Introduction to Bioengineering
Presented to Chabot College ENGR10 • Nov06
Ovijit Chaudhuri
PhD candidate
Department of Bioengineering,
University of California Berkeley
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 1
What is Bioengineering?
• Applying engineering techniques/analysis and
technology to biological and medical problems.
– Some areas (biomedical engineering) are focused
on medical applications and using technology for
solutions to healthcare problems (traditional).
– Others are focused on using engineering principles
and ideas to understand the way biological systems
are constructed.
• Bioengineering is very interdisciplinary encompassing
various fields.
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 2
Prosthetics – Hip replacement
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 3
Medical Imaging
• MRI, PET, CAT, etc …
Cuellar Clinic website
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 4
Biomechanics
• How stiff does the hip replacement need to be?
• What kind of loads will it experience?
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 5
Biomaterials
• Mechanical properties?
• Materials that are easy to
mold?
• What kind of materials are
biocompatible?
• Wear, tear, corrosion.
• Immune Response?
www.machinedesign.com
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 6
Improving healthcare: Lab on a chip
Devices
El-Ali, et al., Nature, 2006
Yager, et al., Nature, 2006
Whitesides,
Nature,
2006of Bioengineering, University of California Berkeley 7
Ovijit Chaudhuri,
PhD candidate
Department
Drug Delivery
Microjet injection device
Fletcher lab, UC Berkeley
Ovijit Chaudhuri, PhD candidate
Glucose sensor/ delivery device
Goughoflab,
UCSD University of California Berkeley
Department
Bioengineering,
8
Industry
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Hip replacement
Other prosthetic devices
Cardiac stents (Guidant, Johnson and Johnson)
Other cardiac devices
Drug delivery devices
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 9
Understanding the “engineering” of
biological systems - Computational Biology
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 10
Max Delbrueck Center Berlin-Buch
Understanding the “engineering” of
biological systems - Synthetic Biology
Keasling
lab, UC
Berkeley
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University
of California
Berkeley
11
Understanding the “engineering” of
biological systems -Tissue Engineering
Engler, et al., Cell, 2006
Kurpinski, et al., Cell, 2006
Nelson, et al., Science, 2006
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 12
Understanding the “engineering” of biological
systems – cell mechanics and motility
David Rogers, Vanderbilt U.
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 13
Atomic Force Microscopy
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 14
Our Atomic Force Microscope
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 15
Growing actin networks power cell
movement and provide rigidity
Ovijit
Chaudhuri,etPhD
candidate
Department of Bioengineering, University of California Berkeley 16
Svitkina,
al.,JCB,
1999
Our studies of actin networks
Parekh, et al., Nat. Cell Bio. 2005
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 17
Questions?
Ovijit Chaudhuri, PhD candidate Department of Bioengineering, University of California Berkeley 18