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Section B Health in Later Life Development, Aging, and Health Most ideas about old age include some idea of health decline So to some extent developmental stage defined by health instead of the reverse If old age is defined by declines in health, can an older adult ever be considered healthy? 3 What Is Health in Later Life? Survival Free of diseases, conditions, and impairments Able to function independently Able to maintain quality of life Meaning of last two may depend on economic and cultural context 4 Unique Features of Health in Later Life Older adults often characterized by complex combinations of disease—often chronic diseases Functional impairments also may be present “Multi-morbidities” can present challenges for medical guidelines Typical “disease” measures often replaced by measures of function and disability 5 Specific Indicators of Health in Later Life Chronic diseases and conditions Mental health Cognitive impairments/functioning Physical impairments/functional limitations Disability Frailty Comorbidity 6 Health Outcomes Included in Contemporary Demographic Surveys Source: Crimmins, E., and Seeman, T. (2001). Integrating biology into demographic research on health and aging (with a focus on the MacArthur study of successful aging). In C. E. Finch, J. W. Vaupel, and K. Kinsella (Eds.), Cells and surveys: Should biological measures be included in social science research? (pp. 9–41). The National Research Council, Committee on Population. 7 Health Care in the Context of Aging Emergency/sickness care, like younger adults Increased need for various levels of care, potentially for long periods of time Importance of informal care 8 Disability Defined as difficulty (or dependence) in doing activities that are essential to independent living - Self-care (ADLs) - Activities associated with living independently at home (IADLs) - Quality of life activities Work disability refers to inability to perform work role Primarily the result of disease or age-related change - Sometimes slow, progressive development - Sometimes acute change (e.g., fall) Source: Fried et al. (2004). Untangling the concepts of disability, frailty, and comorbidity: Implications for improved targeting and care. The Journals of Gerontology: Medical Sciences, 59A, 3, 255–263. 9 Extra-individual Factors Extra-Individual Factors Medical Care & Rehab Medications & Other Therapies External Supports Built, Physical, & Social Environment The Main Pathway Pathology Impairments Functional Limits Disability Intra-Individual Factors Risk Factors Lifestyle & Behavior Changes Psychosocial Attributes & Coping Activity Accommodations Adapted from: Verbrugge and Jette. (1994). 10 Extra-individual Factors The Main Pathway Pathology Impairments Adapted from: Verbrugge and Jette. (1994). Functional Limits Disability 11 Extra-individual Factors Intra-Individual Factors Risk Factors Lifestyle & Behavior Changes Psychosocial Attributes & Coping Activity Accommodations Adapted from: Verbrugge and Jette. (1994). 12 Extra-individual Factors Extra-Individual Factors Medical Care & Rehab Medications & Other Therapies External Supports Built, Physical, & Social Environment Adapted from: Verbrugge and Jette. (1994). 13 Measuring Disability Can be assessed both by self-report questionnaire and by performance evaluations 14 Frailty “Frailty can be defined as a physiologic state of increased vulnerability to stressors that results from decreased physiologic reserves, and even dysregulation, of multiple physiologic systems. This decreased reserve results in difficulty maintaining homeostasis in the face of perturbations.” Not context dependent 15 Cycle of Frailty 16 Measuring Frailty Characteristics of Frailty Cardiovascular Health Study Measure Shrinking: Weight loss (unintentional); Sarcopenia (loss of muscle mass) Baseline: >10 lbs lost unintentionally in prior year Weakness Grip strength: lowest 20% (by gender and BMI) Poor endurance; Exhaustion Self-report Slowness Walking time/15 feet: slowest 20% (by gender and height) Low activity kcals/week: lowest 20% Males: <383 kcals/wk Females: <270 kcals/wk Presence of Frailty Positive for frailty phenotype: ≥ 3 criteria present Intermediate or prefrail: 1 or 2 criteria present Adapted from: Fried, L. P., Tangen, C. M., Walston, J. et al. (2001). Frailty in older adults: Evidence for a phenotype. The Journals of Gerontology: Medical Sciences, 56A, 3, M146–M156. 17 Results Frailty diagnosis was predictive of falls, declines in function, hospitalization, and mortality Frailty was also associated with lower education and income Researchers are now focusing on the biological processes (i.e., etiology) underlying frailty - Frailty etiology 18