425; Fax: (585) 697-1734; Email: jstankaitis@monroeplan.com Research Objective: Neonatal Intensive Care Unit (NICU) Admission Rates are an important birth outcome indicator for Medicaid managed care organizations and a major cost driver for medical expenses. The objective for this quality improvement project was to reduce NICU admission rates by at least 15% and maintain that reduction. This was to be accomplished through the development and implementation of an aggressive prenatal care program that through the use of the Center for Health Care Strategies’ Best Clinical and Administrative Practices (BCAP) Program’s principles would enhance approaches to identification, stratification, outreach, and intervention for high-risk pregnant women. Study Design: The organization performed a longitudinal, population-based review of its birth outcomes from 1997 through and including 2004 focusing on Neonatal Intensive Care Unit (NICU) Admission Rates. Return on Investment evaluation reflected attributable incremental program costs and resultant savings. Interventions initially included: enhanced identification and stratification of high-risk women with the use of a health risk assessment form; outreach through nursing care coordination offering home visits, transportation, support services, social work services, and connection to other community-based organizations; and the implementation of a strong informatics structure. Beginning in 2002, the organization contracted with a community-based organization to provide “high touch” social outreach for women with significant psychosocial problems. Population Studied: The population of concern was that of pregnant women enrolled in a Medicaid managed care program who delivered an infant. The number of live births attributed to this population started at 604 in 1998 and progressively grew to 1,778 in 2004. Principal Findings: NICU admission rates decreased from 108/1,000 births in 1998 to 57/1,000 births in 2003 and continued its sustained results in 2004 with a NICU admission rate of 35/1,000 births. There were no secular trends to impact these observations. The Return on Investment from the incremental program enhancements approaches three dollars for every dollar expended. Conclusions: A program that identifies its high-risk pregnant enrollees in a timely fashion provides outreach using a strong nursing care coordination and social work emphasis, and has a strong informatics structure should form the basis for an effective Medicaid managed care prenatal care program. It appears that the addition of “high touch” social outreach will significantly enhance improved birth outcomes for this highrisk population. The Return on Investment supports the business case for this approach. Implications for Policy, Delivery, or Practice: Implementation of aggressive, high-touch, prenatal care programs can significantly improve birth outcomes and decrease costs for low-income and working poor women enrolled in governmental programs. Primary Funding Source: The Medicaid managed care organization directly funded the project. The Robert Wood Johnson Foundation through the Center for Health Care Strategies provided the support to allow the reporting organization to participate in the BCAP Program. ●Diffusion of Innovation: The VA’s Experiment in Delivering Comprehensive Women’s Health Care Elizabeth Yano, Ph.D., MSPH, Caroline Goldzweig, M.D., M.P.H., Ismelda Canelo, BA, Donna L. Washington, M.D., M.P.H. Presented By: Elizabeth Yano, Ph.D., MSPH, Deputy Director, Research Service, VA Greater Los Angeles HSR&D Center of Excellence, 16111 Plummer Street (Mailcode 152), Sepulveda, CA 91343; Tel: (818) 895-9449; Fax: (818) 895-5838; Email: elizabeth.yano@va.gov Research Objective: Most of the 1.7 million U.S. women veterans obtain all or most of their medical care outside the Veterans Affairs (VA) health care system. However, the changing demographics of today’s military have made women veterans the fastest growing segment of new VA users. Historically, concerns about the availability and quality of women’s health services in VA medical centers led Congress to approve landmark legislation earmarking funds to enhance access to high-quality women’s health care. The VA used a portion of the appropriation to launch eight Comprehensive Women’s Health Centers (comprehensive WHCs), designed to serve as exemplars for the development of VA women’s health care throughout the system. We evaluated the evolution of VA women’s health care over the 10 years since the inception of those first programs to determine the VA’s organizational readiness for taking on women veterans’ health care needs. Study Design: In the first national assessment of how VA women’s health care is organized, we surveyed the network directors, medical center directors and senior women’s health clinicians regarding the organizational structure, service availability, and practice arrangements for delivering primary care and gender-specific services at each geographically distinct health care facility (100%, 91%, and 83% response rates, respectively). Using expert panel methods, we created an organizational taxonomy of women’s health care delivery models, applied it to these results, and compared structural and service quality differences among the original VA Comprehensive WHCs, sites that had subsequently adopted WHCs, and sites with more traditional primary care clinics (PCCs). Population Studied: All VA health care facilities serving 400 or more women veterans in the U.S. (n=166 medical centers and community-based outpatient clinics). Principal Findings: Gender-specific service availability in WHCs is roughly comparable to that of the original centers with important exceptions in mental health care, mammography services and osteoporosis management. Comprehensive WHCs were more likely to offer same-gender providers (p<.05), women’s health training programs (p<.01), separate women’s mental health clinics (p<.001) and separate space and greater privacy (p<.05); they were also open more half-days per week (7.9 vs. 5.4), had on average an additional MD (2.9 vs. 1.8) and were more likely to integrate OB-GYN MDs (2.4 vs. 0.8, p<.0001), as well as other specialty MDs and trainees compared to WHCs. These larger programs were also more likely to have undergone program closures in education (p<.001) and staffing losses (p<.05) over the previous two years compared to WHCs or PCCs. Conclusions: The VA’s investment in establishing comprehensive women’s health care in VA settings has led to a substantial expansion of access to women’s clinics over the past decade, though not of comparable size or scope of practice. Implications for Policy, Delivery, or Practice: While substantial progress has been made, diffusion of comprehensive women’s health care is as yet incomplete. More research is needed to examine the incremental differences in quality and patient satisfaction associated with these different care models and features, while the business case for managers faced with relatively small female patient caseloads should also be examined. Primary Funding Source: VA