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Section B
The Basics of an Immune Response
Lymphocyte Cloning
Š Lymphocytes are
clonally distributed
with respect to
antigen specificity
Š Each clone of
lymphocytes has
unique membrane
receptor for antigen
10
Interaction of Lymphocytes
With Antigen Results in Clonal Expansion
11
Daughter Cells Resulting
from Clonal Expansion
Š They either
remain as
long-lived
memory
cells or
differentiate
into effector
cells
12
Memory Cells and Effector Cells
Š Memory cells
– Provide for an accelerated and more
vigorous response following a second
encounter with the same antigen
Š Effector cells
– Either directly or indirectly cause the
elimination of antigen
13
Two Main Types of Lymphocytes
T Lymphocytes
B Lymphocytes
Memory
Specificity
Distinguish Self
From Non-Self
14
Lymphocyte Maturation
15
Diversity of T Lymphocytes
16
T Effector Cells
Cytotoxic T
Lymphocytes
Š Destruction of
virus-infected host
cells
Cytokine producing
cells
Š Augmentation of
macrophage
function and other
aspects of
protective
immunity
17
18
Cytokines Produced by the Two Main Classes
of TH Cells Exert Reciprocal Antagonistic
Effects on IgE Antibody Production
19
The End-Cell of B Lymphocyte
Differentiation Is the Plasma Cell
20
Antibody Structure
21
Functions of Antibodies
Š
Š
Š
Š
Š
Lysis with complement
Opsonization for phagocytosis
Neutralization of toxins
Protection of mucosal surfaces
Transplacental transfer
22
General Schematic of Antigen
Processing and Presentation
23
T Lymphocytes Recognize Processed
Antigen Presented with “Self” (Major
Histocompatibility Complex) Molecules
24
TH Cells and the Regulation of
IgE Antibody Production
25